Uncovering targets for ex vivo expansion of hematopoietic stem cells to enhance cell therapies of blood disorders

Pubblicazioni

Efficient and nontoxic biomolecule delivery to primary human hematopoietic stem cells using nanostraws

Autori: Ludwig Schmiderer, Agatheeswaran Subramaniam, Kristijonas Žemaitis, Alexandra Bäckström, David Yudovich, Svetlana Soboleva, Roman Galeev, Christelle N. Prinz, Jonas Larsson, Martin Hjort
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 117/35, 2020, Pagina/e 21267-21273, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2001367117

Lysine-specific demethylase 1A restricts ex vivo propagation of human HSCs and is a target of UM171

Autori: Agatheeswaran Subramaniam, Kristijonas Žemaitis, Mehrnaz Safaee Talkhoncheh, David Yudovich, Alexandra Bäckström, Shubhranshu Debnath, Jun Chen, Mayur Vilas Jain, Roman Galeev, Massimiliano Gaetani, Roman A. Zubarev, Jonas Larsson
Pubblicato in: Blood, Numero 136/19, 2020, Pagina/e 2151-2161, ISSN 0006-4971
Editore: American Society of Hematology
DOI: 10.1182/blood.2020005827

Transient inhibition of NF-κB signaling enhances ex vivo propagation of human hematopoietic stem cells

Autori: Mehrnaz Safaee Talkhoncheh, Agatheeswaran Subramaniam, Mattias Magnusson, Praveen Kumar, Jonas Larsson, Aurélie Baudet
Pubblicato in: Haematologica, Numero 103/9, 2018, Pagina/e 1444-1450, ISSN 0390-6078
Editore: Ferrata Storti Foundation
DOI: 10.3324/haematol.2018.188466

Cytohesin 1 regulates homing and engraftment of human hematopoietic stem and progenitor cells

Autori: Justyna Rak, Katie Foster, Katarzyna Potrzebowska, Mehrnaz Safaee Talkhoncheh, Natsumi Miharada, Karolina Komorowska, Therese Torngren, Anders Kvist, Åke Borg, Lena Svensson, Dominique Bonnet, Jonas Larsson
Pubblicato in: Blood, Numero 129/8, 2017, Pagina/e 950-958, ISSN 0006-4971
Editore: American Society of Hematology
DOI: 10.1182/blood-2016-06-720649

Genome-wide RNAi Screen Identifies Cohesin Genes as Modifiers of Renewal and Differentiation in Human HSCs

Autori: Roman Galeev, Aurélie Baudet, Praveen Kumar, Alexandra Rundberg Nilsson, Björn Nilsson, Shamit Soneji, Therese Törngren, Åke Borg, Anders Kvist, Jonas Larsson
Pubblicato in: Cell Reports, Numero 14/12, 2016, Pagina/e 2988-3000, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2016.02.082

Arrayed molecular barcoding identifies TNFSF13 as a positive regulator of acute myeloid leukemia-initiating cells

Autori: Marion Chapellier, Pablo Peña-Martínez, Ramprasad Ramakrishnan, Mia Eriksson, Mehrnaz Safaee Talkhoncheh, Christina Orsmark-Pietras, Henrik Lilljebjörn, Carl Högberg, Anna Hagström-Andersson, Thoas Fioretos, Jonas Larsson, Marcus Järås
Pubblicato in: Haematologica, Numero 104/10, 2019, Pagina/e 2006-2016, ISSN 0390-6078
Editore: Ferrata Storti Foundation
DOI: 10.3324/haematol.2018.192062

HMGA2 promotes long-term engraftment and myeloerythroid differentiation of human hematopoietic stem and progenitor cells

Autori: Praveen Kumar, Dominik Beck, Roman Galeev, Julie A. I. Thoms, Mehrnaz Safaee Talkhoncheh, Ineke de Jong, Ashwin Unnikrishnan, Aurélie Baudet, Agatheeswaran Subramaniam, John E. Pimanda, Jonas Larsson
Pubblicato in: Blood Advances, Numero 3/4, 2019, Pagina/e 681-691, ISSN 2473-9529
Editore: The American Society of Hematology
DOI: 10.1182/bloodadvances.2018023986

Endothelial protein C receptor (EPCR) expression marks human fetal liver hematopoietic stem cells

Autori: Agatheeswaran Subramaniam, Mehrnaz Safaee Talkhoncheh, Mattias Magnusson, Jonas Larsson
Pubblicato in: Haematologica, Numero 104/2, 2019, Pagina/e e47-e50, ISSN 0390-6078
Editore: Ferrata Storti Foundation
DOI: 10.3324/haematol.2018.198515

Combined lentiviral- and RNA-mediated CRISPR/Cas9 delivery for efficient and traceable gene editing in human hematopoietic stem and progenitor cells

Autori: David Yudovich, Alexandra Bäckström, Ludwig Schmiderer, Kristijonas Žemaitis, Agatheeswaran Subramaniam, Jonas Larsson
Pubblicato in: Scientific Reports, Numero 10/1, 2020, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-79724-x

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