Objective
Medis medical imaging systems BV (MEDIS), with 25 years of experience in medical imaging, will introduce a novel imaging-based biomarker as an accurate proxy for functional stenosis severity, creating a breakthrough in the treatment of ischemic heart disease (IHD). This non-invasive imaging algorithm should replace the current standard of using a vascular pressure wire to measure the Fractional Flow Reserve (FFR) - a measure for the physiologic significance of a coronary obstruction on the basis of which the interventional cardiologist decides whether an obstruction needs to be treated with stent placement, or otherwise should be left untreated.
Using pressure-wire FFR is risky, time consuming, costly, associated with additional X-ray radiation, not always accurate and not applicable in highly curved arteries. MEDIS has developed a functional prototype of its imaging algorithm (FFRQCA) that accurately calculates the FFR from readily available 2D X-ray images through 3D reconstruction, advanced image processing algorithms and computational fluid dynamics. In a direct comparison with the current standard, this novel approach showed excellent diagnostic accuracy of 88%. Efforts to further optimise the technology are currently ongoing: a multi-centre investigator-driven trial is being carried out across 2 European countries, the US and China.
In this Stage 1 SME Instrument project, MEDIS will investigate the commercial feasibility of this innovation that has already sparked enthusiasm amongst interventional cardiologists worldwide.
Fields of science
Programme(s)
Topic(s)
Funding Scheme
SME-1 - SME instrument phase 1Coordinator
2316 XG LEIDEN
Netherlands
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.