International Doctoral Programme in Biological Bases of Human Diseases

Rezultaty

1st Periodic Report will be submitted within 60 days following the end of the 1st Reporting Period

2nd Periodic Report will be submitted within 60 days following the end of the 2nd Reporting Period.

2nd Report on dissemination activities will contain the following information: - dates of Call Publication and places where it was published (supporting documents required) - flyers, brochures, or other information produced - presentations from conferences and meetings or other events - a list of published articles in the press (with main articles attached) - any other means of advertising the programme

Researcher Declaration

Researcher Declaration will be submitted within 20 days of the start of the research training activities; one for each researcher.

Final Report
1st Report on dissemination activities

1st Report on dissemination activities will contain the following information: - dates of Call Publication and places where it was published (supporting documents required) - flyers, brochures, or other information produced - presentations from conferences and meetings or other events - a list of published articles in the press (with main articles attached) - any other means of advertising the programme

Link to the Call in the EURAXESS website

The information will be sent to the Project Officer by sending the link to the EURAXESS website where the Call has been published (one per call)

Publikacje

Combinatory Treatment of Canavanine and Arginine Deprivation Efficiently Targets Human Glioblastoma Cells via Pleiotropic Mechanisms

Autorzy: Olena Karatsai, Pavel Shliaha, Ole N. Jensen, Oleh Stasyk, Maria Jolanta Rędowicz
Opublikowane w: Cells, Numer 9/10, 2020, Strona(/y) 2217, ISSN 2073-4409
Wydawca: Cells
DOI: 10.3390/cells9102217

Ruxolitinib-induced defects in DNA repair cause sensitivity to PARP inhibitors in myeloproliferative neoplasms

Autorzy: Margaret Nieborowska-Skorska, Silvia Maifrede, Yashodhara Dasgupta, Katherine Sullivan, Sylwia Flis, Bac Viet Le, Martyna Solecka, Elizaveta A. Belyaeva, Lucia Kubovcakova, Morgan Nawrocki, Martin Kirschner, Huaqing Zhao, Josef T. Prchal, Katarzyna Piwocka, Alison R. Moliterno, Mariusz Wasik, Steffen Koschmieder, Tony R. Green, Radek C. Skoda, Tomasz Skorski
Opublikowane w: Blood, 2017, Strona(/y) blood-2017-05-784942, ISSN 0006-4971
Wydawca: American Society of Hematology
DOI: 10.1182/blood-2017-05-784942

microRNA diagnostic panel for Alzheimer’s disease and epigenetic trade-off between neurodegeneration and cancer

Autorzy: Siranjeevi Nagaraj, Katarzyna Marta Zoltowska, Katarzyna Laskowska-Kaszub, Urszula Wojda
Opublikowane w: Ageing Research Reviews, Numer 49, 2019, Strona(/y) 125-143, ISSN 1568-1637
Wydawca: Elsevier BV
DOI: 10.1016/j.arr.2018.10.008

TDP-43: A Key Therapeutic Target beyond Amyotrophic Lateral Sclerosis

Autorzy: Valle Palomo, Carlota Tosat-Bitrian, Vanesa Nozal, Siranjeevi Nagaraj, Angeles Martin-Requero, Ana Martinez
Opublikowane w: ACS Chemical Neuroscience, Numer 10/3, 2019, Strona(/y) 1183-1196, ISSN 1948-7193
Wydawca: American Chemical Society
DOI: 10.1021/acschemneuro.9b00026

The DNA Repair Protein OGG1 Protects Against Obesity by Altering Mitochondrial Energetics in White Adipose Tissue

Autorzy: Sai Santosh Babu Komakula, Jana Tumova, Deeptha Kumaraswamy, Natalie Burchat, Vladimir Vartanian, Hong Ye, Agnieszka Dobrzyn, R. Stephen Lloyd, Harini Sampath
Opublikowane w: Scientific Reports, Numer 8/1, 2018, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-018-33151-1

Amyloidogenic cross-seeding of Tau protein: Transient emergence of structural variants of fibrils

Autorzy: Bartosz Nizynski, Hanna Nieznanska, Robert Dec, Solomiia Boyko, Wojciech Dzwolak, Krzysztof Nieznanski
Opublikowane w: PLOS ONE, Numer 13/7, 2018, Strona(/y) e0201182, ISSN 1932-6203
Wydawca: Public Library of Science
DOI: 10.1371/journal.pone.0201182

Immune microenvironment of gliomas

Autorzy: Anna Gieryng, Dominika Pszczolkowska, Kacper A Walentynowicz, Wenson D Rajan, Bozena Kaminska
Opublikowane w: Laboratory Investigation, Numer 97/5, 2017, Strona(/y) 498-518, ISSN 0023-6837
Wydawca: Nature Publishing Group
DOI: 10.1038/labinvest.2017.19

In Search for Reliable Markers of Glioma-Induced Polarization of Microglia

Autorzy: Kacper A. Walentynowicz, Natalia Ochocka, Maria Pasierbinska, Kamil Wojnicki, Karolina Stepniak, Jakub Mieczkowski, Iwona A. Ciechomska, Bozena Kaminska
Opublikowane w: Frontiers in Immunology, Numer 9, 2018, ISSN 1664-3224
Wydawca: -
DOI: 10.3389/fimmu.2018.01329

Mitochondrial BK Channel Openers CGS7181 and CGS7184 Exhibit Cytotoxic Properties

Autorzy: Bartłomiej Augustynek, Piotr Koprowski, Daria Rotko, Wolfram Kunz, Adam Szewczyk, Bogusz Kulawiak
Opublikowane w: International Journal of Molecular Sciences, Numer 19/2, 2018, Strona(/y) 353, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms19020353

Spinalization and locomotor training differentially affect muscarinic acetylcholine receptor type 2 abutting on α-motoneurons innervating the ankle extensor and flexor muscles

Autorzy: Angelika Więckowska, Olga Gajewska-Woźniak, Anna Głowacka, Benjun Ji, Kamil Grycz, Julita Czarkowska-Bauch, Małgorzata Skup
Opublikowane w: Journal of Neurochemistry, Numer 147/3, 2018, Strona(/y) 361-379, ISSN 0022-3042
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/jnc.14567

Chronic unpredictable mild stress for modeling depression in rodents: Meta-analysis of model reliability

Autorzy: Svitlana Antoniuk, Monika Bijata, Evgeni Ponimaskin, Jakub Wlodarczyk
Opublikowane w: Neuroscience & Biobehavioral Reviews, Numer 99, 2019, Strona(/y) 101-116, ISSN 0149-7634
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2018.12.002

Liquid–liquid phase separation of tau protein: The crucial role of electrostatic interactions

Autorzy: Solomiia Boyko, Xu Qi, Tien-Hao Chen, Krystyna Surewicz, Witold K. Surewicz
Opublikowane w: Journal of Biological Chemistry, Numer 294/29, 2019, Strona(/y) 11054-11059, ISSN 0021-9258
Wydawca: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ac119.009198

Early pre- and postsynaptic decrease in glutamatergic and cholinergic signaling after spinalization is not modified when stimulating proprioceptive input to the ankle extensor α-motoneurons: Anatomical and neurochemical study

Autorzy: Kamil Grycz, Anna Głowacka, Benjun Ji, Julita Czarkowska-Bauch, Olga Gajewska-Woźniak, Małgorzata Skup
Opublikowane w: PLOS ONE, Numer 14/9, 2019, Strona(/y) e0222849, ISSN 1932-6203
Wydawca: Public Library of Science
DOI: 10.1371/journal.pone.0222849

Role of Mitogen Activated Protein Kinase Signaling in Parkinson’s Disease

Autorzy: Anastasiia Bohush, Grazyna Niewiadomska, Anna Filipek
Opublikowane w: International Journal of Molecular Sciences, Numer 19/10, 2018, Strona(/y) 2973, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms19102973

Domain organization of synaptic components

Autorzy: M Pęziński, TJ Prószyński
Opublikowane w: Current Opinion in Physiology, Numer 4, 2018, Strona(/y) 7-14, ISSN 2468-8673
Wydawca: n/a
DOI: 10.1016/j.cophys.2018.02.008

An improved method for culturing myotubes on laminins for the robust clustering of postsynaptic machinery

Autorzy: Marcin Pęziński, Patrycja Daszczuk, Bhola Shankar Pradhan, Hanns Lochmüller, Tomasz J. Prószyński
Opublikowane w: Scientific Reports, Numer 10/1, 2020, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-020-61347-x

Hsp90 and Its Co-Chaperones in Neurodegenerative Diseases

Autorzy: Anastasiia Bohush, Paweł Bieganowski, Anna Filipek
Opublikowane w: International Journal of Molecular Sciences, Numer 20/20, 2019, Strona(/y) 4976, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20204976

HSP90 and Its Novel Co-Chaperones, SGT1 and CHP-1, in Brain of Patients with Parkinson’s Disease and Dementia with Lewy Bodies

Autorzy: Anastasiia Bohush, Grażyna Niewiadomska, Serge Weis, Anna Filipek
Opublikowane w: Journal of Parkinson's Disease, Numer 9/1, 2019, Strona(/y) 97-107, ISSN 1877-7171
Wydawca: IOS Press
DOI: 10.3233/jpd-181443

Rare Human Diseases: Model Organisms in Deciphering the Molecular Basis of Primary Ciliary Dyskinesia

Autorzy: Martyna Poprzeczko, Marta Bicka, Hanan Farahat, Rafal Bazan, Anna Osinka, Hanna Fabczak, Ewa Joachimiak, Dorota Wloga
Opublikowane w: Cells, Numer 8/12, 2019, Strona(/y) 1614, ISSN 2073-4409
Wydawca: -
DOI: 10.3390/cells8121614

New insight into nucleo α-amino acids – Synthesis and SAR studies on cytotoxic activity of β-pyrimidine alanines

Autorzy: Jolanta Ignatowska, Ewa Mironiuk-Puchalska, Piotr Grześkowiak, Patrycja Wińska, Monika Wielechowska, Maria Bretner, Olena Karatsai, Maria Jolanta Rędowicz, Mariola Koszytkowska-Stawińska
Opublikowane w: Bioorganic Chemistry, Numer 100, 2020, Strona(/y) 103864, ISSN 0045-2068
Wydawca: Academic Press
DOI: 10.1016/j.bioorg.2020.103864

Mitochondrialne kanały potasowe: podsumowanie

Autorzy: Adam Szewczyk, Piotr Bednarczyk, Justyna Jędraszko, Rafał Paweł Kampa, Piotr Koprowski, Milena Krajewska, Shur Kucman, Bogusz Kulawiak, Michał Laskowski, Daria Rotko, Aleksandra Sęk, Agnieszka Walewska, Monika Żochowska, Antoni Wrzosek
Opublikowane w: Postępy Biochemii, Numer 64/3, 2018, Strona(/y) 196-212, ISSN 0032-5422
Wydawca: Polskie Towarzystwo Biochemiczne
DOI: 10.18388/pb.2018_132

Cardiospecific deletion of αE-catenin leads to heart failure and lethality in mice

Autorzy: Volodymyr V. Balatskyi, Larysa L. Macewicz, Ana-Maria Gan, Sergii V. Goncharov, Paulina Pawelec, Georgiy V. Portnichenko, Tetiana Yu Lapikova-Bryginska, Viktor O. Navrulin, Victor E. Dosenko, Adam Olichwier, Pawel Dobrzyn, Oksana O. Piven
Opublikowane w: Pflügers Archiv - European Journal of Physiology, Numer 470/10, 2018, Strona(/y) 1485-1499, ISSN 0031-6768
Wydawca: Springer Verlag
DOI: 10.1007/s00424-018-2168-2

Rola desaturazy stearoilo-CoA w regulacji metabolizmu serca

Autorzy: Paweł Dobrzyń, Sabina Tabaczar, Marcin Wołosiewicz, Adam Olichwier
Opublikowane w: Postępy Biochemii, Numer 64/3, 2018, Strona(/y) 183-189, ISSN 0032-5422
Wydawca: Polskie Towarzystwo Biochemiczne
DOI: 10.18388/pb.2018_130

Tyrosine kinase inhibitor–induced defects in DNA repair sensitize FLT3(ITD)-positive leukemia cells to PARP1 inhibitors

Autorzy: Silvia Maifrede, Margaret Nieborowska-Skorska, Katherine Sullivan-Reed, Yashodhara Dasgupta, Paulina Podszywalow-Bartnicka, Bac Viet Le, Martyna Solecka, Zhaorui Lian, Elizaveta A. Belyaeva, Alina Nersesyan, Marcin M. Machnicki, Monika Toma, Nicolas Chatain, Malgorzata Rydzanicz, Huaqing Zhao, Jaroslav Jelinek, Katarzyna Piwocka, Tomasz Sliwinski, Tomasz Stoklosa, Rafal Ploski, Thomas Fischer, Ste
Opublikowane w: Blood, Numer 132/1, 2018, Strona(/y) 67-77, ISSN 0006-4971
Wydawca: American Society of Hematology
DOI: 10.1182/blood-2018-02-834895

Non-NAD-like PARP1 inhibitor enhanced synthetic lethal effect of NAD-like PARP inhibitors against BRCA1-deficient leukemia

Autorzy: Margaret Nieborowska-Skorska, Silvia Maifrede, Min Ye, Monika Toma, Elizabeth Hewlett, John Gordon, Bac Viet Le, Tomasz Sliwinski, Huaqing Zhao, Katarzyna Piwocka, Peter Valent, Alexei V. Tulin, Wayne Childers, Tomasz Skorski
Opublikowane w: Leukemia & Lymphoma, Numer 60/4, 2019, Strona(/y) 1098-1101, ISSN 1042-8194
Wydawca: Taylor & Francis
DOI: 10.1080/10428194.2018.1520988

PARP1 inhibitor eliminated imatinib-refractory chronic myeloid leukemia cells in bone marrow microenvironment conditions

Autorzy: Paulina Podszywalow-Bartnicka, Silvia Maifrede, Bac Viet Le, Margaret Nieborowska-Skorska, Katarzyna Piwocka, Tomasz Skorski
Opublikowane w: Leukemia & Lymphoma, Numer 60/1, 2019, Strona(/y) 262-264, ISSN 1042-8194
Wydawca: Taylor & Francis
DOI: 10.1080/10428194.2018.1471602

Trafficking of the amino acid transporter B0,+ (SLC6A14) to the plasma membrane involves an exclusive interaction with SEC24C for its exit from the endoplasmic reticulum

Autorzy: Vasylyna Kovalchuk, Łukasz Samluk, Barbara Juraszek, Dominika Jurkiewicz-Trząska, Sonja Sucic, Michael Freissmuth, Katarzyna A. Nałęcz
Opublikowane w: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Numer 1866/2, 2019, Strona(/y) 252-263, ISSN 0167-4889
Wydawca: Elsevier BV
DOI: 10.1016/j.bbamcr.2018.11.005

Lipopolysaccharide Upregulates Palmitoylated Enzymes of the Phosphatidylinositol Cycle: An Insight from Proteomic Studies

Autorzy: Justyna Sobocińska, Paula Roszczenko-Jasińska, Monika Zaręba-Kozioł, Aneta Hromada-Judycka, Orest V. Matveichuk, Gabriela Traczyk, Katarzyna Łukasiuk, Katarzyna Kwiatkowska
Opublikowane w: Molecular & Cellular Proteomics, Numer 17/2, 2018, Strona(/y) 233-254, ISSN 1535-9476
Wydawca: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/mcp.ra117.000050

Transmembrane adaptor protein WBP1L regulates CXCR4 signalling and murine haematopoiesis

Autorzy: Simon Borna, Ales Drobek, Jarmila Kralova, Daniela Glatzova, Iva Splichalova, Matej Fabisik, Jana Pokorna, Tereza Skopcova, Pavla Angelisova, Veronika Kanderova, Julia Starkova, Petr Stanek, Orest V. Matveichuk, Nataliia Pavliuchenko, Katarzyna Kwiatkowska, Majd B. Protty, Michael G. Tomlinson, Meritxell Alberich‐Jorda, Vladimir Korinek, Tomas Brdicka
Opublikowane w: Journal of Cellular and Molecular Medicine, Numer 24/2, 2019, Strona(/y) 1980-1992, ISSN 1582-1838
Wydawca: Wiley-Blackwell
DOI: 10.1111/jcmm.14895

Flotillins: At the Intersection of Protein S-Palmitoylation and Lipid-Mediated Signaling

Autorzy: Katarzyna Kwiatkowska, Orest V. Matveichuk, Jan Fronk, Anna Ciesielska
Opublikowane w: International Journal of Molecular Sciences, Numer 21/7, 2020, Strona(/y) 2283, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21072283

T Lymphocytes and Inflammatory Mediators in the Interplay between Brain and Blood in Alzheimer’s Disease: Potential Pools of New Biomarkers

Autorzy: Anna Mietelska-Porowska, Urszula Wojda
Opublikowane w: Journal of Immunology Research, Numer 2017, 2017, Strona(/y) 1-17, ISSN 2314-8861
Wydawca: Hindawi Publishing Corporation
DOI: 10.1155/2017/4626540

Nitric oxide donor augments antineoplastic effects of arginine deprivation in human melanoma cells

Autorzy: Oksana Mayevska, Oleh Chen, Olena Karatsai, Yaroslav Bobak, Maryna Barska, Liliana Lyniv, Iuliia Pavlyk, Yuriy Rzhepetskyy, Natalia Igumentseva, Maria Jolanta Redowicz, Oleh Stasyk
Opublikowane w: Experimental Cell Research, Numer 355/2, 2017, Strona(/y) 162-171, ISSN 0014-4827
Wydawca: Academic Press
DOI: 10.1016/j.yexcr.2017.04.003

MLL-AF9 leukemias are sensitive to PARP1 inhibitors combined with cytotoxic drugs

Autorzy: Silvia Maifrede, Esteban Martinez, Margaret Nieborowska-Skorska, Daniela Di Marcantonio, Michael Hulse, Bac Viet Le, Huaqing Zhao, Katarzyna Piwocka, Italo Tempera, Stephen M. Sykes, Tomasz Skorski
Opublikowane w: Blood Advances, Numer 1/19, 2017, Strona(/y) 1467-1472, ISSN 2473-9529
Wydawca: American Society of Hematology
DOI: 10.1182/bloodadvances.2017006247

Profile of 6 microRNA in blood plasma distinguish early stage Alzheimer’s disease patients from non-demented subjects

Autorzy: Siranjeevi Nagaraj, Katarzyna Laskowska-Kaszub, Konrad J. Dębski, Joanna Wojsiat, Michał Dąbrowski, Tomasz Gabryelewicz, Jacek Kuźnicki, Urszula Wojda
Opublikowane w: Oncotarget, 2017, ISSN 1949-2553
Wydawca: Impact Journals
DOI: 10.18632/oncotarget.15109

Liprin-α-1 is a novel component of the murine neuromuscular junction and is involved in the organization of the postsynaptic machinery

Autorzy: Krzysztof M. Bernadzki, Marta Gawor, Marcin Pęziński, Paula Mazurek, Paweł Niewiadomski, Maria J. Rędowicz, Tomasz J. Prószyński
Opublikowane w: Scientific Reports, Numer 7/1, 2017, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-017-09590-7

Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases

Autorzy: Carlotta Giorgi, Saverio Marchi, Ines C.M. Simoes, Ziyu Ren, Giampaolo Morciano, Mariasole Perrone, Paulina Patalas-Krawczyk, Sabine Borchard, Paulina Jędrak, Karolina Pierzynowska, Jędrzej Szymański, David Q. Wang, Piero Portincasa, Grzegorz Węgrzyn, Hans Zischka, Pawel Dobrzyn, Massimo Bonora, Jerzy Duszynski, Alessandro Rimessi, Agnieszka Karkucinska-Wieckowska, Agnieszka Dobrzyn, Gyorgy Sz
Opublikowane w: Mitochondria and Longevity, Numer 340, 2018, Strona(/y) 209-344, ISBN 9780-128157367
Wydawca: Elsevier
DOI: 10.1016/bs.ircmb.2018.05.006

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