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Ultrabright Turn-on Fluorescent Organic Nanoparticles for Amplified Molecular Sensing in Living Cells

Publications

Fluorescent Polymer Nanoparticles for Cell Barcoding In Vitro and In Vivo

Author(s): Bohdan Andreiuk, Andreas Reisch, Marion Lindecker, Gautier Follain, Nadine Peyriéras, Jacky G. Goetz, Andrey S. Klymchenko
Published in: Small, Issue 13/38, 2017, Page(s) 1701582, ISSN 1613-6810
DOI: 10.1002/smll.201701582

Giant light-harvesting nanoantenna for single-molecule detection in ambient light

Author(s): Kateryna Trofymchuk, Andreas Reisch, Pascal Didier, François Fras, Pierre Gilliot, Yves Mely, Andrey S. Klymchenko
Published in: Nature Photonics, Issue 11/10, 2017, Page(s) 657-663, ISSN 1749-4885
DOI: 10.1038/s41566-017-0001-7

Light-triggered release from dye-loaded fluorescent lipid nanocarriers in vitro and in vivo

Author(s): Redouane Bouchaala, Nicolas Anton, Halina Anton, Thierry Vandamme, Julien Vermot, Djabi Smail, Yves Mély, Andrey S. Klymchenko
Published in: Colloids and Surfaces B: Biointerfaces, Issue 156, 2017, Page(s) 414-421, ISSN 0927-7765
DOI: 10.1016/j.colsurfb.2017.05.035

PEGylated Red-Emitting Calcium Probe with Improved Sensing Properties for Neuroscience

Author(s): Flavien Ponsot, Weida Shen, Pichandi Ashokkumar, Etienne Audinat, Andrey S. Klymchenko, Mayeul Collot
Published in: ACS Sensors, Issue 2/11, 2017, Page(s) 1706-1712, ISSN 2379-3694
DOI: 10.1021/acssensors.7b00665

Solvatochromic and Fluorogenic Dyes as Environment-Sensitive Probes: Design and Biological Applications

Author(s): Andrey S. Klymchenko
Published in: Accounts of Chemical Research, Issue 50/2, 2017, Page(s) 366-375, ISSN 0001-4842
DOI: 10.1021/acs.accounts.6b00517

Ca-NIR: a ratiometric near-infrared calcium probe based on a dihydroxanthene-hemicyanine fluorophore

Author(s): Mayeul Collot, Flavien Ponsot, Andrey S. Klymchenko
Published in: Chemical Communications, Issue 53/45, 2017, Page(s) 6117-6120, ISSN 1359-7345
DOI: 10.1039/c7cc02418e

Tailoring Fluorescence Brightness and Switching of Nanoparticles through Dye Organization in the Polymer Matrix

Author(s): Andreas Reisch, Kateryna Trofymchuk, Anne Runser, Guillaume Fleith, Michel Rawiso, Andrey S. Klymchenko
Published in: ACS Applied Materials & Interfaces, Issue 9/49, 2017, Page(s) 43030-43042, ISSN 1944-8244
DOI: 10.1021/acsami.7b12292

An aluminium-based fluorinated counterion for enhanced encapsulation and emission of dyes in biodegradable polymer nanoparticles

Author(s): Bohdan Andreiuk, Andreas Reisch, Vasyl G. Pivovarenko, Andrey S. Klymchenko
Published in: Materials Chemistry Frontiers, Issue 1/11, 2017, Page(s) 2309-2316, ISSN 2052-1537
DOI: 10.1039/c7qm00248c

In Vivo FRET Imaging to Predict the Risk Associated with Hepatic Accumulation of Squalene-Based Prodrug Nanoparticles

Author(s): Fanny Cayre, Simona Mura, Bohdan Andreiuk, Dunja Sobot, Sandrine Gouazou, Didier Desmaële, Andrey S. Klymchenko, Patrick Couvreur
Published in: Advanced Healthcare Materials, 2017, Page(s) 1700830, ISSN 2192-2640
DOI: 10.1002/adhm.201700830

Ultrabright and Fluorogenic Probes for Multicolor Imaging and Tracking of Lipid Droplets in Cells and Tissues

Author(s): Mayeul Collot, Tkhe Kyong Fam, Pichandi Ashokkumar, Orestis Faklaris, Thierry Galli, Lydia Danglot, Andrey S. Klymchenko
Published in: Journal of the American Chemical Society, Issue 140/16, 2018, Page(s) 5401-5411, ISSN 0002-7863
DOI: 10.1021/jacs.7b12817

Bright and photostable push-pull pyrene dye visualizes lipid order variation between plasma and intracellular membranes

Author(s): Yosuke Niko, Pascal Didier, Yves Mely, Gen-ichi Konishi, Andrey S. Klymchenko
Published in: Scientific Reports, Issue 6/1, 2016, Page(s) 18870, ISSN 2045-2322
DOI: 10.1038/srep18870

Integrity of lipid nanocarriers in bloodstream and tumor quantified by near-infrared ratiometric FRET imaging in living mice

Author(s): Vandamme, Thierry; Klymchenko, Andrey S; Anton, Nicolas; Mercier, Luc; Andreiuk, Bohdan; Goetz, Jacky G; Mély, Yves; Bouchaala, Redouane
Published in: Journal of Controlled Release, Issue 236, 2016, Page(s) 57–67, ISSN 0168-3659
DOI: 10.1016/j.jconrel.2016.06.027

Non-coordinating anions assemble cyanine amphiphiles into ultra-small fluorescent nanoparticles

Author(s): Ievgen Shulov, Youri Arntz, Yves Mély, Vasyl G. Pivovarenko, Andrey S. Klymchenko
Published in: Chem. Commun., Issue 52/51, 2016, Page(s) 7962-7965, ISSN 1359-7345
DOI: 10.1039/C6CC03716J

Dye-doped silica nanoparticle probes for fluorescence lifetime imaging of reductive environments in living cells

Author(s): Luca Petrizza, Mayeul Collot, Ludovic Richert, Yves Mely, Luca Prodi, Andrey S. Klymchenko
Published in: RSC Adv., Issue 6/106, 2016, Page(s) 104164-104172, ISSN 2046-2069
DOI: 10.1039/C6RA21427D

Fluorinated counterion-enhanced emission of rhodamine aggregates: ultrabright nanoparticles for bioimaging and light-harvesting

Author(s): Ievgen Shulov, Sule Oncul, Andreas Reisch, Youri Arntz, Mayeul Collot, Yves Mely, Andrey S. Klymchenko
Published in: Nanoscale, Issue 7/43, 2015, Page(s) 18198-18210, ISSN 2040-3364
DOI: 10.1039/C5NR04955E

Fluorescent Polymer Nanoparticles Based on Dyes: Seeking Brighter Tools for Bioimaging

Author(s): Andreas Reisch, Andrey S. Klymchenko
Published in: Small, Issue 12/15, 2016, Page(s) 1968-1992, ISSN 1613-6810
DOI: 10.1002/smll.201503396

Protein-Sized Bright Fluorogenic Nanoparticles Based on Cross-Linked Calixarene Micelles with Cyanine Corona

Author(s): Ievgen Shulov, Roman V. Rodik, Youri Arntz, Andreas Reisch, Vitaly I. Kalchenko, Andrey S. Klymchenko
Published in: Angewandte Chemie International Edition, Issue 55/51, 2016, Page(s) 15884-15888, ISSN 1433-7851
DOI: 10.1002/anie.201609138

Push–pull dioxaborine as fluorescent molecular rotor: far-red fluorogenic probe for ligand–receptor interactions

Author(s): Iuliia A. Karpenko, Yosuke Niko, Viktor P. Yakubovskyi, Andriy O. Gerasov, Dominique Bonnet, Yuriy P. Kovtun, Andrey S. Klymchenko
Published in: J. Mater. Chem. C, Issue 4/14, 2016, Page(s) 3002-3009, ISSN 2050-7534
DOI: 10.1039/C5TC03411F

Optimizing the Fluorescence Properties of Nanoemulsions for Single Particle Tracking in Live Cells

Author(s): Xinyue Wang, Nicolas Anton, Pichandi Ashokkumar, Halina Anton, Tkhe Kyong Fam, Thierry Vandamme, Andrey S. Klymchenko, Mayeul Collot
Published in: ACS Applied Materials & Interfaces, Issue 11/14, 2019, Page(s) 13079-13090, ISSN 1944-8244
DOI: 10.1021/acsami.8b22297

Ionic aggregation-induced emission dye with bulky counterions for preparation of bright near-infrared polymeric nanoparticles

Author(s): Nagappanpillai Adarsh, Andrey S. Klymchenko
Published in: Nanoscale, Issue 11/29, 2019, Page(s) 13977-13987, ISSN 2040-3364
DOI: 10.1039/c9nr04085d

BODIPY with Tuned Amphiphilicity as a Fluorogenic Plasma Membrane Probe

Author(s): Mayeul Collot, Emmanuel Boutant, Maxime Lehmann, Andrey S. Klymchenko
Published in: Bioconjugate Chemistry, Issue 30/1, 2018, Page(s) 192-199, ISSN 1043-1802
DOI: 10.1021/acs.bioconjchem.8b00828

Fighting Aggregation‐Caused Quenching and Leakage of Dyes in Fluorescent Polymer Nanoparticles: Universal Role of Counterion

Author(s): Bohdan Andreiuk, Andreas Reisch, Eduard Bernhardt, Andrey S. Klymchenko
Published in: Chemistry – An Asian Journal, Issue 14/6, 2018, Page(s) 836-846, ISSN 1861-4728
DOI: 10.1002/asia.201801592

MemBright: A Family of Fluorescent Membrane Probes for Advanced Cellular Imaging and Neuroscience

Author(s): Mayeul Collot, Pichandi Ashokkumar, Halina Anton, Emmanuel Boutant, Orestis Faklaris, Thierry Galli, Yves Mély, Lydia Danglot, Andrey S. Klymchenko
Published in: Cell Chemical Biology, Issue 26/4, 2019, Page(s) 600-614.e7, ISSN 2451-9456
DOI: 10.1016/j.chembiol.2019.01.009

Probing Polarity and Heterogeneity of Lipid Droplets in Live Cells Using a Push–Pull Fluorophore

Author(s): Mayeul Collot, Sophie Bou, Tkhe Kyong Fam, Ludovic Richert, Yves Mély, Lydia Danglot, Andrey S. Klymchenko
Published in: Analytical Chemistry, Issue 91/3, 2019, Page(s) 1928-1935, ISSN 0003-2700
DOI: 10.1021/acs.analchem.8b04218

A dimerization-based fluorogenic dye-aptamer module for RNA imaging in live cells

Author(s): Farah Bouhedda, Kyong Tkhe Fam, Mayeul Collot, Alexis Autour, Stefano Marzi, Andrey Klymchenko, Michael Ryckelynck
Published in: Nature Chemical Biology, Issue 16/1, 2020, Page(s) 69-76, ISSN 1552-4450
DOI: 10.1038/s41589-019-0381-8

A fluorogenic BODIPY molecular rotor as an apoptosis marker

Author(s): Pichandi Ashokkumar, Anila Hoskere Ashoka, Mayeul Collot, Amitava Das, Andrey S. Klymchenko
Published in: Chemical Communications, Issue 55/48, 2019, Page(s) 6902-6905, ISSN 1359-7345
DOI: 10.1039/c9cc03242h

Recent Advances in Fluorescent Probes for Lipid Droplets

Author(s): Tkhe Fam, Andrey Klymchenko, Mayeul Collot
Published in: Materials, Issue 11/9, 2018, Page(s) 1768, ISSN 1996-1944
DOI: 10.3390/ma11091768

Switchable Solvatochromic Probes for Live-Cell Super-resolution Imaging of Plasma Membrane Organization

Author(s): Dmytro I. Danylchuk, Seonah Moon, Ke Xu, Andrey S. Klymchenko
Published in: Angewandte Chemie International Edition, Issue 58/42, 2019, Page(s) 14920-14924, ISSN 1433-7851
DOI: 10.1002/anie.201907690

Protein‐Sized Dye‐Loaded Polymer Nanoparticles for Free Particle Diffusion in Cytosol

Author(s): Andreas Reisch, Doriane Heimburger, Pauline Ernst, Anne Runser, Pascal Didier, Denis Dujardin, Andrey S. Klymchenko
Published in: Advanced Functional Materials, Issue 28/48, 2018, Page(s) 1805157, ISSN 1616-301X
DOI: 10.1002/adfm.201805157

DNA-Functionalized Dye-Loaded Polymeric Nanoparticles: Ultrabright FRET Platform for Amplified Detection of Nucleic Acids

Author(s): Nina Melnychuk, Andrey S. Klymchenko
Published in: Journal of the American Chemical Society, Issue 140/34, 2018, Page(s) 10856-10865, ISSN 0002-7863
DOI: 10.1021/jacs.8b05840

Lanthanide-Complex-Loaded Polymer Nanoparticles for Background-Free Single-Particle and Live-Cell Imaging

Author(s): Marcelina Cardoso Dos Santos, Anne Runser, Hortense Bartenlian, Aline M. Nonat, Loïc J. Charbonnière, Andrey S. Klymchenko, Niko Hildebrandt, Andreas Reisch
Published in: Chemistry of Materials, Issue 31/11, 2019, Page(s) 4034-4041, ISSN 0897-4756
DOI: 10.1021/acs.chemmater.9b00576

BODIPY-loaded polymer nanoparticles: chemical structure of cargo defines leakage from nanocarrier in living cells

Author(s): Kateryna Trofymchuk, Jurga Valanciunaite, Bohdan Andreiuk, Andreas Reisch, Mayeul Collot, Andrey S. Klymchenko
Published in: Journal of Materials Chemistry B, Issue 7/34, 2019, Page(s) 5199-5210, ISSN 2050-7518
DOI: 10.1039/c8tb02781a

Quantifying Release from Lipid Nanocarriers by Fluorescence Correlation Spectroscopy

Author(s): Redouane Bouchaala, Ludovic Richert, Nicolas Anton, Thierry F. Vandamme, Smail Djabi, Yves Mély, Andrey S. Klymchenko
Published in: ACS Omega, Issue 3/10, 2018, Page(s) 14333-14340, ISSN 2470-1343
DOI: 10.1021/acsomega.8b01488

Controlling Size and Fluorescence of Dye-Loaded Polymer Nanoparticles through Polymer Design

Author(s): Vitalii Rosiuk, Anne Runser, Andrey Klymchenko, Andreas Reisch
Published in: Langmuir, Issue 35/21, 2019, Page(s) 7009-7017, ISSN 0743-7463
DOI: 10.1021/acs.langmuir.9b00721

Light-harvesting nanoparticle probes for FRET-based detection of oligonucleotides with single-molecule sensitivity

Author(s): Nina Melnychuk, Sylvie Egloff, Anne Runser, Andreas Reisch, Andrey S Klymchenko
Published in: Angewandte Chemie International Edition, 2020, ISSN 1433-7851
DOI: 10.1002/anie.201913804

Zwitterionic Stealth Dye-Loaded Polymer Nanoparticles for Intracellular Imaging

Author(s): Anne Runser, Denis Dujardin, Pauline Ernst, Andrey S. Klymchenko, Andreas Reisch
Published in: ACS Applied Materials & Interfaces, Issue 12/1, 2019, Page(s) 117-125, ISSN 1944-8244
DOI: 10.1021/acsami.9b15396

Molecular Tuning of Styryl Dyes Leads to Versatile and Efficient Plasma Membrane Probes for Cell and Tissue Imaging

Author(s): Mayeul Collot, Emmanuel Boutant, Kyong Tkhe Fam, Lydia DANGLOT, Andrey S. Klymchenko
Published in: Bioconjugate Chemistry, 2020, ISSN 1043-1802
DOI: 10.1021/acs.bioconjchem.0c00023

BrightSens - Ultrabright Turn-on Fluorescent Organic Nanoparticles for Amplified Molecular Sensing in Living Cells - H2020

Author(s): Klymchenko, Andrey
Published in: Impact, Issue 6/2017, 2017, Page(s) 78-80, ISSN 2398-7073