Identifying microbiotal triggers of inflammatory bowel disease through the lens of the immune system

Project Information

IMMUNOBIOME

Grant agreement ID: 648889

DOI 10.3030/648889

Project closed

EC signature date 3 July 2015

Start date 1 January 2016

End date 31 December 2020

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 304 375,00

EU contribution € 2 304 375,00

Coordinated by

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom

Publications

Peer reviewed articles (15)

Activating Transcription Factor 6 Mediates Inflammatory Signals in Intestinal Epithelial Cells Upon Endoplasmic Reticulum Stress

Author(s): Stephanie T. Stengel, Antonella Fazio, Simone Lipinski, Martin T. Jahn, Konrad Aden, Go Ito, Felix Wottawa, Jan W.P. Kuiper, Olivia I. Coleman, Florian Tran, Dora Bordoni, Joana P. Bernardes, Marlene Jentzsch, Anne Luzius, Sandra Bierwirth, Berith Messner, Anna Henning, Lina Welz, Nassim Kakavand, Maren Falk-Paulsen, Simon Imm, Finn Hinrichsen, Matthias Zilbauer, Stefan Schreiber, Arthur Kaser, Ri
Published in: Gastroenterology, 2020, ISSN 0016-5085
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2020.06.088

Activation of the GPR35 pathway drives angiogenesis in the tumour microenvironment

Author(s): Ester Pagano, Joshua E Elias, Georg Schneditz, Svetlana Saveljeva, Lorraine M Holland, Francesca Borrelli, Tom H Karlsen, Arthur Kaser, Nicole C Kaneider
Published in: Gut, 2021, Page(s) gutjnl-2020-323363, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2020-323363

FAMIN Is a Multifunctional Purine Enzyme Enabling the Purine Nucleotide Cycle

Author(s): M. Zaeem Cader, Rodrigo Pereira de Almeida Rodrigues, James A. West, Gavin W. Sewell, Muhammad N. Md-Ibrahim, Stephanie Reikine, Giuseppe Sirago, Lukas W. Unger, Ana Belén Iglesias-Romero, Katharina Ramshorn, Lea-Maxie Haag, Svetlana Saveljeva, Jana-Fabienne Ebel, Philip Rosenstiel, Nicole C. Kaneider, James C. Lee, Trevor D. Lawley, Allan Bradley, Gordon Dougan, Yorgo Modis, Julian L. Griffin, A
Published in: Cell, Issue 180/2, 2020, Page(s) 278-295.e23, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2019.12.017

Impaired Autophagy in CD11b + Dendritic Cells Expands CD4 + Regulatory T Cells and Limits Atherosclerosis in Mice

Author(s): Marc Clement, Juliette Raffort, Fabien Lareyre, Dimitrios Tsiantoulas, Stephen Newland, Yuning Lu, Leanne Masters, James Harrison, Svetlana Saveljeva, Marcella K.L. Ma, Maria Ozsvar-Kozma, Brian Y.H. Lam, Giles S.H. Yeo, Christoph J. Binder, Arthur Kaser, Ziad Mallat
Published in: Circulation Research, Issue 125/11, 2019, Page(s) 1019-1034, ISSN 0009-7330
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.119.315248

ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS–STING

Author(s): Konrad Aden, Florian Tran, Go Ito, Raheleh Sheibani-Tezerji, Simone Lipinski, Jan W. Kuiper, Markus Tschurtschenthaler, Svetlana Saveljeva, Joya Bhattacharyya, Robert Häsler, Kareen Bartsch, Anne Luzius, Marlene Jentzsch, Maren Falk-Paulsen, Stephanie T. Stengel, Lina Welz, Robin Schwarzer, Björn Rabe, Winfried Barchet, Stefan Krautwald, Gunther Hartmann, Manolis Pasparakis, Richard S. Blumberg,
Published in: The Journal of Experimental Medicine, 2018, Page(s) jem.20171029, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20171029

Epithelial IL-23R Signaling Licenses Protective IL-22 Responses in Intestinal Inflammation

Author(s): Konrad Aden, Ateequr Rehman, Maren Falk-Paulsen, Thomas Secher, Jan Kuiper, Florian Tran, Steffen Pfeuffer, Raheleh Sheibani-Tezerji, Alexandra Breuer, Anne Luzius, Marlene Jentzsch, Robert Häsler, Susanne Billmann-Born, Olga Will, Simone Lipinski, Richa Bharti, Timon Adolph, Juan L. Iovanna, Sarah L. Kempster, Richard S. Blumberg, Stefan Schreiber, Burkhard Becher, Mathias Chamaillard, Arthur
Published in: Cell Reports, Issue 16/8, 2016, Page(s) 2208-2218, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2016.07.054

Intestinal epithelial cell endoplasmic reticulum stress promotes MULT1 up-regulation and NKG2D-mediated inflammation

Author(s): Shuhei Hosomi, Joep Grootjans, Markus Tschurtschenthaler, Niklas Krupka, Juan D. Matute, Magdalena B. Flak, Eduardo Martinez-Naves, Manuel Gomez del Moral, Jonathan N. Glickman, Mizuki Ohira, Lewis L. Lanier, Arthur Kaser, Richard Blumberg
Published in: The Journal of Experimental Medicine, Issue 214/10, 2017, Page(s) 2985-2997, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20162041

Personalized Treatment in Inflammatory Bowel Disease: For Another Time

Author(s): Nicole C. Kaneider, Arthur Kaser
Published in: Gastroenterology, 2018, ISSN 0016-5085
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2018.09.004

New Insights Into the Regulation of Natural-Killer Group 2 Member D (NKG2D) and NKG2D-Ligands: Endoplasmic Reticulum Stress and CEA-Related Cell Adhesion Molecule 1

Author(s): Shuhei Hosomi, Joep Grootjans, Yu-Hwa Huang, Arthur Kaser, Richard S. Blumberg
Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2018.01324

The unfolded protein response in immunity and inflammation

Author(s): Joep Grootjans, Arthur Kaser, Randal J. Kaufman, Richard S. Blumberg
Published in: Nature Reviews Immunology, Issue 16/8, 2016, Page(s) 469-484, ISSN 1474-1733
Publisher: Nature Publishing Group
DOI: 10.1038/nri.2016.62

GPR35 promotes glycolysis, proliferation, and oncogenic signaling by engaging with the sodium potassium pump

Author(s): Georg Schneditz, Joshua E. Elias, Ester Pagano, M. Zaeem Cader, Svetlana Saveljeva, Kathleen Long, Subhankar Mukhopadhyay, Maryam Arasteh, Trevor D. Lawley, Gordon Dougan, Andrew Bassett, Tom H. Karlsen, Arthur Kaser, Nicole C. Kaneider
Published in: Science Signaling, Issue 12/562, 2019, Page(s) eaau9048, ISSN 1937-9145
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scisignal.aau9048

Epithelial endoplasmic reticulum stress orchestrates a protective IgA response

Author(s): Joep Grootjans, Niklas Krupka, Shuhei Hosomi, Juan D. Matute, Thomas Hanley, Svetlana Saveljeva, Thomas Gensollen, Jarom Heijmans, Hai Li, Julien P. Limenitakis, Stephanie C. Ganal-Vonarburg, Shengbao Suo, Adrienne M. Luoma, Yosuke Shimodaira, Jinzhi Duan, David Q. Shih, Margaret E. Conner, Jonathan N. Glickman, Gwenny M. Fuhler, Noah W. Palm, Marcel R. de Zoete, C. Janneke van der Woude, Guo-Chen
Published in: Science, Issue 363/6430, 2019, Page(s) 993-998, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aat7186

Defective ATG16L1-mediated removal of IRE1α drives Crohn’s disease–like ileitis

Author(s): Markus Tschurtschenthaler, Timon E. Adolph, Jonathan W. Ashcroft, Lukas Niederreiter, Richa Bharti, Svetlana Saveljeva, Joya Bhattacharyya, Magdalena B. Flak, David Q. Shih, Gwenny M. Fuhler, Miles Parkes, Kenji Kohno, Takao Iwawaki, C. Janneke van der Woude, Heather P. Harding, Andrew M. Smith, Maikel P. Peppelenbosch, Stephan R. Targan, David Ron, Philip Rosenstiel, Richard S. Blumberg, Arthur K
Published in: The Journal of Experimental Medicine, Issue 214/2, 2017, Page(s) 401-422, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20160791

The road to Crohn's disease

Author(s): Arthur Kaser, Richard S. Blumberg
Published in: Science, Issue 357/6355, 2017, Page(s) 976-977, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aao4158

Interleukin-22 orchestrates a pathological endoplasmic reticulum stress response transcriptional programme in colonic epithelial cells

Author(s): Nick Powell, Eirini Pantazi, Polychronis Pavlidis, Anastasia Tsakmaki, Katherine Li, Feifei Yang, Aimee Parker, Carmen Pin, Domenico Cozzetto, Danielle Minns, Emilie Stolarczyk, Svetlana Saveljeva, Rami Mohamed, Paul Lavender, Behdad Afzali, Jonathan Digby-Bell, Tsui Tjir-Li, Arthur Kaser, Joshua Friedman, Thomas T MacDonald, Gavin A Bewick, Graham M Lord
Published in: Gut, Issue 69/3, 2020, Page(s) 578-590, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2019-318483

Intellectual Property Rights

Patent (2)

METHODS OF CANCER TREATMENT

Application/Publication number: 20 19084265
Date: 2019-12-09

FAMIN ASSAY METHODS

Application/Publication number: 20 19084256
Date: 2019-12-09