Multimodal glycoconjugates: a molecular Lego approach for antitumoral immunotherapy

Project Information

LEGO

Grant agreement ID: 647938

DOI 10.3030/647938

Project closed

EC signature date 16 July 2015

Start date 1 September 2015

End date 28 February 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 000 000,00

EU contribution € 2 000 000,00

Coordinated by

UNIVERSITE GRENOBLE ALPES
France

Publications

Peer reviewed articles (16)

Structural influence of antibody recruiting glycodendrimers (ARGs) on antitumoral cytotoxicity

Author(s): Biagio Todaro, Silvia Achilli, Benjamin Liet, Eugénie Laigre, Claire Tiertant, David Goyard, Nathalie Berthet, Olivier Renaudet
Published in: Biomaterials Science, Issue 9/11, 2021, Page(s) 4076-4085, ISSN 2047-4830
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1bm00485a

Antibody recruiting molecules (ARMs): synthetic immunotherapeutics to fight cancer

Author(s): Silvia Achilli, Nathalie Berthet, Olivier Renaudet
Published in: RSC Chemical Biology, Issue 2/3, 2021, Page(s) 713-724, ISSN 2633-0679
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1cb00007a

Heterovalent Glycodendrimers as Epitope Carriers for Antitumor Synthetic Vaccines

Author(s): Carlo Pifferi, Baptiste Thomas, David Goyard, Nathalie Berthet, Olivier Renaudet
Published in: Chemistry - A European Journal, Issue 23/64, 2017, Page(s) 16283-16296, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201702708

Synthesis of a New Series of Sialylated Homo- and Heterovalent Glycoclusters by using Orthogonal Ligations

Author(s): Gour Chand Daskhan, Carlo Pifferi, Olivier Renaudet
Published in: ChemistryOpen, Issue 5/5, 2016, Page(s) 477-484, ISSN 2191-1363
Publisher: wiley
DOI: 10.1002/open.201600062

Tailor-made Janus lectin with dual avidity assembles glycoconjugate multilayers and crosslinks protocells

Author(s): João P. Ribeiro, Sarah Villringer, David Goyard, Liliane Coche-Guerente, Manuela Höferlin, Olivier Renaudet, Winfried Römer, Anne Imberty
Published in: Chemical Science, 2018, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/C8SC02730G

The study of multivalent carbohydrate–protein interactions by bio-layer interferometry

Author(s): Eugénie Laigre, David Goyard, Claire Tiertant, Jérôme Dejeu, Olivier Renaudet
Published in: Organic & Biomolecular Chemistry, 2018, ISSN 1477-0520
Publisher: Royal Society of Chemistry
DOI: 10.1039/C8OB01664J

Identification of Nanomolar Lectin Ligands by a Glycodendrimer Microarray

Author(s): Eugénie Laigre, Claire Tiertant, David Goyard, Olivier Renaudet
Published in: ACS Omega, Issue 3/10, 2018, Page(s) 14013-14020, ISSN 2470-1343
Publisher: American Chemical Society
DOI: 10.1021/acsomega.8b01526

Cyclopeptide scaffolds in carbohydrate-based synthetic vaccines

Author(s): Carlo Pifferi, Nathalie Berthet, Olivier Renaudet
Published in: Biomater. Sci., Issue 5/5, 2017, Page(s) 953-965, ISSN 2047-4830
Publisher: Royal Society of Chemistry
DOI: 10.1039/C7BM00072C

Oxime-based glycocluster microarray

Author(s): A Hoang, Eugénie Laigre, David Goyard, Eric Defrancq, Françoise Vinet, Pascal Dumy, Olivier Renaudet
Published in: Org. Biomol. Chem., 2017, ISSN 1477-0520
Publisher: Royal Society of Chemistry
DOI: 10.1039/C7OB00889A

Synthesis of Mannosylated Glycodendrimers and Evaluation against BC2L-A Lectin from Burkholderia Cenocepacia

Author(s): Carlo Pifferi, David Goyard, Emilie Gillon, Anne Imberty, Olivier Renaudet
Published in: ChemPlusChem, Issue 82/3, 2017, Page(s) 390-398, ISSN 2192-6506
Publisher: Wiley-VCH Verlag
DOI: 10.1002/cplu.201600569

Selective high-resolution DNP-enhanced NMR of biomolecular binding sites

Author(s): Ildefonso Marin-Montesinos, David Goyard, Emilie Gillon, Olivier Renaudet, Anne Imberty, Sabine Hediger, Gaël De Paëpe
Published in: Chemical Science, Issue 10/11, 2019, Page(s) 3366-3374, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8sc05696j

Multifunctional Glycoconjugates for Recruiting Natural Antibodies against Cancer Cells

Author(s): Benjamin Liet, Eugénie Laigre, David Goyard, Biagio Todaro, Claire Tiertant, Didier Boturyn, Nathalie Berthet, Olivier Renaudet
Published in: Chemistry – A European Journal, Issue 25/68, 2019, Page(s) 15508-15515, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201903327

Heteroglycoclusters With Dual Nanomolar Affinities for the Lectins LecA and LecB From Pseudomonas aeruginosa

Author(s): David Goyard, Baptiste Thomas, Emilie Gillon, Anne Imberty, Olivier Renaudet
Published in: Frontiers in Chemistry, Issue 7, 2019, ISSN 2296-2646
Publisher: Frontiers
DOI: 10.3389/fchem.2019.00666

Multivalent glycoligands with lectin/enzyme dual specificity: self-deliverable glycosidase regulators

Author(s): Manuel González-Cuesta, David Goyard, Eiji Nanba, Katsumi Higaki, José M. García Fernández, Olivier Renaudet, Carmen Ortiz Mellet
Published in: Chemical Communications, Issue 55/85, 2019, Page(s) 12845-12848, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9cc06376e

Chemical synthesis and immunological evaluation of new generation multivalent anticancer vaccines based on a Tn antigen analogue

Author(s): Carlo Pifferi, Ane Ruiz-de-Angulo, David Goyard, Claire Tiertant, Nagore Sacristán, Diego Barriales, Nathalie Berthet, Juan Anguita, Olivier Renaudet, Alberto Fernández-Tejada
Published in: Chemical Science, Issue 11/17, 2020, Page(s) 4488-4498, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0sc00544d

Multivalent Presentations of Glycomimetic Inhibitor of the Adhesion of Fungal Pathogen Candida albicans to Human Buccal Epithelial Cells

Author(s): Harlei Martin, David Goyard, Anatte Margalit, Kyle Doherty, Olivier Renaudet, Kevin Kavanagh, Trinidad Velasco-Torrijos
Published in: Bioconjugate Chemistry, Issue 32/5, 2021, Page(s) 971-982, ISSN 1043-1802
Publisher: American Chemical Society
DOI: 10.1021/acs.bioconjchem.1c00115