International Doctoral Programme in Biological Bases of Human Diseases

Deliverables

1st Periodic Report will be submitted within 60 days following the end of the 1st Reporting Period

2nd Periodic Report will be submitted within 60 days following the end of the 2nd Reporting Period.

2nd Report on dissemination activities will contain the following information: - dates of Call Publication and places where it was published (supporting documents required) - flyers, brochures, or other information produced - presentations from conferences and meetings or other events - a list of published articles in the press (with main articles attached) - any other means of advertising the programme

Researcher Declaration

Researcher Declaration will be submitted within 20 days of the start of the research training activities; one for each researcher.

Final Report

1st Report on dissemination activities

1st Report on dissemination activities will contain the following information: - dates of Call Publication and places where it was published (supporting documents required) - flyers, brochures, or other information produced - presentations from conferences and meetings or other events - a list of published articles in the press (with main articles attached) - any other means of advertising the programme

Link to the Call in the EURAXESS website

The information will be sent to the Project Officer by sending the link to the EURAXESS website where the Call has been published (one per call)

Publications

Ruxolitinib-induced defects in DNA repair cause sensitivity to PARP inhibitors in myeloproliferative neoplasms

Author(s): Margaret Nieborowska-Skorska, Silvia Maifrede, Yashodhara Dasgupta, Katherine Sullivan, Sylwia Flis, Bac Viet Le, Martyna Solecka, Elizaveta A. Belyaeva, Lucia Kubovcakova, Morgan Nawrocki, Martin Kirschner, Huaqing Zhao, Josef T. Prchal, Katarzyna Piwocka, Alison R. Moliterno, Mariusz Wasik, Steffen Koschmieder, Tony R. Green, Radek C. Skoda, Tomasz Skorski
Published in: Blood, 2017, Page(s) blood-2017-05-784942, ISSN 0006-4971
DOI: 10.1182/blood-2017-05-784942

microRNA diagnostic panel for Alzheimer’s disease and epigenetic trade-off between neurodegeneration and cancer

Author(s): Siranjeevi Nagaraj, Katarzyna Marta Zoltowska, Katarzyna Laskowska-Kaszub, Urszula Wojda
Published in: Ageing Research Reviews, Issue 49, 2019, Page(s) 125-143, ISSN 1568-1637
DOI: 10.1016/j.arr.2018.10.008

TDP-43: A Key Therapeutic Target beyond Amyotrophic Lateral Sclerosis

Author(s): Valle Palomo, Carlota Tosat-Bitrian, Vanesa Nozal, Siranjeevi Nagaraj, Angeles Martin-Requero, Ana Martinez
Published in: ACS Chemical Neuroscience, Issue 10/3, 2019, Page(s) 1183-1196, ISSN 1948-7193
DOI: 10.1021/acschemneuro.9b00026

The DNA Repair Protein OGG1 Protects Against Obesity by Altering Mitochondrial Energetics in White Adipose Tissue

Author(s): Sai Santosh Babu Komakula, Jana Tumova, Deeptha Kumaraswamy, Natalie Burchat, Vladimir Vartanian, Hong Ye, Agnieszka Dobrzyn, R. Stephen Lloyd, Harini Sampath
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
DOI: 10.1038/s41598-018-33151-1

Amyloidogenic cross-seeding of Tau protein: Transient emergence of structural variants of fibrils

Author(s): Bartosz Nizynski, Hanna Nieznanska, Robert Dec, Solomiia Boyko, Wojciech Dzwolak, Krzysztof Nieznanski
Published in: PLOS ONE, Issue 13/7, 2018, Page(s) e0201182, ISSN 1932-6203
DOI: 10.1371/journal.pone.0201182

Immune microenvironment of gliomas

Author(s): Anna Gieryng, Dominika Pszczolkowska, Kacper A Walentynowicz, Wenson D Rajan, Bozena Kaminska
Published in: Laboratory Investigation, Issue 97/5, 2017, Page(s) 498-518, ISSN 0023-6837
DOI: 10.1038/labinvest.2017.19

Recapitulation of Pathological TDP-43 Features in Immortalized Lymphocytes from Sporadic ALS Patients

Author(s): Diana Posa, Loreto Martínez-González, Fernando Bartolomé, Siranjeevi Nagaraj, Gracia Porras, Ana Martínez, Ángeles Martín-Requero
Published in: Molecular Neurobiology, Issue 56/4, 2019, Page(s) 2424-2432, ISSN 0893-7648
DOI: 10.1007/s12035-018-1249-8

Extracellular matrix controls neuronal features that mediate the persistence of fear

Author(s): Annabella Pignataro, Roberto Pagano, Giorgia Guarneri, Silvia Middei, Martine Ammassari-Teule
Published in: Brain Structure and Function, Issue 222/9, 2017, Page(s) 3889-3898, ISSN 1863-2653
DOI: 10.1007/s00429-017-1440-0

Activity-Induced Amyloid-β Oligomers Drive Compensatory Synaptic Rearrangements in Brain Circuits Controlling Memory of Presymptomatic Alzheimer's Disease Mice

Author(s): Annabella Pignataro, Giovanni Meli, Roberto Pagano, Veronica Fontebasso, Roberta Battistella, Giulia Conforto, Martine Ammassari-Teule, Silvia Middei
Published in: Biological Psychiatry, Issue 86/3, 2019, Page(s) 185-195, ISSN 0006-3223
DOI: 10.1016/j.biopsych.2018.10.018

Generation of silent synapses in dentate gyrus correlates with development of alcohol addiction

Author(s): Anna Beroun, Maria Nalberczak-Skóra, Zofia Harda, Małgorzata Piechota, Magdalena Ziółkowska, Anna Cały, Roberto Pagano, Kasia Radwanska
Published in: Neuropsychopharmacology, Issue 43/10, 2018, Page(s) 1989-1999, ISSN 0893-133X
DOI: 10.1038/s41386-018-0119-4

In Search for Reliable Markers of Glioma-Induced Polarization of Microglia

Author(s): Kacper A. Walentynowicz, Natalia Ochocka, Maria Pasierbinska, Kamil Wojnicki, Karolina Stepniak, Jakub Mieczkowski, Iwona A. Ciechomska, Bozena Kaminska
Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224
DOI: 10.3389/fimmu.2018.01329

Mitochondrial BK Channel Openers CGS7181 and CGS7184 Exhibit Cytotoxic Properties

Author(s): Bartłomiej Augustynek, Piotr Koprowski, Daria Rotko, Wolfram Kunz, Adam Szewczyk, Bogusz Kulawiak
Published in: International Journal of Molecular Sciences, Issue 19/2, 2018, Page(s) 353, ISSN 1422-0067
DOI: 10.3390/ijms19020353

Spinalization and locomotor training differentially affect muscarinic acetylcholine receptor type 2 abutting on α-motoneurons innervating the ankle extensor and flexor muscles

Author(s): Angelika Więckowska, Olga Gajewska-Woźniak, Anna Głowacka, Benjun Ji, Kamil Grycz, Julita Czarkowska-Bauch, Małgorzata Skup
Published in: Journal of Neurochemistry, Issue 147/3, 2018, Page(s) 361-379, ISSN 0022-3042
DOI: 10.1111/jnc.14567

Chronic unpredictable mild stress for modeling depression in rodents: Meta-analysis of model reliability

Author(s): Svitlana Antoniuk, Monika Bijata, Evgeni Ponimaskin, Jakub Wlodarczyk
Published in: Neuroscience & Biobehavioral Reviews, Issue 99, 2019, Page(s) 101-116, ISSN 0149-7634
DOI: 10.1016/j.neubiorev.2018.12.002

Immediate and deferred epigenomic signatures of in vivo neuronal activation in mouse hippocampus

Author(s): Jordi Fernandez-Albert, Michal Lipinski, María T. Lopez-Cascales, M. Jordan Rowley, Ana M. Martin-Gonzalez, Beatriz del Blanco, Victor G. Corces, Angel Barco
Published in: Nature Neuroscience, Issue 22/10, 2019, Page(s) 1718-1730, ISSN 1097-6256
DOI: 10.1038/s41593-019-0476-2

Liquid–liquid phase separation of tau protein: The crucial role of electrostatic interactions

Author(s): Solomiia Boyko, Xu Qi, Tien-Hao Chen, Krystyna Surewicz, Witold K. Surewicz
Published in: Journal of Biological Chemistry, Issue 294/29, 2019, Page(s) 11054-11059, ISSN 0021-9258
DOI: 10.1074/jbc.ac119.009198

Early pre- and postsynaptic decrease in glutamatergic and cholinergic signaling after spinalization is not modified when stimulating proprioceptive input to the ankle extensor α-motoneurons: Anatomical and neurochemical study

Author(s): Kamil Grycz, Anna Głowacka, Benjun Ji, Julita Czarkowska-Bauch, Olga Gajewska-Woźniak, Małgorzata Skup
Published in: PLOS ONE, Issue 14/9, 2019, Page(s) e0222849, ISSN 1932-6203
DOI: 10.1371/journal.pone.0222849

Role of Mitogen Activated Protein Kinase Signaling in Parkinson’s Disease

Author(s): Anastasiia Bohush, Grazyna Niewiadomska, Anna Filipek
Published in: International Journal of Molecular Sciences, Issue 19/10, 2018, Page(s) 2973, ISSN 1422-0067
DOI: 10.3390/ijms19102973

Domain organization of synaptic components

Author(s): M Pęziński, TJ Prószyński
Published in: Current Opinion in Physiology, Issue 4, 2018, Page(s) 7-14, ISSN 2468-8673
DOI: 10.1016/j.cophys.2018.02.008

An improved method for culturing myotubes on laminins for the robust clustering of postsynaptic machinery

Author(s): Marcin Pęziński, Patrycja Daszczuk, Bhola Shankar Pradhan, Hanns Lochmüller, Tomasz J. Prószyński
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
DOI: 10.1038/s41598-020-61347-x

Hsp90 and Its Co-Chaperones in Neurodegenerative Diseases

Author(s): Anastasiia Bohush, Paweł Bieganowski, Anna Filipek
Published in: International Journal of Molecular Sciences, Issue 20/20, 2019, Page(s) 4976, ISSN 1422-0067
DOI: 10.3390/ijms20204976

HSP90 and Its Novel Co-Chaperones, SGT1 and CHP-1, in Brain of Patients with Parkinson’s Disease and Dementia with Lewy Bodies

Author(s): Anastasiia Bohush, Grażyna Niewiadomska, Serge Weis, Anna Filipek
Published in: Journal of Parkinson's Disease, Issue 9/1, 2019, Page(s) 97-107, ISSN 1877-7171
DOI: 10.3233/jpd-181443

Rare Human Diseases: Model Organisms in Deciphering the Molecular Basis of Primary Ciliary Dyskinesia

Author(s): Martyna Poprzeczko, Marta Bicka, Hanan Farahat, Rafal Bazan, Anna Osinka, Hanna Fabczak, Ewa Joachimiak, Dorota Wloga
Published in: Cells, Issue 8/12, 2019, Page(s) 1614, ISSN 2073-4409
DOI: 10.3390/cells8121614

Myosin VI in the nucleus of neurosecretory PC12 cells: Stimulation-dependent nuclear translocation and interaction with nuclear proteins

Author(s): Lukasz Majewski, Jolanta Nowak, Magdalena Sobczak, Olena Karatsai, Serhiy Havrylov, Robert Lenartowski, Malgorzata Suszek, Marta Lenartowska, Maria Jolanta Redowicz
Published in: Nucleus, Issue 9/1, 2018, Page(s) 125-141, ISSN 1949-1034
DOI: 10.1080/19491034.2017.1421881

Potential bioisosteres of β-uracilalanines derived from 1H-1,2,3-triazole-C-carboxylic acids

Author(s): Ewa Mironiuk-Puchalska, Włodzimierz Buchowicz, Piotr Grześkowiak, Patrycja Wińska, Monika Wielechowska, Olena Karatsai, Maria Jolanta Rędowicz, Maria Bretner, Mariola Koszytkowska-Stawińska
Published in: Bioorganic Chemistry, Issue 83, 2019, Page(s) 500-510, ISSN 0045-2068
DOI: 10.1016/j.bioorg.2018.10.061

New insight into nucleo α-amino acids – Synthesis and SAR studies on cytotoxic activity of β-pyrimidine alanines

Author(s): Jolanta Ignatowska, Ewa Mironiuk-Puchalska, Piotr Grześkowiak, Patrycja Wińska, Monika Wielechowska, Maria Bretner, Olena Karatsai, Maria Jolanta Rędowicz, Mariola Koszytkowska-Stawińska
Published in: Bioorganic Chemistry, Issue 100, 2020, Page(s) 103864, ISSN 0045-2068
DOI: 10.1016/j.bioorg.2020.103864

Mitochondrialne kanały potasowe: podsumowanie

Author(s): Adam Szewczyk, Piotr Bednarczyk, Justyna Jędraszko, Rafał Paweł Kampa, Piotr Koprowski, Milena Krajewska, Shur Kucman, Bogusz Kulawiak, Michał Laskowski, Daria Rotko, Aleksandra Sęk, Agnieszka Walewska, Monika Żochowska, Antoni Wrzosek
Published in: Postępy Biochemii, Issue 64/3, 2018, Page(s) 196-212, ISSN 0032-5422
DOI: 10.18388/pb.2018_132

Cardiospecific deletion of αE-catenin leads to heart failure and lethality in mice

Author(s): Volodymyr V. Balatskyi, Larysa L. Macewicz, Ana-Maria Gan, Sergii V. Goncharov, Paulina Pawelec, Georgiy V. Portnichenko, Tetiana Yu Lapikova-Bryginska, Viktor O. Navrulin, Victor E. Dosenko, Adam Olichwier, Pawel Dobrzyn, Oksana O. Piven
Published in: Pflügers Archiv - European Journal of Physiology, Issue 470/10, 2018, Page(s) 1485-1499, ISSN 0031-6768
DOI: 10.1007/s00424-018-2168-2

Rola desaturazy stearoilo-CoA w regulacji metabolizmu serca

Author(s): Paweł Dobrzyń, Sabina Tabaczar, Marcin Wołosiewicz, Adam Olichwier
Published in: Postępy Biochemii, Issue 64/3, 2018, Page(s) 183-189, ISSN 0032-5422
DOI: 10.18388/pb.2018_130

IGH/MYC Translocation Associates with BRCA2 Deficiency and Synthetic Lethality to PARP1 Inhibitors

Author(s): Silvia Maifrede, Kayla Martin, Paulina Podszywalow-Bartnicka, Katherine Sullivan-Reed, Samantha K. Langer, Reza Nejati, Yashodhara Dasgupta, Michael Hulse, Daniel Gritsyuk, Margaret Nieborowska-Skorska, Lena N. Lupey-Green, Huaqing Zhao, Katarzyna Piwocka, Mariusz A. Wasik, Italo Tempera, Tomasz Skorski
Published in: Molecular Cancer Research, Issue 15/8, 2017, Page(s) 967-972, ISSN 1541-7786
DOI: 10.1158/1541-7786.mcr-16-0468

Gene expression and mutation-guided synthetic lethality eradicates proliferating and quiescent leukemia cells

Author(s): Margaret Nieborowska-Skorska, Katherine Sullivan, Yashodhara Dasgupta, Paulina Podszywalow-Bartnicka, Grazyna Hoser, Silvia Maifrede, Esteban Martinez, Daniela Di Marcantonio, Elisabeth Bolton-Gillespie, Kimberly Cramer-Morales, Jaewong Lee, Min Li, Artur Slupianek, Daniel Gritsyuk, Sabine Cerny-Reiterer, Ilona Seferynska, Tomasz Stoklosa, Lars Bullinger, Huaqing Zhao, Vera Gorbunova, Katarzyna Pi
Published in: Journal of Clinical Investigation, Issue 127/6, 2017, Page(s) 2392-2406, ISSN 0021-9738
DOI: 10.1172/jci90825

Tyrosine kinase inhibitor–induced defects in DNA repair sensitize FLT3(ITD)-positive leukemia cells to PARP1 inhibitors

Author(s): Silvia Maifrede, Margaret Nieborowska-Skorska, Katherine Sullivan-Reed, Yashodhara Dasgupta, Paulina Podszywalow-Bartnicka, Bac Viet Le, Martyna Solecka, Zhaorui Lian, Elizaveta A. Belyaeva, Alina Nersesyan, Marcin M. Machnicki, Monika Toma, Nicolas Chatain, Malgorzata Rydzanicz, Huaqing Zhao, Jaroslav Jelinek, Katarzyna Piwocka, Tomasz Sliwinski, Tomasz Stoklosa, Rafal Ploski, Thomas Fischer, Ste
Published in: Blood, Issue 132/1, 2018, Page(s) 67-77, ISSN 0006-4971
DOI: 10.1182/blood-2018-02-834895

Non-NAD-like PARP1 inhibitor enhanced synthetic lethal effect of NAD-like PARP inhibitors against BRCA1-deficient leukemia

Author(s): Margaret Nieborowska-Skorska, Silvia Maifrede, Min Ye, Monika Toma, Elizabeth Hewlett, John Gordon, Bac Viet Le, Tomasz Sliwinski, Huaqing Zhao, Katarzyna Piwocka, Peter Valent, Alexei V. Tulin, Wayne Childers, Tomasz Skorski
Published in: Leukemia & Lymphoma, Issue 60/4, 2019, Page(s) 1098-1101, ISSN 1042-8194
DOI: 10.1080/10428194.2018.1520988

PARP1 inhibitor eliminated imatinib-refractory chronic myeloid leukemia cells in bone marrow microenvironment conditions

Author(s): Paulina Podszywalow-Bartnicka, Silvia Maifrede, Bac Viet Le, Margaret Nieborowska-Skorska, Katarzyna Piwocka, Tomasz Skorski
Published in: Leukemia & Lymphoma, Issue 60/1, 2019, Page(s) 262-264, ISSN 1042-8194
DOI: 10.1080/10428194.2018.1471602

Trafficking of the amino acid transporter B0,+ (SLC6A14) to the plasma membrane involves an exclusive interaction with SEC24C for its exit from the endoplasmic reticulum

Author(s): Vasylyna Kovalchuk, Łukasz Samluk, Barbara Juraszek, Dominika Jurkiewicz-Trząska, Sonja Sucic, Michael Freissmuth, Katarzyna A. Nałęcz
Published in: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Issue 1866/2, 2019, Page(s) 252-263, ISSN 0167-4889
DOI: 10.1016/j.bbamcr.2018.11.005

Lipopolysaccharide Upregulates Palmitoylated Enzymes of the Phosphatidylinositol Cycle: An Insight from Proteomic Studies

Author(s): Justyna Sobocińska, Paula Roszczenko-Jasińska, Monika Zaręba-Kozioł, Aneta Hromada-Judycka, Orest V. Matveichuk, Gabriela Traczyk, Katarzyna Łukasiuk, Katarzyna Kwiatkowska
Published in: Molecular & Cellular Proteomics, Issue 17/2, 2018, Page(s) 233-254, ISSN 1535-9476
DOI: 10.1074/mcp.ra117.000050

Transmembrane adaptor protein WBP1L regulates CXCR4 signalling and murine haematopoiesis

Author(s): Simon Borna, Ales Drobek, Jarmila Kralova, Daniela Glatzova, Iva Splichalova, Matej Fabisik, Jana Pokorna, Tereza Skopcova, Pavla Angelisova, Veronika Kanderova, Julia Starkova, Petr Stanek, Orest V. Matveichuk, Nataliia Pavliuchenko, Katarzyna Kwiatkowska, Majd B. Protty, Michael G. Tomlinson, Meritxell Alberich‐Jorda, Vladimir Korinek, Tomas Brdicka
Published in: Journal of Cellular and Molecular Medicine, Issue 24/2, 2019, Page(s) 1980-1992, ISSN 1582-1838
DOI: 10.1111/jcmm.14895

Flotillins: At the Intersection of Protein S-Palmitoylation and Lipid-Mediated Signaling

Author(s): Katarzyna Kwiatkowska, Orest V. Matveichuk, Jan Fronk, Anna Ciesielska
Published in: International Journal of Molecular Sciences, Issue 21/7, 2020, Page(s) 2283, ISSN 1422-0067
DOI: 10.3390/ijms21072283

T Lymphocytes and Inflammatory Mediators in the Interplay between Brain and Blood in Alzheimer’s Disease: Potential Pools of New Biomarkers

Author(s): Anna Mietelska-Porowska, Urszula Wojda
Published in: Journal of Immunology Research, Issue 2017, 2017, Page(s) 1-17, ISSN 2314-8861
DOI: 10.1155/2017/4626540

Nitric oxide donor augments antineoplastic effects of arginine deprivation in human melanoma cells

Author(s): Oksana Mayevska, Oleh Chen, Olena Karatsai, Yaroslav Bobak, Maryna Barska, Liliana Lyniv, Iuliia Pavlyk, Yuriy Rzhepetskyy, Natalia Igumentseva, Maria Jolanta Redowicz, Oleh Stasyk
Published in: Experimental Cell Research, Issue 355/2, 2017, Page(s) 162-171, ISSN 0014-4827
DOI: 10.1016/j.yexcr.2017.04.003

MLL-AF9 leukemias are sensitive to PARP1 inhibitors combined with cytotoxic drugs

Author(s): Silvia Maifrede, Esteban Martinez, Margaret Nieborowska-Skorska, Daniela Di Marcantonio, Michael Hulse, Bac Viet Le, Huaqing Zhao, Katarzyna Piwocka, Italo Tempera, Stephen M. Sykes, Tomasz Skorski
Published in: Blood Advances, Issue 1/19, 2017, Page(s) 1467-1472, ISSN 2473-9529
DOI: 10.1182/bloodadvances.2017006247

Profile of 6 microRNA in blood plasma distinguish early stage Alzheimer’s disease patients from non-demented subjects

Author(s): Siranjeevi Nagaraj, Katarzyna Laskowska-Kaszub, Konrad J. Dębski, Joanna Wojsiat, Michał Dąbrowski, Tomasz Gabryelewicz, Jacek Kuźnicki, Urszula Wojda
Published in: Oncotarget, 2017, ISSN 1949-2553
DOI: 10.18632/oncotarget.15109

Liprin-α-1 is a novel component of the murine neuromuscular junction and is involved in the organization of the postsynaptic machinery

Author(s): Krzysztof M. Bernadzki, Marta Gawor, Marcin Pęziński, Paula Mazurek, Paweł Niewiadomski, Maria J. Rędowicz, Tomasz J. Prószyński
Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
DOI: 10.1038/s41598-017-09590-7

Single-cell RNA sequencing reveals functional heterogeneity and sex differences of glioma-associated brain macrophages

Author(s): Natalia Ochocka, Pawel Segit, Kacper Adam Walentynowicz, Kamil Wojnicki, Salwador Cyranowski, Julian Swatler, Jakub Mieczkowski, Bozena Kaminska
Published in: 2020
DOI: 10.1101/752949

Reduction in spontaneous firing of mouse excitatory layer 4 cortical neurons following visual classical conditioning

Author(s): Marek Bekisz, Ninad Shendye, Ida Raciborska, Andrzej Wróbel, Wioletta J. Waleszczyk
Published in: Photonics Applications in Astronomy, Communications, Industry, and High Energy Physics Experiments 2017, 2017, Page(s) 104452I
DOI: 10.1117/12.2281019

Effects of Arginine and Its Deprivation on Human Glioblastoma Physiology and Signaling

Author(s): Olena Karatsai, Oleh Stasyk, Maria Jolanta Redowicz
Published in: Glioma Signaling, Issue 1202, 2020, Page(s) 243-258
DOI: 10.1007/978-3-030-30651-9_12

Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases

Author(s): Carlotta Giorgi, Saverio Marchi, Ines C.M. Simoes, Ziyu Ren, Giampaolo Morciano, Mariasole Perrone, Paulina Patalas-Krawczyk, Sabine Borchard, Paulina Jędrak, Karolina Pierzynowska, Jędrzej Szymański, David Q. Wang, Piero Portincasa, Grzegorz Węgrzyn, Hans Zischka, Pawel Dobrzyn, Massimo Bonora, Jerzy Duszynski, Alessandro Rimessi, Agnieszka Karkucinska-Wieckowska, Agnieszka Dobrzyn, Gyorgy Sz
Published in: Mitochondria and Longevity, Issue 340, 2018, Page(s) 209-344
DOI: 10.1016/bs.ircmb.2018.05.006

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