Massive Reverse Genomics to Decipher Gene Regulatory Grammar

Informazioni relative al progetto

MRG-GRammar

ID dell’accordo di sovvenzione: 664918

DOI 10.3030/664918

Progetto chiuso

Data della firma CE 31 Maggio 2015

Data di avvio 1 Agosto 2015

Data di completamento 31 Luglio 2018

Finanziato da

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Costo totale € 3 999 661,00

Contributo UE € 3 999 661,00

Coordinato da

TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY
Israel

Risultati finali

Other (1)

Website

Project website for visibility, raising awareness and dissemination purposes. The website will be maintained throughout the execution and will stay alive at least 2 years after the project end.

Documents, reports (4)

Unnatural enhancer data-set and report

Natural enhancer data-set and report

Bottom-up data-set report

Top-down data-set report

Pubblicazioni

Peer reviewed articles (8)

The interaction landscape between transcription factors and the nucleosome

Autori: Fangjie Zhu, Lucas Farnung, Eevi Kaasinen, Biswajyoti Sahu, Yimeng Yin, Bei Wei, Svetlana Dodonova, Patrick Cramer, Jussi Taipale
Pubblicato in: Nature, 2017, ISSN 2520-1158
Editore: Nature
DOI: 10.1101/240598

Gene expression variability across cells and species shapes innate immunity

Autori: Tzachi Hagai, Xi Chen, Ricardo J. Miragaia, Tomas Gomes, Raghd Rostom, Natalia Kunowska, Valentina Proserpio, Giacomo Donati, Lara Bossini-Castillo, Guy Naamati, Guy Emerton, Gosia Trynka, Ivanela Kondova, Mike Denis, Sarah A Teichmann
Pubblicato in: Nature, 2017, ISSN 2520-1158
Editore: Nature
DOI: 10.1101/137992

Genome-wide CRISPR screens in T helper cells reveal pervasive cross-talk between activation and differentiation

Autori: Johan Henriksson, Xi Chen, Tomás Gomes, Ubaid Ullah, Kerstin B Meyer, Ricardo Miragaia, Graham Duddy, Jhuma Pramanik, Kosuke Yusa, Riita Lahesmaa, Sarah A. Teichmann
Pubblicato in: Cell, 2017, ISSN 2073-4409
Editore: Cell
DOI: 10.1101/196022

A rapid and robust method for single cell chromatin accessibility profiling

Autori: Xi Chen, Kedar Nath Natarajan, Sarah A Teichmann
Pubblicato in: Nature Communiction, 2018, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1101/309831

Developmental enhancers and chromosome topology

Autori: Eileen E. M. Furlong, Michael Levine
Pubblicato in: Science, 2018, ISSN 1095-9203
Editore: Science Magazine
DOI: 10.1126/science.aau0320

A Synthetic Oligo Library and Sequencing Approach Reveals an Insulation Mechanism Encoded within Bacterial σ 54 Promoters

Autori: Lior Levy, Leon Anavy, Oz Solomon, Roni Cohen, Michal Brunwasser-Meirom, Shilo Ohayon, Orna Atar, Sarah Goldberg, Zohar Yakhini, Roee Amit
Pubblicato in: Cell Reports, Numero 21/3, 2017, Pagina/e 845-858, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2017.09.063

Genome-wide analysis of fitness data and its application to improve metabolic models

Autori: Edward Vitkin, Oz Solomon, Sharon Sultan, Zohar Yakhini
Pubblicato in: BMC Bioinformatics, Numero 19/1, 2018, ISSN 1471-2105
Editore: BioMed Central
DOI: 10.1186/s12859-018-2341-9

Using synthetic bacterial enhancers to reveal a looping-based mechanism for quenching-like repression

Autori: Michal Brunwasser-Meirom, Yaroslav Pollak, Sarah Goldberg, Lior Levy, Orna Atar, Roee Amit
Pubblicato in: Nature Communications, Numero 7, 2016, Pagina/e 10407, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/ncomms10407

Other (1)

A Looping-Based Model for Quenching Repression

Autori: Yaroslav Pollak, Sarah Goldberg, Roee Amit
Pubblicato in: PLOS, 2017
Editore: plos.org
DOI: 10.1371/journal.pcbi.1005337