Pubblicazioni Peer reviewed articles (21) Overexpression of wild-type IL-7Rα promotes T-cell acute lymphoblastic leukemia/lymphoma Autori: Ana Silva, Afonso R. M. Almeida, Ana Cachucho, João L. Neto, Sofie Demeyer, Mafalda de Matos, Thea Hogan, Yunlei Li, Jules Meijerink, Jan Cools, Ana Rita Grosso, Benedict Seddon, João T. Barata Pubblicato in: Blood, Issue 138/12, 2021, Page(s) 1040-1052, ISSN 0006-4971 Editore: American Society of Hematology DOI: 10.1182/blood.2019000553 Interleukin-7 receptor α mutational activation can initiate precursor B-cell acute lymphoblastic leukemia Autori: Afonso R. M. Almeida, João L. Neto, Ana Cachucho, Mayara Euzébio, Xiangyu Meng, Rathana Kim, Marta B. Fernandes, Beatriz Raposo, Mariana L. Oliveira, Daniel Ribeiro, Rita Fragoso, Priscila P. Zenatti, Tiago Soares, Mafalda R. de Matos, Juliana Ronchi Corrêa, Mafalda Duque, Kathryn G. Roberts, Zhaohui Gu, Chunxu Qu, Clara Pereira, Susan Pyne, Nigel J. Pyne, Vasco M. Barreto, Isabelle Bernard-Pie Pubblicato in: Nature Communications, 2021, ISSN 2041-1723 Editore: Nature Publishing Group DOI: 10.1038/s41467-021-27197-5 IL-7-Induced Proliferation of Human Naive CD4 T-Cells Relies on Continued Thymic Activity Autori: Susana L. Silva, Adriana S. Albuquerque, Paula Matoso, Bénédicte Charmeteau-de-Muylder, Rémi Cheynier, Dário Ligeiro, Miguel Abecasis, Rui Anjos, João T. Barata, Rui M. M. Victorino, Ana E. Sousa Pubblicato in: Frontiers in Immunology, Issue 8, 2017, ISSN 1664-3224 Editore: Frontiers in Immunology DOI: 10.3389/fimmu.2017.00020 Clinical-Grade Peptide-Based Inhibition of CK2 Blocks Viability and Proliferation of T-ALL Cells and Counteracts IL-7 Stimulation and Stromal Support Autori: Yasser Perera, Alice Melão, Ailyn C. Ramón, Dania Vázquez, Daniel Ribeiro, Silvio E. Perea, João T. Barata Pubblicato in: Cancers, Issue 12/6, 2020, Page(s) 1377, ISSN 2072-6694 Editore: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/cancers12061377 Targeting cytokine- and therapy-induced PIM1 activation in preclinical models of T-cell acute lymphoblastic leukemia and lymphoma Autori: Renate De Smedt, Julie Morscio, Lindy Reunes, Juliette Roels, Valentina Bardelli, Beatrice Lintermans, Wouter Van Loocke, Afonso Almeida, Laurence C. Cheung, Rishi S. Kotecha, Marc R. Mansour, Anne Uyttebroeck, Peter Vandenberghe, Roberta La Starza, Cristina Mecucci, Tim Lammens, Nadine Van Roy, Barbara De Moerloose, João T. Barata, Tom Taghon, Steven Goossens, Pieter Van Vlierberghe Pubblicato in: Blood, Issue 135/19, 2020, Page(s) 1685-1695, ISSN 0006-4971 Editore: American Society of Hematology DOI: 10.1182/blood.2019003880 From the outside, from within: Biological and therapeutic relevance of signal transduction in T-cell acute lymphoblastic leukemia Autori: Mariana L. Oliveira, Padma Akkapeddi, Isabel Alcobia, Afonso R. Almeida, Bruno A. Cardoso, Rita Fragoso, Teresa L. Serafim, João T. Barata Pubblicato in: Cellular Signalling, Issue 38, 2017, Page(s) 10-25, ISSN 0898-6568 Editore: Elsevier BV DOI: 10.1016/j.cellsig.2017.06.011 Therapeutic targeting of CK2 in acute and chronic leukemias Autori: F Buontempo, J A McCubrey, E Orsini, M Ruzzene, A Cappellini, A Lonetti, C Evangelisti, F Chiarini, C Evangelisti, J T Barata, A M Martelli Pubblicato in: Leukemia, Issue 32/1, 2017, Page(s) 1-10, ISSN 0887-6924 Editore: Nature Publishing Group DOI: 10.1038/leu.2017.301 IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia: An update Autori: Mariana L. Oliveira, Padma Akkapeddi, Daniel Ribeiro, Alice Melão, João T. Barata Pubblicato in: Advances in Biological Regulation, 2018, ISSN 2212-4926 Editore: Elsevier BV DOI: 10.1016/j.jbior.2018.09.012 STAT5 is essential for IL-7–mediated viability, growth, and proliferation of T-cell acute lymphoblastic leukemia cells Autori: Daniel Ribeiro, Alice Melão, Ruben van Boxtel, Cristina I. Santos, Ana Silva, Milene C. Silva, Bruno A. Cardoso, Paul J. Coffer, João T. Barata Pubblicato in: Blood Advances, Issue 2/17, 2018, Page(s) 2199-2213, ISSN 2473-9529 Editore: American Society of Hematology DOI: 10.1182/bloodadvances.2018021063 Optimal interleukin-7 receptor-mediated signaling, cell cycle progression and viability of T-cell acute lymphoblastic leukemia cells rely on casein kinase 2 activity Autori: Alice Melão, Maureen Spit, Bruno A. Cardoso, João T. Barata Pubblicato in: Haematologica, Issue 101/11, 2016, Page(s) 1368-1379, ISSN 0390-6078 Editore: Ferrata Storti Foundation DOI: 10.3324/haematol.2015.141143 A fully human anti-IL-7Rα antibody promotes antitumor activity against T-cell acute lymphoblastic leukemia Autori: Padma Akkapeddi, Rita Fragoso, Julie A. Hixon, Ana Sofia Ramalho, Mariana L. Oliveira, Tânia Carvalho, Andreas Gloger, Mattia Matasci, Francisco Corzana, Scott K. Durum, Dario Neri, Gonçalo J. L. Bernardes, João T. Barata Pubblicato in: Leukemia, Issue 33/9, 2019, Page(s) 2155-2168, ISSN 0887-6924 Editore: Nature Publishing Group DOI: 10.1038/s41375-019-0434-8 MicroRNAs and their involvement in T-ALL: A brief overview Autori: Nádia C. Correia, João T. Barata Pubblicato in: Advances in Biological Regulation, Issue 74, 2019, Page(s) 100650, ISSN 2212-4926 Editore: Elsevier BV DOI: 10.1016/j.jbior.2019.100650 NRARP displays either pro- or anti-tumoral roles in T-cell acute lymphoblastic leukemia depending on Notch and Wnt signaling Autori: Inês Pinto, Mafalda Duque, Joana Gonçalves, Padma Akkapeddi, Mariana L. Oliveira, Rita Cabrita, J. Andrés Yunes, Scott K. Durum, João T. Barata, Rita Fragoso Pubblicato in: Oncogene, Issue 39/5, 2020, Page(s) 975-986, ISSN 0950-9232 Editore: Nature Publishing Group DOI: 10.1038/s41388-019-1042-9 Flip the coin: IL-7 and IL-7R in health and disease Autori: João T. Barata, Scott K. Durum, Benedict Seddon Pubblicato in: Nature Immunology, Issue 20/12, 2019, Page(s) 1584-1593, ISSN 1529-2908 Editore: Nature Publishing Group DOI: 10.1038/s41590-019-0479-x Introduction to the special issue on T-cell acute lymphoblastic leukemia genetics, biology and therapeutics Autori: João T. Barata Pubblicato in: Advances in Biological Regulation, Issue 74, 2019, Page(s) 100671, ISSN 2212-4926 Editore: Elsevier BV DOI: 10.1016/j.jbior.2019.100671 T-cell acute lymphoblastic leukemia displays autocrine production of Interleukin-7 Autori: Anne Buffière, Benjamin Uzan, Romain Aucagne, François Hermetet, Manon Mas, Sandra Nassurdine, Aziza Aznague, Virginie Carmignac, Benjamin Tournier, Olivier Bouchot, Paola Ballerini, João T. Barata, Jean-Noël Bastie, Laurent Delva, Françoise Pflumio, Ronan Quéré Pubblicato in: Oncogene, Issue 38/48, 2019, Page(s) 7357-7365, ISSN 0950-9232 Editore: Nature Publishing Group DOI: 10.1038/s41388-019-0921-4 New anti-IL-7Rα monoclonal antibodies show efficacy against T cell acute lymphoblastic leukemia in pre-clinical models Autori: Julie A. Hixon, Caroline Andrews, Lila Kashi, Casey L. Kohnhorst, Emilee Senkevitch, Kelli Czarra, Joao T. Barata, Wenqing Li, Joel P. Schneider, Scott T. R. Walsh, Scott K. Durum Pubblicato in: Leukemia, Issue 34/1, 2020, Page(s) 35-49, ISSN 0887-6924 Editore: Nature Publishing Group DOI: 10.1038/s41375-019-0531-8 PRL3 enhances T-cell acute lymphoblastic leukemia growth through suppressing T-cell signaling pathways and apoptosis Autori: E. G. Garcia, A. Veloso, M. L. Oliveira, J. R. Allen, S. Loontiens, D. Brunson, D. Do, C. Yan, R. Morris, S. Iyer, S. P. Garcia, N. Iftimia, W. Van Loocke, F. Matthijssens, K. McCarthy, J. T. Barata, F. Speleman, T. Taghon, A. Gutierrez, P. Van Vlierberghe, W. Haas, J. S. Blackburn, D. M. Langenau Pubblicato in: Leukemia, Issue 35/3, 2021, Page(s) 679-690, ISSN 0887-6924 Editore: Nature Publishing Group DOI: 10.1038/s41375-020-0937-3 Immunophenotype of Gastric Tumors Unveils a Pleiotropic Role of Regulatory T Cells in Tumor Development Autori: Sara Rocha, Afonso P Basto, Marieke E Ijsselsteijn, Sara P Teles, Maria M Azevedo, Gilza Gonçalves, Irene Gullo, Gabriela M Almeida, Joaquín J Maqueda, Marta I Oliveira, Fátima Carneiro, João T Barata, Luís Graça, Noel F C C de Miranda, Joana Carvalho, Carla Oliveira Pubblicato in: Cancers, Issue 13/3, 2021, Page(s) 421, ISSN 2072-6694 Editore: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/cancers13030421 Casein kinase 2 controls the survival of normal thymic and leukemic γδ T cells via promotion of AKT signaling Autori: S T Ribeiro, M Tesio, J C Ribot, E Macintyre, J T Barata, B Silva-Santos Pubblicato in: Leukemia, Issue 31/7, 2017, Page(s) 1603-1610, ISSN 0887-6924 Editore: Nature Publishing Group DOI: 10.1038/leu.2016.363 Human naïve regulatory T-cells feature high steady-state turnover and are maintained by IL-7 Autori: Susana L Silva, Adriana S Albuquerque, Ana Serra-Caetano, Russell B Foxall, Ana R Pires, Paula Matoso, Susana M Fernandes, João Ferreira, Rémi Cheynier, Rui M M Victorino, Iris Caramalho, João T Barata, Ana E Sousa Pubblicato in: Oncotarget, 2016, ISSN 1949-2553 Editore: Impact Journals DOI: 10.18632/oncotarget.7512 Book chapters (1) Cell Signaling in Cancer Autori: João T. Barata, Mariana L. Oliveira Pubblicato in: Molecular and Cell Biology of Cancer - When Cells Break the Rules and Hijack Their Own Planet, 2019, Page(s) 31-49, ISBN 978-3-030-11811-2 Editore: Springer International Publishing DOI: 10.1007/978-3-030-11812-9_3 È in corso la ricerca di dati su OpenAIRE... Si è verificato un errore durante la ricerca dei dati su OpenAIRE Nessun risultato disponibile
