Biological signal processing via multisite phosphorylation networks

Project Information

Phosphoprocessors

Grant agreement ID: 649124

DOI

10.3030/649124

Project closed

EC signature date 7 April 2015

Start date 1 May 2015

End date 31 October 2020

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 999 288,67

EU contribution

€ 1 999 288,67

Coordinated by

TARTU ULIKOOL
Estonia

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Other (3)

Differentially accessible Cdc4 phospho-degrons regulate Ctf19CCAN kinetochore subunit stability in mitosis

Author(s): Miriam Böhm, Kerstin Killinger, Alexander Dudziak, Pradeep Pant, Karolin Jänen, Simone Hohoff, Karl Mechtler, Mihkel Örd, Mart Loog, Elsa Sanchez-Garcia, Stefan Westermann
Published in: 2021
Publisher: bioRxiv
DOI: 10.1101/2021.02.12.430993

Cell cycle-balanced expression of pluripotency regulators via cyclin-dependent kinase 1

Author(s): Sergo Kasvandik, Reelika Schilf, Merilin Saarma, Mart Loog, Kersti Jääger
Published in: 2019
Publisher: BioRxiv
DOI: 10.1101/764639

Multisite phosphorylation by Cdk1 initiates delayed negative feedback to control mitotic transcription

Author(s): Jonathan B. Asfaha, Mihkel Örd, Mart Loog, David O. Morgan
Published in: 2021
Publisher: bioRxiv
DOI: 10.1101/2021.02.14.431158

Peer reviewed articles (12)

A new linear cyclin docking motif that mediates exclusively S‐phase CDK‐specific signaling

Author(s): Ilona Faustova, Luka Bulatovic, Frida Matiyevskaya, Ervin Valk, Mihkel Örd, Mart Loog
Published in: The EMBO Journal, Issue 40/2, 2021, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2020105839

Regulation of trehalase activity by multi-site phosphorylation and 14-3-3 interaction

Author(s): Lisa Dengler, Mihkel Örd, Lucca M. Schwab, Mart Loog, Jennifer C. Ewald
Published in: Scientific Reports, Issue 11/1, 2021, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-80357-3

A processive phosphorylation circuit with multiple kinase inputs and mutually diversional routes controls G1/S decision

Author(s): Rainis Venta, Ervin Valk, Mihkel Örd, Oleg Košik, Kaur Pääbo, Artemi Maljavin, Rait Kivi, Ilona Faustova, Nastassia Shtaida, Martin Lepiku, Kaidi Möll, Andreas Doncic, Mardo Kõivomägi, Mart Loog
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-15685-z

Comprehensive Analysis of G1 Cyclin Docking Motif Sequences that Control CDK Regulatory Potency In Vivo

Author(s): Sushobhana Bandyopadhyay, Samyabrata Bhaduri, Mihkel Örd, Norman E. Davey, Mart Loog, Peter M. Pryciak
Published in: Current Biology, Issue 30/22, 2020, Page(s) 4454-4466.e5, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2020.08.099

Natural Variation in Arabidopsis Cvi-0 Accession Reveals an Important Role of MPK12 in Guard Cell CO2 Signaling.

Author(s): Jakobson L, Vaahtera L, Tõldsepp K, Nuhkat M, Wang C, Wang YS, Hõrak H, Valk E, Pechter P, Sindarovska Y, Tang J, Xiao C, Xu Y, Gerst Talas U, García-Sosa AT, Kangasjärvi S, Maran U, Remm M, Roelfsema MR, Hu H, Kangasjärvi J, Loog M, Schroeder JI, Kollist H, Brosché M.
Published in: Plos Biology, 2016, ISSN 1544-9173
Publisher: Public Library of Science

A Dominant Mutation in the HT1 Kinase Uncovers Roles of MAP Kinases and GHR1 in CO2-Induced Stomatal Closure.

Author(s): Hõrak H, Sierla M, Tõldsepp K, Wang C, Wang YS, Nuhkat M, Valk E, Pechter P, Merilo E, Salojärvi J, Overmyer K, Loog M, Brosché M, Schroeder JI, Kangasjärvi J, Kollist H.
Published in: Plant Cell, 2016, ISSN 1040-4651
Publisher: American Society of Plant Biologists

Multisite phosphorylation code of CDK

Author(s): Mihkel Örd, Kaidi Möll, Alissa Agerova, Rait Kivi, Ilona Faustova, Rainis Venta, Ervin Valk, Mart Loog
Published in: Nature Structural & Molecular Biology, Issue 26/7, 2019, Page(s) 649-658, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1038/s41594-019-0256-4

Three Cdk1 sites in the kinesin-5 Cin8 catalytic domain coordinate motor localization and activity during anaphase

Author(s): Alina Goldstein, Nurit Siegler, Darya Goldman, Haim Judah, Ervin Valk, Mardo Kõivomägi, Mart Loog, Larisa Gheber
Published in: Cellular and Molecular Life Sciences, Issue 74/18, 2017, Page(s) 3395-3412, ISSN 1420-682X
Publisher: Birkhauser Verlag
DOI: 10.1007/s00018-017-2523-z

Cyclin-Specific Docking Mechanisms Reveal the Complexity of M-CDK Function in the Cell Cycle

Author(s): Mihkel Örd, Rainis Venta, Kaidi Möll, Ervin Valk, Mart Loog
Published in: Molecular Cell, Issue 75/1, 2019, Page(s) 76-89.e3, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2019.04.026

How the cell cycle clock ticks

Author(s): Mihkel Örd, Mart Loog
Published in: Molecular Biology of the Cell, Issue 30/2, 2019, Page(s) 169-172, ISSN 1059-1524
Publisher: American Society for Cell Biology
DOI: 10.1091/mbc.e18-05-0272

Synthetic-Evolution Reveals Narrow Paths to Regulation of the Saccharomyces cerevisiae Mitotic Kinesin-5 Cin8

Author(s): Alina Goldstein, Darya Goldman, Ervin Valk, Mart Loog, Liam J. Holt, Larisa Gheber
Published in: International Journal of Biological Sciences, Issue 15/6, 2019, Page(s) 1125-1138, ISSN 1449-2288
Publisher: Ivyspring International Publisher
DOI: 10.7150/ijbs.30543

Proline-Rich Motifs Control G2-CDK Target Phosphorylation and Priming an Anchoring Protein for Polo Kinase Localization

Author(s): Mihkel Örd, Kait Kaarel Puss, Rait Kivi, Kaidi Möll, Tuuliki Ojala, Irina Borovko, Ilona Faustova, Rainis Venta, Ervin Valk, Mardo Kõivomägi, Mart Loog
Published in: Cell Reports, Issue 31/11, 2020, Page(s) 107757, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.107757