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Ultrabright Turn-on Fluorescent Organic Nanoparticles for Amplified Molecular Sensing in Living Cells

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Fluorescent labeling of biocompatible block copolymers: synthetic strategies and applications in bioimaging

Auteurs: Sophie Bou, Andrey S. Klymchenko, Mayeul Collot
Publié dans: Materials Advances, 2021, ISSN 2633-5409
DOI: 10.1039/d1ma00110h

Stealth and Bright Monomolecular Fluorescent Organic Nanoparticles Based on Folded Amphiphilic Polymer

Auteurs: Mayeul Collot, Jérémy Schild, Kyong T. Fam, Redouane Bouchaala, Andrey S. Klymchenko
Publié dans: ACS Nano, Issue 14/10, 2020, Page(s) 13924-13937, ISSN 1936-0851
DOI: 10.1021/acsnano.0c06348

Solvatochromic Near-Infrared Probe for Polarity Mapping of Biomembranes and Lipid Droplets in Cells under Stress

Auteurs: Anila Hoskere Ashoka, Pichandi Ashokkumar, Yuriy P. Kovtun, Andrey S. Klymchenko
Publié dans: The Journal of Physical Chemistry Letters, Issue 10/10, 2019, Page(s) 2414-2421, ISSN 1948-7185
DOI: 10.1021/acs.jpclett.9b00668

Polarity Mapping of Cells and Embryos by Improved Fluorescent Solvatochromic Pyrene Probe

Auteurs: Jurga Valanciunaite, Emilie Kempf, Hitomi Seki, Dmytro I. Danylchuk, Nadine Peyriéras, Yosuke Niko, Andrey S. Klymchenko
Publié dans: Analytical Chemistry, Issue 92/9, 2020, Page(s) 6512-6520, ISSN 0003-2700
DOI: 10.1021/acs.analchem.0c00023

Further insights into release mechanisms from nano-emulsions, assessed by a simple fluorescence-based method

Auteurs: Xinyue Wang, Mayeul Collot, Ziad Omran, Thierry F. Vandamme, Andrey Klymchenko, Nicolas Anton
Publié dans: Journal of Colloid and Interface Science, Issue 578, 2020, Page(s) 768-778, ISSN 0021-9797
DOI: 10.1016/j.jcis.2020.06.028

Probing biotin receptors in cancer cells with rationally designed fluorogenic squaraine dimers

Auteurs: Kyong T. Fam, Mayeul Collot, Andrey S. Klymchenko
Publié dans: Chemical Science, Issue 11/31, 2020, Page(s) 8240-8248, ISSN 2041-6520
DOI: 10.1039/d0sc01973a

A near-infrared fluorogenic dimer enables background-free imaging of endogenous GPCRs in living mice

Auteurs: Lucie Esteoulle, François Daubeuf, Mayeul Collot, Stéphanie Riché, Thierry Durroux, David Brasse, Patrice Marchand, Iuliia A. Karpenko, Andrey S. Klymchenko, Dominique Bonnet
Publié dans: Chemical Science, Issue 11/26, 2020, Page(s) 6824-6829, ISSN 2041-6520
DOI: 10.1039/d0sc01018a

Dye‐Loaded Nanoemulsions: Biomimetic Fluorescent Nanocarriers for Bioimaging and Nanomedicine

Auteurs: Andrey S. Klymchenko, Fei Liu, Mayeul Collot, Nicolas Anton
Publié dans: Advanced Healthcare Materials, Issue 10/1, 2021, Page(s) 2001289, ISSN 2192-2640
DOI: 10.1002/adhm.202001289

Smartphone-assisted detection of nucleic acids by light-harvesting FRET-based nanoprobe

Auteurs: Caterina Severi, Nina Melnychuk, Andrey S. Klymchenko
Publié dans: Biosensors and Bioelectronics, Issue 168, 2020, Page(s) 112515, ISSN 0956-5663
DOI: 10.1016/j.bios.2020.112515

Lipid-core/polymer-shell hybrid nanoparticles: synthesis and characterization by fluorescence labeling and electrophoresis

Auteurs: Sophie Bou, Xinyue Wang, Nicolas Anton, Redouane Bouchaala, Andrey S. Klymchenko, Mayeul Collot
Publié dans: Soft Matter, Issue 16/17, 2020, Page(s) 4173-4181, ISSN 1744-683X
DOI: 10.1039/d0sm00077a

Drug‐Sponge Lipid Nanocarrier for in Situ Cargo Loading and Release Using Dynamic Covalent Chemistry

Auteurs: Fei Liu, Yosuke Niko, Redouane Bouchaala, Luc Mercier, Olivier Lefebvre, Bohdan Andreiuk, Thierry Vandamme, Jacky G. Goetz, Nicolas Anton, Andrey Klymchenko
Publié dans: Angewandte Chemie International Edition, Issue 60/12, 2021, Page(s) 6573-6580, ISSN 1433-7851
DOI: 10.1002/anie.202014259

Targeted Solvatochromic Fluorescent Probes for Imaging Lipid Order in Organelles under Oxidative and Mechanical Stress

Auteurs: Dmytro I. Danylchuk, Pierre-Henri Jouard, Andrey S. Klymchenko
Publié dans: Journal of the American Chemical Society, Issue 143/2, 2021, Page(s) 912-924, ISSN 0002-7863
DOI: 10.1021/jacs.0c10972

Redesigning Solvatochromic Probe Laurdan for Imaging Lipid Order Selectively in Cell Plasma Membranes

Auteurs: Dmytro I. Danylchuk, Erdinc Sezgin, Philippe Chabert, Andrey S. Klymchenko
Publié dans: Analytical Chemistry, Issue 92/21, 2020, Page(s) 14798-14805, ISSN 0003-2700
DOI: 10.1021/acs.analchem.0c03559

Near infrared fluorogenic probe as a prodrug model for evaluating cargo release by nanoemulsions

Auteurs: Sophie Bou, Xinyue Wang, Nicolas Anton, Andrey S. Klymchenko, Mayeul Collot
Publié dans: Journal of Materials Chemistry B, Issue 8/27, 2020, Page(s) 5938-5944, ISSN 2050-7518
DOI: 10.1039/d0tb00783h

Ionic Aggregation‐Induced Emission: Bulky Hydrophobic Counterions Light Up Dyes in Polymeric Nanoparticles

Auteurs: Ilya O. Aparin, Nina Melnychuk, Andrey S. Klymchenko
Publié dans: Advanced Optical Materials, Issue 8/14, 2020, Page(s) 2000027, ISSN 2195-1071
DOI: 10.1002/adom.202000027

Ultrabright Fluorescent Polymeric Nanoparticles with a Stealth Pluronic Shell for Live Tracking in the Mouse Brain

Auteurs: Igor Khalin, Doriane Heimburger, Nina Melnychuk, Mayeul Collot, Bernhard Groschup, Farida Hellal, Andreas Reisch, Nikolaus Plesnila, Andrey S. Klymchenko
Publié dans: ACS Nano, Issue 14/8, 2020, Page(s) 9755-9770, ISSN 1936-0851
DOI: 10.1021/acsnano.0c01505

Fluorescent Polymer Nanoparticles for Cell Barcoding In Vitro and In Vivo

Auteurs: Bohdan Andreiuk, Andreas Reisch, Marion Lindecker, Gautier Follain, Nadine Peyriéras, Jacky G. Goetz, Andrey S. Klymchenko
Publié dans: Small, Issue 13/38, 2017, Page(s) 1701582, ISSN 1613-6810
DOI: 10.1002/smll.201701582

Giant light-harvesting nanoantenna for single-molecule detection in ambient light

Auteurs: Kateryna Trofymchuk, Andreas Reisch, Pascal Didier, François Fras, Pierre Gilliot, Yves Mely, Andrey S. Klymchenko
Publié dans: Nature Photonics, Issue 11/10, 2017, Page(s) 657-663, ISSN 1749-4885
DOI: 10.1038/s41566-017-0001-7

Light-triggered release from dye-loaded fluorescent lipid nanocarriers in vitro and in vivo

Auteurs: Redouane Bouchaala, Nicolas Anton, Halina Anton, Thierry Vandamme, Julien Vermot, Djabi Smail, Yves Mély, Andrey S. Klymchenko
Publié dans: Colloids and Surfaces B: Biointerfaces, Issue 156, 2017, Page(s) 414-421, ISSN 0927-7765
DOI: 10.1016/j.colsurfb.2017.05.035

PEGylated Red-Emitting Calcium Probe with Improved Sensing Properties for Neuroscience

Auteurs: Flavien Ponsot, Weida Shen, Pichandi Ashokkumar, Etienne Audinat, Andrey S. Klymchenko, Mayeul Collot
Publié dans: ACS Sensors, Issue 2/11, 2017, Page(s) 1706-1712, ISSN 2379-3694
DOI: 10.1021/acssensors.7b00665

Solvatochromic and Fluorogenic Dyes as Environment-Sensitive Probes: Design and Biological Applications

Auteurs: Andrey S. Klymchenko
Publié dans: Accounts of Chemical Research, Issue 50/2, 2017, Page(s) 366-375, ISSN 0001-4842
DOI: 10.1021/acs.accounts.6b00517

Ca-NIR: a ratiometric near-infrared calcium probe based on a dihydroxanthene-hemicyanine fluorophore

Auteurs: Mayeul Collot, Flavien Ponsot, Andrey S. Klymchenko
Publié dans: Chemical Communications, Issue 53/45, 2017, Page(s) 6117-6120, ISSN 1359-7345
DOI: 10.1039/c7cc02418e

Tailoring Fluorescence Brightness and Switching of Nanoparticles through Dye Organization in the Polymer Matrix

Auteurs: Andreas Reisch, Kateryna Trofymchuk, Anne Runser, Guillaume Fleith, Michel Rawiso, Andrey S. Klymchenko
Publié dans: ACS Applied Materials & Interfaces, Issue 9/49, 2017, Page(s) 43030-43042, ISSN 1944-8244
DOI: 10.1021/acsami.7b12292

An aluminium-based fluorinated counterion for enhanced encapsulation and emission of dyes in biodegradable polymer nanoparticles

Auteurs: Bohdan Andreiuk, Andreas Reisch, Vasyl G. Pivovarenko, Andrey S. Klymchenko
Publié dans: Materials Chemistry Frontiers, Issue 1/11, 2017, Page(s) 2309-2316, ISSN 2052-1537
DOI: 10.1039/c7qm00248c

In Vivo FRET Imaging to Predict the Risk Associated with Hepatic Accumulation of Squalene-Based Prodrug Nanoparticles

Auteurs: Fanny Cayre, Simona Mura, Bohdan Andreiuk, Dunja Sobot, Sandrine Gouazou, Didier Desmaële, Andrey S. Klymchenko, Patrick Couvreur
Publié dans: Advanced Healthcare Materials, 2017, Page(s) 1700830, ISSN 2192-2640
DOI: 10.1002/adhm.201700830

Ultrabright and Fluorogenic Probes for Multicolor Imaging and Tracking of Lipid Droplets in Cells and Tissues

Auteurs: Mayeul Collot, Tkhe Kyong Fam, Pichandi Ashokkumar, Orestis Faklaris, Thierry Galli, Lydia Danglot, Andrey S. Klymchenko
Publié dans: Journal of the American Chemical Society, Issue 140/16, 2018, Page(s) 5401-5411, ISSN 0002-7863
DOI: 10.1021/jacs.7b12817

Bright and photostable push-pull pyrene dye visualizes lipid order variation between plasma and intracellular membranes

Auteurs: Yosuke Niko, Pascal Didier, Yves Mely, Gen-ichi Konishi, Andrey S. Klymchenko
Publié dans: Scientific Reports, Issue 6/1, 2016, Page(s) 18870, ISSN 2045-2322
DOI: 10.1038/srep18870

Integrity of lipid nanocarriers in bloodstream and tumor quantified by near-infrared ratiometric FRET imaging in living mice

Auteurs: Vandamme, Thierry; Klymchenko, Andrey S; Anton, Nicolas; Mercier, Luc; Andreiuk, Bohdan; Goetz, Jacky G; Mély, Yves; Bouchaala, Redouane
Publié dans: Journal of Controlled Release, Issue 236, 2016, Page(s) 57–67, ISSN 0168-3659
DOI: 10.1016/j.jconrel.2016.06.027

Non-coordinating anions assemble cyanine amphiphiles into ultra-small fluorescent nanoparticles

Auteurs: Ievgen Shulov, Youri Arntz, Yves Mély, Vasyl G. Pivovarenko, Andrey S. Klymchenko
Publié dans: Chem. Commun., Issue 52/51, 2016, Page(s) 7962-7965, ISSN 1359-7345
DOI: 10.1039/C6CC03716J

Dye-doped silica nanoparticle probes for fluorescence lifetime imaging of reductive environments in living cells

Auteurs: Luca Petrizza, Mayeul Collot, Ludovic Richert, Yves Mely, Luca Prodi, Andrey S. Klymchenko
Publié dans: RSC Adv., Issue 6/106, 2016, Page(s) 104164-104172, ISSN 2046-2069
DOI: 10.1039/C6RA21427D

Fluorinated counterion-enhanced emission of rhodamine aggregates: ultrabright nanoparticles for bioimaging and light-harvesting

Auteurs: Ievgen Shulov, Sule Oncul, Andreas Reisch, Youri Arntz, Mayeul Collot, Yves Mely, Andrey S. Klymchenko
Publié dans: Nanoscale, Issue 7/43, 2015, Page(s) 18198-18210, ISSN 2040-3364
DOI: 10.1039/C5NR04955E

Fluorescent Polymer Nanoparticles Based on Dyes: Seeking Brighter Tools for Bioimaging

Auteurs: Andreas Reisch, Andrey S. Klymchenko
Publié dans: Small, Issue 12/15, 2016, Page(s) 1968-1992, ISSN 1613-6810
DOI: 10.1002/smll.201503396

Protein-Sized Bright Fluorogenic Nanoparticles Based on Cross-Linked Calixarene Micelles with Cyanine Corona

Auteurs: Ievgen Shulov, Roman V. Rodik, Youri Arntz, Andreas Reisch, Vitaly I. Kalchenko, Andrey S. Klymchenko
Publié dans: Angewandte Chemie International Edition, Issue 55/51, 2016, Page(s) 15884-15888, ISSN 1433-7851
DOI: 10.1002/anie.201609138

Push–pull dioxaborine as fluorescent molecular rotor: far-red fluorogenic probe for ligand–receptor interactions

Auteurs: Iuliia A. Karpenko, Yosuke Niko, Viktor P. Yakubovskyi, Andriy O. Gerasov, Dominique Bonnet, Yuriy P. Kovtun, Andrey S. Klymchenko
Publié dans: J. Mater. Chem. C, Issue 4/14, 2016, Page(s) 3002-3009, ISSN 2050-7534
DOI: 10.1039/C5TC03411F

Optimizing the Fluorescence Properties of Nanoemulsions for Single Particle Tracking in Live Cells

Auteurs: Xinyue Wang, Nicolas Anton, Pichandi Ashokkumar, Halina Anton, Tkhe Kyong Fam, Thierry Vandamme, Andrey S. Klymchenko, Mayeul Collot
Publié dans: ACS Applied Materials & Interfaces, Issue 11/14, 2019, Page(s) 13079-13090, ISSN 1944-8244
DOI: 10.1021/acsami.8b22297

Ionic aggregation-induced emission dye with bulky counterions for preparation of bright near-infrared polymeric nanoparticles

Auteurs: Nagappanpillai Adarsh, Andrey S. Klymchenko
Publié dans: Nanoscale, Issue 11/29, 2019, Page(s) 13977-13987, ISSN 2040-3364
DOI: 10.1039/c9nr04085d

BODIPY with Tuned Amphiphilicity as a Fluorogenic Plasma Membrane Probe

Auteurs: Mayeul Collot, Emmanuel Boutant, Maxime Lehmann, Andrey S. Klymchenko
Publié dans: Bioconjugate Chemistry, Issue 30/1, 2018, Page(s) 192-199, ISSN 1043-1802
DOI: 10.1021/acs.bioconjchem.8b00828

Fighting Aggregation‐Caused Quenching and Leakage of Dyes in Fluorescent Polymer Nanoparticles: Universal Role of Counterion

Auteurs: Bohdan Andreiuk, Andreas Reisch, Eduard Bernhardt, Andrey S. Klymchenko
Publié dans: Chemistry – An Asian Journal, Issue 14/6, 2018, Page(s) 836-846, ISSN 1861-4728
DOI: 10.1002/asia.201801592

MemBright: A Family of Fluorescent Membrane Probes for Advanced Cellular Imaging and Neuroscience

Auteurs: Mayeul Collot, Pichandi Ashokkumar, Halina Anton, Emmanuel Boutant, Orestis Faklaris, Thierry Galli, Yves Mély, Lydia Danglot, Andrey S. Klymchenko
Publié dans: Cell Chemical Biology, Issue 26/4, 2019, Page(s) 600-614.e7, ISSN 2451-9456
DOI: 10.1016/j.chembiol.2019.01.009

Probing Polarity and Heterogeneity of Lipid Droplets in Live Cells Using a Push–Pull Fluorophore

Auteurs: Mayeul Collot, Sophie Bou, Tkhe Kyong Fam, Ludovic Richert, Yves Mély, Lydia Danglot, Andrey S. Klymchenko
Publié dans: Analytical Chemistry, Issue 91/3, 2019, Page(s) 1928-1935, ISSN 0003-2700
DOI: 10.1021/acs.analchem.8b04218

A dimerization-based fluorogenic dye-aptamer module for RNA imaging in live cells

Auteurs: Farah Bouhedda, Kyong Tkhe Fam, Mayeul Collot, Alexis Autour, Stefano Marzi, Andrey Klymchenko, Michael Ryckelynck
Publié dans: Nature Chemical Biology, Issue 16/1, 2020, Page(s) 69-76, ISSN 1552-4450
DOI: 10.1038/s41589-019-0381-8

A fluorogenic BODIPY molecular rotor as an apoptosis marker

Auteurs: Pichandi Ashokkumar, Anila Hoskere Ashoka, Mayeul Collot, Amitava Das, Andrey S. Klymchenko
Publié dans: Chemical Communications, Issue 55/48, 2019, Page(s) 6902-6905, ISSN 1359-7345
DOI: 10.1039/c9cc03242h

Recent Advances in Fluorescent Probes for Lipid Droplets

Auteurs: Tkhe Fam, Andrey Klymchenko, Mayeul Collot
Publié dans: Materials, Issue 11/9, 2018, Page(s) 1768, ISSN 1996-1944
DOI: 10.3390/ma11091768

Switchable Solvatochromic Probes for Live-Cell Super-resolution Imaging of Plasma Membrane Organization

Auteurs: Dmytro I. Danylchuk, Seonah Moon, Ke Xu, Andrey S. Klymchenko
Publié dans: Angewandte Chemie International Edition, Issue 58/42, 2019, Page(s) 14920-14924, ISSN 1433-7851
DOI: 10.1002/anie.201907690

Protein‐Sized Dye‐Loaded Polymer Nanoparticles for Free Particle Diffusion in Cytosol

Auteurs: Andreas Reisch, Doriane Heimburger, Pauline Ernst, Anne Runser, Pascal Didier, Denis Dujardin, Andrey S. Klymchenko
Publié dans: Advanced Functional Materials, Issue 28/48, 2018, Page(s) 1805157, ISSN 1616-301X
DOI: 10.1002/adfm.201805157

DNA-Functionalized Dye-Loaded Polymeric Nanoparticles: Ultrabright FRET Platform for Amplified Detection of Nucleic Acids

Auteurs: Nina Melnychuk, Andrey S. Klymchenko
Publié dans: Journal of the American Chemical Society, Issue 140/34, 2018, Page(s) 10856-10865, ISSN 0002-7863
DOI: 10.1021/jacs.8b05840

Lanthanide-Complex-Loaded Polymer Nanoparticles for Background-Free Single-Particle and Live-Cell Imaging

Auteurs: Marcelina Cardoso Dos Santos, Anne Runser, Hortense Bartenlian, Aline M. Nonat, Loïc J. Charbonnière, Andrey S. Klymchenko, Niko Hildebrandt, Andreas Reisch
Publié dans: Chemistry of Materials, Issue 31/11, 2019, Page(s) 4034-4041, ISSN 0897-4756
DOI: 10.1021/acs.chemmater.9b00576

BODIPY-loaded polymer nanoparticles: chemical structure of cargo defines leakage from nanocarrier in living cells

Auteurs: Kateryna Trofymchuk, Jurga Valanciunaite, Bohdan Andreiuk, Andreas Reisch, Mayeul Collot, Andrey S. Klymchenko
Publié dans: Journal of Materials Chemistry B, Issue 7/34, 2019, Page(s) 5199-5210, ISSN 2050-7518
DOI: 10.1039/c8tb02781a

Quantifying Release from Lipid Nanocarriers by Fluorescence Correlation Spectroscopy

Auteurs: Redouane Bouchaala, Ludovic Richert, Nicolas Anton, Thierry F. Vandamme, Smail Djabi, Yves Mély, Andrey S. Klymchenko
Publié dans: ACS Omega, Issue 3/10, 2018, Page(s) 14333-14340, ISSN 2470-1343
DOI: 10.1021/acsomega.8b01488

Controlling Size and Fluorescence of Dye-Loaded Polymer Nanoparticles through Polymer Design

Auteurs: Vitalii Rosiuk, Anne Runser, Andrey Klymchenko, Andreas Reisch
Publié dans: Langmuir, Issue 35/21, 2019, Page(s) 7009-7017, ISSN 0743-7463
DOI: 10.1021/acs.langmuir.9b00721

Light-harvesting nanoparticle probes for FRET-based detection of oligonucleotides with single-molecule sensitivity

Auteurs: Nina Melnychuk, Sylvie Egloff, Anne Runser, Andreas Reisch, Andrey S Klymchenko
Publié dans: Angewandte Chemie International Edition, 2020, ISSN 1433-7851
DOI: 10.1002/anie.201913804

Zwitterionic Stealth Dye-Loaded Polymer Nanoparticles for Intracellular Imaging

Auteurs: Anne Runser, Denis Dujardin, Pauline Ernst, Andrey S. Klymchenko, Andreas Reisch
Publié dans: ACS Applied Materials & Interfaces, Issue 12/1, 2019, Page(s) 117-125, ISSN 1944-8244
DOI: 10.1021/acsami.9b15396

Molecular Tuning of Styryl Dyes Leads to Versatile and Efficient Plasma Membrane Probes for Cell and Tissue Imaging

Auteurs: Mayeul Collot, Emmanuel Boutant, Kyong Tkhe Fam, Lydia DANGLOT, Andrey S. Klymchenko
Publié dans: Bioconjugate Chemistry, 2020, ISSN 1043-1802
DOI: 10.1021/acs.bioconjchem.0c00023

Ratiometric Nanoparticle Probe Based on FRET‐Amplified Phosphorescence for Oxygen Sensing with Minimal Phototoxicity

Auteurs: Pichandi Ashokkumar, Nagappanpillai Adarsh, Andrey S. Klymchenko
Publié dans: Small, Issue 16/32, 2020, Page(s) 2002494, ISSN 1613-6810
DOI: 10.1002/smll.202002494

Ultrabright Green-Emitting Nanoemulsions Based on Natural Lipids-BODIPY Conjugates

Auteurs: Xinyue Wang, Sophie Bou, Andrey S. Klymchenko, Nicolas Anton, Mayeul Collot
Publié dans: Nanomaterials, Issue 11/3, 2021, Page(s) 826, ISSN 2079-4991
DOI: 10.3390/nano11030826

Size‐Dependent Electroporation of Dye‐Loaded Polymer Nanoparticles for Efficient and Safe Intracellular Delivery

Auteurs: Sylvie Egloff, Anne Runser, Andrey Klymchenko, Andreas Reisch
Publié dans: Small Methods, Issue 5/2, 2021, Page(s) 2000947, ISSN 2366-9608
DOI: 10.1002/smtd.202000947

Near-infrared fluorescent coatings of medical devices for image-guided surgery

Auteurs: Anila Hoskere Ashoka, Seong-Ho Kong, Barbara Seeliger, Bohdan Andreiuk, Renato Vianna Soares, Manuel Barberio, Michele Diana, Andrey S. Klymchenko
Publié dans: Biomaterials, Issue 261, 2020, Page(s) 120306, ISSN 0142-9612
DOI: 10.1016/j.biomaterials.2020.120306

BrightSens - Ultrabright Turn-on Fluorescent Organic Nanoparticles for Amplified Molecular Sensing in Living Cells - H2020

Auteurs: Klymchenko, Andrey
Publié dans: Impact, Issue 6/2017, 2017, Page(s) 78-80, ISSN 2398-7073