Skip to main content
Go to the home page of the European Commission (opens in new window)
English English
CORDIS - EU research results
CORDIS

Controlling Cell Fate through Smart Nanoheaters

Objective

Achieving the control of cellular processes is one of the most intriguing challenges in cell biology and medicine. Forefront approaches based on bioengineered nanoparticles might have the potential to target specific cell pathways, thus controlling downstream cell activities in a space and time selective fashion. The present project aims to develop and to validate a smart nanovectorable to activate a specific cell signalling and, on demand, to induce heat mediated cell death of nanovector targeted cells. As proof of concept, CONFINES is conceived to target the Wnt canonical pathway, one of the most studied and fascinating cell signalling, which orchestrates central mechanisms that govern cell proliferation, polarity and stem cell fate. To achieve the proposed objectives, a controlled synthetic approach will tailor Wnt ligands on magnetic nanoparticles, combining targeting and magnetic properties in a uniquenanovector. Owing to its chemico-physical features, NanoWnt will enable complete control of the cell signalling, and it will operate in vitro (human cell cultures) and in vivo (the aquatic invertebrateHydra vulgaris), in a dual mode: i) as an activator of the canonical Wnt pathway in those contexts where it is inactive ii) or upon exposure to a magnetic field, as a nanoheater, enabling specific cell ablation by hyperthermia. From a technological point of view, the project will advance basic knowledge on thermal ablation (via magnetic hyperthermia) and holds promises for translational medicine, providing a breakthrough tool to shape cell fate of nanovector receiving cells. Furthermore, combining diverse expertise, CONFINES will offer the applicant advanced and multidisciplinarytraining in the field of nanomaterial synthesis, characterization and functionalisation as well as in hyperthermia technology, which will complement his current skills based on nanobiotechnology and cellular/molecular biology.

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.

You need to log in or register to use this function

Keywords

Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)

Programme(s)

Multi-annual funding programmes that define the EU’s priorities for research and innovation.

Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)

See all projects funded under this funding scheme

Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) H2020-MSCA-IF-2014

See all projects funded under this call

Coordinator

UNIVERSIDAD DE ZARAGOZA
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 170 121,60
Address
CALLE PEDRO CERBUNA 12
50009 ZARAGOZA
Spain

See on map

Region
Noreste Aragón Zaragoza
Activity type
Higher or Secondary Education Establishments
Links
Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 170 121,60
My booklet 0 0