IgEPath - Contributions of IgE-antibodies and IgE effector cells to host defense against pathogenic bacteria

Información del proyecto

IgEPath

Identificador del acuerdo de subvención: 655153

DOI

10.3030/655153

Proyecto cerrado

Fecha de la firma de la CE 10 Abril 2015

Fecha de inicio 3 Agosto 2015

Fecha de finalización 2 Agosto 2017

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 166 156,80

Aportación de la UE

€ 166 156,80

Coordinado por

MEDIZINISCHE UNIVERSITAET WIEN
Austria

Periodic Reporting for period 1 - IgEPath (IgEPath - Contributions of IgE-antibodies and IgE effector cells to host defense against pathogenic bacteria)

Período documentado: 2015-08-03 hasta 2017-08-02

Resumen del contexto y de los objetivos generales del proyecto

Allergic individuals have developed an immune response against apparently harmless environmental proteins (known as allergens). Subsequent contact with the allergen activates mast cells and these immune cells immediately respond with rapid release of compounds that cause allergic symptoms and, in extreme cases, anaphylaxis. It is unclear whether there is a beneficial function of such allergic reactions. Recent research showed that immune responses similar to allergies can protect mice against bee and snake venoms. Such results provide evidence that allergic reactions represent an important component of the host defense against noxious substances, such as toxins and venoms.
Immune responses that resemble allergies are also developed during infections with certain toxin-producing bacteria. Such bacteria represent a major health threat as infections with certain species cannot be effectively treated and vaccines are not available.
The main objective of this study is to decipher the roles of allergic immune responses in host defense against pathogenic bacteria.

Trabajo realizado desde el comienzo del proyecto hasta el final del período abarcado por el informe y los principales resultados hasta la fecha

Throughout the project, we established all the experimental models in order to investigate the question. Using these tools, we found that the immune response against a pathogenic bacterium induces the development of an allergic immune response. The antibodies developed during this immune response had the potential to prime effector cells and increase the potential of these cells to kill the bacteria.

Avances que van más allá del estado de la técnica e impacto potencial esperado (incluida la repercusión socioeconómica y las implicaciones sociales más amplias del proyecto hasta la fecha)

Our project so far showed that the immune response against the bacterial pathogens indeed resembles an allergy. The immune response can increase immune protection against the bacteria. We will further elucidate the exact mechanisms underlying this protective immune response in future work. Ideally, the results will be the basis for new vaccination and therapeutic approaches against toxin producing, pathogenic bacteria.

Pollen allergy