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Bio-Inspired Tools for Glycoscience

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Publications

Norbornene-Functionalized Chitosan Hydrogels and Microgels via Unprecedented Photoinitiated Self-Assembly for Potential Biomedical Applications

Author(s): Sarah S. E. Michel, Alice Kilner, Jean-Charles Eloi, Sarah E. Rogers, Wuge H. Briscoe, M. Carmen Galan
Published in: ACS Applied Bio Materials, 3/8, 2020, Page(s) 5253-5262, ISSN 2576-6422
Publisher: American Chemical Society
DOI: 10.1021/acsabm.0c00629

Biocatalytic Transfer of Pseudaminic Acid (Pse5Ac7Ac) Using Promiscuous Sialyltransferases in a Chemoenzymatic Approach to Pse5Ac7Ac-Containing Glycosides

Author(s): Emily K. P. Flack, Harriet S. Chidwick, Goutam Guchhait, Tessa Keenan, Darshita Budhadev, Kun Huang, Peter Both, Jordi Mas Pons, Helene Ledru, Shengtao Rui, Graham P. Stafford, Jonathan G. Shaw, M. Carmen Galan, Sabine Flitsch, Gavin H. Thomas, Martin A. Fascione
Published in: ACS Catalysis, 10/17, 2020, Page(s) 9986-9993, ISSN 2155-5435
Publisher: American Chemical Society
DOI: 10.1021/acscatal.0c02189

Enhanced sampling molecular dynamics simulations correctly predict the diverse activities of a series of stiff-stilbene G-quadruplex DNA ligands

Author(s): Michael P. O'Hagan, Susanta Haldar, Juan C. Morales, Adrian J. Mulholland, M. Carmen Galan
Published in: Chemical Science, 12/4, 2021, Page(s) 1415-1426, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0sc05223j

Tunable Thiol–Ene Photo-Cross-Linked Chitosan-Based Hydrogels for Biomedical Applications

Author(s): Sarah E. S Michel, Sarah E. Rogers, Wuge H. Briscoe, M. Carmen Galan
Published in: ACS Applied Bio Materials, 3/11, 2020, Page(s) 8075-8083, ISSN 2576-6422
Publisher: American Chemical Society
DOI: 10.1021/acsabm.0c01171

Photosynthesis and crop productivity are enhanced by glucose‐functionalised carbon dots

Author(s): Thomas A. Swift, Daniel Fagan, David Benito‐Alifonso, Stephen A. Hill, Marian L. Yallop, Thomas A. A. Oliver, Tracy Lawson, M. Carmen Galan, Heather M. Whitney
Published in: New Phytologist, 229/2, 2021, Page(s) 783-790, ISSN 0028-646X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/nph.16886

Palladium-Catalyzed Direct Stereoselective Synthesis of Deoxyglycosides from Glycals

Author(s): Abhijit Sau, Ryan Williams, Carlos Palo-Nieto, Antonio Franconetti, Sandra Medina, M. Carmen Galan
Published in: Angewandte Chemie International Edition, 56/13, 2017, Page(s) 3640-3644, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201612071

Divalent Naphthalene Diimide Ligands Display High Selectivity for the Human Telomeric G-quadruplex in K + Buffer

Author(s): Steven T. G. Street, Donovan N. Chin, Gregory J. Hollingworth, Monica Berry, Juan C. Morales, M. Carmen Galan
Published in: Chemistry - A European Journal, 23/29, 2017, Page(s) 6953-6958, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201700140

Practical Three-Minute Synthesis of Acid-Coated Fluorescent Carbon Dots with Tuneable Core Structure

Author(s): Stephen A. Hill, David Benito-Alifonso, Sean A. Davis, David J. Morgan, Monica Berry, M. Carmen Galan
Published in: Scientific Reports, 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-29674-2

Surface functionalisation significantly changes the physical and electronic properties of carbon nano-dots

Author(s): Thomas A. Swift, Marta Duchi, Stephen A. Hill, David Benito-Alifonso, Robert L. Harniman, Sadiyah Sheikh, Sean A. Davis, Annela M. Seddon, Heather M. Whitney, M. Carmen Galan, Thomas A. A. Oliver
Published in: Nanoscale, 10/29, 2018, Page(s) 13908-13912, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8nr03430c

Stereoselective Glycosylation of 2-Nitrogalactals Catalyzed by a Bifunctional Organocatalyst

Author(s): Sandra Medina, Matthew J. Harper, Edward I. Balmond, Silvia Miranda, Giacomo E. M. Crisenza, Diane M. Coe, Eoghan M. McGarrigle, M. Carmen Galan
Published in: Organic Letters, 18/17, 2016, Page(s) 4222-4225, ISSN 1523-7060
Publisher: American Chemical Society
DOI: 10.1021/acs.orglett.6b01962

Three-minute synthesis of sp 3 nanocrystalline carbon dots as non-toxic fluorescent platforms for intracellular delivery

Author(s): Stephen A. Hill, David. Benito-Alifonso, David J. Morgan, Sean A. Davis, Monica Berry, M. Carmen Galan
Published in: Nanoscale, 8/44, 2016, Page(s) 18630-18634, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/C6NR07336K

Carbohydrates as enantioinduction components in stereoselective catalysis

Author(s): Alexander S. Henderson, John F. Bower, M. Carmen Galan
Published in: Org. Biomol. Chem., 14/17, 2016, Page(s) 4008-4017, ISSN 1477-0520
Publisher: Royal Society of Chemistry
DOI: 10.1039/C6OB00368K

Imidazolium-tagged glycan probes for non-covalent labeling of live cells

Author(s): David Benito-Alifonso, Shirley Tremell, Joanna C. Sadler, Monica Berry, M. Carmen Galan
Published in: Chem. Commun., 52/27, 2016, Page(s) 4906-4909, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/C5CC10040B

Palladium-Catalyzed ?-Stereoselective O -Glycosylation of O(3)-Acylated Glycals

Author(s): Abhijit Sau, M. Carmen Galan
Published in: Organic Letters, 19/11, 2017, Page(s) 2857-2860, ISSN 1523-7060
Publisher: American Chemical Society
DOI: 10.1021/acs.orglett.7b01092

Imidazolium-labeled glycosides as probes to harness glycosyltransferase activity in human breast milk

Author(s): I. Sittel, M. C. Galan
Published in: Org. Biomol. Chem., 15/17, 2017, Page(s) 3575-3579, ISSN 1477-0520
Publisher: Royal Society of Chemistry
DOI: 10.1039/C7OB00550D

Fluorescent carbon dots from mono- and polysaccharides: synthesis, properties and applications

Author(s): Stephen Hill, M Carmen Galan
Published in: Beilstein Journal of Organic Chemistry, 13, 2017, Page(s) 675-693, ISSN 1860-5397
Publisher: Beilstein-Institut
DOI: 10.3762/bjoc.13.67

Binding and Beyond: What Else Can G-Quadruplex Ligands Do?

Author(s): Michael P. O'Hagan, Juan C. Morales, M. Carmen Galan
Published in: European Journal of Organic Chemistry, 2019/31-32, 2019, Page(s) 4995-5017, ISSN 1434-193X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/ejoc.201900692

Facile Synthesis of Chitosan-Based Hydrogels and Microgels through Thiol–Ene Photoclick Cross-Linking

Author(s): Sarah E. S. Michel, Fabien Dutertre, Mark L. Denbow, M. Carmen Galan, Wuge H. Briscoe
Published in: ACS Applied Bio Materials, 2/8, 2019, Page(s) 3257-3268, ISSN 2576-6422
Publisher: American Chemical Society
DOI: 10.1021/acsabm.9b00218

Methods for 2-Deoxyglycoside Synthesis

Author(s): Clay S. Bennett, M. Carmen Galan
Published in: Chemical Reviews, 118/17, 2018, Page(s) 7931-7985, ISSN 0009-2665
Publisher: American Chemical Society
DOI: 10.1021/acs.chemrev.7b00731

A Photoresponsive Stiff‐Stilbene Ligand Fuels the Reversible Unfolding of G‐Quadruplex DNA

Author(s): Michael P. O'Hagan, Susanta Haldar, Marta Duchi, Thomas A. A. Oliver, Adrian J. Mulholland, Juan C. Morales, M. Carmen Galan
Published in: Angewandte Chemie International Edition, 58/13, 2019, Page(s) 4334-4338, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201900740

Substrate-Controlled Direct α-Stereoselective Synthesis of Deoxyglycosides from Glycals Using B(C 6 F 5 ) 3 as Catalyst

Author(s): Abhijit Sau, Carlos Palo-Nieto, M. Carmen Galan
Published in: The Journal of Organic Chemistry, 84/5, 2019, Page(s) 2415-2424, ISSN 0022-3263
Publisher: American Chemical Society
DOI: 10.1021/acs.joc.8b02613

Exploring ultraviolet photoinduced charge-transfer dynamics in a model dinucleotide of guanine and thymine

Author(s): Marta Duchi, Michael P. O’Hagan, Rhea Kumar, Simon J. Bennie, M. Carmen Galan, Basile F. E. Curchod, Thomas A. A. Oliver
Published in: Physical Chemistry Chemical Physics, 21/26, 2019, Page(s) 14407-14417, ISSN 1463-9076
Publisher: Royal Society of Chemistry
DOI: 10.1039/C8CP07864E

Selective photothermal killing of cancer cells using LED-activated nucleus targeting fluorescent carbon dots

Author(s): Stephen A. Hill, Sadiyah Sheikh, Qiaoyu Zhang, Lorena Sueiro Ballesteros, Andrew Herman, Sean A. Davis, David J. Morgan, Monica Berry, David Benito-Alifonso, M. Carmen Galan
Published in: Nanoscale Advances, 1/8, 2019, Page(s) 2840-2846, ISSN 2516-0230
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9na00293f

Stiff‐Stilbene Ligands Target G‐Quadruplex DNA and Exhibit Selective Anticancer and Antiparasitic Activity

Author(s): Michael O'Hagan, Pablo Peñalver, Rosina Fisher, Juan Carlos Morales, M. Carmen Galan
Published in: Chemistry – A European Journal, 2020, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201905753

Recent Advances in Organocatalytic Glycosylations

Author(s): Ryan Williams, M. Carmen Galan
Published in: European Journal of Organic Chemistry, 2017/42, 2017, Page(s) 6247-6264, ISSN 1434-193X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/ejoc.201700785

Copper Reactivity Can Be Tuned to Catalyze the Stereoselective Synthesis of 2-Deoxyglycosides from Glycals

Author(s): Carlos Palo-Nieto, Abhijit Sau, Robin Jeanneret, Pierre-Adrien Payard, Aude Salamé, Maristela Braga Martins-Teixeira, Ivone Carvalho, Laurence Grimaud, M. Carmen Galan
Published in: Organic Letters, 22/5, 2020, Page(s) 1991-1996, ISSN 1523-7060
Publisher: American Chemical Society
DOI: 10.1021/acs.orglett.9b04525

Gold(I)-Catalyzed Direct Stereoselective Synthesis of Deoxyglycosides from Glycals

Author(s): Carlos Palo-Nieto, Abhijit Sau, M. Carmen Galan
Published in: Journal of the American Chemical Society, 139/40, 2017, Page(s) 14041-14044, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.7b08898

Biochemical characterisation of an α1,4 galactosyltransferase from Neisseria weaveri for the synthesis of α1,4-linked galactosides

Author(s): Kun Huang, Andrea Marchesi, Kristian Hollingsworth, Peter Both, Ashley P. Mattey, Edward Pallister, Helene Ledru, Simon J. Charnock, M. Carmen Galan, W. Bruce Turnbull, Fabio Parmeggiani, Sabine L. Flitsch
Published in: Organic & Biomolecular Chemistry, 2020, ISSN 1477-0520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0ob00407c

Is UV-Induced Electron-Driven Proton Transfer Active in a Chemically Modified A·T DNA Base Pair?

Author(s): Katharina Röttger, Hugo J. B. Marroux, Arsène F. M. Chemin, Emma Elsdon, Thomas A. A. Oliver, Steven T. G. Street, Alexander S. Henderson, M. Carmen Galan, Andrew J. Orr-Ewing, Gareth M. Roberts
Published in: The Journal of Physical Chemistry B, 121/17, 2017, Page(s) 4448-4455, ISSN 1520-6106
Publisher: American Chemical Society
DOI: 10.1021/acs.jpcb.7b02679

Quantum Dot-Based Probes for Labeling and Imaging of Cells that Express Matrix Metalloproteinases

Author(s): David Benito-Alifonso, Barbara Richichi, Veronica Baldoneschi, Monica Berry, Marco Fragai, Gianluca Salerno, M. Carmen Galan, Cristina Nativi
Published in: ACS Omega, 3/8, 2018, Page(s) 9822-9826, ISSN 2470-1343
Publisher: American Chemical Society
DOI: 10.1021/acsomega.8b00633

Chemo-selective Rh-catalysed hydrogenation of azides into amines

Author(s): Mattia Ghirardello, Helene Ledru, Abhijit Sau, M. Carmen Galan
Published in: Carbohydrate Research, 489, 2020, Page(s) 107948, ISSN 0008-6215
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.carres.2020.107948

Functional nanomaterials to augment photosynthesis: evidence and considerations for their responsible use in agricultural applications

Author(s): Thomas A. Swift, Thomas A. A. Oliver, M. Carmen Galan, Heather M. Whitney
Published in: Interface Focus, 9/1, 2018, Page(s) 20180048, ISSN 2042-8898
Publisher: Royal Society Publishing
DOI: 10.1098/rsfs.2018.0048

Pseudo-enantiomeric carbohydrate-based N-heterocyclic carbenes as promising chiral ligands for enantiotopic discrimination

Author(s): Alexander S. Henderson, John F. Bower, M. Carmen Galan
Published in: Organic & Biomolecular Chemistry, 2020, ISSN 1477-0520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0ob00155d

Visible-light photoswitching of ligand binding mode suggests G-quadruplex DNA as a target for photopharmacology

Author(s): Michael P. O’Hagan, Javier Ramos-Soriano, Susanta Haldar, Sadiyah Sheikh, Juan C. Morales, Adrian J. Mulholland, M. Carmen Galan
Published in: Chemical Communications, 2020, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0cc01581d

Enzymatic synthesis of N -acetyllactosamine from lactose enabled by recombinant β1,4-galactosyltransferases

Author(s): Kun Huang, Fabio Parmeggiani, Helene Ledru, Kristian Hollingsworth, Jordi Mas Pons, Andrea Marchesi, Peter Both, Ashley P. Mattey, Edward Pallister, Gregory S. Bulmer, Jolanda M. van Munster, W. Bruce Turnbull, M. Carmen Galan, Sabine L. Flitsch
Published in: Organic & Biomolecular Chemistry, 17/24, 2019, Page(s) 5920-5924, ISSN 1477-0520
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9ob01089k

Direct Evidence of Lack of Colocalisation of Fluorescently Labelled Gold Labels Used in Correlative Light Electron Microscopy

Author(s): Benjamin T. Miles, Alexander B. Greenwood, David Benito-Alifonso, Hugh Tanner, M. Carmen Galan, Paul Verkade, Henkjan Gersen
Published in: Scientific Reports, 7/1, 2017, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/srep44666

Stereoselective Synthesis of Iminosugar 2-Deoxy(thio)glycosides from Bicyclic Iminoglycal Carbamates Promoted by Cerium(IV) Ammonium Nitrate and Cooperative Brønsted Acid-Type Organocatalysis

Author(s): Irene Herrera-González, Elena M. Sánchez-Fernández, Abhijit Sau, Cristina Nativi, José M. García Fernández, M. Carmen Galán, Carmen Ortiz Mellet
Published in: The Journal of Organic Chemistry, 85/7, 2020, Page(s) 5038-5047, ISSN 0022-3263
Publisher: American Chemical Society
DOI: 10.1021/acs.joc.0c00324

Cooperative Brønsted Acid-Type Organocatalysis for the Stereoselective Synthesis of Deoxyglycosides

Author(s): Carlos Palo-Nieto, Abhijit Sau, Ryan Williams, M. Carmen Galan
Published in: The Journal of Organic Chemistry, 82/1, 2016, Page(s) 407-414, ISSN 0022-3263
Publisher: American Chemical Society
DOI: 10.1021/acs.joc.6b02498

Chemoenzymatic synthesis of 3-deoxy-3-fluoro- l -fucose and its enzymatic incorporation into glycoconjugates

Author(s): Pablo Valverde, Jean-Baptiste Vendeville, Kristian Hollingsworth, Ashley P. Mattey, Tessa Keenan, Harriet Chidwick, Helene Ledru, Kler Huonnic, Kun Huang, Mark E. Light, Nicholas Turner, Jesús Jiménez-Barbero, M. Carmen Galan, Martin A. Fascione, Sabine Flitsch, W. Bruce Turnbull, Bruno Linclau
Published in: Chemical Communications, 56/47, 2020, Page(s) 6408-6411, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0cc02209h

Conformationally Constrained Glycosyl Donors as Tools to Control Glycosylation Outcomes

Author(s): Robin A. Jeanneret, Simon E. Johnson, M. Carmen Galan
Published in: The Journal of Organic Chemistry, 85/24, 2020, ISSN 0022-3263
Publisher: American Chemical Society
DOI: 10.1021/acs.joc.0c02045