Multimodal glycoconjugates: a molecular Lego approach for antitumoral immunotherapy

Informazioni relative al progetto

LEGO

ID dell’accordo di sovvenzione: 647938

DOI 10.3030/647938

Progetto chiuso

Data della firma CE 16 Luglio 2015

Data di avvio 1 Settembre 2015

Data di completamento 28 Febbraio 2021

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 2 000 000,00

Contributo UE € 2 000 000,00

Coordinato da

UNIVERSITE GRENOBLE ALPES
France

Pubblicazioni

Peer reviewed articles (16)

Structural influence of antibody recruiting glycodendrimers (ARGs) on antitumoral cytotoxicity

Autori: Biagio Todaro, Silvia Achilli, Benjamin Liet, Eugénie Laigre, Claire Tiertant, David Goyard, Nathalie Berthet, Olivier Renaudet
Pubblicato in: Biomaterials Science, Numero 9/11, 2021, Pagina/e 4076-4085, ISSN 2047-4830
Editore: Royal Society of Chemistry
DOI: 10.1039/d1bm00485a

Antibody recruiting molecules (ARMs): synthetic immunotherapeutics to fight cancer

Autori: Silvia Achilli, Nathalie Berthet, Olivier Renaudet
Pubblicato in: RSC Chemical Biology, Numero 2/3, 2021, Pagina/e 713-724, ISSN 2633-0679
Editore: Royal Society of Chemistry
DOI: 10.1039/d1cb00007a

Heterovalent Glycodendrimers as Epitope Carriers for Antitumor Synthetic Vaccines

Autori: Carlo Pifferi, Baptiste Thomas, David Goyard, Nathalie Berthet, Olivier Renaudet
Pubblicato in: Chemistry - A European Journal, Numero 23/64, 2017, Pagina/e 16283-16296, ISSN 0947-6539
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201702708

Synthesis of a New Series of Sialylated Homo- and Heterovalent Glycoclusters by using Orthogonal Ligations

Autori: Gour Chand Daskhan, Carlo Pifferi, Olivier Renaudet
Pubblicato in: ChemistryOpen, Numero 5/5, 2016, Pagina/e 477-484, ISSN 2191-1363
Editore: wiley
DOI: 10.1002/open.201600062

Tailor-made Janus lectin with dual avidity assembles glycoconjugate multilayers and crosslinks protocells

Autori: João P. Ribeiro, Sarah Villringer, David Goyard, Liliane Coche-Guerente, Manuela Höferlin, Olivier Renaudet, Winfried Römer, Anne Imberty
Pubblicato in: Chemical Science, 2018, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/C8SC02730G

The study of multivalent carbohydrate–protein interactions by bio-layer interferometry

Autori: Eugénie Laigre, David Goyard, Claire Tiertant, Jérôme Dejeu, Olivier Renaudet
Pubblicato in: Organic & Biomolecular Chemistry, 2018, ISSN 1477-0520
Editore: Royal Society of Chemistry
DOI: 10.1039/C8OB01664J

Identification of Nanomolar Lectin Ligands by a Glycodendrimer Microarray

Autori: Eugénie Laigre, Claire Tiertant, David Goyard, Olivier Renaudet
Pubblicato in: ACS Omega, Numero 3/10, 2018, Pagina/e 14013-14020, ISSN 2470-1343
Editore: American Chemical Society
DOI: 10.1021/acsomega.8b01526

Cyclopeptide scaffolds in carbohydrate-based synthetic vaccines

Autori: Carlo Pifferi, Nathalie Berthet, Olivier Renaudet
Pubblicato in: Biomater. Sci., Numero 5/5, 2017, Pagina/e 953-965, ISSN 2047-4830
Editore: Royal Society of Chemistry
DOI: 10.1039/C7BM00072C

Oxime-based glycocluster microarray

Autori: A Hoang, Eugénie Laigre, David Goyard, Eric Defrancq, Françoise Vinet, Pascal Dumy, Olivier Renaudet
Pubblicato in: Org. Biomol. Chem., 2017, ISSN 1477-0520
Editore: Royal Society of Chemistry
DOI: 10.1039/C7OB00889A

Synthesis of Mannosylated Glycodendrimers and Evaluation against BC2L-A Lectin from Burkholderia Cenocepacia

Autori: Carlo Pifferi, David Goyard, Emilie Gillon, Anne Imberty, Olivier Renaudet
Pubblicato in: ChemPlusChem, Numero 82/3, 2017, Pagina/e 390-398, ISSN 2192-6506
Editore: Wiley-VCH Verlag
DOI: 10.1002/cplu.201600569

Selective high-resolution DNP-enhanced NMR of biomolecular binding sites

Autori: Ildefonso Marin-Montesinos, David Goyard, Emilie Gillon, Olivier Renaudet, Anne Imberty, Sabine Hediger, Gaël De Paëpe
Pubblicato in: Chemical Science, Numero 10/11, 2019, Pagina/e 3366-3374, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/c8sc05696j

Multifunctional Glycoconjugates for Recruiting Natural Antibodies against Cancer Cells

Autori: Benjamin Liet, Eugénie Laigre, David Goyard, Biagio Todaro, Claire Tiertant, Didier Boturyn, Nathalie Berthet, Olivier Renaudet
Pubblicato in: Chemistry – A European Journal, Numero 25/68, 2019, Pagina/e 15508-15515, ISSN 0947-6539
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201903327

Heteroglycoclusters With Dual Nanomolar Affinities for the Lectins LecA and LecB From Pseudomonas aeruginosa

Autori: David Goyard, Baptiste Thomas, Emilie Gillon, Anne Imberty, Olivier Renaudet
Pubblicato in: Frontiers in Chemistry, Numero 7, 2019, ISSN 2296-2646
Editore: Frontiers
DOI: 10.3389/fchem.2019.00666

Multivalent glycoligands with lectin/enzyme dual specificity: self-deliverable glycosidase regulators

Autori: Manuel González-Cuesta, David Goyard, Eiji Nanba, Katsumi Higaki, José M. García Fernández, Olivier Renaudet, Carmen Ortiz Mellet
Pubblicato in: Chemical Communications, Numero 55/85, 2019, Pagina/e 12845-12848, ISSN 1359-7345
Editore: Royal Society of Chemistry
DOI: 10.1039/c9cc06376e

Chemical synthesis and immunological evaluation of new generation multivalent anticancer vaccines based on a Tn antigen analogue

Autori: Carlo Pifferi, Ane Ruiz-de-Angulo, David Goyard, Claire Tiertant, Nagore Sacristán, Diego Barriales, Nathalie Berthet, Juan Anguita, Olivier Renaudet, Alberto Fernández-Tejada
Pubblicato in: Chemical Science, Numero 11/17, 2020, Pagina/e 4488-4498, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/d0sc00544d

Multivalent Presentations of Glycomimetic Inhibitor of the Adhesion of Fungal Pathogen Candida albicans to Human Buccal Epithelial Cells

Autori: Harlei Martin, David Goyard, Anatte Margalit, Kyle Doherty, Olivier Renaudet, Kevin Kavanagh, Trinidad Velasco-Torrijos
Pubblicato in: Bioconjugate Chemistry, Numero 32/5, 2021, Pagina/e 971-982, ISSN 1043-1802
Editore: American Chemical Society
DOI: 10.1021/acs.bioconjchem.1c00115