Bis(alkyl-imidazolyl)propionate (BAIP) based bio-inspired mono-nuclear non-heme iron(II) complexes that catalyze challenging oxidative transformations of organic compounds

Información del proyecto

BAIPFeOTC

Identificador del acuerdo de subvención: 657765

DOI

10.3030/657765

Proyecto cerrado

Fecha de la firma de la CE 19 Marzo 2015

Fecha de inicio 1 Septiembre 2015

Fecha de finalización 31 Agosto 2017

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 165 598,80

Aportación de la UE

€ 165 598,80

Coordinado por

UNIVERSITEIT UTRECHT
Netherlands

Objetivo

Here we propose the development of a new class of facial triad N,N,O ligands based on the bis(alkyl-imidazolyl)propionate (BAIP) architecture for the synthesis of bio-inspired mono-nuclear non-heme iron(II) complexes that have the ability to selective catalyze challenging oxidative transformations of organic compounds using oxidants like H2O2 or O2. Our specific aims will be:
(i) To develop new sterically encumbered BAIP-ligands for the generation of highly reactive 1:1 Fe/ligand complexes,
(ii) To develop ‘inverted amide’ versions of these ligands to generate Fe-amido complexes with low oxidation potentials for O2 activation,
(iii) To study the reactivity towards oxidants (H2O2, O2) and the catalytic properties in challenging oxidation transformations (alkane hydroxylation, alkene cis-dihydroxylation) of the corresponding iron complexes.
(iv) To carry out detailed mechanistic investigations on isolated and/or spectroscopically well-characterized iron complexes and intermediates that are involved in the reactivity of the new Fe-N,N,O complexes.
The project will follow the so-called ‘synthetic analogue approach’, where small model compounds are developed to mimic the structural and functional features of metallo-enzyme active sites. In doing so, the model compounds may aid in the further understanding of metallo-enzyme reactivity and mechanism. At the same time the model compounds may be further developed into new synthetic catalysts. Carrying out this project within the Organic Chemistry and Catalysis (OCC) group at Utrecht University will place the candidate in the middle of the research activities of the Catalysis Centre Utrecht (CCU). This will allow the candidate to develop his knowledge and skills in the fields of bioinorganic chemistry and homogeneous catalysis, to further shape him for a future research career in the broader fields of molecular inorganic chemistry and molecular catalysis.

Ámbito científico (EuroSciVoc)

• ciencias naturales › ciencias químicas › química inorgánica › química bioinorgánica
• ciencias naturales › ciencias químicas › electroquímica › electrólisis
• ciencias naturales › ciencias químicas › química inorgánica › metales de transición
• ciencias naturales › ciencias químicas › catálisis
• ciencias naturales › ciencias biológicas › bioquímica › biomoléculas › proteínas › enzima

Programa(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions PROGRAMA PRINCIPAL
  
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
  

Tema(s)

• MSCA-IF-2014-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF)
  

Régimen de financiación

MSCA-IF-EF-ST - Standard EF

Convocatoria de propuestas

H2020-MSCA-IF-2014

Coordinador

UNIVERSITEIT UTRECHT

• Aportación neta de la UEn: € 165 598,80
• Dirección: HEIDELBERGLAAN 8 ; 3584 CS Utrecht ; Países Bajos
• Tipo de actividad: Higher or Secondary Education Establishments
• Coste total: € 165 598,80