Tumor cell death supports recurrence of cancer

Project Information

Cancer-Recurrence

Grant agreement ID: 648804

DOI 10.3030/648804

Project closed

EC signature date 12 August 2015

Start date 1 September 2015

End date 31 August 2020

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 000 000,00

EU contribution € 2 000 000,00

Coordinated by

STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
Netherlands

Publications

Peer reviewed articles (17)

Intravital imaging of glioma border morphology reveals distinctive cellular dynamics and contribution to tumor cell invasion

Author(s): Maria Alieva, Verena Leidgens, Markus J. Riemenschneider, Christoph A. Klein, Peter Hau, Jacco van Rheenen
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-38625-4

A CRISPR-Cas9-based reporter system for single-cell detection of extracellular vesicle-mediated functional transfer of RNA

Author(s): Olivier G. de Jong, Daniel E. Murphy, Imre Mäger, Eduard Willms, Antonio Garcia-Guerra, Jerney J. Gitz-Francois, Juliet Lefferts, Dhanu Gupta, Sander C. Steenbeek, Jacco van Rheenen, Samir El Andaloussi, Raymond M. Schiffelers, Matthew J. A. Wood, Pieter Vader
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-14977-8

Rebalancing of actomyosin contractility enables mammary tumor formation upon loss of E-cadherin

Author(s): Koen Schipper, Danielle Seinstra, Anne Paulien Drenth, Eline van der Burg, Veronika Ramovs, Arnoud Sonnenberg, Jacco van Rheenen, Micha Nethe, Jos Jonkers
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-11716-6

In Vivo Imaging Reveals Existence of Crypt Fission and Fusion in Adult Mouse Intestine

Author(s): Lotte Bruens, Saskia I.J. Ellenbroek, Jacco van Rheenen, Hugo J. Snippert
Published in: Gastroenterology, Issue 153/3, 2017, Page(s) 674-677.e3, ISSN 0016-5085
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2017.05.019

A Unifying Theory of Branching Morphogenesis

Author(s): Edouard Hannezo, Colinda L.G.J. Scheele, Mohammad Moad, Nicholas Drogo, Rakesh Heer, Rosemary V. Sampogna, Jacco van Rheenen, Benjamin D. Simons
Published in: Cell, Issue 171/1, 2017, Page(s) 242-255.e27, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2017.08.026

Preventing inflammation inhibits biopsy-mediated changes in tumor cell behavior

Author(s): Maria Alieva, Andreia S. Margarido, Tamara Wieles, Erik R. Abels, Burcin Colak, Carla Boquetale, Herke Jan Noordmans, Tom J. Snijders, Marike L. Broekman, Jacco van Rheenen
Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-017-07660-4

From good to bad: Intravital imaging of the hijack of physiological processes by cancer cells

Author(s): Saskia J.E. Suijkerbuijk, Jacco van Rheenen
Published in: Developmental Biology, Issue 428/2, 2017, Page(s) 328-337, ISSN 0012-1606
Publisher: Academic Press
DOI: 10.1016/j.ydbio.2017.04.015

Plasticity between Epithelial and Mesenchymal States Unlinks EMT from Metastasis-Enhancing Stem Cell Capacity

Author(s): Evelyne Beerling, Daniëlle Seinstra, Elzo de Wit, Lennart Kester, Daphne van der Velden, Carrie Maynard, Ronny Schäfer, Paul van Diest, Emile Voest, Alexander van Oudenaarden, Nienke Vrisekoop, Jacco van Rheenen
Published in: Cell Reports, Issue 14/10, 2016, Page(s) 2281-2288, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2016.02.034

A surgical orthotopic organoid transplantation approach in mice to visualize and study colorectal cancer progression

Author(s): Arianna Fumagalli, Saskia J E Suijkerbuijk, Harry Begthel, Evelyne Beerling, Koen C Oost, Hugo J Snippert, Jacco van Rheenen, Jarno Drost
Published in: Nature Protocols, Issue 13/2, 2018, Page(s) 235-247, ISSN 1754-2189
Publisher: Nature Publishing Group
DOI: 10.1038/nprot.2017.137

Specific Labeling of Stem Cell Activity in Human Colorectal Organoids Using an ASCL2-Responsive Minigene

Author(s): Koen C. Oost, Lisa van Voorthuijsen, Arianna Fumagalli, Rik G.H. Lindeboom, Joep Sprangers, Manja Omerzu, Maria J. Rodriguez-Colman, Maria C. Heinz, Ingrid Verlaan-Klink, Madelon M. Maurice, Boudewijn M.T. Burgering, Jacco van Rheenen, Michiel Vermeulen, Hugo J.G. Snippert
Published in: Cell Reports, Issue 22/6, 2018, Page(s) 1600-1614, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2018.01.033

Cancer cells copy migratory behavior and exchange signaling networks via extracellular vesicles

Author(s): Sander C Steenbeek, Thang V Pham, Joep de Ligt, Anoek Zomer, Jaco C Knol, Sander R Piersma, Tim Schelfhorst, Rick Huisjes, Raymond M Schiffelers, Edwin Cuppen, Connie R Jimenez, Jacco van Rheenen
Published in: The EMBO Journal, Issue 37/15, 2018, Page(s) e98357, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.201798357

Identity and dynamics of mammary stem cells during branching morphogenesis

Author(s): Scheele, Colinda L. G. J.; Hannezo, Edouard; Muraro, Mauro J.; Zomer, Anoek; Langedijk, Nathalia S. M.; van Oudenaarden, Alexander; Simons, Benjamin D.; van Rheenen, Jacco
Published in: Nature, Issue 1, 2017, ISSN 1476-4687
Publisher: Nature group
DOI: 10.17863/CAM.8101

Wnt ligands influence tumour initiation by controlling the number of intestinal stem cells

Author(s): D. J. Huels, L. Bruens, M. C. Hodder, P. Cammareri, A. D. Campbell, R. A. Ridgway, D. M. Gay, M. Solar-Abboud, W. J. Faller, C. Nixon, L. B. Zeiger, M. E. McLaughlin, E. Morrissey, D. J. Winton, H. J. Snippert, J. van Rheenen, O. J. Sansom
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-03426-2

Intravital Insights into Heterogeneity, Metastasis, and Therapy Responses

Author(s): Colinda L.G.J. Scheele, Carrie Maynard, Jacco van Rheenen
Published in: Trends in Cancer, Issue 2/4, 2016, Page(s) 205-216, ISSN 2405-8033
Publisher: Cell press
DOI: 10.1016/j.trecan.2016.03.001

Potential impact of invasive surgical procedures on primary tumor growth and metastasis

Author(s): Maria Alieva, Jacco van Rheenen, Marike L. D. Broekman
Published in: Clinical & Experimental Metastasis, Issue 35/4, 2018, Page(s) 319-331, ISSN 0262-0898
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10585-018-9896-8

Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids

Author(s): Arianna Fumagalli, Jarno Drost, Saskia J. E. Suijkerbuijk, Ruben van Boxtel, Joep de Ligt, G. Johan Offerhaus, Harry Begthel, Evelyne Beerling, Ee Hong Tan, Owen J. Sansom, Edwin Cuppen, Hans Clevers, Jacco van Rheenen
Published in: Proceedings of the National Academy of Sciences, Issue 114/12, 2017, Page(s) E2357-E2364, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1701219114

Intravital characterization of tumor cell migration in pancreatic cancer

Author(s): Evelyne Beerling, Ilse Oosterom, Emile Voest, Martijn Lolkema, Jacco van Rheenen
Published in: IntraVital, Issue 5/3, 2016, Page(s) e1261773, ISSN 2165-9087
Publisher: Taylor&Francis Online
DOI: 10.1080/21659087.2016.1261773