Uncovering targets for ex vivo expansion of hematopoietic stem cells to enhance cell therapies of blood disorders

Project Information

UNEXPECTED

Grant agreement ID: 648894

DOI 10.3030/648894

Project closed

EC signature date 30 July 2015

Start date 1 August 2015

End date 31 January 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 000 000,00

EU contribution € 2 000 000,00

Coordinated by

LUNDS UNIVERSITET
Sweden

Publications

Peer reviewed articles (9)

Efficient and nontoxic biomolecule delivery to primary human hematopoietic stem cells using nanostraws

Author(s): Ludwig Schmiderer, Agatheeswaran Subramaniam, Kristijonas Žemaitis, Alexandra Bäckström, David Yudovich, Svetlana Soboleva, Roman Galeev, Christelle N. Prinz, Jonas Larsson, Martin Hjort
Published in: Proceedings of the National Academy of Sciences, Issue 117/35, 2020, Page(s) 21267-21273, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2001367117

Lysine-specific demethylase 1A restricts ex vivo propagation of human HSCs and is a target of UM171

Author(s): Agatheeswaran Subramaniam, Kristijonas Žemaitis, Mehrnaz Safaee Talkhoncheh, David Yudovich, Alexandra Bäckström, Shubhranshu Debnath, Jun Chen, Mayur Vilas Jain, Roman Galeev, Massimiliano Gaetani, Roman A. Zubarev, Jonas Larsson
Published in: Blood, Issue 136/19, 2020, Page(s) 2151-2161, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood.2020005827

Transient inhibition of NF-κB signaling enhances ex vivo propagation of human hematopoietic stem cells

Author(s): Mehrnaz Safaee Talkhoncheh, Agatheeswaran Subramaniam, Mattias Magnusson, Praveen Kumar, Jonas Larsson, Aurélie Baudet
Published in: Haematologica, Issue 103/9, 2018, Page(s) 1444-1450, ISSN 0390-6078
Publisher: Ferrata Storti Foundation
DOI: 10.3324/haematol.2018.188466

Cytohesin 1 regulates homing and engraftment of human hematopoietic stem and progenitor cells

Author(s): Justyna Rak, Katie Foster, Katarzyna Potrzebowska, Mehrnaz Safaee Talkhoncheh, Natsumi Miharada, Karolina Komorowska, Therese Torngren, Anders Kvist, Åke Borg, Lena Svensson, Dominique Bonnet, Jonas Larsson
Published in: Blood, Issue 129/8, 2017, Page(s) 950-958, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood-2016-06-720649

Genome-wide RNAi Screen Identifies Cohesin Genes as Modifiers of Renewal and Differentiation in Human HSCs

Author(s): Roman Galeev, Aurélie Baudet, Praveen Kumar, Alexandra Rundberg Nilsson, Björn Nilsson, Shamit Soneji, Therese Törngren, Åke Borg, Anders Kvist, Jonas Larsson
Published in: Cell Reports, Issue 14/12, 2016, Page(s) 2988-3000, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2016.02.082

Arrayed molecular barcoding identifies TNFSF13 as a positive regulator of acute myeloid leukemia-initiating cells

Author(s): Marion Chapellier, Pablo Peña-Martínez, Ramprasad Ramakrishnan, Mia Eriksson, Mehrnaz Safaee Talkhoncheh, Christina Orsmark-Pietras, Henrik Lilljebjörn, Carl Högberg, Anna Hagström-Andersson, Thoas Fioretos, Jonas Larsson, Marcus Järås
Published in: Haematologica, Issue 104/10, 2019, Page(s) 2006-2016, ISSN 0390-6078
Publisher: Ferrata Storti Foundation
DOI: 10.3324/haematol.2018.192062

HMGA2 promotes long-term engraftment and myeloerythroid differentiation of human hematopoietic stem and progenitor cells

Author(s): Praveen Kumar, Dominik Beck, Roman Galeev, Julie A. I. Thoms, Mehrnaz Safaee Talkhoncheh, Ineke de Jong, Ashwin Unnikrishnan, Aurélie Baudet, Agatheeswaran Subramaniam, John E. Pimanda, Jonas Larsson
Published in: Blood Advances, Issue 3/4, 2019, Page(s) 681-691, ISSN 2473-9529
Publisher: The American Society of Hematology
DOI: 10.1182/bloodadvances.2018023986

Endothelial protein C receptor (EPCR) expression marks human fetal liver hematopoietic stem cells

Author(s): Agatheeswaran Subramaniam, Mehrnaz Safaee Talkhoncheh, Mattias Magnusson, Jonas Larsson
Published in: Haematologica, Issue 104/2, 2019, Page(s) e47-e50, ISSN 0390-6078
Publisher: Ferrata Storti Foundation
DOI: 10.3324/haematol.2018.198515

Combined lentiviral- and RNA-mediated CRISPR/Cas9 delivery for efficient and traceable gene editing in human hematopoietic stem and progenitor cells

Author(s): David Yudovich, Alexandra Bäckström, Ludwig Schmiderer, Kristijonas Žemaitis, Agatheeswaran Subramaniam, Jonas Larsson
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-79724-x