IL-7/IL-7R signaling networks in health and malignancy

Pubblicazioni

Overexpression of wild-type IL-7Rα promotes T-cell acute lymphoblastic leukemia/lymphoma

Autori: Ana Silva, Afonso R. M. Almeida, Ana Cachucho, João L. Neto, Sofie Demeyer, Mafalda de Matos, Thea Hogan, Yunlei Li, Jules Meijerink, Jan Cools, Ana Rita Grosso, Benedict Seddon, João T. Barata
Pubblicato in: Blood, Numero 138/12, 2021, Pagina/e 1040-1052, ISSN 0006-4971
Editore: American Society of Hematology
DOI: 10.1182/blood.2019000553

Interleukin-7 receptor α mutational activation can initiate precursor B-cell acute lymphoblastic leukemia

Autori: Afonso R. M. Almeida, João L. Neto, Ana Cachucho, Mayara Euzébio, Xiangyu Meng, Rathana Kim, Marta B. Fernandes, Beatriz Raposo, Mariana L. Oliveira, Daniel Ribeiro, Rita Fragoso, Priscila P. Zenatti, Tiago Soares, Mafalda R. de Matos, Juliana Ronchi Corrêa, Mafalda Duque, Kathryn G. Roberts, Zhaohui Gu, Chunxu Qu, Clara Pereira, Susan Pyne, Nigel J. Pyne, Vasco M. Barreto, Isabelle Bernard-Pie
Pubblicato in: Nature Communications, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-27197-5

IL-7-Induced Proliferation of Human Naive CD4 T-Cells Relies on Continued Thymic Activity

Autori: Susana L. Silva, Adriana S. Albuquerque, Paula Matoso, Bénédicte Charmeteau-de-Muylder, Rémi Cheynier, Dário Ligeiro, Miguel Abecasis, Rui Anjos, João T. Barata, Rui M. M. Victorino, Ana E. Sousa
Pubblicato in: Frontiers in Immunology, Numero 8, 2017, ISSN 1664-3224
Editore: Frontiers in Immunology
DOI: 10.3389/fimmu.2017.00020

Clinical-Grade Peptide-Based Inhibition of CK2 Blocks Viability and Proliferation of T-ALL Cells and Counteracts IL-7 Stimulation and Stromal Support

Autori: Yasser Perera, Alice Melão, Ailyn C. Ramón, Dania Vázquez, Daniel Ribeiro, Silvio E. Perea, João T. Barata
Pubblicato in: Cancers, Numero 12/6, 2020, Pagina/e 1377, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12061377

Targeting cytokine- and therapy-induced PIM1 activation in preclinical models of T-cell acute lymphoblastic leukemia and lymphoma

Autori: Renate De Smedt, Julie Morscio, Lindy Reunes, Juliette Roels, Valentina Bardelli, Beatrice Lintermans, Wouter Van Loocke, Afonso Almeida, Laurence C. Cheung, Rishi S. Kotecha, Marc R. Mansour, Anne Uyttebroeck, Peter Vandenberghe, Roberta La Starza, Cristina Mecucci, Tim Lammens, Nadine Van Roy, Barbara De Moerloose, João T. Barata, Tom Taghon, Steven Goossens, Pieter Van Vlierberghe
Pubblicato in: Blood, Numero 135/19, 2020, Pagina/e 1685-1695, ISSN 0006-4971
Editore: American Society of Hematology
DOI: 10.1182/blood.2019003880

From the outside, from within: Biological and therapeutic relevance of signal transduction in T-cell acute lymphoblastic leukemia

Autori: Mariana L. Oliveira, Padma Akkapeddi, Isabel Alcobia, Afonso R. Almeida, Bruno A. Cardoso, Rita Fragoso, Teresa L. Serafim, João T. Barata
Pubblicato in: Cellular Signalling, Numero 38, 2017, Pagina/e 10-25, ISSN 0898-6568
Editore: Elsevier BV
DOI: 10.1016/j.cellsig.2017.06.011

Therapeutic targeting of CK2 in acute and chronic leukemias

Autori: F Buontempo, J A McCubrey, E Orsini, M Ruzzene, A Cappellini, A Lonetti, C Evangelisti, F Chiarini, C Evangelisti, J T Barata, A M Martelli
Pubblicato in: Leukemia, Numero 32/1, 2017, Pagina/e 1-10, ISSN 0887-6924
Editore: Nature Publishing Group
DOI: 10.1038/leu.2017.301

IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia: An update

Autori: Mariana L. Oliveira, Padma Akkapeddi, Daniel Ribeiro, Alice Melão, João T. Barata
Pubblicato in: Advances in Biological Regulation, 2018, ISSN 2212-4926
Editore: Elsevier BV
DOI: 10.1016/j.jbior.2018.09.012

STAT5 is essential for IL-7–mediated viability, growth, and proliferation of T-cell acute lymphoblastic leukemia cells

Autori: Daniel Ribeiro, Alice Melão, Ruben van Boxtel, Cristina I. Santos, Ana Silva, Milene C. Silva, Bruno A. Cardoso, Paul J. Coffer, João T. Barata
Pubblicato in: Blood Advances, Numero 2/17, 2018, Pagina/e 2199-2213, ISSN 2473-9529
Editore: American Society of Hematology
DOI: 10.1182/bloodadvances.2018021063

Optimal interleukin-7 receptor-mediated signaling, cell cycle progression and viability of T-cell acute lymphoblastic leukemia cells rely on casein kinase 2 activity

Autori: Alice Melão, Maureen Spit, Bruno A. Cardoso, João T. Barata
Pubblicato in: Haematologica, Numero 101/11, 2016, Pagina/e 1368-1379, ISSN 0390-6078
Editore: Ferrata Storti Foundation
DOI: 10.3324/haematol.2015.141143

A fully human anti-IL-7Rα antibody promotes antitumor activity against T-cell acute lymphoblastic leukemia

Autori: Padma Akkapeddi, Rita Fragoso, Julie A. Hixon, Ana Sofia Ramalho, Mariana L. Oliveira, Tânia Carvalho, Andreas Gloger, Mattia Matasci, Francisco Corzana, Scott K. Durum, Dario Neri, Gonçalo J. L. Bernardes, João T. Barata
Pubblicato in: Leukemia, Numero 33/9, 2019, Pagina/e 2155-2168, ISSN 0887-6924
Editore: Nature Publishing Group
DOI: 10.1038/s41375-019-0434-8

MicroRNAs and their involvement in T-ALL: A brief overview

Autori: Nádia C. Correia, João T. Barata
Pubblicato in: Advances in Biological Regulation, Numero 74, 2019, Pagina/e 100650, ISSN 2212-4926
Editore: Elsevier BV
DOI: 10.1016/j.jbior.2019.100650

NRARP displays either pro- or anti-tumoral roles in T-cell acute lymphoblastic leukemia depending on Notch and Wnt signaling

Autori: Inês Pinto, Mafalda Duque, Joana Gonçalves, Padma Akkapeddi, Mariana L. Oliveira, Rita Cabrita, J. Andrés Yunes, Scott K. Durum, João T. Barata, Rita Fragoso
Pubblicato in: Oncogene, Numero 39/5, 2020, Pagina/e 975-986, ISSN 0950-9232
Editore: Nature Publishing Group
DOI: 10.1038/s41388-019-1042-9

Flip the coin: IL-7 and IL-7R in health and disease

Autori: João T. Barata, Scott K. Durum, Benedict Seddon
Pubblicato in: Nature Immunology, Numero 20/12, 2019, Pagina/e 1584-1593, ISSN 1529-2908
Editore: Nature Publishing Group
DOI: 10.1038/s41590-019-0479-x

Introduction to the special issue on T-cell acute lymphoblastic leukemia genetics, biology and therapeutics

Autori: João T. Barata
Pubblicato in: Advances in Biological Regulation, Numero 74, 2019, Pagina/e 100671, ISSN 2212-4926
Editore: Elsevier BV
DOI: 10.1016/j.jbior.2019.100671

T-cell acute lymphoblastic leukemia displays autocrine production of Interleukin-7

Autori: Anne Buffière, Benjamin Uzan, Romain Aucagne, François Hermetet, Manon Mas, Sandra Nassurdine, Aziza Aznague, Virginie Carmignac, Benjamin Tournier, Olivier Bouchot, Paola Ballerini, João T. Barata, Jean-Noël Bastie, Laurent Delva, Françoise Pflumio, Ronan Quéré
Pubblicato in: Oncogene, Numero 38/48, 2019, Pagina/e 7357-7365, ISSN 0950-9232
Editore: Nature Publishing Group
DOI: 10.1038/s41388-019-0921-4

New anti-IL-7Rα monoclonal antibodies show efficacy against T cell acute lymphoblastic leukemia in pre-clinical models

Autori: Julie A. Hixon, Caroline Andrews, Lila Kashi, Casey L. Kohnhorst, Emilee Senkevitch, Kelli Czarra, Joao T. Barata, Wenqing Li, Joel P. Schneider, Scott T. R. Walsh, Scott K. Durum
Pubblicato in: Leukemia, Numero 34/1, 2020, Pagina/e 35-49, ISSN 0887-6924
Editore: Nature Publishing Group
DOI: 10.1038/s41375-019-0531-8

PRL3 enhances T-cell acute lymphoblastic leukemia growth through suppressing T-cell signaling pathways and apoptosis

Autori: E. G. Garcia, A. Veloso, M. L. Oliveira, J. R. Allen, S. Loontiens, D. Brunson, D. Do, C. Yan, R. Morris, S. Iyer, S. P. Garcia, N. Iftimia, W. Van Loocke, F. Matthijssens, K. McCarthy, J. T. Barata, F. Speleman, T. Taghon, A. Gutierrez, P. Van Vlierberghe, W. Haas, J. S. Blackburn, D. M. Langenau
Pubblicato in: Leukemia, Numero 35/3, 2021, Pagina/e 679-690, ISSN 0887-6924
Editore: Nature Publishing Group
DOI: 10.1038/s41375-020-0937-3

Immunophenotype of Gastric Tumors Unveils a Pleiotropic Role of Regulatory T Cells in Tumor Development

Autori: Sara Rocha, Afonso P Basto, Marieke E Ijsselsteijn, Sara P Teles, Maria M Azevedo, Gilza Gonçalves, Irene Gullo, Gabriela M Almeida, Joaquín J Maqueda, Marta I Oliveira, Fátima Carneiro, João T Barata, Luís Graça, Noel F C C de Miranda, Joana Carvalho, Carla Oliveira
Pubblicato in: Cancers, Numero 13/3, 2021, Pagina/e 421, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13030421

Casein kinase 2 controls the survival of normal thymic and leukemic γδ T cells via promotion of AKT signaling

Autori: S T Ribeiro, M Tesio, J C Ribot, E Macintyre, J T Barata, B Silva-Santos
Pubblicato in: Leukemia, Numero 31/7, 2017, Pagina/e 1603-1610, ISSN 0887-6924
Editore: Nature Publishing Group
DOI: 10.1038/leu.2016.363

Human naïve regulatory T-cells feature high steady-state turnover and are maintained by IL-7

Autori: Susana L Silva, Adriana S Albuquerque, Ana Serra-Caetano, Russell B Foxall, Ana R Pires, Paula Matoso, Susana M Fernandes, João Ferreira, Rémi Cheynier, Rui M M Victorino, Iris Caramalho, João T Barata, Ana E Sousa
Pubblicato in: Oncotarget, 2016, ISSN 1949-2553
Editore: Impact Journals
DOI: 10.18632/oncotarget.7512

Cell Signaling in Cancer

Autori: João T. Barata, Mariana L. Oliveira
Pubblicato in: Molecular and Cell Biology of Cancer - When Cells Break the Rules and Hijack Their Own Planet, 2019, Pagina/e 31-49, ISBN 978-3-030-11811-2
Editore: Springer International Publishing
DOI: 10.1007/978-3-030-11812-9_3

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