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IL-7/IL-7R signaling networks in health and malignancy

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Publications

From the outside, from within: Biological and therapeutic relevance of signal transduction in T-cell acute lymphoblastic leukemia

Author(s): Mariana L. Oliveira, Padma Akkapeddi, Isabel Alcobia, Afonso R. Almeida, Bruno A. Cardoso, Rita Fragoso, Teresa L. Serafim, João T. Barata
Published in: Cellular Signalling, Issue 38, 2017, Page(s) 10-25, ISSN 0898-6568
DOI: 10.1016/j.cellsig.2017.06.011

Therapeutic targeting of CK2 in acute and chronic leukemias

Author(s): F Buontempo, J A McCubrey, E Orsini, M Ruzzene, A Cappellini, A Lonetti, C Evangelisti, F Chiarini, C Evangelisti, J T Barata, A M Martelli
Published in: Leukemia, Issue 32/1, 2017, Page(s) 1-10, ISSN 0887-6924
DOI: 10.1038/leu.2017.301

IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia: An update

Author(s): Mariana L. Oliveira, Padma Akkapeddi, Daniel Ribeiro, Alice Melão, João T. Barata
Published in: Advances in Biological Regulation, 2018, ISSN 2212-4926
DOI: 10.1016/j.jbior.2018.09.012

STAT5 is essential for IL-7–mediated viability, growth, and proliferation of T-cell acute lymphoblastic leukemia cells

Author(s): Daniel Ribeiro, Alice Melão, Ruben van Boxtel, Cristina I. Santos, Ana Silva, Milene C. Silva, Bruno A. Cardoso, Paul J. Coffer, João T. Barata
Published in: Blood Advances, Issue 2/17, 2018, Page(s) 2199-2213, ISSN 2473-9529
DOI: 10.1182/bloodadvances.2018021063

Optimal interleukin-7 receptor-mediated signaling, cell cycle progression and viability of T-cell acute lymphoblastic leukemia cells rely on casein kinase 2 activity

Author(s): Alice Melão, Maureen Spit, Bruno A. Cardoso, João T. Barata
Published in: Haematologica, Issue 101/11, 2016, Page(s) 1368-1379, ISSN 0390-6078
DOI: 10.3324/haematol.2015.141143

A fully human anti-IL-7Rα antibody promotes antitumor activity against T-cell acute lymphoblastic leukemia

Author(s): Padma Akkapeddi, Rita Fragoso, Julie A. Hixon, Ana Sofia Ramalho, Mariana L. Oliveira, Tânia Carvalho, Andreas Gloger, Mattia Matasci, Francisco Corzana, Scott K. Durum, Dario Neri, Gonçalo J. L. Bernardes, João T. Barata
Published in: Leukemia, Issue 33/9, 2019, Page(s) 2155-2168, ISSN 0887-6924
DOI: 10.1038/s41375-019-0434-8

MicroRNAs and their involvement in T-ALL: A brief overview

Author(s): Nádia C. Correia, João T. Barata
Published in: Advances in Biological Regulation, Issue 74, 2019, Page(s) 100650, ISSN 2212-4926
DOI: 10.1016/j.jbior.2019.100650

NRARP displays either pro- or anti-tumoral roles in T-cell acute lymphoblastic leukemia depending on Notch and Wnt signaling

Author(s): Inês Pinto, Mafalda Duque, Joana Gonçalves, Padma Akkapeddi, Mariana L. Oliveira, Rita Cabrita, J. Andrés Yunes, Scott K. Durum, João T. Barata, Rita Fragoso
Published in: Oncogene, Issue 39/5, 2020, Page(s) 975-986, ISSN 0950-9232
DOI: 10.1038/s41388-019-1042-9

Flip the coin: IL-7 and IL-7R in health and disease

Author(s): João T. Barata, Scott K. Durum, Benedict Seddon
Published in: Nature Immunology, Issue 20/12, 2019, Page(s) 1584-1593, ISSN 1529-2908
DOI: 10.1038/s41590-019-0479-x

Introduction to the special issue on T-cell acute lymphoblastic leukemia genetics, biology and therapeutics

Author(s): João T. Barata
Published in: Advances in Biological Regulation, Issue 74, 2019, Page(s) 100671, ISSN 2212-4926
DOI: 10.1016/j.jbior.2019.100671

T-cell acute lymphoblastic leukemia displays autocrine production of Interleukin-7

Author(s): Anne Buffière, Benjamin Uzan, Romain Aucagne, François Hermetet, Manon Mas, Sandra Nassurdine, Aziza Aznague, Virginie Carmignac, Benjamin Tournier, Olivier Bouchot, Paola Ballerini, João T. Barata, Jean-Noël Bastie, Laurent Delva, Françoise Pflumio, Ronan Quéré
Published in: Oncogene, Issue 38/48, 2019, Page(s) 7357-7365, ISSN 0950-9232
DOI: 10.1038/s41388-019-0921-4

New anti-IL-7Rα monoclonal antibodies show efficacy against T cell acute lymphoblastic leukemia in pre-clinical models

Author(s): Julie A. Hixon, Caroline Andrews, Lila Kashi, Casey L. Kohnhorst, Emilee Senkevitch, Kelli Czarra, Joao T. Barata, Wenqing Li, Joel P. Schneider, Scott T. R. Walsh, Scott K. Durum
Published in: Leukemia, Issue 34/1, 2020, Page(s) 35-49, ISSN 0887-6924
DOI: 10.1038/s41375-019-0531-8