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Generation and Application of Nucleophilic Allylmetal Species by Catalytic 1,4-Metal Migration

Objective

This proposed Fellowship brings together an Experienced Researcher from India with expertise in click chemistry, transition metal catalysis, and topochemical synthesis, with an internationally recognized Host Laboratory in the UK with expertise in the development of new catalytic reactions for organic synthesis. This project will:
• Provide high-quality, tailored training for an outstanding scientist (possessing an excellent publication record) who is primed for an independent research career by complementing and enhancing his competencies.
• Enhance European excellence in organic synthesis and catalysis, which are fundamentally important branches of chemistry that greatly impact upon many fields, such as the fine chemicals, pharmaceutical, agrochemical, materials, and biochemical industries.
The proposed research is based upon a completely new synthetic method recently discovered in the Host Laboratory that enables the generation of nucleophilic allylmetal species, which are widely employed in organic synthesis to prepare diverse compounds of interest. This method involves the catalytic carbometallation of the alkyne of a 1,3-enyne, followed by 1,4-migration of the resulting alkenylmetal species to the cis-allylic position of the enyne, which constitutes a special type of C–H functionalization reaction. The resulting allylmetal species may then be trapped by an electrophile stereoselectively. It is our strong conviction that the possibilities of this chemistry are enormous, and the end result will be a generally useful synthetic method for the preparation of valuable building blocks as single enantiomers. This fellowship will therefore help Europe to remain globally competitive in the chemical sciences.

Fields of science (EuroSciVoc)

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MSCA-IF-EF-ST - Standard EF

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Call for proposal

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(opens in new window) H2020-MSCA-IF-2014

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Coordinator

THE UNIVERSITY OF NOTTINGHAM
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 183 454,80
Address
University Park
NG7 2RD Nottingham
United Kingdom

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Region
East Midlands (England) Derbyshire and Nottinghamshire Nottingham
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 183 454,80
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