Objective
Here we propose the development of a new class of facial triad N,N,O ligands based on the bis(alkyl-imidazolyl)propionate (BAIP) architecture for the synthesis of bio-inspired mono-nuclear non-heme iron(II) complexes that have the ability to selective catalyze challenging oxidative transformations of organic compounds using oxidants like H2O2 or O2. Our specific aims will be:
(i) To develop new sterically encumbered BAIP-ligands for the generation of highly reactive 1:1 Fe/ligand complexes,
(ii) To develop ‘inverted amide’ versions of these ligands to generate Fe-amido complexes with low oxidation potentials for O2 activation,
(iii) To study the reactivity towards oxidants (H2O2, O2) and the catalytic properties in challenging oxidation transformations (alkane hydroxylation, alkene cis-dihydroxylation) of the corresponding iron complexes.
(iv) To carry out detailed mechanistic investigations on isolated and/or spectroscopically well-characterized iron complexes and intermediates that are involved in the reactivity of the new Fe-N,N,O complexes.
The project will follow the so-called ‘synthetic analogue approach’, where small model compounds are developed to mimic the structural and functional features of metallo-enzyme active sites. In doing so, the model compounds may aid in the further understanding of metallo-enzyme reactivity and mechanism. At the same time the model compounds may be further developed into new synthetic catalysts. Carrying out this project within the Organic Chemistry and Catalysis (OCC) group at Utrecht University will place the candidate in the middle of the research activities of the Catalysis Centre Utrecht (CCU). This will allow the candidate to develop his knowledge and skills in the fields of bioinorganic chemistry and homogeneous catalysis, to further shape him for a future research career in the broader fields of molecular inorganic chemistry and molecular catalysis.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences inorganic chemistry bioinorganic chemistry
- natural sciences chemical sciences electrochemistry electrolysis
- natural sciences chemical sciences inorganic chemistry transition metals
- natural sciences chemical sciences catalysis
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2014
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
3584 CS Utrecht
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.