Objective This project will develop a new, highly enantioselective, state-of-the-art synthetic route to the daphniyunnine family of alkaloids based on a novel dual organo / metal catalysed desymmetrization reaction of alkene-linked cyclohexanones as a key step, which will allow the rapid and efficient construction of the AB rings ready for subsequent advancement to the majority of the family members. Evaluation of the anti-cancer biological activity of the different target molecules and late stage intermediates will be carried out. This Fellowship project combines total synthesis, new asymmetric methodology development and biological evaluation. It has been designed to augment and complement the research and transferable skills sets of the Marie Curie fellow, Dr Sonawane, and will greatly enhance his career prospects accordingly. Through the training and the research results arising, the Fellowship will be beneficial to the fellow, the host institution and European science. Fields of science natural scienceschemical sciencesorganic chemistryketonesnatural scienceschemical sciencesinorganic chemistrytransition metalsnatural scienceschemical sciencesorganic chemistryalcoholsnatural scienceschemical sciencescatalysisnatural scienceschemical sciencesorganic chemistryamines Keywords Organic synthesis catalysis desymmetrization total synthesis alkaloids enantioselective reactions Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Topic(s) MSCA-IF-2014-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF) Call for proposal H2020-MSCA-IF-2014 See other projects for this call Funding Scheme MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF) Coordinator THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Net EU contribution € 195 454,80 Address Wellington square university offices OX1 2JD Oxford United Kingdom See on map Region South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
