Identifying microbiotal triggers of inflammatory bowel disease through the lens of the immune system

Publicaciones

Activating Transcription Factor 6 Mediates Inflammatory Signals in Intestinal Epithelial Cells Upon Endoplasmic Reticulum Stress

Autores: Stephanie T. Stengel, Antonella Fazio, Simone Lipinski, Martin T. Jahn, Konrad Aden, Go Ito, Felix Wottawa, Jan W.P. Kuiper, Olivia I. Coleman, Florian Tran, Dora Bordoni, Joana P. Bernardes, Marlene Jentzsch, Anne Luzius, Sandra Bierwirth, Berith Messner, Anna Henning, Lina Welz, Nassim Kakavand, Maren Falk-Paulsen, Simon Imm, Finn Hinrichsen, Matthias Zilbauer, Stefan Schreiber, Arthur Kaser, Ri
Publicado en: Gastroenterology, 2020, ISSN 0016-5085
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2020.06.088

Activation of the GPR35 pathway drives angiogenesis in the tumour microenvironment

Autores: Ester Pagano, Joshua E Elias, Georg Schneditz, Svetlana Saveljeva, Lorraine M Holland, Francesca Borrelli, Tom H Karlsen, Arthur Kaser, Nicole C Kaneider
Publicado en: Gut, 2021, Página(s) gutjnl-2020-323363, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2020-323363

FAMIN Is a Multifunctional Purine Enzyme Enabling the Purine Nucleotide Cycle

Autores: M. Zaeem Cader, Rodrigo Pereira de Almeida Rodrigues, James A. West, Gavin W. Sewell, Muhammad N. Md-Ibrahim, Stephanie Reikine, Giuseppe Sirago, Lukas W. Unger, Ana Belén Iglesias-Romero, Katharina Ramshorn, Lea-Maxie Haag, Svetlana Saveljeva, Jana-Fabienne Ebel, Philip Rosenstiel, Nicole C. Kaneider, James C. Lee, Trevor D. Lawley, Allan Bradley, Gordon Dougan, Yorgo Modis, Julian L. Griffin, A
Publicado en: Cell, Edición 180/2, 2020, Página(s) 278-295.e23, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2019.12.017

Impaired Autophagy in CD11b + Dendritic Cells Expands CD4 + Regulatory T Cells and Limits Atherosclerosis in Mice

Autores: Marc Clement, Juliette Raffort, Fabien Lareyre, Dimitrios Tsiantoulas, Stephen Newland, Yuning Lu, Leanne Masters, James Harrison, Svetlana Saveljeva, Marcella K.L. Ma, Maria Ozsvar-Kozma, Brian Y.H. Lam, Giles S.H. Yeo, Christoph J. Binder, Arthur Kaser, Ziad Mallat
Publicado en: Circulation Research, Edición 125/11, 2019, Página(s) 1019-1034, ISSN 0009-7330
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.119.315248

ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS–STING

Autores: Konrad Aden, Florian Tran, Go Ito, Raheleh Sheibani-Tezerji, Simone Lipinski, Jan W. Kuiper, Markus Tschurtschenthaler, Svetlana Saveljeva, Joya Bhattacharyya, Robert Häsler, Kareen Bartsch, Anne Luzius, Marlene Jentzsch, Maren Falk-Paulsen, Stephanie T. Stengel, Lina Welz, Robin Schwarzer, Björn Rabe, Winfried Barchet, Stefan Krautwald, Gunther Hartmann, Manolis Pasparakis, Richard S. Blumberg,
Publicado en: The Journal of Experimental Medicine, 2018, Página(s) jem.20171029, ISSN 0022-1007
Editor: Rockefeller University Press
DOI: 10.1084/jem.20171029

Epithelial IL-23R Signaling Licenses Protective IL-22 Responses in Intestinal Inflammation

Autores: Konrad Aden, Ateequr Rehman, Maren Falk-Paulsen, Thomas Secher, Jan Kuiper, Florian Tran, Steffen Pfeuffer, Raheleh Sheibani-Tezerji, Alexandra Breuer, Anne Luzius, Marlene Jentzsch, Robert Häsler, Susanne Billmann-Born, Olga Will, Simone Lipinski, Richa Bharti, Timon Adolph, Juan L. Iovanna, Sarah L. Kempster, Richard S. Blumberg, Stefan Schreiber, Burkhard Becher, Mathias Chamaillard, Arthur
Publicado en: Cell Reports, Edición 16/8, 2016, Página(s) 2208-2218, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2016.07.054

Intestinal epithelial cell endoplasmic reticulum stress promotes MULT1 up-regulation and NKG2D-mediated inflammation

Autores: Shuhei Hosomi, Joep Grootjans, Markus Tschurtschenthaler, Niklas Krupka, Juan D. Matute, Magdalena B. Flak, Eduardo Martinez-Naves, Manuel Gomez del Moral, Jonathan N. Glickman, Mizuki Ohira, Lewis L. Lanier, Arthur Kaser, Richard Blumberg
Publicado en: The Journal of Experimental Medicine, Edición 214/10, 2017, Página(s) 2985-2997, ISSN 0022-1007
Editor: Rockefeller University Press
DOI: 10.1084/jem.20162041

Personalized Treatment in Inflammatory Bowel Disease: For Another Time

Autores: Nicole C. Kaneider, Arthur Kaser
Publicado en: Gastroenterology, 2018, ISSN 0016-5085
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2018.09.004

New Insights Into the Regulation of Natural-Killer Group 2 Member D (NKG2D) and NKG2D-Ligands: Endoplasmic Reticulum Stress and CEA-Related Cell Adhesion Molecule 1

Autores: Shuhei Hosomi, Joep Grootjans, Yu-Hwa Huang, Arthur Kaser, Richard S. Blumberg
Publicado en: Frontiers in Immunology, Edición 9, 2018, ISSN 1664-3224
Editor: Frontiers
DOI: 10.3389/fimmu.2018.01324

The unfolded protein response in immunity and inflammation

Autores: Joep Grootjans, Arthur Kaser, Randal J. Kaufman, Richard S. Blumberg
Publicado en: Nature Reviews Immunology, Edición 16/8, 2016, Página(s) 469-484, ISSN 1474-1733
Editor: Nature Publishing Group
DOI: 10.1038/nri.2016.62

GPR35 promotes glycolysis, proliferation, and oncogenic signaling by engaging with the sodium potassium pump

Autores: Georg Schneditz, Joshua E. Elias, Ester Pagano, M. Zaeem Cader, Svetlana Saveljeva, Kathleen Long, Subhankar Mukhopadhyay, Maryam Arasteh, Trevor D. Lawley, Gordon Dougan, Andrew Bassett, Tom H. Karlsen, Arthur Kaser, Nicole C. Kaneider
Publicado en: Science Signaling, Edición 12/562, 2019, Página(s) eaau9048, ISSN 1937-9145
Editor: American Association for the Advancement of Science
DOI: 10.1126/scisignal.aau9048

Epithelial endoplasmic reticulum stress orchestrates a protective IgA response

Autores: Joep Grootjans, Niklas Krupka, Shuhei Hosomi, Juan D. Matute, Thomas Hanley, Svetlana Saveljeva, Thomas Gensollen, Jarom Heijmans, Hai Li, Julien P. Limenitakis, Stephanie C. Ganal-Vonarburg, Shengbao Suo, Adrienne M. Luoma, Yosuke Shimodaira, Jinzhi Duan, David Q. Shih, Margaret E. Conner, Jonathan N. Glickman, Gwenny M. Fuhler, Noah W. Palm, Marcel R. de Zoete, C. Janneke van der Woude, Guo-Chen
Publicado en: Science, Edición 363/6430, 2019, Página(s) 993-998, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.aat7186

Defective ATG16L1-mediated removal of IRE1α drives Crohn’s disease–like ileitis

Autores: Markus Tschurtschenthaler, Timon E. Adolph, Jonathan W. Ashcroft, Lukas Niederreiter, Richa Bharti, Svetlana Saveljeva, Joya Bhattacharyya, Magdalena B. Flak, David Q. Shih, Gwenny M. Fuhler, Miles Parkes, Kenji Kohno, Takao Iwawaki, C. Janneke van der Woude, Heather P. Harding, Andrew M. Smith, Maikel P. Peppelenbosch, Stephan R. Targan, David Ron, Philip Rosenstiel, Richard S. Blumberg, Arthur K
Publicado en: The Journal of Experimental Medicine, Edición 214/2, 2017, Página(s) 401-422, ISSN 0022-1007
Editor: Rockefeller University Press
DOI: 10.1084/jem.20160791

The road to Crohn's disease

Autores: Arthur Kaser, Richard S. Blumberg
Publicado en: Science, Edición 357/6355, 2017, Página(s) 976-977, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.aao4158

Interleukin-22 orchestrates a pathological endoplasmic reticulum stress response transcriptional programme in colonic epithelial cells

Autores: Nick Powell, Eirini Pantazi, Polychronis Pavlidis, Anastasia Tsakmaki, Katherine Li, Feifei Yang, Aimee Parker, Carmen Pin, Domenico Cozzetto, Danielle Minns, Emilie Stolarczyk, Svetlana Saveljeva, Rami Mohamed, Paul Lavender, Behdad Afzali, Jonathan Digby-Bell, Tsui Tjir-Li, Arthur Kaser, Joshua Friedman, Thomas T MacDonald, Gavin A Bewick, Graham M Lord
Publicado en: Gut, Edición 69/3, 2020, Página(s) 578-590, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2019-318483

Derechos de propiedad intelectual

METHODS OF CANCER TREATMENT

Número de solicitud/publicación: 20 19084265
Fecha: 2019-12-09

FAMIN ASSAY METHODS

Número de solicitud/publicación: 20 19084256
Fecha: 2019-12-09

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