Objective
Intravascular delivery of microcapsules is emerging as a novel and effective approach in targeted therapeutic and diagnostic procedures in cancer and cardiovascular diseases. It encapsulates drugs or imaging-contrast agents and functionalizes the surface of the capsule to target specific diseased sites. However, a major challenge in its applications is to improve the adhesion efficiency of capsules to the endothelium (a monolayer of cells that lines the luminal surface of blood vessels) under complex blood flow conditions. While extensive research has focused on identifying disease-associated biomolecules on the endothelium, or suitable antibody/peptides targeting these molecules, much less attention has been given to the margination of the drug carriers from the blood stream to the vascular wall, especially in arteries where many diseases develop. Margination represents the crucial first step before adhesion. The aim of this project is therefore to investigate the cross-sectional migration of microcapsules in arterial blood flows and to develop scientific understanding of how the size, shape and deformability of capsules, as well as system parameters such as the blood haematocrit, blood flow inertia and pulsatility, and vessel geometry affect the margination of the microcapsules. The project will unit the state-of-the-art in-vitro, ex-vivo experimentation and numerical modeling resolving blood flow at a cellular level. A second aim of the project is to develop practical principles for designing microcapsules with optimum margination property in arteries. The project will pave the way for novel designs of injectable medicines or imaging-contrast agents with enhanced vascular targeting efficiency.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs
- medical and health sciences clinical medicine cardiology cardiovascular diseases
- medical and health sciences clinical medicine oncology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2014
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
E1 4NS LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.