IgEPath - Contributions of IgE-antibodies and IgE effector cells to host defense against pathogenic bacteria

Informations projet

IgEPath

N° de convention de subvention: 655153

DOI

10.3030/655153

Projet clôturé

Date de signature de la CE 10 Avril 2015

Date de début 3 Août 2015

Date de fin 2 Août 2017

Financé au titre de

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coût total

€ 166 156,80

Contribution de l’UE

€ 166 156,80

Coordonné par

MEDIZINISCHE UNIVERSITAET WIEN
Austria

Periodic Reporting for period 1 - IgEPath (IgEPath - Contributions of IgE-antibodies and IgE effector cells to host defense against pathogenic bacteria)

Période du rapport: 2015-08-03 au 2017-08-02

Résumé du contexte et des objectifs généraux du projet

Allergic individuals have developed an immune response against apparently harmless environmental proteins (known as allergens). Subsequent contact with the allergen activates mast cells and these immune cells immediately respond with rapid release of compounds that cause allergic symptoms and, in extreme cases, anaphylaxis. It is unclear whether there is a beneficial function of such allergic reactions. Recent research showed that immune responses similar to allergies can protect mice against bee and snake venoms. Such results provide evidence that allergic reactions represent an important component of the host defense against noxious substances, such as toxins and venoms.
Immune responses that resemble allergies are also developed during infections with certain toxin-producing bacteria. Such bacteria represent a major health threat as infections with certain species cannot be effectively treated and vaccines are not available.
The main objective of this study is to decipher the roles of allergic immune responses in host defense against pathogenic bacteria.

Travail effectué depuis le début du projet jusqu’à la fin de la période considérée dans le rapport et principaux résultats atteints jusqu’à présent

Throughout the project, we established all the experimental models in order to investigate the question. Using these tools, we found that the immune response against a pathogenic bacterium induces the development of an allergic immune response. The antibodies developed during this immune response had the potential to prime effector cells and increase the potential of these cells to kill the bacteria.

Progrès au-delà de l’état des connaissances et impact potentiel prévu (y compris l’impact socio-économique et les conséquences sociétales plus larges du projet jusqu’à présent)

Our project so far showed that the immune response against the bacterial pathogens indeed resembles an allergy. The immune response can increase immune protection against the bacteria. We will further elucidate the exact mechanisms underlying this protective immune response in future work. Ideally, the results will be the basis for new vaccination and therapeutic approaches against toxin producing, pathogenic bacteria.

Pollen allergy