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Uncovering targets for ex vivo expansion of hematopoietic stem cells to enhance cell therapies of blood disorders

Publications

Efficient and nontoxic biomolecule delivery to primary human hematopoietic stem cells using nanostraws

Author(s): Ludwig Schmiderer, Agatheeswaran Subramaniam, Kristijonas Žemaitis, Alexandra Bäckström, David Yudovich, Svetlana Soboleva, Roman Galeev, Christelle N. Prinz, Jonas Larsson, Martin Hjort
Published in: Proceedings of the National Academy of Sciences, Issue 117/35, 2020, Page(s) 21267-21273, ISSN 0027-8424
DOI: 10.1073/pnas.2001367117

Lysine-specific demethylase 1A restricts ex vivo propagation of human HSCs and is a target of UM171

Author(s): Agatheeswaran Subramaniam, Kristijonas Žemaitis, Mehrnaz Safaee Talkhoncheh, David Yudovich, Alexandra Bäckström, Shubhranshu Debnath, Jun Chen, Mayur Vilas Jain, Roman Galeev, Massimiliano Gaetani, Roman A. Zubarev, Jonas Larsson
Published in: Blood, Issue 136/19, 2020, Page(s) 2151-2161, ISSN 0006-4971
DOI: 10.1182/blood.2020005827

Transient inhibition of NF-κB signaling enhances ex vivo propagation of human hematopoietic stem cells

Author(s): Mehrnaz Safaee Talkhoncheh, Agatheeswaran Subramaniam, Mattias Magnusson, Praveen Kumar, Jonas Larsson, Aurélie Baudet
Published in: Haematologica, Issue 103/9, 2018, Page(s) 1444-1450, ISSN 0390-6078
DOI: 10.3324/haematol.2018.188466

Cytohesin 1 regulates homing and engraftment of human hematopoietic stem and progenitor cells

Author(s): Justyna Rak, Katie Foster, Katarzyna Potrzebowska, Mehrnaz Safaee Talkhoncheh, Natsumi Miharada, Karolina Komorowska, Therese Torngren, Anders Kvist, Åke Borg, Lena Svensson, Dominique Bonnet, Jonas Larsson
Published in: Blood, Issue 129/8, 2017, Page(s) 950-958, ISSN 0006-4971
DOI: 10.1182/blood-2016-06-720649

Genome-wide RNAi Screen Identifies Cohesin Genes as Modifiers of Renewal and Differentiation in Human HSCs

Author(s): Roman Galeev, Aurélie Baudet, Praveen Kumar, Alexandra Rundberg Nilsson, Björn Nilsson, Shamit Soneji, Therese Törngren, Åke Borg, Anders Kvist, Jonas Larsson
Published in: Cell Reports, Issue 14/12, 2016, Page(s) 2988-3000, ISSN 2211-1247
DOI: 10.1016/j.celrep.2016.02.082

Arrayed molecular barcoding identifies TNFSF13 as a positive regulator of acute myeloid leukemia-initiating cells

Author(s): Marion Chapellier, Pablo Peña-Martínez, Ramprasad Ramakrishnan, Mia Eriksson, Mehrnaz Safaee Talkhoncheh, Christina Orsmark-Pietras, Henrik Lilljebjörn, Carl Högberg, Anna Hagström-Andersson, Thoas Fioretos, Jonas Larsson, Marcus Järås
Published in: Haematologica, Issue 104/10, 2019, Page(s) 2006-2016, ISSN 0390-6078
DOI: 10.3324/haematol.2018.192062

HMGA2 promotes long-term engraftment and myeloerythroid differentiation of human hematopoietic stem and progenitor cells

Author(s): Praveen Kumar, Dominik Beck, Roman Galeev, Julie A. I. Thoms, Mehrnaz Safaee Talkhoncheh, Ineke de Jong, Ashwin Unnikrishnan, Aurélie Baudet, Agatheeswaran Subramaniam, John E. Pimanda, Jonas Larsson
Published in: Blood Advances, Issue 3/4, 2019, Page(s) 681-691, ISSN 2473-9529
DOI: 10.1182/bloodadvances.2018023986

Endothelial protein C receptor (EPCR) expression marks human fetal liver hematopoietic stem cells

Author(s): Agatheeswaran Subramaniam, Mehrnaz Safaee Talkhoncheh, Mattias Magnusson, Jonas Larsson
Published in: Haematologica, Issue 104/2, 2019, Page(s) e47-e50, ISSN 0390-6078
DOI: 10.3324/haematol.2018.198515

Combined lentiviral- and RNA-mediated CRISPR/Cas9 delivery for efficient and traceable gene editing in human hematopoietic stem and progenitor cells

Author(s): David Yudovich, Alexandra Bäckström, Ludwig Schmiderer, Kristijonas Žemaitis, Agatheeswaran Subramaniam, Jonas Larsson
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
DOI: 10.1038/s41598-020-79724-x