International Doctoral Programme in Biological Bases of Human Diseases

Livrables

1st Periodic Report will be submitted within 60 days following the end of the 1st Reporting Period

2nd Periodic Report will be submitted within 60 days following the end of the 2nd Reporting Period.

2nd Report on dissemination activities will contain the following information: - dates of Call Publication and places where it was published (supporting documents required) - flyers, brochures, or other information produced - presentations from conferences and meetings or other events - a list of published articles in the press (with main articles attached) - any other means of advertising the programme

Researcher Declaration

Researcher Declaration will be submitted within 20 days of the start of the research training activities; one for each researcher.

Final Report
1st Report on dissemination activities

1st Report on dissemination activities will contain the following information: - dates of Call Publication and places where it was published (supporting documents required) - flyers, brochures, or other information produced - presentations from conferences and meetings or other events - a list of published articles in the press (with main articles attached) - any other means of advertising the programme

Link to the Call in the EURAXESS website

The information will be sent to the Project Officer by sending the link to the EURAXESS website where the Call has been published (one per call)

Publications

Combinatory Treatment of Canavanine and Arginine Deprivation Efficiently Targets Human Glioblastoma Cells via Pleiotropic Mechanisms

Auteurs: Olena Karatsai, Pavel Shliaha, Ole N. Jensen, Oleh Stasyk, Maria Jolanta Rędowicz
Publié dans: Cells, Numéro 9/10, 2020, Page(s) 2217, ISSN 2073-4409
Éditeur: Cells
DOI: 10.3390/cells9102217

Ruxolitinib-induced defects in DNA repair cause sensitivity to PARP inhibitors in myeloproliferative neoplasms

Auteurs: Margaret Nieborowska-Skorska, Silvia Maifrede, Yashodhara Dasgupta, Katherine Sullivan, Sylwia Flis, Bac Viet Le, Martyna Solecka, Elizaveta A. Belyaeva, Lucia Kubovcakova, Morgan Nawrocki, Martin Kirschner, Huaqing Zhao, Josef T. Prchal, Katarzyna Piwocka, Alison R. Moliterno, Mariusz Wasik, Steffen Koschmieder, Tony R. Green, Radek C. Skoda, Tomasz Skorski
Publié dans: Blood, 2017, Page(s) blood-2017-05-784942, ISSN 0006-4971
Éditeur: American Society of Hematology
DOI: 10.1182/blood-2017-05-784942

microRNA diagnostic panel for Alzheimer’s disease and epigenetic trade-off between neurodegeneration and cancer

Auteurs: Siranjeevi Nagaraj, Katarzyna Marta Zoltowska, Katarzyna Laskowska-Kaszub, Urszula Wojda
Publié dans: Ageing Research Reviews, Numéro 49, 2019, Page(s) 125-143, ISSN 1568-1637
Éditeur: Elsevier BV
DOI: 10.1016/j.arr.2018.10.008

TDP-43: A Key Therapeutic Target beyond Amyotrophic Lateral Sclerosis

Auteurs: Valle Palomo, Carlota Tosat-Bitrian, Vanesa Nozal, Siranjeevi Nagaraj, Angeles Martin-Requero, Ana Martinez
Publié dans: ACS Chemical Neuroscience, Numéro 10/3, 2019, Page(s) 1183-1196, ISSN 1948-7193
Éditeur: American Chemical Society
DOI: 10.1021/acschemneuro.9b00026

The DNA Repair Protein OGG1 Protects Against Obesity by Altering Mitochondrial Energetics in White Adipose Tissue

Auteurs: Sai Santosh Babu Komakula, Jana Tumova, Deeptha Kumaraswamy, Natalie Burchat, Vladimir Vartanian, Hong Ye, Agnieszka Dobrzyn, R. Stephen Lloyd, Harini Sampath
Publié dans: Scientific Reports, Numéro 8/1, 2018, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-018-33151-1

Amyloidogenic cross-seeding of Tau protein: Transient emergence of structural variants of fibrils

Auteurs: Bartosz Nizynski, Hanna Nieznanska, Robert Dec, Solomiia Boyko, Wojciech Dzwolak, Krzysztof Nieznanski
Publié dans: PLOS ONE, Numéro 13/7, 2018, Page(s) e0201182, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0201182

Immune microenvironment of gliomas

Auteurs: Anna Gieryng, Dominika Pszczolkowska, Kacper A Walentynowicz, Wenson D Rajan, Bozena Kaminska
Publié dans: Laboratory Investigation, Numéro 97/5, 2017, Page(s) 498-518, ISSN 0023-6837
Éditeur: Nature Publishing Group
DOI: 10.1038/labinvest.2017.19

In Search for Reliable Markers of Glioma-Induced Polarization of Microglia

Auteurs: Kacper A. Walentynowicz, Natalia Ochocka, Maria Pasierbinska, Kamil Wojnicki, Karolina Stepniak, Jakub Mieczkowski, Iwona A. Ciechomska, Bozena Kaminska
Publié dans: Frontiers in Immunology, Numéro 9, 2018, ISSN 1664-3224
Éditeur: -
DOI: 10.3389/fimmu.2018.01329

Mitochondrial BK Channel Openers CGS7181 and CGS7184 Exhibit Cytotoxic Properties

Auteurs: Bartłomiej Augustynek, Piotr Koprowski, Daria Rotko, Wolfram Kunz, Adam Szewczyk, Bogusz Kulawiak
Publié dans: International Journal of Molecular Sciences, Numéro 19/2, 2018, Page(s) 353, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms19020353

Spinalization and locomotor training differentially affect muscarinic acetylcholine receptor type 2 abutting on α-motoneurons innervating the ankle extensor and flexor muscles

Auteurs: Angelika Więckowska, Olga Gajewska-Woźniak, Anna Głowacka, Benjun Ji, Kamil Grycz, Julita Czarkowska-Bauch, Małgorzata Skup
Publié dans: Journal of Neurochemistry, Numéro 147/3, 2018, Page(s) 361-379, ISSN 0022-3042
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/jnc.14567

Chronic unpredictable mild stress for modeling depression in rodents: Meta-analysis of model reliability

Auteurs: Svitlana Antoniuk, Monika Bijata, Evgeni Ponimaskin, Jakub Wlodarczyk
Publié dans: Neuroscience & Biobehavioral Reviews, Numéro 99, 2019, Page(s) 101-116, ISSN 0149-7634
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2018.12.002

Liquid–liquid phase separation of tau protein: The crucial role of electrostatic interactions

Auteurs: Solomiia Boyko, Xu Qi, Tien-Hao Chen, Krystyna Surewicz, Witold K. Surewicz
Publié dans: Journal of Biological Chemistry, Numéro 294/29, 2019, Page(s) 11054-11059, ISSN 0021-9258
Éditeur: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ac119.009198

Early pre- and postsynaptic decrease in glutamatergic and cholinergic signaling after spinalization is not modified when stimulating proprioceptive input to the ankle extensor α-motoneurons: Anatomical and neurochemical study

Auteurs: Kamil Grycz, Anna Głowacka, Benjun Ji, Julita Czarkowska-Bauch, Olga Gajewska-Woźniak, Małgorzata Skup
Publié dans: PLOS ONE, Numéro 14/9, 2019, Page(s) e0222849, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0222849

Role of Mitogen Activated Protein Kinase Signaling in Parkinson’s Disease

Auteurs: Anastasiia Bohush, Grazyna Niewiadomska, Anna Filipek
Publié dans: International Journal of Molecular Sciences, Numéro 19/10, 2018, Page(s) 2973, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms19102973

Domain organization of synaptic components

Auteurs: M Pęziński, TJ Prószyński
Publié dans: Current Opinion in Physiology, Numéro 4, 2018, Page(s) 7-14, ISSN 2468-8673
Éditeur: n/a
DOI: 10.1016/j.cophys.2018.02.008

An improved method for culturing myotubes on laminins for the robust clustering of postsynaptic machinery

Auteurs: Marcin Pęziński, Patrycja Daszczuk, Bhola Shankar Pradhan, Hanns Lochmüller, Tomasz J. Prószyński
Publié dans: Scientific Reports, Numéro 10/1, 2020, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-020-61347-x

Hsp90 and Its Co-Chaperones in Neurodegenerative Diseases

Auteurs: Anastasiia Bohush, Paweł Bieganowski, Anna Filipek
Publié dans: International Journal of Molecular Sciences, Numéro 20/20, 2019, Page(s) 4976, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20204976

HSP90 and Its Novel Co-Chaperones, SGT1 and CHP-1, in Brain of Patients with Parkinson’s Disease and Dementia with Lewy Bodies

Auteurs: Anastasiia Bohush, Grażyna Niewiadomska, Serge Weis, Anna Filipek
Publié dans: Journal of Parkinson's Disease, Numéro 9/1, 2019, Page(s) 97-107, ISSN 1877-7171
Éditeur: IOS Press
DOI: 10.3233/jpd-181443

Rare Human Diseases: Model Organisms in Deciphering the Molecular Basis of Primary Ciliary Dyskinesia

Auteurs: Martyna Poprzeczko, Marta Bicka, Hanan Farahat, Rafal Bazan, Anna Osinka, Hanna Fabczak, Ewa Joachimiak, Dorota Wloga
Publié dans: Cells, Numéro 8/12, 2019, Page(s) 1614, ISSN 2073-4409
Éditeur: -
DOI: 10.3390/cells8121614

New insight into nucleo α-amino acids – Synthesis and SAR studies on cytotoxic activity of β-pyrimidine alanines

Auteurs: Jolanta Ignatowska, Ewa Mironiuk-Puchalska, Piotr Grześkowiak, Patrycja Wińska, Monika Wielechowska, Maria Bretner, Olena Karatsai, Maria Jolanta Rędowicz, Mariola Koszytkowska-Stawińska
Publié dans: Bioorganic Chemistry, Numéro 100, 2020, Page(s) 103864, ISSN 0045-2068
Éditeur: Academic Press
DOI: 10.1016/j.bioorg.2020.103864

Mitochondrialne kanały potasowe: podsumowanie

Auteurs: Adam Szewczyk, Piotr Bednarczyk, Justyna Jędraszko, Rafał Paweł Kampa, Piotr Koprowski, Milena Krajewska, Shur Kucman, Bogusz Kulawiak, Michał Laskowski, Daria Rotko, Aleksandra Sęk, Agnieszka Walewska, Monika Żochowska, Antoni Wrzosek
Publié dans: Postępy Biochemii, Numéro 64/3, 2018, Page(s) 196-212, ISSN 0032-5422
Éditeur: Polskie Towarzystwo Biochemiczne
DOI: 10.18388/pb.2018_132

Cardiospecific deletion of αE-catenin leads to heart failure and lethality in mice

Auteurs: Volodymyr V. Balatskyi, Larysa L. Macewicz, Ana-Maria Gan, Sergii V. Goncharov, Paulina Pawelec, Georgiy V. Portnichenko, Tetiana Yu Lapikova-Bryginska, Viktor O. Navrulin, Victor E. Dosenko, Adam Olichwier, Pawel Dobrzyn, Oksana O. Piven
Publié dans: Pflügers Archiv - European Journal of Physiology, Numéro 470/10, 2018, Page(s) 1485-1499, ISSN 0031-6768
Éditeur: Springer Verlag
DOI: 10.1007/s00424-018-2168-2

Rola desaturazy stearoilo-CoA w regulacji metabolizmu serca

Auteurs: Paweł Dobrzyń, Sabina Tabaczar, Marcin Wołosiewicz, Adam Olichwier
Publié dans: Postępy Biochemii, Numéro 64/3, 2018, Page(s) 183-189, ISSN 0032-5422
Éditeur: Polskie Towarzystwo Biochemiczne
DOI: 10.18388/pb.2018_130

Tyrosine kinase inhibitor–induced defects in DNA repair sensitize FLT3(ITD)-positive leukemia cells to PARP1 inhibitors

Auteurs: Silvia Maifrede, Margaret Nieborowska-Skorska, Katherine Sullivan-Reed, Yashodhara Dasgupta, Paulina Podszywalow-Bartnicka, Bac Viet Le, Martyna Solecka, Zhaorui Lian, Elizaveta A. Belyaeva, Alina Nersesyan, Marcin M. Machnicki, Monika Toma, Nicolas Chatain, Malgorzata Rydzanicz, Huaqing Zhao, Jaroslav Jelinek, Katarzyna Piwocka, Tomasz Sliwinski, Tomasz Stoklosa, Rafal Ploski, Thomas Fischer, Ste
Publié dans: Blood, Numéro 132/1, 2018, Page(s) 67-77, ISSN 0006-4971
Éditeur: American Society of Hematology
DOI: 10.1182/blood-2018-02-834895

Non-NAD-like PARP1 inhibitor enhanced synthetic lethal effect of NAD-like PARP inhibitors against BRCA1-deficient leukemia

Auteurs: Margaret Nieborowska-Skorska, Silvia Maifrede, Min Ye, Monika Toma, Elizabeth Hewlett, John Gordon, Bac Viet Le, Tomasz Sliwinski, Huaqing Zhao, Katarzyna Piwocka, Peter Valent, Alexei V. Tulin, Wayne Childers, Tomasz Skorski
Publié dans: Leukemia & Lymphoma, Numéro 60/4, 2019, Page(s) 1098-1101, ISSN 1042-8194
Éditeur: Taylor & Francis
DOI: 10.1080/10428194.2018.1520988

PARP1 inhibitor eliminated imatinib-refractory chronic myeloid leukemia cells in bone marrow microenvironment conditions

Auteurs: Paulina Podszywalow-Bartnicka, Silvia Maifrede, Bac Viet Le, Margaret Nieborowska-Skorska, Katarzyna Piwocka, Tomasz Skorski
Publié dans: Leukemia & Lymphoma, Numéro 60/1, 2019, Page(s) 262-264, ISSN 1042-8194
Éditeur: Taylor & Francis
DOI: 10.1080/10428194.2018.1471602

Trafficking of the amino acid transporter B0,+ (SLC6A14) to the plasma membrane involves an exclusive interaction with SEC24C for its exit from the endoplasmic reticulum

Auteurs: Vasylyna Kovalchuk, Łukasz Samluk, Barbara Juraszek, Dominika Jurkiewicz-Trząska, Sonja Sucic, Michael Freissmuth, Katarzyna A. Nałęcz
Publié dans: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Numéro 1866/2, 2019, Page(s) 252-263, ISSN 0167-4889
Éditeur: Elsevier BV
DOI: 10.1016/j.bbamcr.2018.11.005

Lipopolysaccharide Upregulates Palmitoylated Enzymes of the Phosphatidylinositol Cycle: An Insight from Proteomic Studies

Auteurs: Justyna Sobocińska, Paula Roszczenko-Jasińska, Monika Zaręba-Kozioł, Aneta Hromada-Judycka, Orest V. Matveichuk, Gabriela Traczyk, Katarzyna Łukasiuk, Katarzyna Kwiatkowska
Publié dans: Molecular & Cellular Proteomics, Numéro 17/2, 2018, Page(s) 233-254, ISSN 1535-9476
Éditeur: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/mcp.ra117.000050

Transmembrane adaptor protein WBP1L regulates CXCR4 signalling and murine haematopoiesis

Auteurs: Simon Borna, Ales Drobek, Jarmila Kralova, Daniela Glatzova, Iva Splichalova, Matej Fabisik, Jana Pokorna, Tereza Skopcova, Pavla Angelisova, Veronika Kanderova, Julia Starkova, Petr Stanek, Orest V. Matveichuk, Nataliia Pavliuchenko, Katarzyna Kwiatkowska, Majd B. Protty, Michael G. Tomlinson, Meritxell Alberich‐Jorda, Vladimir Korinek, Tomas Brdicka
Publié dans: Journal of Cellular and Molecular Medicine, Numéro 24/2, 2019, Page(s) 1980-1992, ISSN 1582-1838
Éditeur: Wiley-Blackwell
DOI: 10.1111/jcmm.14895

Flotillins: At the Intersection of Protein S-Palmitoylation and Lipid-Mediated Signaling

Auteurs: Katarzyna Kwiatkowska, Orest V. Matveichuk, Jan Fronk, Anna Ciesielska
Publié dans: International Journal of Molecular Sciences, Numéro 21/7, 2020, Page(s) 2283, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21072283

T Lymphocytes and Inflammatory Mediators in the Interplay between Brain and Blood in Alzheimer’s Disease: Potential Pools of New Biomarkers

Auteurs: Anna Mietelska-Porowska, Urszula Wojda
Publié dans: Journal of Immunology Research, Numéro 2017, 2017, Page(s) 1-17, ISSN 2314-8861
Éditeur: Hindawi Publishing Corporation
DOI: 10.1155/2017/4626540

Nitric oxide donor augments antineoplastic effects of arginine deprivation in human melanoma cells

Auteurs: Oksana Mayevska, Oleh Chen, Olena Karatsai, Yaroslav Bobak, Maryna Barska, Liliana Lyniv, Iuliia Pavlyk, Yuriy Rzhepetskyy, Natalia Igumentseva, Maria Jolanta Redowicz, Oleh Stasyk
Publié dans: Experimental Cell Research, Numéro 355/2, 2017, Page(s) 162-171, ISSN 0014-4827
Éditeur: Academic Press
DOI: 10.1016/j.yexcr.2017.04.003

MLL-AF9 leukemias are sensitive to PARP1 inhibitors combined with cytotoxic drugs

Auteurs: Silvia Maifrede, Esteban Martinez, Margaret Nieborowska-Skorska, Daniela Di Marcantonio, Michael Hulse, Bac Viet Le, Huaqing Zhao, Katarzyna Piwocka, Italo Tempera, Stephen M. Sykes, Tomasz Skorski
Publié dans: Blood Advances, Numéro 1/19, 2017, Page(s) 1467-1472, ISSN 2473-9529
Éditeur: American Society of Hematology
DOI: 10.1182/bloodadvances.2017006247

Profile of 6 microRNA in blood plasma distinguish early stage Alzheimer’s disease patients from non-demented subjects

Auteurs: Siranjeevi Nagaraj, Katarzyna Laskowska-Kaszub, Konrad J. Dębski, Joanna Wojsiat, Michał Dąbrowski, Tomasz Gabryelewicz, Jacek Kuźnicki, Urszula Wojda
Publié dans: Oncotarget, 2017, ISSN 1949-2553
Éditeur: Impact Journals
DOI: 10.18632/oncotarget.15109

Liprin-α-1 is a novel component of the murine neuromuscular junction and is involved in the organization of the postsynaptic machinery

Auteurs: Krzysztof M. Bernadzki, Marta Gawor, Marcin Pęziński, Paula Mazurek, Paweł Niewiadomski, Maria J. Rędowicz, Tomasz J. Prószyński
Publié dans: Scientific Reports, Numéro 7/1, 2017, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-017-09590-7

Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases

Auteurs: Carlotta Giorgi, Saverio Marchi, Ines C.M. Simoes, Ziyu Ren, Giampaolo Morciano, Mariasole Perrone, Paulina Patalas-Krawczyk, Sabine Borchard, Paulina Jędrak, Karolina Pierzynowska, Jędrzej Szymański, David Q. Wang, Piero Portincasa, Grzegorz Węgrzyn, Hans Zischka, Pawel Dobrzyn, Massimo Bonora, Jerzy Duszynski, Alessandro Rimessi, Agnieszka Karkucinska-Wieckowska, Agnieszka Dobrzyn, Gyorgy Sz
Publié dans: Mitochondria and Longevity, Numéro 340, 2018, Page(s) 209-344, ISBN 9780-128157367
Éditeur: Elsevier
DOI: 10.1016/bs.ircmb.2018.05.006

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