Biological signal processing via multisite phosphorylation networks

Informazioni relative al progetto

Phosphoprocessors

ID dell’accordo di sovvenzione: 649124

DOI 10.3030/649124

Progetto chiuso

Data della firma CE 7 Aprile 2015

Data di avvio 1 Maggio 2015

Data di completamento 31 Ottobre 2020

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 1 999 288,67

Contributo UE € 1 999 288,67

Coordinato da

TARTU ULIKOOL
Estonia

Pubblicazioni

Other (3)

Differentially accessible Cdc4 phospho-degrons regulate Ctf19CCAN kinetochore subunit stability in mitosis

Autori: Miriam Böhm, Kerstin Killinger, Alexander Dudziak, Pradeep Pant, Karolin Jänen, Simone Hohoff, Karl Mechtler, Mihkel Örd, Mart Loog, Elsa Sanchez-Garcia, Stefan Westermann
Pubblicato in: 2021
Editore: bioRxiv
DOI: 10.1101/2021.02.12.430993

Cell cycle-balanced expression of pluripotency regulators via cyclin-dependent kinase 1

Autori: Sergo Kasvandik, Reelika Schilf, Merilin Saarma, Mart Loog, Kersti Jääger
Pubblicato in: 2019
Editore: BioRxiv
DOI: 10.1101/764639

Multisite phosphorylation by Cdk1 initiates delayed negative feedback to control mitotic transcription

Autori: Jonathan B. Asfaha, Mihkel Örd, Mart Loog, David O. Morgan
Pubblicato in: 2021
Editore: bioRxiv
DOI: 10.1101/2021.02.14.431158

Peer reviewed articles (12)

A new linear cyclin docking motif that mediates exclusively S‐phase CDK‐specific signaling

Autori: Ilona Faustova, Luka Bulatovic, Frida Matiyevskaya, Ervin Valk, Mihkel Örd, Mart Loog
Pubblicato in: The EMBO Journal, Numero 40/2, 2021, ISSN 0261-4189
Editore: Nature Publishing Group
DOI: 10.15252/embj.2020105839

Regulation of trehalase activity by multi-site phosphorylation and 14-3-3 interaction

Autori: Lisa Dengler, Mihkel Örd, Lucca M. Schwab, Mart Loog, Jennifer C. Ewald
Pubblicato in: Scientific Reports, Numero 11/1, 2021, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-80357-3

A processive phosphorylation circuit with multiple kinase inputs and mutually diversional routes controls G1/S decision

Autori: Rainis Venta, Ervin Valk, Mihkel Örd, Oleg Košik, Kaur Pääbo, Artemi Maljavin, Rait Kivi, Ilona Faustova, Nastassia Shtaida, Martin Lepiku, Kaidi Möll, Andreas Doncic, Mardo Kõivomägi, Mart Loog
Pubblicato in: Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-15685-z

Comprehensive Analysis of G1 Cyclin Docking Motif Sequences that Control CDK Regulatory Potency In Vivo

Autori: Sushobhana Bandyopadhyay, Samyabrata Bhaduri, Mihkel Örd, Norman E. Davey, Mart Loog, Peter M. Pryciak
Pubblicato in: Current Biology, Numero 30/22, 2020, Pagina/e 4454-4466.e5, ISSN 0960-9822
Editore: Cell Press
DOI: 10.1016/j.cub.2020.08.099

Natural Variation in Arabidopsis Cvi-0 Accession Reveals an Important Role of MPK12 in Guard Cell CO2 Signaling.

Autori: Jakobson L, Vaahtera L, Tõldsepp K, Nuhkat M, Wang C, Wang YS, Hõrak H, Valk E, Pechter P, Sindarovska Y, Tang J, Xiao C, Xu Y, Gerst Talas U, García-Sosa AT, Kangasjärvi S, Maran U, Remm M, Roelfsema MR, Hu H, Kangasjärvi J, Loog M, Schroeder JI, Kollist H, Brosché M.
Pubblicato in: Plos Biology, 2016, ISSN 1544-9173
Editore: Public Library of Science

A Dominant Mutation in the HT1 Kinase Uncovers Roles of MAP Kinases and GHR1 in CO2-Induced Stomatal Closure.

Autori: Hõrak H, Sierla M, Tõldsepp K, Wang C, Wang YS, Nuhkat M, Valk E, Pechter P, Merilo E, Salojärvi J, Overmyer K, Loog M, Brosché M, Schroeder JI, Kangasjärvi J, Kollist H.
Pubblicato in: Plant Cell, 2016, ISSN 1040-4651
Editore: American Society of Plant Biologists

Multisite phosphorylation code of CDK

Autori: Mihkel Örd, Kaidi Möll, Alissa Agerova, Rait Kivi, Ilona Faustova, Rainis Venta, Ervin Valk, Mart Loog
Pubblicato in: Nature Structural & Molecular Biology, Numero 26/7, 2019, Pagina/e 649-658, ISSN 1545-9993
Editore: Nature Publishing Group
DOI: 10.1038/s41594-019-0256-4

Three Cdk1 sites in the kinesin-5 Cin8 catalytic domain coordinate motor localization and activity during anaphase

Autori: Alina Goldstein, Nurit Siegler, Darya Goldman, Haim Judah, Ervin Valk, Mardo Kõivomägi, Mart Loog, Larisa Gheber
Pubblicato in: Cellular and Molecular Life Sciences, Numero 74/18, 2017, Pagina/e 3395-3412, ISSN 1420-682X
Editore: Birkhauser Verlag
DOI: 10.1007/s00018-017-2523-z

Cyclin-Specific Docking Mechanisms Reveal the Complexity of M-CDK Function in the Cell Cycle

Autori: Mihkel Örd, Rainis Venta, Kaidi Möll, Ervin Valk, Mart Loog
Pubblicato in: Molecular Cell, Numero 75/1, 2019, Pagina/e 76-89.e3, ISSN 1097-2765
Editore: Cell Press
DOI: 10.1016/j.molcel.2019.04.026

How the cell cycle clock ticks

Autori: Mihkel Örd, Mart Loog
Pubblicato in: Molecular Biology of the Cell, Numero 30/2, 2019, Pagina/e 169-172, ISSN 1059-1524
Editore: American Society for Cell Biology
DOI: 10.1091/mbc.e18-05-0272

Synthetic-Evolution Reveals Narrow Paths to Regulation of the Saccharomyces cerevisiae Mitotic Kinesin-5 Cin8

Autori: Alina Goldstein, Darya Goldman, Ervin Valk, Mart Loog, Liam J. Holt, Larisa Gheber
Pubblicato in: International Journal of Biological Sciences, Numero 15/6, 2019, Pagina/e 1125-1138, ISSN 1449-2288
Editore: Ivyspring International Publisher
DOI: 10.7150/ijbs.30543

Proline-Rich Motifs Control G2-CDK Target Phosphorylation and Priming an Anchoring Protein for Polo Kinase Localization

Autori: Mihkel Örd, Kait Kaarel Puss, Rait Kivi, Kaidi Möll, Tuuliki Ojala, Irina Borovko, Ilona Faustova, Rainis Venta, Ervin Valk, Mardo Kõivomägi, Mart Loog
Pubblicato in: Cell Reports, Numero 31/11, 2020, Pagina/e 107757, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2020.107757