Objectif The BioGuidePCa project is designed to validate previously reported biomarkers for prostate cancer (PCa) management during surveillance of early and advanced PCa. With availability of PSA-screening an increase of insignificant PCa has been observed leading to over-diagnosis and overtreatment. Consequently active surveillance (AS) is an alternative to immediate therapy. AS is expectant management with curative intervention only for those patients with local tumor progression. Neuhaus et. al reported a peptide panel, derived from seminal plasma for the estimation of PCa aggressiveness. A main objective of the project is the validation of these biomarkers in regards of its use in AS. On the other hand, advanced metastasized PCa is still a deadly disease. The majority of patients initially responding to therapy progress after a median duration of 30 months. Therapy of castrate resistant prostate cancer (CRPC) relies on hormone therapy and cytotoxic chemotherapy. Recent developments have resulted in novel substances for treatment. However the optimal sequence of the drugs has not been determined. Thus there is a clear clinical need for the development of new approaches for early detection of metastatic disease to guide initiation of alternative therapy. We have recently identified urine based biomarkers, specific for cancer progression. The second main objective of this project is to validate these peptides for their use in assessment of risk of progression and development of metastatic disease. Both biomarker panels will be developed into a non-invasive urine tests for the routine monitoring of CRPC and PCa progression. The study uniquely integrates leading PCa clinical experts with experts on proteome analysis and in an implementation-oriented workflow. The proposed study will provide strong evidence for utility of the new BMs and will set the foundation for diagnostic devices to guide early patient management and personalized therapeutic intervention in PCa and CRPC. Champ scientifique medical and health sciencesclinical medicineoncologyprostate cancernatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicssocial sciencessociologydemographymortalityengineering and technologymedical engineeringmedical laboratory technologylaboratory samples analysis Programme(s) H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and well-being Main Programme H2020-EU.3.1.3. - Treating and managing disease Thème(s) PHC-12-2014-1 - Clinical research for the validation of biomarkers and/or diagnostic medical devices Appel à propositions H2020-SMEInst-2014-2015 Voir d’autres projets de cet appel Sous appel H2020-SMEINST-1-2014 Régime de financement SME-1 - SME instrument phase 1 Coordinateur MOSAIQUES DIAGNOSTICS GMBH Contribution nette de l'UE € 50 000,00 Adresse ROTENBURGER STRASSE 20 30659 Hannover Allemagne Voir sur la carte PME L’entreprise s’est définie comme une PME (petite et moyenne entreprise) au moment de la signature de la convention de subvention. Oui Région Niedersachsen Hannover Region Hannover Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 71 429,00
