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Uncovering targets for ex vivo expansion of hematopoietic stem cells to enhance cell therapies of blood disorders

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Publications

Transient inhibition of NF-κB signaling enhances ex vivo propagation of human hematopoietic stem cells

Author(s): Mehrnaz Safaee Talkhoncheh, Agatheeswaran Subramaniam, Mattias Magnusson, Praveen Kumar, Jonas Larsson, Aurélie Baudet
Published in: Haematologica, Issue 103/9, 2018, Page(s) 1444-1450, ISSN 0390-6078
DOI: 10.3324/haematol.2018.188466

Cytohesin 1 regulates homing and engraftment of human hematopoietic stem and progenitor cells

Author(s): Justyna Rak, Katie Foster, Katarzyna Potrzebowska, Mehrnaz Safaee Talkhoncheh, Natsumi Miharada, Karolina Komorowska, Therese Torngren, Anders Kvist, Åke Borg, Lena Svensson, Dominique Bonnet, Jonas Larsson
Published in: Blood, Issue 129/8, 2017, Page(s) 950-958, ISSN 0006-4971
DOI: 10.1182/blood-2016-06-720649

Genome-wide RNAi Screen Identifies Cohesin Genes as Modifiers of Renewal and Differentiation in Human HSCs

Author(s): Roman Galeev, Aurélie Baudet, Praveen Kumar, Alexandra Rundberg Nilsson, Björn Nilsson, Shamit Soneji, Therese Törngren, Åke Borg, Anders Kvist, Jonas Larsson
Published in: Cell Reports, Issue 14/12, 2016, Page(s) 2988-3000, ISSN 2211-1247
DOI: 10.1016/j.celrep.2016.02.082

Arrayed molecular barcoding identifies TNFSF13 as a positive regulator of acute myeloid leukemia-initiating cells

Author(s): Marion Chapellier, Pablo Peña-Martínez, Ramprasad Ramakrishnan, Mia Eriksson, Mehrnaz Safaee Talkhoncheh, Christina Orsmark-Pietras, Henrik Lilljebjörn, Carl Högberg, Anna Hagström-Andersson, Thoas Fioretos, Jonas Larsson, Marcus Järås
Published in: Haematologica, Issue 104/10, 2019, Page(s) 2006-2016, ISSN 0390-6078
DOI: 10.3324/haematol.2018.192062

HMGA2 promotes long-term engraftment and myeloerythroid differentiation of human hematopoietic stem and progenitor cells

Author(s): Praveen Kumar, Dominik Beck, Roman Galeev, Julie A. I. Thoms, Mehrnaz Safaee Talkhoncheh, Ineke de Jong, Ashwin Unnikrishnan, Aurélie Baudet, Agatheeswaran Subramaniam, John E. Pimanda, Jonas Larsson
Published in: Blood Advances, Issue 3/4, 2019, Page(s) 681-691, ISSN 2473-9529
DOI: 10.1182/bloodadvances.2018023986

Endothelial protein C receptor (EPCR) expression marks human fetal liver hematopoietic stem cells

Author(s): Agatheeswaran Subramaniam, Mehrnaz Safaee Talkhoncheh, Mattias Magnusson, Jonas Larsson
Published in: Haematologica, Issue 104/2, 2019, Page(s) e47-e50, ISSN 0390-6078
DOI: 10.3324/haematol.2018.198515