Bio-Inspired Tools for Glycoscience

Informazioni relative al progetto

GLYCO-TOOLS

ID dell’accordo di sovvenzione: 648239

DOI 10.3030/648239

Progetto chiuso

Data della firma CE 8 Aprile 2015

Data di avvio 1 Luglio 2015

Data di completamento 31 Dicembre 2020

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 1 986 356,00

Contributo UE € 1 986 356,00

Coordinato da

UNIVERSITY OF BRISTOL
United Kingdom

Pubblicazioni

Peer reviewed articles (40)

Norbornene-Functionalized Chitosan Hydrogels and Microgels via Unprecedented Photoinitiated Self-Assembly for Potential Biomedical Applications

Autori: Sarah S. E. Michel, Alice Kilner, Jean-Charles Eloi, Sarah E. Rogers, Wuge H. Briscoe, M. Carmen Galan
Pubblicato in: ACS Applied Bio Materials, Numero 3/8, 2020, Pagina/e 5253-5262, ISSN 2576-6422
Editore: American Chemical Society
DOI: 10.1021/acsabm.0c00629

Biocatalytic Transfer of Pseudaminic Acid (Pse5Ac7Ac) Using Promiscuous Sialyltransferases in a Chemoenzymatic Approach to Pse5Ac7Ac-Containing Glycosides

Autori: Emily K. P. Flack, Harriet S. Chidwick, Goutam Guchhait, Tessa Keenan, Darshita Budhadev, Kun Huang, Peter Both, Jordi Mas Pons, Helene Ledru, Shengtao Rui, Graham P. Stafford, Jonathan G. Shaw, M. Carmen Galan, Sabine Flitsch, Gavin H. Thomas, Martin A. Fascione
Pubblicato in: ACS Catalysis, Numero 10/17, 2020, Pagina/e 9986-9993, ISSN 2155-5435
Editore: American Chemical Society
DOI: 10.1021/acscatal.0c02189

Enhanced sampling molecular dynamics simulations correctly predict the diverse activities of a series of stiff-stilbene G-quadruplex DNA ligands

Autori: Michael P. O'Hagan, Susanta Haldar, Juan C. Morales, Adrian J. Mulholland, M. Carmen Galan
Pubblicato in: Chemical Science, Numero 12/4, 2021, Pagina/e 1415-1426, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/d0sc05223j

Tunable Thiol–Ene Photo-Cross-Linked Chitosan-Based Hydrogels for Biomedical Applications

Autori: Sarah E. S Michel, Sarah E. Rogers, Wuge H. Briscoe, M. Carmen Galan
Pubblicato in: ACS Applied Bio Materials, Numero 3/11, 2020, Pagina/e 8075-8083, ISSN 2576-6422
Editore: American Chemical Society
DOI: 10.1021/acsabm.0c01171

Photosynthesis and crop productivity are enhanced by glucose‐functionalised carbon dots

Autori: Thomas A. Swift, Daniel Fagan, David Benito‐Alifonso, Stephen A. Hill, Marian L. Yallop, Thomas A. A. Oliver, Tracy Lawson, M. Carmen Galan, Heather M. Whitney
Pubblicato in: New Phytologist, Numero 229/2, 2021, Pagina/e 783-790, ISSN 0028-646X
Editore: Blackwell Publishing Inc.
DOI: 10.1111/nph.16886

Palladium-Catalyzed Direct Stereoselective Synthesis of Deoxyglycosides from Glycals

Autori: Abhijit Sau, Ryan Williams, Carlos Palo-Nieto, Antonio Franconetti, Sandra Medina, M. Carmen Galan
Pubblicato in: Angewandte Chemie International Edition, Numero 56/13, 2017, Pagina/e 3640-3644, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201612071

Divalent Naphthalene Diimide Ligands Display High Selectivity for the Human Telomeric G-quadruplex in K + Buffer

Autori: Steven T. G. Street, Donovan N. Chin, Gregory J. Hollingworth, Monica Berry, Juan C. Morales, M. Carmen Galan
Pubblicato in: Chemistry - A European Journal, Numero 23/29, 2017, Pagina/e 6953-6958, ISSN 0947-6539
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201700140

Practical Three-Minute Synthesis of Acid-Coated Fluorescent Carbon Dots with Tuneable Core Structure

Autori: Stephen A. Hill, David Benito-Alifonso, Sean A. Davis, David J. Morgan, Monica Berry, M. Carmen Galan
Pubblicato in: Scientific Reports, Numero 8/1, 2018, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-018-29674-2

Surface functionalisation significantly changes the physical and electronic properties of carbon nano-dots

Autori: Thomas A. Swift, Marta Duchi, Stephen A. Hill, David Benito-Alifonso, Robert L. Harniman, Sadiyah Sheikh, Sean A. Davis, Annela M. Seddon, Heather M. Whitney, M. Carmen Galan, Thomas A. A. Oliver
Pubblicato in: Nanoscale, Numero 10/29, 2018, Pagina/e 13908-13912, ISSN 2040-3364
Editore: Royal Society of Chemistry
DOI: 10.1039/c8nr03430c

Stereoselective Glycosylation of 2-Nitrogalactals Catalyzed by a Bifunctional Organocatalyst

Autori: Sandra Medina, Matthew J. Harper, Edward I. Balmond, Silvia Miranda, Giacomo E. M. Crisenza, Diane M. Coe, Eoghan M. McGarrigle, M. Carmen Galan
Pubblicato in: Organic Letters, Numero 18/17, 2016, Pagina/e 4222-4225, ISSN 1523-7060
Editore: American Chemical Society
DOI: 10.1021/acs.orglett.6b01962

Three-minute synthesis of sp 3 nanocrystalline carbon dots as non-toxic fluorescent platforms for intracellular delivery

Autori: Stephen A. Hill, David. Benito-Alifonso, David J. Morgan, Sean A. Davis, Monica Berry, M. Carmen Galan
Pubblicato in: Nanoscale, Numero 8/44, 2016, Pagina/e 18630-18634, ISSN 2040-3364
Editore: Royal Society of Chemistry
DOI: 10.1039/C6NR07336K

Carbohydrates as enantioinduction components in stereoselective catalysis

Autori: Alexander S. Henderson, John F. Bower, M. Carmen Galan
Pubblicato in: Org. Biomol. Chem., Numero 14/17, 2016, Pagina/e 4008-4017, ISSN 1477-0520
Editore: Royal Society of Chemistry
DOI: 10.1039/C6OB00368K

Imidazolium-tagged glycan probes for non-covalent labeling of live cells

Autori: David Benito-Alifonso, Shirley Tremell, Joanna C. Sadler, Monica Berry, M. Carmen Galan
Pubblicato in: Chem. Commun., Numero 52/27, 2016, Pagina/e 4906-4909, ISSN 1359-7345
Editore: Royal Society of Chemistry
DOI: 10.1039/C5CC10040B

Palladium-Catalyzed ?-Stereoselective O -Glycosylation of O(3)-Acylated Glycals

Autori: Abhijit Sau, M. Carmen Galan
Pubblicato in: Organic Letters, Numero 19/11, 2017, Pagina/e 2857-2860, ISSN 1523-7060
Editore: American Chemical Society
DOI: 10.1021/acs.orglett.7b01092

Imidazolium-labeled glycosides as probes to harness glycosyltransferase activity in human breast milk

Autori: I. Sittel, M. C. Galan
Pubblicato in: Org. Biomol. Chem., Numero 15/17, 2017, Pagina/e 3575-3579, ISSN 1477-0520
Editore: Royal Society of Chemistry
DOI: 10.1039/C7OB00550D

Fluorescent carbon dots from mono- and polysaccharides: synthesis, properties and applications

Autori: Stephen Hill, M Carmen Galan
Pubblicato in: Beilstein Journal of Organic Chemistry, Numero 13, 2017, Pagina/e 675-693, ISSN 1860-5397
Editore: Beilstein-Institut
DOI: 10.3762/bjoc.13.67

Binding and Beyond: What Else Can G-Quadruplex Ligands Do?

Autori: Michael P. O'Hagan, Juan C. Morales, M. Carmen Galan
Pubblicato in: European Journal of Organic Chemistry, Numero 2019/31-32, 2019, Pagina/e 4995-5017, ISSN 1434-193X
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/ejoc.201900692

Facile Synthesis of Chitosan-Based Hydrogels and Microgels through Thiol–Ene Photoclick Cross-Linking

Autori: Sarah E. S. Michel, Fabien Dutertre, Mark L. Denbow, M. Carmen Galan, Wuge H. Briscoe
Pubblicato in: ACS Applied Bio Materials, Numero 2/8, 2019, Pagina/e 3257-3268, ISSN 2576-6422
Editore: American Chemical Society
DOI: 10.1021/acsabm.9b00218

Methods for 2-Deoxyglycoside Synthesis

Autori: Clay S. Bennett, M. Carmen Galan
Pubblicato in: Chemical Reviews, Numero 118/17, 2018, Pagina/e 7931-7985, ISSN 0009-2665
Editore: American Chemical Society
DOI: 10.1021/acs.chemrev.7b00731

A Photoresponsive Stiff‐Stilbene Ligand Fuels the Reversible Unfolding of G‐Quadruplex DNA

Autori: Michael P. O'Hagan, Susanta Haldar, Marta Duchi, Thomas A. A. Oliver, Adrian J. Mulholland, Juan C. Morales, M. Carmen Galan
Pubblicato in: Angewandte Chemie International Edition, Numero 58/13, 2019, Pagina/e 4334-4338, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201900740

Substrate-Controlled Direct α-Stereoselective Synthesis of Deoxyglycosides from Glycals Using B(C 6 F 5 ) 3 as Catalyst

Autori: Abhijit Sau, Carlos Palo-Nieto, M. Carmen Galan
Pubblicato in: The Journal of Organic Chemistry, Numero 84/5, 2019, Pagina/e 2415-2424, ISSN 0022-3263
Editore: American Chemical Society
DOI: 10.1021/acs.joc.8b02613

Exploring ultraviolet photoinduced charge-transfer dynamics in a model dinucleotide of guanine and thymine

Autori: Marta Duchi, Michael P. O’Hagan, Rhea Kumar, Simon J. Bennie, M. Carmen Galan, Basile F. E. Curchod, Thomas A. A. Oliver
Pubblicato in: Physical Chemistry Chemical Physics, Numero 21/26, 2019, Pagina/e 14407-14417, ISSN 1463-9076
Editore: Royal Society of Chemistry
DOI: 10.1039/C8CP07864E

Selective photothermal killing of cancer cells using LED-activated nucleus targeting fluorescent carbon dots

Autori: Stephen A. Hill, Sadiyah Sheikh, Qiaoyu Zhang, Lorena Sueiro Ballesteros, Andrew Herman, Sean A. Davis, David J. Morgan, Monica Berry, David Benito-Alifonso, M. Carmen Galan
Pubblicato in: Nanoscale Advances, Numero 1/8, 2019, Pagina/e 2840-2846, ISSN 2516-0230
Editore: Royal Society of Chemistry
DOI: 10.1039/c9na00293f

Stiff‐Stilbene Ligands Target G‐Quadruplex DNA and Exhibit Selective Anticancer and Antiparasitic Activity

Autori: Michael O'Hagan, Pablo Peñalver, Rosina Fisher, Juan Carlos Morales, M. Carmen Galan
Pubblicato in: Chemistry – A European Journal, 2020, ISSN 0947-6539
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201905753

Recent Advances in Organocatalytic Glycosylations

Autori: Ryan Williams, M. Carmen Galan
Pubblicato in: European Journal of Organic Chemistry, Numero 2017/42, 2017, Pagina/e 6247-6264, ISSN 1434-193X
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/ejoc.201700785

Copper Reactivity Can Be Tuned to Catalyze the Stereoselective Synthesis of 2-Deoxyglycosides from Glycals

Autori: Carlos Palo-Nieto, Abhijit Sau, Robin Jeanneret, Pierre-Adrien Payard, Aude Salamé, Maristela Braga Martins-Teixeira, Ivone Carvalho, Laurence Grimaud, M. Carmen Galan
Pubblicato in: Organic Letters, Numero 22/5, 2020, Pagina/e 1991-1996, ISSN 1523-7060
Editore: American Chemical Society
DOI: 10.1021/acs.orglett.9b04525

Gold(I)-Catalyzed Direct Stereoselective Synthesis of Deoxyglycosides from Glycals

Autori: Carlos Palo-Nieto, Abhijit Sau, M. Carmen Galan
Pubblicato in: Journal of the American Chemical Society, Numero 139/40, 2017, Pagina/e 14041-14044, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.7b08898

Biochemical characterisation of an α1,4 galactosyltransferase from Neisseria weaveri for the synthesis of α1,4-linked galactosides

Autori: Kun Huang, Andrea Marchesi, Kristian Hollingsworth, Peter Both, Ashley P. Mattey, Edward Pallister, Helene Ledru, Simon J. Charnock, M. Carmen Galan, W. Bruce Turnbull, Fabio Parmeggiani, Sabine L. Flitsch
Pubblicato in: Organic & Biomolecular Chemistry, 2020, ISSN 1477-0520
Editore: Royal Society of Chemistry
DOI: 10.1039/d0ob00407c

Is UV-Induced Electron-Driven Proton Transfer Active in a Chemically Modified A·T DNA Base Pair?

Autori: Katharina Röttger, Hugo J. B. Marroux, Arsène F. M. Chemin, Emma Elsdon, Thomas A. A. Oliver, Steven T. G. Street, Alexander S. Henderson, M. Carmen Galan, Andrew J. Orr-Ewing, Gareth M. Roberts
Pubblicato in: The Journal of Physical Chemistry B, Numero 121/17, 2017, Pagina/e 4448-4455, ISSN 1520-6106
Editore: American Chemical Society
DOI: 10.1021/acs.jpcb.7b02679

Quantum Dot-Based Probes for Labeling and Imaging of Cells that Express Matrix Metalloproteinases

Autori: David Benito-Alifonso, Barbara Richichi, Veronica Baldoneschi, Monica Berry, Marco Fragai, Gianluca Salerno, M. Carmen Galan, Cristina Nativi
Pubblicato in: ACS Omega, Numero 3/8, 2018, Pagina/e 9822-9826, ISSN 2470-1343
Editore: American Chemical Society
DOI: 10.1021/acsomega.8b00633

Chemo-selective Rh-catalysed hydrogenation of azides into amines

Autori: Mattia Ghirardello, Helene Ledru, Abhijit Sau, M. Carmen Galan
Pubblicato in: Carbohydrate Research, Numero 489, 2020, Pagina/e 107948, ISSN 0008-6215
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.carres.2020.107948

Functional nanomaterials to augment photosynthesis: evidence and considerations for their responsible use in agricultural applications

Autori: Thomas A. Swift, Thomas A. A. Oliver, M. Carmen Galan, Heather M. Whitney
Pubblicato in: Interface Focus, Numero 9/1, 2018, Pagina/e 20180048, ISSN 2042-8898
Editore: Royal Society Publishing
DOI: 10.1098/rsfs.2018.0048

Pseudo-enantiomeric carbohydrate-based N-heterocyclic carbenes as promising chiral ligands for enantiotopic discrimination

Autori: Alexander S. Henderson, John F. Bower, M. Carmen Galan
Pubblicato in: Organic & Biomolecular Chemistry, 2020, ISSN 1477-0520
Editore: Royal Society of Chemistry
DOI: 10.1039/d0ob00155d

Visible-light photoswitching of ligand binding mode suggests G-quadruplex DNA as a target for photopharmacology

Autori: Michael P. O’Hagan, Javier Ramos-Soriano, Susanta Haldar, Sadiyah Sheikh, Juan C. Morales, Adrian J. Mulholland, M. Carmen Galan
Pubblicato in: Chemical Communications, 2020, ISSN 1359-7345
Editore: Royal Society of Chemistry
DOI: 10.1039/d0cc01581d

Enzymatic synthesis of N -acetyllactosamine from lactose enabled by recombinant β1,4-galactosyltransferases

Autori: Kun Huang, Fabio Parmeggiani, Helene Ledru, Kristian Hollingsworth, Jordi Mas Pons, Andrea Marchesi, Peter Both, Ashley P. Mattey, Edward Pallister, Gregory S. Bulmer, Jolanda M. van Munster, W. Bruce Turnbull, M. Carmen Galan, Sabine L. Flitsch
Pubblicato in: Organic & Biomolecular Chemistry, Numero 17/24, 2019, Pagina/e 5920-5924, ISSN 1477-0520
Editore: Royal Society of Chemistry
DOI: 10.1039/c9ob01089k

Direct Evidence of Lack of Colocalisation of Fluorescently Labelled Gold Labels Used in Correlative Light Electron Microscopy

Autori: Benjamin T. Miles, Alexander B. Greenwood, David Benito-Alifonso, Hugh Tanner, M. Carmen Galan, Paul Verkade, Henkjan Gersen
Pubblicato in: Scientific Reports, Numero 7/1, 2017, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/srep44666

Stereoselective Synthesis of Iminosugar 2-Deoxy(thio)glycosides from Bicyclic Iminoglycal Carbamates Promoted by Cerium(IV) Ammonium Nitrate and Cooperative Brønsted Acid-Type Organocatalysis

Autori: Irene Herrera-González, Elena M. Sánchez-Fernández, Abhijit Sau, Cristina Nativi, José M. García Fernández, M. Carmen Galán, Carmen Ortiz Mellet
Pubblicato in: The Journal of Organic Chemistry, Numero 85/7, 2020, Pagina/e 5038-5047, ISSN 0022-3263
Editore: American Chemical Society
DOI: 10.1021/acs.joc.0c00324

Cooperative Brønsted Acid-Type Organocatalysis for the Stereoselective Synthesis of Deoxyglycosides

Autori: Carlos Palo-Nieto, Abhijit Sau, Ryan Williams, M. Carmen Galan
Pubblicato in: The Journal of Organic Chemistry, Numero 82/1, 2016, Pagina/e 407-414, ISSN 0022-3263
Editore: American Chemical Society
DOI: 10.1021/acs.joc.6b02498

Chemoenzymatic synthesis of 3-deoxy-3-fluoro- l -fucose and its enzymatic incorporation into glycoconjugates

Autori: Pablo Valverde, Jean-Baptiste Vendeville, Kristian Hollingsworth, Ashley P. Mattey, Tessa Keenan, Harriet Chidwick, Helene Ledru, Kler Huonnic, Kun Huang, Mark E. Light, Nicholas Turner, Jesús Jiménez-Barbero, M. Carmen Galan, Martin A. Fascione, Sabine Flitsch, W. Bruce Turnbull, Bruno Linclau
Pubblicato in: Chemical Communications, Numero 56/47, 2020, Pagina/e 6408-6411, ISSN 1359-7345
Editore: Royal Society of Chemistry
DOI: 10.1039/d0cc02209h

Conformationally Constrained Glycosyl Donors as Tools to Control Glycosylation Outcomes

Autori: Robin A. Jeanneret, Simon E. Johnson, M. Carmen Galan
Pubblicato in: The Journal of Organic Chemistry, Numero 85/24, 2020, ISSN 0022-3263
Editore: American Chemical Society
DOI: 10.1021/acs.joc.0c02045