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CORDIS

PhenoMeNal: A comprehensive and standardised e-infrastructure for analysing medical metabolic phenotype data

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

D5.1 Build System with continuous integration, providing development snapshots of PhenoMeNal Virtual Machine Images (opens in new window)

Build System with continuous integration, providing development snapshots of PhenoMeNal Virtual Machine Images

D7.1.1 Workshop 1 on best practices in handling sensitive human data, taking into account National and Institutional legal policies (opens in new window)

Workshop 1 on best practices in handling sensitive human data, taking into account National and Institutional legal policies

D9.5.2 Updated Data Processing Virtual Machine Image 2 (opens in new window)

Updated Data Processing Virtual Machine Image 2

D9.5.1 Updated Preprocess Virtual Machine Image 1 (opens in new window)

Updated Preprocess Virtual Machine Image 1

D7.1.2 Workshop 2 on best practices in handling sensitive human data, taking into account National and Institutional legal policies (opens in new window)

Workshop 2 on best practices in handling sensitive human data, taking into account National and Institutional legal policies

D8.4.2 Reference implementation guidelines and validation rules (opens in new window)

Reference implementation guidelines and validation rules

D3.4.2 Two training workshops on omics data deposition, grid processing, dissemination and access (opens in new window)

Two training workshops on omics data deposition, grid processing, dissemination and access.

D5.3 Operational grid/cloud allowing for combining data, tools, and compute VMIs. Most services available. Functional integration with EGI federated cloud/grid for compute resources. Demonstrated analysis on private/sensitive data in secure environment (opens in new window)

Operational grid/cloud allowing for combining data, tools, and compute VMIs. Most services available. Functional integration with EGI federated cloud/grid for compute resources. Demonstrated analysis on private/sensitive data in secure environment

D9.2.1 PhenoMeNal-Preprocess Virtual Machine Image 1 to enable data producers to locally process raw data into standard formats supported in PhenoMeNal (opens in new window)

PhenoMeNal-Preprocess Virtual Machine Image 1 to enable data producers to locally process raw data into standard formats supported in PhenoMeNal

D5.2 A beta-version of PhenoMeNal integration VMI capable of proof- of-concept integration with other VMIs. Initial services online supporting PhenoMeNal data standards (opens in new window)

A beta-version of PhenoMeNal integration VMI capable of proof- of-concept integration with other VMIs. Initial services online supporting PhenoMeNal data standards

D6.4 Participating Biobanks and repositories connected to the VRC (opens in new window)

Participating Biobanks and repositories connected to the VRC

D9.2.2 PhenoMeNal-Data Virtual Machine Image 2 to enable sharing and dissemination of standardised and processed omics data to participating online repositories, like MetaboLights (opens in new window)

PhenoMeNal-Data Virtual Machine Image 2 to enable sharing and dissemination of standardised and processed omics data to participating online repositories, like MetaboLights

D8.4 Signal processing and analysis data exchange format (opens in new window)

Signal processing and analysis data exchange format

D8.4.1 Specifications for derived data matrices specifications and terminology for description of analysis and statistical results (opens in new window)

Specifications for derived data matrices specifications and terminology for description of analysis and statistical results

D8.3 nmrML, mzML data exchange formats and associated terminologies for instrument raw, with reference implementation guidelines and validation rules (opens in new window)

nmrML, mzML data exchange formats and associated terminologies for instrument raw, with reference implementation guidelines and validation rules

D9.5.5 Updated Portal Virtual Machine Image 5 (opens in new window)

Updated Portal Virtual Machine Image 5

D9.2.4 Compute Virtual Machine Image 4 to enable standardised compute capabilities for all the grid supplying partners (opens in new window)

Compute Virtual Machine Image 4 to enable standardised compute capabilities for all the grid supplying partners

D3.4.1 Two training workshops on omics data deposition, grid processing, dissemination and access (opens in new window)

Two training workshops on omics data deposition, grid processing, dissemination and access.

D9.2.3 Services Virtual Machine Image 3 to facilitate the PhenoMeNal toolsets and pipelines, both locally and in the grid (opens in new window)

Services Virtual Machine Image 3 to facilitate the PhenoMeNal toolsets and pipelines, both locally and in the grid

D9.5.4 Updated Compute Virtual Machine Image 4 (opens in new window)

Updated Compute Virtual Machine Image 4

D5.4 A federated cloud/grid system running on partners’ infrastructures for public data and tools. All services available. Operational installation at ICL clinical site for decision support (opens in new window)

A federated cloud/grid system running on partners’ infrastructures for public data and tools. All services available. Operational installation at ICL clinical site for decision support

D9.2.5 Portal Virtual Machine Image 5 that is capable of integrating other PhenoMeNal-VMIs (in local federated clouds) and make all functionality available via command-line, Web-APIs, and graphical user interfaces (opens in new window)

Portal Virtual Machine Image 5 that is capable of integrating other PhenoMeNal-VMIs (in local federated clouds) and make all functionality available via command-line, Web-APIs, and graphical user interfaces

D9.5.3 Updated Services Virtual Machine Image 3 (opens in new window)

Updated Services Virtual Machine Image 3

D7.4 Process to extract maximum information from sensitive datasets with minimum compromise, in collaboration with BBMRI and BioMedBridges (opens in new window)

Workflows to extract maximum information from sensitive datasets with minimum compromise, in collaboration with BBMRI and BioMedBridges

D8.2 Modularized ISA model and format: biospecimen centric schema, corresponding xml schemas, reference implementation guidelines and validation rules (opens in new window)

Modularized ISA model and format: biospecimen centric schema, corresponding xml schemas, reference implementation guidelines and validation rules

D9.3 Report API access to PhenoMeNal Resources (opens in new window)

Report API access to PhenoMeNal Resources

D4.2 Report describing the activity and output of working groups (opens in new window)

Establish and convene working groups involving the PhenoMeNal consortium as well as participants in other biomedical infrastructure and research projects. Report describing the activity and output of working groups.

D4.4 Report on State-of-The-Art and Perspectives in the field (opens in new window)

Report on State-of-The-Art and Perspectives in the field

D4.1Report on requirements for relevant research centers producing and/or consuming metabolomics data with respect to computational aspects, data storage, and infrastructural needs (opens in new window)

Reporting on requirements expressed/formalised by relevant biomedical infrastructures, both physical and electronic, with regard to data storage, retrieval, exchange, management and analysis.

D8.1 Report on community standards for reporting, access and integrity supported in the PhenoMeNal grid; to be disseminated in a dedicated BioSharing page and via the project website (opens in new window)

Report on community standards for reporting, access and integrity supported in the PhenoMeNal grid; to be disseminated in a dedicated BioSharing page and via the project website

D9.4 Updated report on existing software tools, workflows and analytical pipelines supported in PhenoMeNal (opens in new window)

Updated report on existing software tools, workflows and analytical pipelines supported in PhenoMeNal

D9.1 Report on existing software tools, workflows and analytical pipelines initially supported in the PhenoMeNal grid (opens in new window)

Report on existing software tools, workflows and analytical pipelines initially supported in the PhenoMeNal grid

D7.2 Report on policies and procedures for sensitive human data management (opens in new window)

Report on policies and procedures for sensitive human data management

D4.3 Consensus agreement document from the working groups (opens in new window)

Consensus agreement document from the working groups

"D3.3.2 Web-based Tutorial release 2 about ""Metabolomics Data Deposition and Analysis through PhenoMeNal”, in the form of video clips" (opens in new window)

"Web-based Tutorial release 2 about ""Metabolomics Data Deposition and Analysis through PhenoMeNal”, in the form of video clips"

"D3.3.1 Web-based Tutorial release 1 about ""Metabolomics Data Deposition and Analysis through PhenoMeNal”, in the form of video clips" (opens in new window)

"Web-based Tutorial release 1 about ""Metabolomics Data Deposition and Analysis through PhenoMeNal”, in the form of video clips"

D6.3 Online user feedback form (opens in new window)

An Online feedback form will be available for user requests and initiate direct communication with interested parties.

D6.2 PhenoMeNal VRC (static) portal publicly available (opens in new window)

PhenoMeNal VRC (static) portal publicly available

D6.5 Training and online tutorial for the general use of the PhenoMeNal (opens in new window)

Training and online tutorial for the general use of the PhenoMeNal

Publications

A design framework and exemplar metrics for FAIRness (opens in new window)

Author(s): Mark D. Wilkinson, Susanna-Assunta Sansone, Erik Schultes, Peter Doorn, Luiz Olavo Bonino da Silva Santos, Michel Dumontier
Published in: Scientific Data, Issue 5, 2018, Page(s) 180118, ISSN 2052-4463
Publisher: Nature Scientific Data
DOI: 10.1038/sdata.2018.118

From correlation to causation: analysis of metabolomics data using systems biology approaches (opens in new window)

Author(s): Antonio Rosato, Leonardo Tenori, Marta Cascante, Pedro Ramon De Atauri Carulla, Vitor A. P. Martins dos Santos, Edoardo Saccenti
Published in: Metabolomics, Issue 14/4, 2018, ISSN 1573-3882
Publisher: Springer Verlag
DOI: 10.1007/s11306-018-1335-y

The future of metabolomics in ELIXIR (opens in new window)

Author(s): Van Rijswijk, Merlijn; Beirnaert, Charlie; Caron, Christophe; Cascante, Marta; Dominguez, Victoria; Dunn, Warwick B.; Ebbels, Timothy M. D.; Giacomoni, Franck; Gonzalez-beltran, Alejandra; Hankemeier, Thomas; Haug, Kenneth; Izquierdo-garcia, Jose L.; Jimenez, Rafael C.; Jourdan, Fabien; Kale, Namrata; Klapa, Maria I.; Kohlbacher, Oliver; Koort, Kairi; Kultima, Kim; Le Corguillé, Gildas; Moreno, P
Published in: F1000Research, 6, Issue 8, 2017, ISSN 2046-1402
Publisher: F1000 Research Ltd.
DOI: 10.17863/CAM.17780

Bayesian estimation of the number of protonation sites for urinary metabolites from NMR spectroscopic data (opens in new window)

Author(s): Lifeng Ye, Maria De Iorio, Timothy M. D. Ebbels
Published in: Metabolomics, Issue 14/5, 2018, ISSN 1573-3882
Publisher: Springer Verlag
DOI: 10.1007/s11306-018-1351-y

Metabomatching: Using genetic association to identify metabolites in proton NMR spectroscopy (opens in new window)

Author(s): Rico Rueedi, Roger Mallol, Johannes Raffler, David Lamparter, Nele Friedrich, Peter Vollenweider, Gérard Waeber, Gabi Kastenmüller, Zoltán Kutalik, Sven Bergmann
Published in: PLOS Computational Biology, Issue 13/12, 2017, Page(s) e1005839, ISSN 1553-7358
Publisher: PLOS
DOI: 10.1371/journal.pcbi.1005839

MetExploreViz: web component for interactive metabolic network visualization (opens in new window)

Author(s): Maxime Chazalviel, Clément Frainay, Nathalie Poupin, Florence Vinson, Benjamin Merlet, Yoann Gloaguen, Ludovic Cottret, Fabien Jourdan
Published in: Bioinformatics, Issue 34/2, 2017, Page(s) 312-313, ISSN 1367-4803
Publisher: Oxford University Press
DOI: 10.1093/bioinformatics/btx588

Bayesian inference for multiple Gaussian graphical models with application to metabolic association networks (opens in new window)

Author(s): Linda S. L. Tan, Ajay Jasra, Maria De Iorio, Timothy M. D. Ebbels
Published in: The Annals of Applied Statistics, Issue 11/4, 2017, Page(s) 2222-2251, ISSN 1932-6157
Publisher: Institute of Mathematical Statistics
DOI: 10.1214/17-AOAS1076

Deconvoluting interrelationships between concentrations and chemical shifts in urine provides a powerful analysis tool (opens in new window)

Author(s): Panteleimon G. Takis, Hartmut Schäfer, Manfred Spraul, Claudio Luchinat
Published in: Nature Communications, Issue 8/1, 2017, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-017-01587-0

Mass spectrometry based metabolomics for in vitro systems pharmacology: pitfalls, challenges, and computational solutions (opens in new window)

Author(s): Stephanie Herman, Payam Emami Khoonsari, Obaid Aftab, Shibu Krishnan, Emil Strömbom, Rolf Larsson, Ulf Hammerling, Ola Spjuth, Kim Kultima, Mats Gustafsson
Published in: Metabolomics, Issue 13/7, 2017, ISSN 1573-3882
Publisher: Springer Verlag
DOI: 10.1007/s11306-017-1213-z

Navigating freely-available software tools for metabolomics analysis (opens in new window)

Author(s): Spicer, Rachel; Salek, RM; Moreno, P; Cañueto, C; Steinbeck, C
Published in: Metabolomics, Issue 5, 2017, ISSN 1573-3882
Publisher: Springer Verlag
DOI: 10.17863/CAM.13427

Plasma and urinary metabolomic profiles of Down syndrome correlate with alteration of mitochondrial metabolism (opens in new window)

Author(s): Maria Caracausi, Veronica Ghini, Chiara Locatelli, Martina Mericio, Allison Piovesan, Francesca Antonaros, Maria Chiara Pelleri, Lorenza Vitale, Rosa Anna Vacca, Federica Bedetti, Maria Chiara Mimmi, Claudio Luchinat, Paola Turano, Pierluigi Strippoli, Guido Cocchi
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-20834-y

A computational solution to automatically map metabolite libraries in the context of genome scale metabolic networks (opens in new window)

Author(s): Nils ePaulhe; Benjamin eMerlet; Yoann eGloaguen; Clément eFrainay; Nathalie ePoupin; Fabien eJourdan; Maxime eChazalviel; Florence eVinson; Franck eGiacomoni
Published in: Frontiers in Molecular Biosciences, Vol 3 (2016), Issue 3, 2016, ISSN 2296-889X
Publisher: Holtzbrinck Publishing Group
DOI: 10.3389/fmolb.2016.00002

Entropy-Based Network Representation of the Individual Metabolic Phenotype (opens in new window)

Author(s): Edoardo Saccenti, Giulia Menichetti, Veronica Ghini, Daniel Remondini, Leonardo Tenori, Claudio Luchinat
Published in: Journal of Proteome Research, Issue 15/9, 2016, Page(s) 3298-3307, ISSN 1535-3893
Publisher: American Chemical Society
DOI: 10.1021/acs.jproteome.6b00454

Global open data management in metabolomics (opens in new window)

Author(s): Kenneth Haug, Reza M Salek, Christoph Steinbeck
Published in: Current Opinion in Chemical Biology, Issue 36, 2017, Page(s) 58-63, ISSN 1367-5931
Publisher: Elsevier BV
DOI: 10.1016/j.cbpa.2016.12.024

Power Analysis and Sample Size Determination in Metabolic Phenotyping (opens in new window)

Author(s): Benjamin J. Blaise, Gonçalo Correia, Adrienne Tin, J. Hunter Young, Anne-Claire Vergnaud, Matthew Lewis, Jake T. M. Pearce, Paul Elliott, Jeremy K. Nicholson, Elaine Holmes, Timothy M. D. Ebbels
Published in: Analytical Chemistry, Issue 88/10, 2016, Page(s) 5179-5188, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.6b00188

Data standards can boost metabolomics research, and if there is a will, there is a way (opens in new window)

Author(s): Philippe Rocca-Serra, Reza M. Salek, Masanori Arita, Elon Correa, Saravanan Dayalan, Alejandra Gonzalez-Beltran, Tim Ebbels, Royston Goodacre, Janna Hastings, Kenneth Haug, Albert Koulman, Macha Nikolski, Matej Oresic, Susanna-Assunta Sansone, Daniel Schober, James Smith, Christoph Steinbeck, Mark R. Viant, Steffen Neumann
Published in: Metabolomics, Issue 12/1, 2016, ISSN 1573-3882
Publisher: Springer Verlag
DOI: 10.1007/s11306-015-0879-3

Workflow for Integrated Processing of Multicohort Untargeted 1 H NMR Metabolomics Data in Large-Scale Metabolic Epidemiology (opens in new window)

Author(s): Ibrahim Karaman, Diana L. S. Ferreira, Claire L. Boulangé, Manuja R. Kaluarachchi, David Herrington, Anthony C. Dona, Raphaële Castagné, Alireza Moayyeri, Benjamin Lehne, Marie Loh, Paul S. de Vries, Abbas Dehghan, Oscar H. Franco, Albert Hofman, Evangelos Evangelou, Ioanna Tzoulaki, Paul Elliott, John C. Lindon, Timothy M. D. Ebbels
Published in: Journal of Proteome Research, Issue 15/12, 2016, Page(s) 4188-4194, ISSN 1535-3893
Publisher: American Chemical Society
DOI: 10.1021/acs.jproteome.6b00125

MIDcor, an R-program for deciphering mass interferences in mass spectra of metabolites enriched in stable isotopes (opens in new window)

Author(s): Vitaly A. Selivanov, Adrián Benito, Anibal Miranda, Esther Aguilar, Ibrahim Halil Polat, Josep J. Centelles, Anusha Jayaraman, Paul W. N. Lee, Silvia Marin, Marta Cascante
Published in: BMC Bioinformatics, Issue 18/1, 2017, ISSN 1471-2105
Publisher: BioMed Central
DOI: 10.1186/s12859-017-1513-3

The Ontology for Biomedical Investigations (opens in new window)

Author(s): Anita Bandrowski, Ryan Brinkman, Mathias Brochhausen, Matthew H. Brush, Bill Bug, Marcus C. Chibucos, Kevin Clancy, Mélanie Courtot, Dirk Derom, Michel Dumontier, Liju Fan, Jennifer Fostel, Gilberto Fragoso, Frank Gibson, Alejandra Gonzalez-Beltran, Melissa A. Haendel, Yongqun He, Mervi Heiskanen, Tina Hernandez-Boussard, Mark Jensen, Yu Lin, Allyson L. Lister, Phillip Lord, James Malone, Elisabe
Published in: PLOS ONE, Issue 11/4, 2016, Page(s) e0154556, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0154556

KODAMA: an R package for knowledge discovery and data mining (opens in new window)

Author(s): Stefano Cacciatore, Leonardo Tenori, Claudio Luchinat, Phillip R. Bennett, David A. MacIntyre
Published in: Bioinformatics, 2016, Page(s) btw705, ISSN 1367-4803
Publisher: Oxford University Press
DOI: 10.1093/bioinformatics/btw705

Gelified Biofluids for High-Resolution Magic Angle Spinning 1 H NMR Analysis: The Case of Urine (opens in new window)

Author(s): Panteleimon G. Takis, Leonardo Tenori, Enrico Ravera, Claudio Luchinat
Published in: Analytical Chemistry, Issue 89/2, 2017, Page(s) 1054-1058, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.6b04318

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