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Multimodal glycoconjugates: a molecular Lego approach for antitumoral immunotherapy

Objective

Despite significant progress in cancer therapy, current treatments are still controversial due to intolerable side effects. Targeted immunotherapy has recently emerged as an ideal alternative to improve treatment modalities for cancers patients. However, very limited approaches are available today and major issues remain to be addressed. The ERC grant offers a unique opportunity to propose a new paradigm for treating cancer. Through a ground-breaking interdisciplinary program, at the crossroad of supramolecular chemistry, synthetic chemistry, molecular engineering, biophysics, biochemistry, immunochemistry and glycoscience, it is my ambition to design, synthesize and study smart biomolecular structures with unprecedented combinations, complexity and immunological properties against cancers. To achieve this purpose, I will develop a “molecular LEGO” approach to construct synthetic molecules capable of redirecting endogenous antibodies present in the human bloodstream against tumors without preliminary immunization. Efficient tumoral killing by immune effectors will be provided by molecules combining innovative antibody and tumor binding modules that will be selected in vitro beforehand. To be successful, I will address fundamental questions that are still unresolved in chemical and biological sciences. The expected breakthroughs will represent a landmark achievement in these fields and will open promising horizons in cancer immunotherapy. Beyond this, it can be expected that our findings will pave the way to future development of synthetic molecules embedded with recognition, labeling, and/or therapeutic functions. They will thus find wider medicinal, diagnostic and even theranostic applications for which the development of more effective and selective biomolecular systems is of the utmost importance.

Field of science

  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins
  • /natural sciences/biological sciences/biochemistry/biomolecules/carbohydrates
  • /medical and health sciences/basic medicine/immunology/immunotherapy
  • /engineering and technology/other engineering and technologies/microtechnology/molecular engineering
  • /medical and health sciences/clinical medicine/cancer

Call for proposal

ERC-2014-CoG
See other projects for this call

Funding Scheme

ERC-COG - Consolidator Grant

Host institution

UNIVERSITE GRENOBLE ALPES
Address
621 Avenue Centrale
38058 Grenoble
France
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 000 000

Beneficiaries (1)

UNIVERSITE GRENOBLE ALPES
France
EU contribution
€ 2 000 000
Address
621 Avenue Centrale
38058 Grenoble
Activity type
Higher or Secondary Education Establishments