Skip to main content

IL-7/IL-7R signaling networks in health and malignancy

Searching for OpenAIRE data...

Publications

Overexpression of wild-type IL-7Rα promotes T-cell acute lymphoblastic leukemia/lymphoma

Author(s): Ana Silva, Afonso R. M. Almeida, Ana Cachucho, João L. Neto, Sofie Demeyer, Mafalda de Matos, Thea Hogan, Yunlei Li, Jules Meijerink, Jan Cools, Ana Rita Grosso, Benedict Seddon, João T. Barata
Published in: Blood, 138/12, 2021, Page(s) 1040-1052, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood.2019000553

Interleukin-7 receptor α mutational activation can initiate precursor B-cell acute lymphoblastic leukemia

Author(s): Afonso R. M. Almeida, João L. Neto, Ana Cachucho, Mayara Euzébio, Xiangyu Meng, Rathana Kim, Marta B. Fernandes, Beatriz Raposo, Mariana L. Oliveira, Daniel Ribeiro, Rita Fragoso, Priscila P. Zenatti, Tiago Soares, Mafalda R. de Matos, Juliana Ronchi Corrêa, Mafalda Duque, Kathryn G. Roberts, Zhaohui Gu, Chunxu Qu, Clara Pereira, Susan Pyne, Nigel J. Pyne, Vasco M. Barreto, Isabelle Bernard-Pie
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-27197-5

IL-7-Induced Proliferation of Human Naive CD4 T-Cells Relies on Continued Thymic Activity

Author(s): Susana L. Silva, Adriana S. Albuquerque, Paula Matoso, Bénédicte Charmeteau-de-Muylder, Rémi Cheynier, Dário Ligeiro, Miguel Abecasis, Rui Anjos, João T. Barata, Rui M. M. Victorino, Ana E. Sousa
Published in: Frontiers in Immunology, 8, 2017, ISSN 1664-3224
Publisher: Frontiers in Immunology
DOI: 10.3389/fimmu.2017.00020

Clinical-Grade Peptide-Based Inhibition of CK2 Blocks Viability and Proliferation of T-ALL Cells and Counteracts IL-7 Stimulation and Stromal Support

Author(s): Yasser Perera, Alice Melão, Ailyn C. Ramón, Dania Vázquez, Daniel Ribeiro, Silvio E. Perea, João T. Barata
Published in: Cancers, 12/6, 2020, Page(s) 1377, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12061377

Targeting cytokine- and therapy-induced PIM1 activation in preclinical models of T-cell acute lymphoblastic leukemia and lymphoma

Author(s): Renate De Smedt, Julie Morscio, Lindy Reunes, Juliette Roels, Valentina Bardelli, Beatrice Lintermans, Wouter Van Loocke, Afonso Almeida, Laurence C. Cheung, Rishi S. Kotecha, Marc R. Mansour, Anne Uyttebroeck, Peter Vandenberghe, Roberta La Starza, Cristina Mecucci, Tim Lammens, Nadine Van Roy, Barbara De Moerloose, João T. Barata, Tom Taghon, Steven Goossens, Pieter Van Vlierberghe
Published in: Blood, 135/19, 2020, Page(s) 1685-1695, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood.2019003880

From the outside, from within: Biological and therapeutic relevance of signal transduction in T-cell acute lymphoblastic leukemia

Author(s): Mariana L. Oliveira, Padma Akkapeddi, Isabel Alcobia, Afonso R. Almeida, Bruno A. Cardoso, Rita Fragoso, Teresa L. Serafim, João T. Barata
Published in: Cellular Signalling, 38, 2017, Page(s) 10-25, ISSN 0898-6568
Publisher: Elsevier BV
DOI: 10.1016/j.cellsig.2017.06.011

Therapeutic targeting of CK2 in acute and chronic leukemias

Author(s): F Buontempo, J A McCubrey, E Orsini, M Ruzzene, A Cappellini, A Lonetti, C Evangelisti, F Chiarini, C Evangelisti, J T Barata, A M Martelli
Published in: Leukemia, 32/1, 2017, Page(s) 1-10, ISSN 0887-6924
Publisher: Nature Publishing Group
DOI: 10.1038/leu.2017.301

IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia: An update

Author(s): Mariana L. Oliveira, Padma Akkapeddi, Daniel Ribeiro, Alice Melão, João T. Barata
Published in: Advances in Biological Regulation, 2018, ISSN 2212-4926
Publisher: Elsevier BV
DOI: 10.1016/j.jbior.2018.09.012

STAT5 is essential for IL-7–mediated viability, growth, and proliferation of T-cell acute lymphoblastic leukemia cells

Author(s): Daniel Ribeiro, Alice Melão, Ruben van Boxtel, Cristina I. Santos, Ana Silva, Milene C. Silva, Bruno A. Cardoso, Paul J. Coffer, João T. Barata
Published in: Blood Advances, 2/17, 2018, Page(s) 2199-2213, ISSN 2473-9529
Publisher: American Society of Hematology
DOI: 10.1182/bloodadvances.2018021063

Optimal interleukin-7 receptor-mediated signaling, cell cycle progression and viability of T-cell acute lymphoblastic leukemia cells rely on casein kinase 2 activity

Author(s): Alice Melão, Maureen Spit, Bruno A. Cardoso, João T. Barata
Published in: Haematologica, 101/11, 2016, Page(s) 1368-1379, ISSN 0390-6078
Publisher: Ferrata Storti Foundation
DOI: 10.3324/haematol.2015.141143

A fully human anti-IL-7Rα antibody promotes antitumor activity against T-cell acute lymphoblastic leukemia

Author(s): Padma Akkapeddi, Rita Fragoso, Julie A. Hixon, Ana Sofia Ramalho, Mariana L. Oliveira, Tânia Carvalho, Andreas Gloger, Mattia Matasci, Francisco Corzana, Scott K. Durum, Dario Neri, Gonçalo J. L. Bernardes, João T. Barata
Published in: Leukemia, 33/9, 2019, Page(s) 2155-2168, ISSN 0887-6924
Publisher: Nature Publishing Group
DOI: 10.1038/s41375-019-0434-8

MicroRNAs and their involvement in T-ALL: A brief overview

Author(s): Nádia C. Correia, João T. Barata
Published in: Advances in Biological Regulation, 74, 2019, Page(s) 100650, ISSN 2212-4926
Publisher: Elsevier BV
DOI: 10.1016/j.jbior.2019.100650

NRARP displays either pro- or anti-tumoral roles in T-cell acute lymphoblastic leukemia depending on Notch and Wnt signaling

Author(s): Inês Pinto, Mafalda Duque, Joana Gonçalves, Padma Akkapeddi, Mariana L. Oliveira, Rita Cabrita, J. Andrés Yunes, Scott K. Durum, João T. Barata, Rita Fragoso
Published in: Oncogene, 39/5, 2020, Page(s) 975-986, ISSN 0950-9232
Publisher: Nature Publishing Group
DOI: 10.1038/s41388-019-1042-9

Flip the coin: IL-7 and IL-7R in health and disease

Author(s): João T. Barata, Scott K. Durum, Benedict Seddon
Published in: Nature Immunology, 20/12, 2019, Page(s) 1584-1593, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-019-0479-x

Introduction to the special issue on T-cell acute lymphoblastic leukemia genetics, biology and therapeutics

Author(s): João T. Barata
Published in: Advances in Biological Regulation, 74, 2019, Page(s) 100671, ISSN 2212-4926
Publisher: Elsevier BV
DOI: 10.1016/j.jbior.2019.100671

T-cell acute lymphoblastic leukemia displays autocrine production of Interleukin-7

Author(s): Anne Buffière, Benjamin Uzan, Romain Aucagne, François Hermetet, Manon Mas, Sandra Nassurdine, Aziza Aznague, Virginie Carmignac, Benjamin Tournier, Olivier Bouchot, Paola Ballerini, João T. Barata, Jean-Noël Bastie, Laurent Delva, Françoise Pflumio, Ronan Quéré
Published in: Oncogene, 38/48, 2019, Page(s) 7357-7365, ISSN 0950-9232
Publisher: Nature Publishing Group
DOI: 10.1038/s41388-019-0921-4

New anti-IL-7Rα monoclonal antibodies show efficacy against T cell acute lymphoblastic leukemia in pre-clinical models

Author(s): Julie A. Hixon, Caroline Andrews, Lila Kashi, Casey L. Kohnhorst, Emilee Senkevitch, Kelli Czarra, Joao T. Barata, Wenqing Li, Joel P. Schneider, Scott T. R. Walsh, Scott K. Durum
Published in: Leukemia, 34/1, 2020, Page(s) 35-49, ISSN 0887-6924
Publisher: Nature Publishing Group
DOI: 10.1038/s41375-019-0531-8

PRL3 enhances T-cell acute lymphoblastic leukemia growth through suppressing T-cell signaling pathways and apoptosis

Author(s): E. G. Garcia, A. Veloso, M. L. Oliveira, J. R. Allen, S. Loontiens, D. Brunson, D. Do, C. Yan, R. Morris, S. Iyer, S. P. Garcia, N. Iftimia, W. Van Loocke, F. Matthijssens, K. McCarthy, J. T. Barata, F. Speleman, T. Taghon, A. Gutierrez, P. Van Vlierberghe, W. Haas, J. S. Blackburn, D. M. Langenau
Published in: Leukemia, 35/3, 2021, Page(s) 679-690, ISSN 0887-6924
Publisher: Nature Publishing Group
DOI: 10.1038/s41375-020-0937-3

Immunophenotype of Gastric Tumors Unveils a Pleiotropic Role of Regulatory T Cells in Tumor Development

Author(s): Sara Rocha, Afonso P Basto, Marieke E Ijsselsteijn, Sara P Teles, Maria M Azevedo, Gilza Gonçalves, Irene Gullo, Gabriela M Almeida, Joaquín J Maqueda, Marta I Oliveira, Fátima Carneiro, João T Barata, Luís Graça, Noel F C C de Miranda, Joana Carvalho, Carla Oliveira
Published in: Cancers, 13/3, 2021, Page(s) 421, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13030421

Casein kinase 2 controls the survival of normal thymic and leukemic γδ T cells via promotion of AKT signaling

Author(s): S T Ribeiro, M Tesio, J C Ribot, E Macintyre, J T Barata, B Silva-Santos
Published in: Leukemia, 31/7, 2017, Page(s) 1603-1610, ISSN 0887-6924
Publisher: Nature Publishing Group
DOI: 10.1038/leu.2016.363

Human naïve regulatory T-cells feature high steady-state turnover and are maintained by IL-7

Author(s): Susana L Silva, Adriana S Albuquerque, Ana Serra-Caetano, Russell B Foxall, Ana R Pires, Paula Matoso, Susana M Fernandes, João Ferreira, Rémi Cheynier, Rui M M Victorino, Iris Caramalho, João T Barata, Ana E Sousa
Published in: Oncotarget, 2016, ISSN 1949-2553
Publisher: Impact Journals
DOI: 10.18632/oncotarget.7512

Cell Signaling in Cancer

Author(s): João T. Barata, Mariana L. Oliveira
Published in: Molecular and Cell Biology of Cancer - When Cells Break the Rules and Hijack Their Own Planet, 2019, Page(s) 31-49, ISBN 978-3-030-11811-2
Publisher: Springer International Publishing
DOI: 10.1007/978-3-030-11812-9_3