Massive Reverse Genomics to Decipher Gene Regulatory Grammar

Informations projet

MRG-GRammar

N° de convention de subvention: 664918

DOI 10.3030/664918

Projet clôturé

Date de signature de la CE 31 Mai 2015

Date de début 1 Août 2015

Date de fin 31 Juillet 2018

Financé au titre de

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Coût total € 3 999 661,00

Contribution de l’UE € 3 999 661,00

Coordonné par

TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY
Israel

Livrables

Other (1)

Website

Project website for visibility, raising awareness and dissemination purposes. The website will be maintained throughout the execution and will stay alive at least 2 years after the project end.

Documents, reports (4)

Unnatural enhancer data-set and report

Natural enhancer data-set and report

Bottom-up data-set report

Top-down data-set report

Publications

Peer reviewed articles (8)

The interaction landscape between transcription factors and the nucleosome

Auteurs: Fangjie Zhu, Lucas Farnung, Eevi Kaasinen, Biswajyoti Sahu, Yimeng Yin, Bei Wei, Svetlana Dodonova, Patrick Cramer, Jussi Taipale
Publié dans: Nature, 2017, ISSN 2520-1158
Éditeur: Nature
DOI: 10.1101/240598

Gene expression variability across cells and species shapes innate immunity

Auteurs: Tzachi Hagai, Xi Chen, Ricardo J. Miragaia, Tomas Gomes, Raghd Rostom, Natalia Kunowska, Valentina Proserpio, Giacomo Donati, Lara Bossini-Castillo, Guy Naamati, Guy Emerton, Gosia Trynka, Ivanela Kondova, Mike Denis, Sarah A Teichmann
Publié dans: Nature, 2017, ISSN 2520-1158
Éditeur: Nature
DOI: 10.1101/137992

Genome-wide CRISPR screens in T helper cells reveal pervasive cross-talk between activation and differentiation

Auteurs: Johan Henriksson, Xi Chen, Tomás Gomes, Ubaid Ullah, Kerstin B Meyer, Ricardo Miragaia, Graham Duddy, Jhuma Pramanik, Kosuke Yusa, Riita Lahesmaa, Sarah A. Teichmann
Publié dans: Cell, 2017, ISSN 2073-4409
Éditeur: Cell
DOI: 10.1101/196022

A rapid and robust method for single cell chromatin accessibility profiling

Auteurs: Xi Chen, Kedar Nath Natarajan, Sarah A Teichmann
Publié dans: Nature Communiction, 2018, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1101/309831

Developmental enhancers and chromosome topology

Auteurs: Eileen E. M. Furlong, Michael Levine
Publié dans: Science, 2018, ISSN 1095-9203
Éditeur: Science Magazine
DOI: 10.1126/science.aau0320

A Synthetic Oligo Library and Sequencing Approach Reveals an Insulation Mechanism Encoded within Bacterial σ 54 Promoters

Auteurs: Lior Levy, Leon Anavy, Oz Solomon, Roni Cohen, Michal Brunwasser-Meirom, Shilo Ohayon, Orna Atar, Sarah Goldberg, Zohar Yakhini, Roee Amit
Publié dans: Cell Reports, Numéro 21/3, 2017, Page(s) 845-858, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2017.09.063

Genome-wide analysis of fitness data and its application to improve metabolic models

Auteurs: Edward Vitkin, Oz Solomon, Sharon Sultan, Zohar Yakhini
Publié dans: BMC Bioinformatics, Numéro 19/1, 2018, ISSN 1471-2105
Éditeur: BioMed Central
DOI: 10.1186/s12859-018-2341-9

Using synthetic bacterial enhancers to reveal a looping-based mechanism for quenching-like repression

Auteurs: Michal Brunwasser-Meirom, Yaroslav Pollak, Sarah Goldberg, Lior Levy, Orna Atar, Roee Amit
Publié dans: Nature Communications, Numéro 7, 2016, Page(s) 10407, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/ncomms10407

Other (1)

A Looping-Based Model for Quenching Repression

Auteurs: Yaroslav Pollak, Sarah Goldberg, Roee Amit
Publié dans: PLOS, 2017
Éditeur: plos.org
DOI: 10.1371/journal.pcbi.1005337