New Enantioselective Desymmetrization Reactions in Alkaloid Total Synthesis

Projektinformationen

NEDRATS

ID Finanzhilfevereinbarung: 660322

DOI 10.3030/660322

Das Projekt endete am 30 September 2016

EK-Unterschriftsdatum 27 März 2015

Startdatum 6 Juli 2015

Enddatum 5 Juli 2017

Finanziert unter

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Gesamtkosten € 195 454,80

EU-Beitrag € 195 454,80

Koordiniert durch

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom

Ziel

This project will develop a new, highly enantioselective, state-of-the-art synthetic route to the daphniyunnine family of alkaloids based on a novel dual organo / metal catalysed desymmetrization reaction of alkene-linked cyclohexanones as a key step, which will allow the rapid and efficient construction of the AB rings ready for subsequent advancement to the majority of the family members. Evaluation of the anti-cancer biological activity of the different target molecules and late stage intermediates will be carried out. This Fellowship project combines total synthesis, new asymmetric methodology development and biological evaluation. It has been designed to augment and complement the research and transferable skills sets of the Marie Curie fellow, Dr Sonawane, and will greatly enhance his career prospects accordingly. Through the training and the research results arising, the Fellowship will be beneficial to the fellow, the host institution and European science.

Wissenschaftliches Gebiet

• natural sciences › chemical sciences › organic chemistry › ketones
• natural sciences › chemical sciences › inorganic chemistry › transition metals
• natural sciences › chemical sciences › organic chemistry › alcohols
• natural sciences › chemical sciences › catalysis
• natural sciences › chemical sciences › organic chemistry › amines

Schlüsselbegriffe

• Organic synthesis
• catalysis
• desymmetrization
• total synthesis
• alkaloids
• enantioselective reactions

Programm/Programme

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Thema/Themen

• MSCA-IF-2014-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF)

Aufforderung zur Vorschlagseinreichung

H2020-MSCA-IF-2014

Finanzierungsplan

MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)

Koordinator

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

• Netto-EU-Beitrag: € 195 454,80
• Adresse: WELLINGTON SQUARE UNIVERSITY OFFICES ; OX1 2JD Oxford ; Vereinigtes Königreich
• Region: South East (England) › Berkshire, Buckinghamshire and Oxfordshire › Oxfordshire
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: € 195 454,80