Development of a systems biomedicine approach for risk identification, prevention and treatment of type 2 diabetes

Deliverables

Publications (abstracts, full papers in peer-reviewed journals, electronic newsletters)

Report on all of the dissemination activities that have taken place for the project

Release of the first version of the project website. Continual update will take place during the project with refreshing of the site at Month 24 and 48 of the project

Training workshops on the theoretical background and research tools for T2DSystems

Training workshops undertaken to provide access to the TIGER system

Publications

Pancreatic β-cell protection from inflammatory stress by the endoplasmic reticulum proteins thrombospondin 1 and mesencephalic astrocyte-derived neutrotrophic factor (MANF)

Author(s): Daniel A. Cunha, Monia Cito, Fabio Arturo Grieco, Cristina Cosentino, Tatiana Danilova, Laurence Ladrière, Maria Lindahl, Andrii Domanskyi, Marco Bugliani, Piero Marchetti, Décio L. Eizirik, Miriam Cnop
Published in: Journal of Biological Chemistry, Issue 292/36, 2017, Page(s) 14977-14988, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.M116.769877

Exercise training protects human and rodent β cells against endoplasmic reticulum stress and apoptosis

Author(s): Flavia M. M. Paula, Nayara C. Leite, Patricia C. Borck, Ricardo Freitas-Dias, Miriam Cnop, Mara P. T. Chacon-Mikahil, Claudia R. Cavaglieri, Piero Marchetti, Antonio C. Boschero, Claudio C. Zoppi, Decio L. Eizirik
Published in: The FASEB Journal, Issue 32/3, 2018, Page(s) 1524-1536, ISSN 0892-6638
Publisher: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.201700710R

Palmitate-induced lipotoxicity alters acetylation of multiple proteins in clonal β cells and human pancreatic islets

Author(s): Federica Ciregia, Marco Bugliani, Maurizio Ronci, Laura Giusti, Claudia Boldrini, Maria R Mazzoni, Sandra Mossuto, Francesca Grano, Miriam Cnop, Lorella Marselli, Gino Giannaccini, Andrea Urbani, Antonio Lucacchini, Piero Marchetti
Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-017-13908-w

Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells

Author(s): Miriam Cnop, Sanna Toivonen, Mariana Igoillo-Esteve, Paraskevi Salpea
Published in: Molecular Metabolism, Issue 6/9, 2017, Page(s) 1024-1039, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2017.06.001

Europe has to step up its efforts to produce innovative and safe diabetes technology

Author(s): Miriam Cnop, Tomasz Klupa, Nikolaos Tentolouris, Anna Novials, Rémy Burcelin, Mischa van Eimeren
Published in: Diabetologia, Issue 60/12, 2017, Page(s) 2532-2533, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-017-4455-4

Heterozygous RFX6 protein truncating variants are associated with MODY with reduced penetrance

Author(s): Kashyap A. Patel, Jarno Kettunen, Markku Laakso, Alena Stančáková, Thomas W. Laver, Kevin Colclough, Matthew B. Johnson, Marc Abramowicz, Leif Groop, Päivi J. Miettinen, Maggie H. Shepherd, Sarah E. Flanagan, Sian Ellard, Nobuya Inagaki, Andrew T. Hattersley, Tiinamaija Tuomi, Miriam Cnop, Michael N. Weedon
Published in: Nature Communications, Issue 8/1, 2017, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-017-00895-9

Imaging of Human Insulin Secreting Cells with Gd-DOTA-P88, a Paramagnetic Contrast Agent Targeting the Beta Cell Biomarker FXYD2γa

Author(s): Stéphane Demine, Alexander Balhuizen, Vinciane Debaille, Lieke Joosten, Maïté Fereau, Satya Chilla, Isabelle Millard, Raphaël Scharfmann, Dominique Egrise, Serge Goldman, Piero Marchetti, Martin Gotthardt, Sophie Laurent, Carmen Burtea, Decio Eizirik
Published in: Molecules, Issue 23/9, 2018, Page(s) 2100, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules23092100

Common variants in the hERG (KCNH2) voltage-gated potassium channel are associated with altered fasting and glucose-stimulated plasma incretin and glucagon responses

Author(s): Line Engelbrechtsen, Yuvaraj Mahendran, Anna Jonsson, Anette Prior Gjesing, Peter E. Weeke, Marit E. Jørgensen, Kristine Færch, Daniel R. Witte, Jens J. Holst, Torben Jørgensen, Niels Grarup, Oluf Pedersen, Henrik Vestergaard, Signe Torekov, Jørgen K. Kanters, Torben Hansen
Published in: BMC Genetics, Issue 19/1, 2018, ISSN 1471-2156
Publisher: BioMed Central
DOI: 10.1186/s12863-018-0602-2

CXCL14, a Brown Adipokine that Mediates Brown-Fat-to-Macrophage Communication in Thermogenic Adaptation

Author(s): Rubén Cereijo, Aleix Gavaldà-Navarro, Montserrat Cairó, Tania Quesada-López, Joan Villarroya, Samantha Morón-Ros, David Sánchez-Infantes, Marion Peyrou, Roser Iglesias, Teresa Mampel, Jean-Valery Turatsinze, Décio L. Eizirik, Marta Giralt, Francesc Villarroya
Published in: Cell Metabolism, 2018, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2018.07.015

Electrophysiological properties of human beta-cell lines EndoC-βH1 and -βH2 conform with human beta-cells

Author(s): Benoît Hastoy, Mahdieh Godazgar, Anne Clark, Vibe Nylander, Ioannis Spiliotis, Martijn van de Bunt, Margarita V. Chibalina, Amy Barrett, Carla Burrows, Andrei I. Tarasov, Raphael Scharfmann, Anna L. Gloyn, Patrik Rorsman
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-34743-7

Modulation of Autophagy Influences the Function and Survival of Human Pancreatic Beta Cells Under Endoplasmic Reticulum Stress Conditions and in Type 2 Diabetes

Author(s): M. Bugliani, S. Mossuto, F. Grano, M. Suleiman, L. Marselli, U. Boggi, P. De Simone, D. L. Eizirik, M. Cnop, P. Marchetti, V. De Tata
Published in: Frontiers in Endocrinology, Issue 10, 2019, ISSN 1664-2392
Publisher: Frontiers Media
DOI: 10.3389/fendo.2019.00052

Insulin secretory granules labelled with phogrin-fluorescent proteins show alterations in size, mobility and responsiveness to glucose stimulation in living β-cells

Author(s): Gianmarco Ferri, Luca Digiacomo, Zeno Lavagnino, Margherita Occhipinti, Marco Bugliani, Valentina Cappello, Giulio Caracciolo, Piero Marchetti, David W. Piston, Francesco Cardarelli
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-39329-5

Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes

Author(s): Sílvia Bonàs-Guarch, Marta Guindo-Martínez, Irene Miguel-Escalada, Niels Grarup, David Sebastian, Elias Rodriguez-Fos, Friman Sánchez, Mercè Planas-Fèlix, Paula Cortes-Sánchez, Santi González, Pascal Timshel, Tune H. Pers, Claire C. Morgan, Ignasi Moran, Goutham Atla, Juan R. González, Montserrat Puiggros, Jonathan Martí, Ehm A. Andersson, Carlos Díaz, Rosa M. Badia, Miriam Udler, Aaron
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-017-02380-9

Organ donor pancreases for the study of human islet cell histology and pathophysiology: a precious and valuable resource

Author(s): Piero Marchetti, Mara Suleiman, Lorella Marselli
Published in: Diabetologia, Issue 61/4, 2018, Page(s) 770-774, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-018-4546-x

MicroRNAs in islet hormone secretion

Author(s): Jonathan L. S. Esguerra, Mototsugu Nagao, Jones K. Ofori, Anna Wendt, Lena Eliasson
Published in: Diabetes, Obesity and Metabolism, Issue 20, 2018, Page(s) 11-19, ISSN 1462-8902
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/dom.13382

Pancreatic β-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes

Author(s): Cristina Cosentino, Sanna Toivonen, Esteban Diaz Villamil, Mohamed Atta, Jean-Luc Ravanat, Stéphane Demine, Andrea Alex Schiavo, Nathalie Pachera, Jean-Philippe Deglasse, Jean-Christophe Jonas, Diego Balboa, Timo Otonkoski, Ewan R Pearson, Piero Marchetti, Décio L Eizirik, Miriam Cnop, Mariana Igoillo-Esteve
Published in: Nucleic Acids Research, Issue 46/19, 2018, Page(s) 10302-10318, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gky839

Islet microRNAs in health and type-2 diabetes

Author(s): Anna Wendt, Jonathan LS Esguerra, Lena Eliasson
Published in: Current Opinion in Pharmacology, Issue 43, 2018, Page(s) 46-52, ISSN 1471-4892
Publisher: Elsevier BV
DOI: 10.1016/j.coph.2018.08.003

Inflammatory stress in islet β-cells: therapeutic implications for type 2 diabetes?

Author(s): Maria Lytrivi, Mariana Igoillo-Esteve, Miriam Cnop
Published in: Current Opinion in Pharmacology, Issue 43, 2018, Page(s) 40-45, ISSN 1471-4892
Publisher: Elsevier BV
DOI: 10.1016/j.coph.2018.08.002

Coxsackievirus B Tailors the Unfolded Protein Response to Favour Viral Amplification in Pancreatic β Cells

Author(s): Maikel L. Colli, Flavia M. Paula, Lorella Marselli, Piero Marchetti, Merja Roivainen, Decio L. Eizirik, Anne Op de beeck
Published in: Journal of Innate Immunity, Issue 11/4, 2019, Page(s) 375-390, ISSN 1662-811X
Publisher: Karger AG
DOI: 10.1159/000496034

In Vivo Silencing of MicroRNA-132 Reduces Blood Glucose and Improves Insulin Secretion

Author(s): Roel Bijkerk, Jonathan L.S. Esguerra, Johanne H. Ellenbroek, Yu Wah Au, Maaike A.J. Hanegraaf, Eelco J. de Koning, Lena Eliasson, Anton Jan van Zonneveld
Published in: Nucleic Acid Therapeutics, Issue 29/2, 2019, Page(s) 67-72, ISSN 2159-3337
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/nat.2018.0763

Human pancreatic islet three-dimensional chromatin architecture provides insights into the genetics of type 2 diabetes

Author(s): Irene Miguel-Escalada, Silvia Bonàs-Guarch, Inês Cebola, Joan Ponsa-Cobas, Julen Mendieta-Esteban, Goutham Atla, Biola M. Javierre, Delphine M. Y. Rolando, Irene Farabella, Claire C. Morgan, Javier García-Hurtado, Anthony Beucher, Ignasi Morán, Lorenzo Pasquali, Mireia Ramos-Rodríguez, Emil V. R. Appel, Allan Linneberg, Anette P. Gjesing, Daniel R. Witte, Oluf Pedersen, Niels Grarup, Philip
Published in: Nature Genetics, Issue 51/7, 2019, Page(s) 1137-1148, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-019-0457-0

Fostering improved human islet research: a European perspective

Author(s): Piero Marchetti, Anke M. Schulte, Lorella Marselli, Eyke Schoniger, Marco Bugliani, Werner Kramer, Lut Overbergh, Susanne Ullrich, Anna L. Gloyn, Mark Ibberson, Guy Rutter, Philippe Froguel, Leif Groop, Mark I. McCarthy, Francesco Dotta, Raphael Scharfmann, Christophe Magnan, Decio L. Eizirik, Chantal Mathieu, Miriam Cnop, Bernard Thorens, Michele Solimena
Published in: Diabetologia, Issue 62/8, 2019, Page(s) 1514-1516, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-019-4911-4

Loss of ZnT8 function protects against diabetes by enhanced insulin secretion

Author(s): Om Prakash Dwivedi, Mikko Lehtovirta, Benoit Hastoy, Vikash Chandra, Nicole A. J. Krentz, Sandra Kleiner, Deepak Jain, Ann-Marie Richard, Fernando Abaitua, Nicola L. Beer, Antje Grotz, Rashmi B. Prasad, Ola Hansson, Emma Ahlqvist, Ulrika Krus, Isabella Artner, Anu Suoranta, Daniel Gomez, Aris Baras, Benoite Champon, Anthony J. Payne, Daniela Moralli, Soren K. Thomsen, Philipp Kramer, Ioannis Spili
Published in: Nature Genetics, Issue 51/11, 2019, Page(s) 1596-1606, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-019-0513-9

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

Author(s): Anubha Mahajan, Daniel Taliun, Matthias Thurner, Neil R. Robertson, Jason M. Torres, N. William Rayner, Anthony J. Payne, Valgerdur Steinthorsdottir, Robert A. Scott, Niels Grarup, James P. Cook, Ellen M. Schmidt, Matthias Wuttke, Chloé Sarnowski, Reedik Mägi, Jana Nano, Christian Gieger, Stella Trompet, Cécile Lecoeur, Michael H. Preuss, Bram Peter Prins, Xiuqing Guo, Lawrence F. Bielak, Jenni
Published in: Nature Genetics, Issue 50/11, 2018, Page(s) 1505-1513, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-018-0241-6

The miRNAs miR-211-5p and miR-204-5p modulate ER stress in human beta cells

Author(s): Fabio Arturo Grieco, Andrea Alex Schiavo, Flora Brozzi, Jonas Juan-Mateu, Marco Bugliani, Piero Marchetti, Décio L Eizirik
Published in: Journal of Molecular Endocrinology, Issue 63/2, 2019, Page(s) 139-149, ISSN 0952-5041
Publisher: Society for Endocrinology
DOI: 10.1530/jme-19-0066

Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic β-cells

Author(s): Soren K. Thomsen, Anne Raimondo, Benoit Hastoy, Shahana Sengupta, Xiao-Qing Dai, Austin Bautista, Jenny Censin, Anthony J. Payne, Mahesh M. Umapathysivam, Aliya F. Spigelman, Amy Barrett, Christopher J. Groves, Nicola L. Beer, Jocelyn E. Manning Fox, Mark I. McCarthy, Anne Clark, Anubha Mahajan, Patrik Rorsman, Patrick E. MacDonald, Anna L. Gloyn
Published in: Nature Genetics, Issue 50/8, 2018, Page(s) 1122-1131, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-018-0173-1

The impact of proinflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes

Author(s): Mireia Ramos-Rodríguez, Helena Raurell-Vila, Maikel L. Colli, Maria Inês Alvelos, Marc Subirana-Granés, Jonàs Juan-Mateu, Richard Norris, Jean-Valery Turatsinze, Ernesto S. Nakayasu, Bobbie-Jo M. Webb-Robertson, Jamie R. J. Inshaw, Piero Marchetti, Lorenzo Piemonti, Manel Esteller, John A. Todd, Thomas O. Metz, Décio L. Eizirik, Lorenzo Pasquali
Published in: Nature Genetics, Issue 51/11, 2019, Page(s) 1588-1595, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-019-0524-6

Integration of human pancreatic islet genomic data refines regulatory mechanisms at Type 2 Diabetes susceptibility loci

Author(s): Matthias Thurner, Martijn van de Bunt, Jason M Torres, Anubha Mahajan, Vibe Nylander, Amanda J Bennett, Kyle J Gaulton, Amy Barrett, Carla Burrows, Christopher G Bell, Robert Lowe, Stephan Beck, Vardhman K Rakyan, Anna L Gloyn, Mark I McCarthy
Published in: eLife, Issue 7, 2018, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.31977

Sequencing reveals protective and pathogenic effects on development of diabetes of rare GLIS3 variants

Author(s): Jihua Sun, Christian Theil Have, Mette Hollensted, Niels Grarup, Allan Linneberg, Oluf Pedersen, Jens Steen Nielsen, Jørgen Rungby, Cramer Christensen, Ivan Brandslund, Karsten Kristiansen, Wang Jun, Torben Hansen, Anette P. Gjesing
Published in: PLOS ONE, Issue 14/8, 2019, Page(s) e0220805, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0220805

OGTT is recommended for glucose homeostasis assessments in Friedreich ataxia

Author(s): Anne-Sophie Azzi, Cristina Cosentino, Jésabelle Kibanda, Françoise Féry, Miriam Cnop
Published in: Annals of Clinical and Translational Neurology, Issue 6/1, 2019, Page(s) 161-166, ISSN 2328-9503
Publisher: Wiley Periodicals, Inc on behalf of American Neurological Association.
DOI: 10.1002/acn3.686

Glucocorticoid induces human beta cell dysfunction by involving riborepressor GAS5 LincRNA

Author(s): Jonathan L.S. Esguerra, Jones K. Ofori, Mototsugu Nagao, Yuki Shuto, Alexandros Karagiannopoulos, Joao Fadista, Hitoshi Sugihara, Leif Groop, Lena Eliasson
Published in: Molecular Metabolism, Issue 32, 2020, Page(s) 160-167, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2019.12.012

Stearoyl CoA desaturase is a gatekeeper that protects human beta cells against lipotoxicity and maintains their identity

Author(s): Masaya Oshima, Séverine Pechberty, Lara Bellini, Sven O. Göpel, Mélanie Campana, Claude Rouch, Julien Dairou, Cristina Cosentino, Federica Fantuzzi, Sanna Toivonen, Piero Marchetti, Christophe Magnan, Miriam Cnop, Hervé Le Stunff, Raphaël Scharfmann
Published in: Diabetologia, Issue 63/2, 2020, Page(s) 395-409, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-019-05046-x

Metabolomics Analysis of Nutrient Metabolism in β-Cells

Author(s): Peter Spégel, Hindrik Mulder
Published in: Journal of Molecular Biology, 2019, ISSN 0022-2836
Publisher: Academic Press
DOI: 10.1016/j.jmb.2019.07.020

Analysis of Differentiation Protocols Defines a Common Pancreatic Progenitor Molecular Signature and Guides Refinement of Endocrine Differentiation

Author(s): Agata Wesolowska-Andersen, Rikke Rejnholdt Jensen, Marta Pérez Alcántara, Nicola L. Beer, Claire Duff, Vibe Nylander, Matthew Gosden, Lorna Witty, Rory Bowden, Mark I. McCarthy, Mattias Hansson, Anna L. Gloyn, Christian Honore
Published in: Stem Cell Reports, Issue 14/1, 2020, Page(s) 138-153, ISSN 2213-6711
Publisher: Cell Press
DOI: 10.1016/j.stemcr.2019.11.010

The tRNA Epitranscriptome and Diabetes: Emergence of tRNA Hypomodifications as a Cause of Pancreatic β-Cell Failure

Author(s): Cristina Cosentino, Miriam Cnop, Mariana Igoillo-Esteve
Published in: Endocrinology, Issue 160/5, 2019, Page(s) 1262-1274, ISSN 1945-7170
Publisher: Los Angeles, Calif. : Association for the Study of Internal Secretions,
DOI: 10.1210/en.2019-00098

Recent Insights Into Mechanisms of β-Cell Lipo- and Glucolipotoxicity in Type 2 Diabetes

Author(s): Maria Lytrivi, Anne-Laure Castell, Vincent Poitout, Miriam Cnop
Published in: Journal of Molecular Biology, 2019, ISSN 0022-2836
Publisher: Academic Press
DOI: 10.1016/j.jmb.2019.09.016

Deep learning models predict regulatory variants in pancreatic islets and refine type 2 diabetes association signals

Author(s): Agata Wesolowska-Andersen, Grace Zhuo Yu, Vibe Nylander, Fernando Abaitua, Matthias Thurner, Jason M Torres, Anubha Mahajan, Anna L Gloyn, Mark I McCarthy
Published in: eLife, Issue 9, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.51503

Pancreatic α-cells – The unsung heroes in islet function

Author(s): Anna Wendt, Lena Eliasson
Published in: Seminars in Cell & Developmental Biology, 2020, ISSN 1084-9521
Publisher: Academic Press
DOI: 10.1016/j.semcdb.2020.01.006

Exenatide induces frataxin expression and improves mitochondrial function in Friedreich ataxia

Author(s): Mariana Igoillo-Esteve, Ana F. Oliveira, Cristina Cosentino, Federica Fantuzzi, Céline Demarez, Sanna Toivonen, Amélie Hu, Satyan Chintawar, Miguel Lopes, Nathalie Pachera, Ying Cai, Baroj Abdulkarim, Myriam Rai, Lorella Marselli, Piero Marchetti, Mohammad Tariq, Jean-Christophe Jonas, Marina Boscolo, Massimo Pandolfo, Décio L. Eizirik, Miriam Cnop
Published in: JCI Insight, Issue 5/2, 2020, ISSN 2379-3708
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.134221

Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells

Author(s): Stéphane Demine, Andrea Alex Schiavo, Sandra Marín-Cañas, Piero Marchetti, Miriam Cnop, Decio L. Eizirik
Published in: Stem Cell Research & Therapy, Issue 11/1, 2020, ISSN 1757-6512
Publisher: BioMed Central
DOI: 10.1186/s13287-019-1523-3

Inter-Individual Heterogeneity of SGLT2 Expression and Function in Human Pancreatic Islets

Author(s): Chiara Saponaro, Markus Mühlemann, Ana Acosta-Montalvo, Anthony Piron, Valery Gmyr, Nathalie Delalleau, Ericka Moerman, Julien Thévenet, Gianni Pasquetti, Anais Coddeville, Miriam Cnop, Julie Kerr-Conte, Bart Staels, François Pattou, Caroline Bonner
Published in: Diabetes, 2020, Page(s) db190888, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/db19-0888

Pancreatic Beta Cell Identity in Humans and the Role of Type 2 Diabetes

Author(s): Piero Marchetti, Marco Bugliani, Vincenzo De Tata, Mara Suleiman, Lorella Marselli
Published in: Frontiers in Cell and Developmental Biology, Issue 5, 2017, ISSN 2296-634X
Publisher: Frontiers in Cell and Developmental Biology
DOI: 10.3389/fcell.2017.00055

Human Pancreatic β Cell lncRNAs Control Cell-Specific Regulatory Networks

Author(s): Ildem Akerman, Zhidong Tu, Anthony Beucher, Delphine M.Y. Rolando, Claire Sauty-Colace, Marion Benazra, Nikolina Nakic, Jialiang Yang, Huan Wang, Lorenzo Pasquali, Ignasi Moran, Javier Garcia-Hurtado, Natalia Castro, Roser Gonzalez-Franco, Andrew F. Stewart, Caroline Bonner, Lorenzo Piemonti, Thierry Berney, Leif Groop, Julie Kerr-Conte, Francois Pattou, Carmen Argmann, Eric Schadt, Philippe Ravas
Published in: Cell Metabolism, Issue 25/2, 2017, Page(s) 400-411, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2016.11.016

Checks and Balances—The Limits of β-Cell Endurance to ER Stress

Author(s): Decio L. Eizirik, Alexandra Coomans de Brachène
Published in: Diabetes, Issue 66/6, 2017, Page(s) 1467-1469, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/dbi17-0018

The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes

Author(s): Tania Quesada-López, Rubén Cereijo, Jean-Valery Turatsinze, Anna Planavila, Montserrat Cairó, Aleix Gavaldà-Navarro, Marion Peyrou, Ricardo Moure, Roser Iglesias, Marta Giralt, Decio L. Eizirik, Francesc Villarroya
Published in: Nature Communications, Issue 7, 2016, Page(s) 13479, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms13479

Co-localization of acinar markers and insulin in pancreatic cells of subjects with type 2 diabetes

Author(s): Matilde Masini, Lorella Marselli, Eddy Himpe, Luisa Martino, Marco Bugliani, Mara Suleiman, Ugo Boggi, Franco Filipponi, Margherita Occhipinti, Luc Bouwens, Vincenzo De Tata, Piero Marchetti
Published in: PLOS ONE, Issue 12/6, 2017, Page(s) e0179398, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0179398

High Prevalence of Diabetes-Predisposing Variants in MODY Genes Among Danish Women With Gestational Diabetes Mellitus

Author(s): Anette P. Gjesing, Gao Rui, Jeannet Lauenborg, Christian Theil Have, Mette Hollensted, Ehm Andersson, Niels Grarup, Jihua Sun, Shi Quan, Ivan Brandslund, Peter Damm, Oluf Pedersen, Jun Wang, Torben Hansen
Published in: Journal of the Endocrine Society, Issue 1/6, 2017, Page(s) 681-690, ISSN 2472-1972
Publisher: Journal of the Endocrine Society, Oxford University Press
DOI: 10.1210/js.2017-00040

Guanabenz Sensitizes Pancreatic β Cells to Lipotoxic Endoplasmic Reticulum Stress and Apoptosis

Author(s): Baroj Abdulkarim, Miriam Hernangomez, Mariana Igoillo-Esteve, Daniel A. Cunha, Lorella Marselli, Piero Marchetti, Laurence Ladriere, Miriam Cnop
Published in: Endocrinology, Issue 158/6, 2017, Page(s) 1659-1670, ISSN 0013-7227
Publisher: The Endocrine Society
DOI: 10.1210/en.2016-1773

Protective role of complement C3 against cytokine-mediated β-cell apoptosis

Author(s): Reinaldo S. Dos Santos, Laura Marroqui, Fabio A. Grieco, Lorella Marselli, Mara Suleiman, Stefan R. Henz, Piero Marchetti, Rasmus Wernersson, Decio L. Eizirik
Published in: Endocrinology, 2017, ISSN 0013-7227
Publisher: The Endocrine Society
DOI: 10.1210/en.2017-00104

High-throughput screening and bioinformatic analysis to ascertain compounds that prevent saturated fatty acid-induced β-cell apoptosis

Author(s): Seung-Hee Lee, Daniel Cunha, Carlo Piermarocchi, Giovanni Paternostro, Anthony Pinkerton, Laurence Ladriere, Piero Marchetti, Decio L. Eizirik, Miriam Cnop, Fred Levine
Published in: Biochemical Pharmacology, Issue 138, 2017, Page(s) 140-149, ISSN 0006-2952
Publisher: Elsevier BV
DOI: 10.1016/j.bcp.2017.05.007

Interferon-α mediates human beta cell HLA class I overexpression, endoplasmic reticulum stress and apoptosis, three hallmarks of early human type 1 diabetes

Author(s): Laura Marroqui, Reinaldo S. Dos Santos, Anne Op de beeck, Alexandra Coomans de Brachène, Lorella Marselli, Piero Marchetti, Decio L. Eizirik
Published in: Diabetologia, Issue 60/4, 2017, Page(s) 656-667, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-016-4201-3

MicroRNAs miR-23a-3p, miR-23b-3p, and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic β-Cells

Author(s): Fabio Arturo Grieco, Guido Sebastiani, Jonas Juan-Mateu, Olatz Villate, Laura Marroqui, Laurence Ladrière, Ksenya Tugay, Romano Regazzi, Marco Bugliani, Piero Marchetti, Francesco Dotta, Décio L. Eizirik
Published in: Diabetes, Issue 66/1, 2016, Page(s) 100-112, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/db16-0592

Neuron-enriched RNA-binding Proteins Regulate Pancreatic Beta Cell Function and Survival

Author(s): Jonàs Juan-Mateu, Tatiana H. Rech, Olatz Villate, Esther Lizarraga-Mollinedo, Anna Wendt, Jean-Valery Turatsinze, Letícia A. Brondani, Tarlliza R. Nardelli, Tatiane C. Nogueira, Jonathan L. S. Esguerra, Maria Inês Alvelos, Piero Marchetti, Lena Eliasson, Décio L. Eizirik
Published in: Journal of Biological Chemistry, Issue 292/8, 2017, Page(s) 3466-3480, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.M116.748335

Perturbed Mitochondrial Metabolism in Islets from Donors with Type-2 Diabetes

Author(s): Jiangming Sun, Ruchi Jain, Lotta E. Andersson, Anya Medina, Petter Storm, Peter Spegel, Hindrik Mulder
Published in: Bio RXiv, 2017
Publisher: Cold Spring Harbour Laboratory
DOI: 10.1101/212548

Developing a network view of type 2 diabetes risk pathways through integration of genetic, genomic and functional data

Author(s): Juan Fernandez-Tajes, Kyle J Gaulton, Martijn van de Bunt, Jason Torres, Mathias Turner, Anubha Mahajan, Anna L Gloyn, Kasper Lage, Mark I McCarthy
Published in: bioRxiv, 2018
Publisher: Cold Spring Harbour Laboratories
DOI: 10.1101/350181

Developing a network view of type 2 diabetes risk pathways through integration of genetic, genomic and functional data

Author(s): Fernandez-Tajes, Juan; Gaulton, Kyle J; van de Bunt, Martijn; Torres, Jason; Turner, Mathias; Mahajan, Anubha; Gloyn, Anna L; Lage, Kasper; McCarthy, Mark I
Published in: bioRxiv - biorxiv;350181v2, Issue 7, 2018
Publisher: Cold Spring Harbour Laboratory
DOI: 10.1101/350181

Perturbed Mitochondrial Metabolism in Islets from Donors with Type-2 Diabetes

Author(s): Sun, Jiangming; Jain, Ruchi; Andersson, Lotta E.; Medina, Anya; Storm, Petter; Spegel, Peter; Mulder, Hindrik
Published in: bioRxiv - biorxiv;212548v1, Issue 8, 2017
Publisher: Cold Spring Harbour Laboratory
DOI: 10.1101/212548

Unsupervised clustering of missense variants in the HNF1A gene using multidimensional functional data aids clinical interpretation

Author(s): Sara Althari, Laeya A. Najmi, Amanda J. Bennett, Ingvild Aukrust, Jana K. Rundle, Kevin Colclough, Janne Molnes, Alba Kaci, Sameena Nawaz, Timme van der Lugt, Neelam Hassanali, Anders Molven, Sian Ellard, Mark I. McCarthy, Lise Bjorkhaug, Pal Rasmus Njolstad, Anna L Gloyn
Published in: medRxiv, 2019
Publisher: Cold Spring Harbour Laboratory
DOI: 10.1101/19010900

Influence of genetic variants on gene expression in human pancreatic islets – implications for type 2 diabetes

Author(s): Viñuela, A., Varshney A., van de Bunt M., Prasad R.B., Asplund O., Bennett A., Boehnke M, Brown A, Erdos M.R., Fadista J., Hansson O, Hatem G, Howald C, Iyengar A.K., Johnson P., Krus U, MacDonald P.E., Mahajan A, Manning Fox J., Narisu J., Nylander N., Orchard P., Oskolkov N., Panousis N.I., Payne A., Stitzel M.L., Vadlamudi S., Welch R., Collins F.S., Mohlke K.L., Gloyn AL, Scott L.E, Dermitzak
Published in: bioRxiv, 2019
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/655670

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