PROTEASES VISUALIZATION DURING TUMOR PROGRESSION

Información del proyecto

PROVIST

Identificador del acuerdo de subvención: 661187

DOI 10.3030/661187

Proyecto cerrado

Fecha de la firma de la CE 24 Abril 2015

Fecha de inicio 1 Enero 2016

Fecha de finalización 31 Diciembre 2018

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total € 227 361,60

Aportación de la UE € 227 361,60

Coordinado por

POLITECHNIKA WROCLAWSKA
Poland

Publicaciones

Peer reviewed articles (11)

Counter Selection Substrate Library Strategy for Developing Specific Protease Substrates and Probes

Autores: Marcin Poreba, Rigmor Solberg, Wioletta Rut, Ngoc Nguyen Lunde, Paulina Kasperkiewicz, Scott J. Snipas, Marko Mihelic, Dusan Turk, Boris Turk, Guy S. Salvesen, Marcin Drag
Publicado en: Cell Chemical Biology, Edición 23/8, 2016, Página(s) 1023-1035, ISSN 2451-9456
Editor: Cell Press
DOI: 10.1016/j.chembiol.2016.05.020

Synthesis of a HyCoSuL peptide substrate library to dissect protease substrate specificity

Autores: Marcin Poreba, Guy S Salvesen, Marcin Drag
Publicado en: Nature Protocols, Edición 12/10, 2017, Página(s) 2189-2214, ISSN 1754-2189
Editor: Nature Publishing Group
DOI: 10.1038/nprot.2017.091

Highly sensitive and adaptable fluorescence-quenched pair discloses the substrate specificity profiles in diverse protease families

Autores: Marcin Poreba, Aleksandra Szalek, Wioletta Rut, Paulina Kasperkiewicz, Izabela Rutkowska-Wlodarczyk, Scott J. Snipas, Yoshifumi Itoh, Dusan Turk, Boris Turk, Christopher M. Overall, Leszek Kaczmarek, Guy S. Salvesen, Marcin Drag
Publicado en: Scientific Reports, Edición 7, 2017, Página(s) 43135, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/srep43135

Selective imaging of cathepsin L in breast cancer by fluorescent activity-based probes

Autores: Marcin Poreba, Wioletta Rut, Matej Vizovisek, Katarzyna Groborz, Paulina Kasperkiewicz, Darren Finlay, Kristiina Vuori, Dusan Turk, Boris Turk, Guy S. Salvesen, Marcin Drag
Publicado en: Chemical Science, Edición 9, 2018, Página(s) 2113-2129, ISSN 2041-6520
Editor: Royal Society of Chemistry
DOI: 10.1039/C7SC04303A

Extensive peptide and natural protein substrate screens reveal that mouse caspase-11 has much narrower substrate specificity than caspase-1

Autores: Monica L Gonzalez Ramirez, Marcin Poreba, Scott J Snipas, Katarzyna Groborz, Marcin Drag, Guy S Salvesen
Publicado en: Journal of Biological Chemistry, Edición 293(18):7058-7067, 2018, Página(s) jbc.RA117.001329, ISSN 0021-9258
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.RA117.001329

Emerging challenges in the design of selective substrates, inhibitors and activity-based probes for indistinguishable proteases

Autores: Paulina Kasperkiewicz, Marcin Poreba, Katarzyna Groborz, Marcin Drag
Publicado en: The FEBS Journal, Edición 284/10, 2017, Página(s) 1518-1539, ISSN 1742-464X
Editor: Blackwell Publishing Inc.
DOI: 10.1111/febs.14001

Caspase selective reagents for diagnosing apoptotic mechanisms

Autores: Marcin Poreba, Katarzyna Groborz, Mario Navarro, Scott J. Snipas, Marcin Drag, Guy S. Salvesen
Publicado en: Cell Death & Differentiation, Edición 26/2, 2019, Página(s) 229-244, ISSN 1350-9047
Editor: Nature Publishing Group
DOI: 10.1038/s41418-018-0110-y

Exploring the prime site in caspases as a novel chemical strategy for understanding the mechanisms of cell death: a proof of concept study on necroptosis in cancer cells

Autores: Katarzyna Groborz, Monica L. Gonzalez Ramirez, Scott J. Snipas, Guy S. Salvesen, Marcin Drąg, Marcin Poręba
Publicado en: Cell Death & Differentiation, Edición Epub ahead of print, 2019, ISSN 1350-9047
Editor: Nature Publishing Group
DOI: 10.1038/s41418-019-0364-z

Potent and selective caspase-2 inhibitor prevents MDM-2 cleavage in reversine-treated colon cancer cells

Autores: Marcin Poreba, Wioletta Rut, Katarzyna Groborz, Scott J. Snipas, Guy S. Salvesen, Marcin Drag
Publicado en: Cell Death & Differentiation, Edición Epub ahead of print, 2019, ISSN 1350-9047
Editor: Nature Publishing Group
DOI: 10.1038/s41418-019-0329-2

Fluorescent probes towards selective cathepsin B detection and visualization in cancer cells and patient samples

Autores: Marcin Poreba, Katarzyna Groborz, Matej Vizovisek, Marco Maruggi, Dusan Turk, Boris Turk, Garth Powis, Marcin Drag, Guy S. Salvesen
Publicado en: Chemical Science, Edición Just accepted, 2019, ISSN 2041-6520
Editor: Royal Society of Chemistry
DOI: 10.1039/c9sc00997c

Selective Substrates and Activity-Based Probes for Imaging of the Human Constitutive 20S Proteasome in Cells and Blood Samples

Autores: Wioletta Rut, Marcin Poręba, Paulina Kasperkiewicz, Scott J. Snipas, Marcin Drąg
Publicado en: Journal of Medicinal Chemistry, Edición 61/12, 2017, Página(s) 5222-5234, ISSN 0022-2623
Editor: American Chemical Society
DOI: 10.1021/acs.jmedchem.8b00026

Non-peer reviewed articles (1)

The Activome: multiplexed probing of activity of proteolytic enzymes using mass cytometry-compatible activity-based probes (TOF-probes)

Autores: Marcin Poreba, Katarzyna Groborz, Wioletta Rut, Milind Pore, Scott J. Snipas, Matej Vizovisek, Boris Turk, Peter Kuhn, Marcin Drag, Guy S. Salvesen
Publicado en: bioRxiv, 2019, ISSN 1350-9047
Editor: Nature Publishing Group
DOI: 10.1101/775627