Tumor cell death supports recurrence of cancer

Informazioni relative al progetto

Cancer-Recurrence

ID dell’accordo di sovvenzione: 648804

DOI 10.3030/648804

Progetto chiuso

Data della firma CE 12 Agosto 2015

Data di avvio 1 Settembre 2015

Data di completamento 31 Agosto 2020

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 2 000 000,00

Contributo UE € 2 000 000,00

Coordinato da

STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
Netherlands

Pubblicazioni

Peer reviewed articles (17)

Intravital imaging of glioma border morphology reveals distinctive cellular dynamics and contribution to tumor cell invasion

Autori: Maria Alieva, Verena Leidgens, Markus J. Riemenschneider, Christoph A. Klein, Peter Hau, Jacco van Rheenen
Pubblicato in: Scientific Reports, Numero 9/1, 2019, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-019-38625-4

A CRISPR-Cas9-based reporter system for single-cell detection of extracellular vesicle-mediated functional transfer of RNA

Autori: Olivier G. de Jong, Daniel E. Murphy, Imre Mäger, Eduard Willms, Antonio Garcia-Guerra, Jerney J. Gitz-Francois, Juliet Lefferts, Dhanu Gupta, Sander C. Steenbeek, Jacco van Rheenen, Samir El Andaloussi, Raymond M. Schiffelers, Matthew J. A. Wood, Pieter Vader
Pubblicato in: Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-14977-8

Rebalancing of actomyosin contractility enables mammary tumor formation upon loss of E-cadherin

Autori: Koen Schipper, Danielle Seinstra, Anne Paulien Drenth, Eline van der Burg, Veronika Ramovs, Arnoud Sonnenberg, Jacco van Rheenen, Micha Nethe, Jos Jonkers
Pubblicato in: Nature Communications, Numero 10/1, 2019, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-019-11716-6

In Vivo Imaging Reveals Existence of Crypt Fission and Fusion in Adult Mouse Intestine

Autori: Lotte Bruens, Saskia I.J. Ellenbroek, Jacco van Rheenen, Hugo J. Snippert
Pubblicato in: Gastroenterology, Numero 153/3, 2017, Pagina/e 674-677.e3, ISSN 0016-5085
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2017.05.019

A Unifying Theory of Branching Morphogenesis

Autori: Edouard Hannezo, Colinda L.G.J. Scheele, Mohammad Moad, Nicholas Drogo, Rakesh Heer, Rosemary V. Sampogna, Jacco van Rheenen, Benjamin D. Simons
Pubblicato in: Cell, Numero 171/1, 2017, Pagina/e 242-255.e27, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2017.08.026

Preventing inflammation inhibits biopsy-mediated changes in tumor cell behavior

Autori: Maria Alieva, Andreia S. Margarido, Tamara Wieles, Erik R. Abels, Burcin Colak, Carla Boquetale, Herke Jan Noordmans, Tom J. Snijders, Marike L. Broekman, Jacco van Rheenen
Pubblicato in: Scientific Reports, Numero 7/1, 2017, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-017-07660-4

From good to bad: Intravital imaging of the hijack of physiological processes by cancer cells

Autori: Saskia J.E. Suijkerbuijk, Jacco van Rheenen
Pubblicato in: Developmental Biology, Numero 428/2, 2017, Pagina/e 328-337, ISSN 0012-1606
Editore: Academic Press
DOI: 10.1016/j.ydbio.2017.04.015

Plasticity between Epithelial and Mesenchymal States Unlinks EMT from Metastasis-Enhancing Stem Cell Capacity

Autori: Evelyne Beerling, Daniëlle Seinstra, Elzo de Wit, Lennart Kester, Daphne van der Velden, Carrie Maynard, Ronny Schäfer, Paul van Diest, Emile Voest, Alexander van Oudenaarden, Nienke Vrisekoop, Jacco van Rheenen
Pubblicato in: Cell Reports, Numero 14/10, 2016, Pagina/e 2281-2288, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2016.02.034

A surgical orthotopic organoid transplantation approach in mice to visualize and study colorectal cancer progression

Autori: Arianna Fumagalli, Saskia J E Suijkerbuijk, Harry Begthel, Evelyne Beerling, Koen C Oost, Hugo J Snippert, Jacco van Rheenen, Jarno Drost
Pubblicato in: Nature Protocols, Numero 13/2, 2018, Pagina/e 235-247, ISSN 1754-2189
Editore: Nature Publishing Group
DOI: 10.1038/nprot.2017.137

Specific Labeling of Stem Cell Activity in Human Colorectal Organoids Using an ASCL2-Responsive Minigene

Autori: Koen C. Oost, Lisa van Voorthuijsen, Arianna Fumagalli, Rik G.H. Lindeboom, Joep Sprangers, Manja Omerzu, Maria J. Rodriguez-Colman, Maria C. Heinz, Ingrid Verlaan-Klink, Madelon M. Maurice, Boudewijn M.T. Burgering, Jacco van Rheenen, Michiel Vermeulen, Hugo J.G. Snippert
Pubblicato in: Cell Reports, Numero 22/6, 2018, Pagina/e 1600-1614, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2018.01.033

Cancer cells copy migratory behavior and exchange signaling networks via extracellular vesicles

Autori: Sander C Steenbeek, Thang V Pham, Joep de Ligt, Anoek Zomer, Jaco C Knol, Sander R Piersma, Tim Schelfhorst, Rick Huisjes, Raymond M Schiffelers, Edwin Cuppen, Connie R Jimenez, Jacco van Rheenen
Pubblicato in: The EMBO Journal, Numero 37/15, 2018, Pagina/e e98357, ISSN 0261-4189
Editore: Nature Publishing Group
DOI: 10.15252/embj.201798357

Identity and dynamics of mammary stem cells during branching morphogenesis

Autori: Scheele, Colinda L. G. J.; Hannezo, Edouard; Muraro, Mauro J.; Zomer, Anoek; Langedijk, Nathalia S. M.; van Oudenaarden, Alexander; Simons, Benjamin D.; van Rheenen, Jacco
Pubblicato in: Nature, Numero 1, 2017, ISSN 1476-4687
Editore: Nature group
DOI: 10.17863/CAM.8101

Wnt ligands influence tumour initiation by controlling the number of intestinal stem cells

Autori: D. J. Huels, L. Bruens, M. C. Hodder, P. Cammareri, A. D. Campbell, R. A. Ridgway, D. M. Gay, M. Solar-Abboud, W. J. Faller, C. Nixon, L. B. Zeiger, M. E. McLaughlin, E. Morrissey, D. J. Winton, H. J. Snippert, J. van Rheenen, O. J. Sansom
Pubblicato in: Nature Communications, Numero 9/1, 2018, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-018-03426-2

Intravital Insights into Heterogeneity, Metastasis, and Therapy Responses

Autori: Colinda L.G.J. Scheele, Carrie Maynard, Jacco van Rheenen
Pubblicato in: Trends in Cancer, Numero 2/4, 2016, Pagina/e 205-216, ISSN 2405-8033
Editore: Cell press
DOI: 10.1016/j.trecan.2016.03.001

Potential impact of invasive surgical procedures on primary tumor growth and metastasis

Autori: Maria Alieva, Jacco van Rheenen, Marike L. D. Broekman
Pubblicato in: Clinical & Experimental Metastasis, Numero 35/4, 2018, Pagina/e 319-331, ISSN 0262-0898
Editore: Kluwer Academic Publishers
DOI: 10.1007/s10585-018-9896-8

Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids

Autori: Arianna Fumagalli, Jarno Drost, Saskia J. E. Suijkerbuijk, Ruben van Boxtel, Joep de Ligt, G. Johan Offerhaus, Harry Begthel, Evelyne Beerling, Ee Hong Tan, Owen J. Sansom, Edwin Cuppen, Hans Clevers, Jacco van Rheenen
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 114/12, 2017, Pagina/e E2357-E2364, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.1701219114

Intravital characterization of tumor cell migration in pancreatic cancer

Autori: Evelyne Beerling, Ilse Oosterom, Emile Voest, Martijn Lolkema, Jacco van Rheenen
Pubblicato in: IntraVital, Numero 5/3, 2016, Pagina/e e1261773, ISSN 2165-9087
Editore: Taylor&Francis Online
DOI: 10.1080/21659087.2016.1261773