Objective
Cell walls provide plant cells with structural support during growth and differentiation as well as with protection against environmental stress. Cell wall composition and structure is adapted to these functional requirements by a dedicated mechanism to maintain cell wall integrity (CWI). The available evidence suggests that the CWI mechanism is an important regulator of cell wall and carbohydrate metabolism and that signalling of sugar levels and osmotic conditions is vital for its function. Furthermore, interdependencies between pathogen defence and the CWI mechanism are becoming apparent.
By performing a forward genetic screen in Arabidopsis, I will identify novel components involved in sugar-signalling in the context of CWI maintenance and pathogen defence. Using a combination of genetic mapping and next-generation sequencing, I will determine the identity of the components, whose specific activities will be identified through targeted functional analyses. In the second part of my project I will determine functions of the signalling metabolites trehalose-6-phosphate and glycerol-3-phophate in CWI maintenance and analyse the osmo-sensitive regulation of these functions. After characterizing time-dependent quantitative changes in metabolite levels and related enzyme activities upon impaired CWI and in combination with osmotic support, I will examine specific functions of metabolites / enzymes by analysing developmental, hormonal and structural responses in Arabidopsis overexpression and knockout lines.
This project takes advantage of CWI maintenance involvement in a variety of biological processes to identify signalling components and osmo-sensitive mechanisms for the coordination of carbohydrate metabolism with cell wall metabolism and pathogen defence. The knowledge generated in this project will provide novel functional insights into metabolic processes relevant for facilitating bioenergy production and increasing the yield of food crops.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics
- natural sciences chemical sciences polymer sciences
- natural sciences biological sciences biochemistry biomolecules carbohydrates
- natural sciences mathematics pure mathematics mathematical analysis functional analysis
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2014
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
7491 TRONDHEIM
Norway
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.