Development of a systems biomedicine approach for risk identification, prevention and treatment of type 2 diabetes

Risultati finali

Publications (abstracts, full papers in peer-reviewed journals, electronic newsletters)

Report on all of the dissemination activities that have taken place for the project

Release of the first version of the project website. Continual update will take place during the project with refreshing of the site at Month 24 and 48 of the project

Training workshops on the theoretical background and research tools for T2DSystems

Training workshops undertaken to provide access to the TIGER system

Pubblicazioni

Pancreatic β-cell protection from inflammatory stress by the endoplasmic reticulum proteins thrombospondin 1 and mesencephalic astrocyte-derived neutrotrophic factor (MANF)

Autori: Daniel A. Cunha, Monia Cito, Fabio Arturo Grieco, Cristina Cosentino, Tatiana Danilova, Laurence Ladrière, Maria Lindahl, Andrii Domanskyi, Marco Bugliani, Piero Marchetti, Décio L. Eizirik, Miriam Cnop
Pubblicato in: Journal of Biological Chemistry, Numero 292/36, 2017, Pagina/e 14977-14988, ISSN 0021-9258
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.M116.769877

Exercise training protects human and rodent β cells against endoplasmic reticulum stress and apoptosis

Autori: Flavia M. M. Paula, Nayara C. Leite, Patricia C. Borck, Ricardo Freitas-Dias, Miriam Cnop, Mara P. T. Chacon-Mikahil, Claudia R. Cavaglieri, Piero Marchetti, Antonio C. Boschero, Claudio C. Zoppi, Decio L. Eizirik
Pubblicato in: The FASEB Journal, Numero 32/3, 2018, Pagina/e 1524-1536, ISSN 0892-6638
Editore: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.201700710R

Palmitate-induced lipotoxicity alters acetylation of multiple proteins in clonal β cells and human pancreatic islets

Autori: Federica Ciregia, Marco Bugliani, Maurizio Ronci, Laura Giusti, Claudia Boldrini, Maria R Mazzoni, Sandra Mossuto, Francesca Grano, Miriam Cnop, Lorella Marselli, Gino Giannaccini, Andrea Urbani, Antonio Lucacchini, Piero Marchetti
Pubblicato in: Scientific Reports, Numero 7/1, 2017, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-017-13908-w

Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells

Autori: Miriam Cnop, Sanna Toivonen, Mariana Igoillo-Esteve, Paraskevi Salpea
Pubblicato in: Molecular Metabolism, Numero 6/9, 2017, Pagina/e 1024-1039, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.1016/j.molmet.2017.06.001

Europe has to step up its efforts to produce innovative and safe diabetes technology

Autori: Miriam Cnop, Tomasz Klupa, Nikolaos Tentolouris, Anna Novials, Rémy Burcelin, Mischa van Eimeren
Pubblicato in: Diabetologia, Numero 60/12, 2017, Pagina/e 2532-2533, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-017-4455-4

Heterozygous RFX6 protein truncating variants are associated with MODY with reduced penetrance

Autori: Kashyap A. Patel, Jarno Kettunen, Markku Laakso, Alena Stančáková, Thomas W. Laver, Kevin Colclough, Matthew B. Johnson, Marc Abramowicz, Leif Groop, Päivi J. Miettinen, Maggie H. Shepherd, Sarah E. Flanagan, Sian Ellard, Nobuya Inagaki, Andrew T. Hattersley, Tiinamaija Tuomi, Miriam Cnop, Michael N. Weedon
Pubblicato in: Nature Communications, Numero 8/1, 2017, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-017-00895-9

Imaging of Human Insulin Secreting Cells with Gd-DOTA-P88, a Paramagnetic Contrast Agent Targeting the Beta Cell Biomarker FXYD2γa

Autori: Stéphane Demine, Alexander Balhuizen, Vinciane Debaille, Lieke Joosten, Maïté Fereau, Satya Chilla, Isabelle Millard, Raphaël Scharfmann, Dominique Egrise, Serge Goldman, Piero Marchetti, Martin Gotthardt, Sophie Laurent, Carmen Burtea, Decio Eizirik
Pubblicato in: Molecules, Numero 23/9, 2018, Pagina/e 2100, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules23092100

Common variants in the hERG (KCNH2) voltage-gated potassium channel are associated with altered fasting and glucose-stimulated plasma incretin and glucagon responses

Autori: Line Engelbrechtsen, Yuvaraj Mahendran, Anna Jonsson, Anette Prior Gjesing, Peter E. Weeke, Marit E. Jørgensen, Kristine Færch, Daniel R. Witte, Jens J. Holst, Torben Jørgensen, Niels Grarup, Oluf Pedersen, Henrik Vestergaard, Signe Torekov, Jørgen K. Kanters, Torben Hansen
Pubblicato in: BMC Genetics, Numero 19/1, 2018, ISSN 1471-2156
Editore: BioMed Central
DOI: 10.1186/s12863-018-0602-2

CXCL14, a Brown Adipokine that Mediates Brown-Fat-to-Macrophage Communication in Thermogenic Adaptation

Autori: Rubén Cereijo, Aleix Gavaldà-Navarro, Montserrat Cairó, Tania Quesada-López, Joan Villarroya, Samantha Morón-Ros, David Sánchez-Infantes, Marion Peyrou, Roser Iglesias, Teresa Mampel, Jean-Valery Turatsinze, Décio L. Eizirik, Marta Giralt, Francesc Villarroya
Pubblicato in: Cell Metabolism, 2018, ISSN 1550-4131
Editore: Cell Press
DOI: 10.1016/j.cmet.2018.07.015

Electrophysiological properties of human beta-cell lines EndoC-βH1 and -βH2 conform with human beta-cells

Autori: Benoît Hastoy, Mahdieh Godazgar, Anne Clark, Vibe Nylander, Ioannis Spiliotis, Martijn van de Bunt, Margarita V. Chibalina, Amy Barrett, Carla Burrows, Andrei I. Tarasov, Raphael Scharfmann, Anna L. Gloyn, Patrik Rorsman
Pubblicato in: Scientific Reports, Numero 8/1, 2018, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-018-34743-7

Modulation of Autophagy Influences the Function and Survival of Human Pancreatic Beta Cells Under Endoplasmic Reticulum Stress Conditions and in Type 2 Diabetes

Autori: M. Bugliani, S. Mossuto, F. Grano, M. Suleiman, L. Marselli, U. Boggi, P. De Simone, D. L. Eizirik, M. Cnop, P. Marchetti, V. De Tata
Pubblicato in: Frontiers in Endocrinology, Numero 10, 2019, ISSN 1664-2392
Editore: Frontiers Media
DOI: 10.3389/fendo.2019.00052

Insulin secretory granules labelled with phogrin-fluorescent proteins show alterations in size, mobility and responsiveness to glucose stimulation in living β-cells

Autori: Gianmarco Ferri, Luca Digiacomo, Zeno Lavagnino, Margherita Occhipinti, Marco Bugliani, Valentina Cappello, Giulio Caracciolo, Piero Marchetti, David W. Piston, Francesco Cardarelli
Pubblicato in: Scientific Reports, Numero 9/1, 2019, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-019-39329-5

Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes

Autori: Sílvia Bonàs-Guarch, Marta Guindo-Martínez, Irene Miguel-Escalada, Niels Grarup, David Sebastian, Elias Rodriguez-Fos, Friman Sánchez, Mercè Planas-Fèlix, Paula Cortes-Sánchez, Santi González, Pascal Timshel, Tune H. Pers, Claire C. Morgan, Ignasi Moran, Goutham Atla, Juan R. González, Montserrat Puiggros, Jonathan Martí, Ehm A. Andersson, Carlos Díaz, Rosa M. Badia, Miriam Udler, Aaron
Pubblicato in: Nature Communications, Numero 9/1, 2018, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-017-02380-9

Organ donor pancreases for the study of human islet cell histology and pathophysiology: a precious and valuable resource

Autori: Piero Marchetti, Mara Suleiman, Lorella Marselli
Pubblicato in: Diabetologia, Numero 61/4, 2018, Pagina/e 770-774, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-018-4546-x

MicroRNAs in islet hormone secretion

Autori: Jonathan L. S. Esguerra, Mototsugu Nagao, Jones K. Ofori, Anna Wendt, Lena Eliasson
Pubblicato in: Diabetes, Obesity and Metabolism, Numero 20, 2018, Pagina/e 11-19, ISSN 1462-8902
Editore: Blackwell Publishing Inc.
DOI: 10.1111/dom.13382

Pancreatic β-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes

Autori: Cristina Cosentino, Sanna Toivonen, Esteban Diaz Villamil, Mohamed Atta, Jean-Luc Ravanat, Stéphane Demine, Andrea Alex Schiavo, Nathalie Pachera, Jean-Philippe Deglasse, Jean-Christophe Jonas, Diego Balboa, Timo Otonkoski, Ewan R Pearson, Piero Marchetti, Décio L Eizirik, Miriam Cnop, Mariana Igoillo-Esteve
Pubblicato in: Nucleic Acids Research, Numero 46/19, 2018, Pagina/e 10302-10318, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gky839

Islet microRNAs in health and type-2 diabetes

Autori: Anna Wendt, Jonathan LS Esguerra, Lena Eliasson
Pubblicato in: Current Opinion in Pharmacology, Numero 43, 2018, Pagina/e 46-52, ISSN 1471-4892
Editore: Elsevier BV
DOI: 10.1016/j.coph.2018.08.003

Inflammatory stress in islet β-cells: therapeutic implications for type 2 diabetes?

Autori: Maria Lytrivi, Mariana Igoillo-Esteve, Miriam Cnop
Pubblicato in: Current Opinion in Pharmacology, Numero 43, 2018, Pagina/e 40-45, ISSN 1471-4892
Editore: Elsevier BV
DOI: 10.1016/j.coph.2018.08.002

Coxsackievirus B Tailors the Unfolded Protein Response to Favour Viral Amplification in Pancreatic β Cells

Autori: Maikel L. Colli, Flavia M. Paula, Lorella Marselli, Piero Marchetti, Merja Roivainen, Decio L. Eizirik, Anne Op de beeck
Pubblicato in: Journal of Innate Immunity, Numero 11/4, 2019, Pagina/e 375-390, ISSN 1662-811X
Editore: Karger AG
DOI: 10.1159/000496034

In Vivo Silencing of MicroRNA-132 Reduces Blood Glucose and Improves Insulin Secretion

Autori: Roel Bijkerk, Jonathan L.S. Esguerra, Johanne H. Ellenbroek, Yu Wah Au, Maaike A.J. Hanegraaf, Eelco J. de Koning, Lena Eliasson, Anton Jan van Zonneveld
Pubblicato in: Nucleic Acid Therapeutics, Numero 29/2, 2019, Pagina/e 67-72, ISSN 2159-3337
Editore: Mary Ann Liebert Inc.
DOI: 10.1089/nat.2018.0763

Human pancreatic islet three-dimensional chromatin architecture provides insights into the genetics of type 2 diabetes

Autori: Irene Miguel-Escalada, Silvia Bonàs-Guarch, Inês Cebola, Joan Ponsa-Cobas, Julen Mendieta-Esteban, Goutham Atla, Biola M. Javierre, Delphine M. Y. Rolando, Irene Farabella, Claire C. Morgan, Javier García-Hurtado, Anthony Beucher, Ignasi Morán, Lorenzo Pasquali, Mireia Ramos-Rodríguez, Emil V. R. Appel, Allan Linneberg, Anette P. Gjesing, Daniel R. Witte, Oluf Pedersen, Niels Grarup, Philip
Pubblicato in: Nature Genetics, Numero 51/7, 2019, Pagina/e 1137-1148, ISSN 1061-4036
Editore: Nature Publishing Group
DOI: 10.1038/s41588-019-0457-0

Fostering improved human islet research: a European perspective

Autori: Piero Marchetti, Anke M. Schulte, Lorella Marselli, Eyke Schoniger, Marco Bugliani, Werner Kramer, Lut Overbergh, Susanne Ullrich, Anna L. Gloyn, Mark Ibberson, Guy Rutter, Philippe Froguel, Leif Groop, Mark I. McCarthy, Francesco Dotta, Raphael Scharfmann, Christophe Magnan, Decio L. Eizirik, Chantal Mathieu, Miriam Cnop, Bernard Thorens, Michele Solimena
Pubblicato in: Diabetologia, Numero 62/8, 2019, Pagina/e 1514-1516, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-019-4911-4

Loss of ZnT8 function protects against diabetes by enhanced insulin secretion

Autori: Om Prakash Dwivedi, Mikko Lehtovirta, Benoit Hastoy, Vikash Chandra, Nicole A. J. Krentz, Sandra Kleiner, Deepak Jain, Ann-Marie Richard, Fernando Abaitua, Nicola L. Beer, Antje Grotz, Rashmi B. Prasad, Ola Hansson, Emma Ahlqvist, Ulrika Krus, Isabella Artner, Anu Suoranta, Daniel Gomez, Aris Baras, Benoite Champon, Anthony J. Payne, Daniela Moralli, Soren K. Thomsen, Philipp Kramer, Ioannis Spili
Pubblicato in: Nature Genetics, Numero 51/11, 2019, Pagina/e 1596-1606, ISSN 1061-4036
Editore: Nature Publishing Group
DOI: 10.1038/s41588-019-0513-9

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

Autori: Anubha Mahajan, Daniel Taliun, Matthias Thurner, Neil R. Robertson, Jason M. Torres, N. William Rayner, Anthony J. Payne, Valgerdur Steinthorsdottir, Robert A. Scott, Niels Grarup, James P. Cook, Ellen M. Schmidt, Matthias Wuttke, Chloé Sarnowski, Reedik Mägi, Jana Nano, Christian Gieger, Stella Trompet, Cécile Lecoeur, Michael H. Preuss, Bram Peter Prins, Xiuqing Guo, Lawrence F. Bielak, Jenni
Pubblicato in: Nature Genetics, Numero 50/11, 2018, Pagina/e 1505-1513, ISSN 1061-4036
Editore: Nature Publishing Group
DOI: 10.1038/s41588-018-0241-6

The miRNAs miR-211-5p and miR-204-5p modulate ER stress in human beta cells

Autori: Fabio Arturo Grieco, Andrea Alex Schiavo, Flora Brozzi, Jonas Juan-Mateu, Marco Bugliani, Piero Marchetti, Décio L Eizirik
Pubblicato in: Journal of Molecular Endocrinology, Numero 63/2, 2019, Pagina/e 139-149, ISSN 0952-5041
Editore: Society for Endocrinology
DOI: 10.1530/jme-19-0066

Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic β-cells

Autori: Soren K. Thomsen, Anne Raimondo, Benoit Hastoy, Shahana Sengupta, Xiao-Qing Dai, Austin Bautista, Jenny Censin, Anthony J. Payne, Mahesh M. Umapathysivam, Aliya F. Spigelman, Amy Barrett, Christopher J. Groves, Nicola L. Beer, Jocelyn E. Manning Fox, Mark I. McCarthy, Anne Clark, Anubha Mahajan, Patrik Rorsman, Patrick E. MacDonald, Anna L. Gloyn
Pubblicato in: Nature Genetics, Numero 50/8, 2018, Pagina/e 1122-1131, ISSN 1061-4036
Editore: Nature Publishing Group
DOI: 10.1038/s41588-018-0173-1

The impact of proinflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes

Autori: Mireia Ramos-Rodríguez, Helena Raurell-Vila, Maikel L. Colli, Maria Inês Alvelos, Marc Subirana-Granés, Jonàs Juan-Mateu, Richard Norris, Jean-Valery Turatsinze, Ernesto S. Nakayasu, Bobbie-Jo M. Webb-Robertson, Jamie R. J. Inshaw, Piero Marchetti, Lorenzo Piemonti, Manel Esteller, John A. Todd, Thomas O. Metz, Décio L. Eizirik, Lorenzo Pasquali
Pubblicato in: Nature Genetics, Numero 51/11, 2019, Pagina/e 1588-1595, ISSN 1061-4036
Editore: Nature Publishing Group
DOI: 10.1038/s41588-019-0524-6

Integration of human pancreatic islet genomic data refines regulatory mechanisms at Type 2 Diabetes susceptibility loci

Autori: Matthias Thurner, Martijn van de Bunt, Jason M Torres, Anubha Mahajan, Vibe Nylander, Amanda J Bennett, Kyle J Gaulton, Amy Barrett, Carla Burrows, Christopher G Bell, Robert Lowe, Stephan Beck, Vardhman K Rakyan, Anna L Gloyn, Mark I McCarthy
Pubblicato in: eLife, Numero 7, 2018, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.31977

Sequencing reveals protective and pathogenic effects on development of diabetes of rare GLIS3 variants

Autori: Jihua Sun, Christian Theil Have, Mette Hollensted, Niels Grarup, Allan Linneberg, Oluf Pedersen, Jens Steen Nielsen, Jørgen Rungby, Cramer Christensen, Ivan Brandslund, Karsten Kristiansen, Wang Jun, Torben Hansen, Anette P. Gjesing
Pubblicato in: PLOS ONE, Numero 14/8, 2019, Pagina/e e0220805, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0220805

OGTT is recommended for glucose homeostasis assessments in Friedreich ataxia

Autori: Anne-Sophie Azzi, Cristina Cosentino, Jésabelle Kibanda, Françoise Féry, Miriam Cnop
Pubblicato in: Annals of Clinical and Translational Neurology, Numero 6/1, 2019, Pagina/e 161-166, ISSN 2328-9503
Editore: Wiley Periodicals, Inc on behalf of American Neurological Association.
DOI: 10.1002/acn3.686

Glucocorticoid induces human beta cell dysfunction by involving riborepressor GAS5 LincRNA

Autori: Jonathan L.S. Esguerra, Jones K. Ofori, Mototsugu Nagao, Yuki Shuto, Alexandros Karagiannopoulos, Joao Fadista, Hitoshi Sugihara, Leif Groop, Lena Eliasson
Pubblicato in: Molecular Metabolism, Numero 32, 2020, Pagina/e 160-167, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.1016/j.molmet.2019.12.012

Stearoyl CoA desaturase is a gatekeeper that protects human beta cells against lipotoxicity and maintains their identity

Autori: Masaya Oshima, Séverine Pechberty, Lara Bellini, Sven O. Göpel, Mélanie Campana, Claude Rouch, Julien Dairou, Cristina Cosentino, Federica Fantuzzi, Sanna Toivonen, Piero Marchetti, Christophe Magnan, Miriam Cnop, Hervé Le Stunff, Raphaël Scharfmann
Pubblicato in: Diabetologia, Numero 63/2, 2020, Pagina/e 395-409, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-019-05046-x

Metabolomics Analysis of Nutrient Metabolism in β-Cells

Autori: Peter Spégel, Hindrik Mulder
Pubblicato in: Journal of Molecular Biology, 2019, ISSN 0022-2836
Editore: Academic Press
DOI: 10.1016/j.jmb.2019.07.020

Analysis of Differentiation Protocols Defines a Common Pancreatic Progenitor Molecular Signature and Guides Refinement of Endocrine Differentiation

Autori: Agata Wesolowska-Andersen, Rikke Rejnholdt Jensen, Marta Pérez Alcántara, Nicola L. Beer, Claire Duff, Vibe Nylander, Matthew Gosden, Lorna Witty, Rory Bowden, Mark I. McCarthy, Mattias Hansson, Anna L. Gloyn, Christian Honore
Pubblicato in: Stem Cell Reports, Numero 14/1, 2020, Pagina/e 138-153, ISSN 2213-6711
Editore: Cell Press
DOI: 10.1016/j.stemcr.2019.11.010

The tRNA Epitranscriptome and Diabetes: Emergence of tRNA Hypomodifications as a Cause of Pancreatic β-Cell Failure

Autori: Cristina Cosentino, Miriam Cnop, Mariana Igoillo-Esteve
Pubblicato in: Endocrinology, Numero 160/5, 2019, Pagina/e 1262-1274, ISSN 1945-7170
Editore: Los Angeles, Calif. : Association for the Study of Internal Secretions,
DOI: 10.1210/en.2019-00098

Recent Insights Into Mechanisms of β-Cell Lipo- and Glucolipotoxicity in Type 2 Diabetes

Autori: Maria Lytrivi, Anne-Laure Castell, Vincent Poitout, Miriam Cnop
Pubblicato in: Journal of Molecular Biology, 2019, ISSN 0022-2836
Editore: Academic Press
DOI: 10.1016/j.jmb.2019.09.016

Deep learning models predict regulatory variants in pancreatic islets and refine type 2 diabetes association signals

Autori: Agata Wesolowska-Andersen, Grace Zhuo Yu, Vibe Nylander, Fernando Abaitua, Matthias Thurner, Jason M Torres, Anubha Mahajan, Anna L Gloyn, Mark I McCarthy
Pubblicato in: eLife, Numero 9, 2020, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.51503

Pancreatic α-cells – The unsung heroes in islet function

Autori: Anna Wendt, Lena Eliasson
Pubblicato in: Seminars in Cell & Developmental Biology, 2020, ISSN 1084-9521
Editore: Academic Press
DOI: 10.1016/j.semcdb.2020.01.006

Exenatide induces frataxin expression and improves mitochondrial function in Friedreich ataxia

Autori: Mariana Igoillo-Esteve, Ana F. Oliveira, Cristina Cosentino, Federica Fantuzzi, Céline Demarez, Sanna Toivonen, Amélie Hu, Satyan Chintawar, Miguel Lopes, Nathalie Pachera, Ying Cai, Baroj Abdulkarim, Myriam Rai, Lorella Marselli, Piero Marchetti, Mohammad Tariq, Jean-Christophe Jonas, Marina Boscolo, Massimo Pandolfo, Décio L. Eizirik, Miriam Cnop
Pubblicato in: JCI Insight, Numero 5/2, 2020, ISSN 2379-3708
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.134221

Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells

Autori: Stéphane Demine, Andrea Alex Schiavo, Sandra Marín-Cañas, Piero Marchetti, Miriam Cnop, Decio L. Eizirik
Pubblicato in: Stem Cell Research & Therapy, Numero 11/1, 2020, ISSN 1757-6512
Editore: BioMed Central
DOI: 10.1186/s13287-019-1523-3

Inter-Individual Heterogeneity of SGLT2 Expression and Function in Human Pancreatic Islets

Autori: Chiara Saponaro, Markus Mühlemann, Ana Acosta-Montalvo, Anthony Piron, Valery Gmyr, Nathalie Delalleau, Ericka Moerman, Julien Thévenet, Gianni Pasquetti, Anais Coddeville, Miriam Cnop, Julie Kerr-Conte, Bart Staels, François Pattou, Caroline Bonner
Pubblicato in: Diabetes, 2020, Pagina/e db190888, ISSN 0012-1797
Editore: American Diabetes Association
DOI: 10.2337/db19-0888

Pancreatic Beta Cell Identity in Humans and the Role of Type 2 Diabetes

Autori: Piero Marchetti, Marco Bugliani, Vincenzo De Tata, Mara Suleiman, Lorella Marselli
Pubblicato in: Frontiers in Cell and Developmental Biology, Numero 5, 2017, ISSN 2296-634X
Editore: Frontiers in Cell and Developmental Biology
DOI: 10.3389/fcell.2017.00055

Human Pancreatic β Cell lncRNAs Control Cell-Specific Regulatory Networks

Autori: Ildem Akerman, Zhidong Tu, Anthony Beucher, Delphine M.Y. Rolando, Claire Sauty-Colace, Marion Benazra, Nikolina Nakic, Jialiang Yang, Huan Wang, Lorenzo Pasquali, Ignasi Moran, Javier Garcia-Hurtado, Natalia Castro, Roser Gonzalez-Franco, Andrew F. Stewart, Caroline Bonner, Lorenzo Piemonti, Thierry Berney, Leif Groop, Julie Kerr-Conte, Francois Pattou, Carmen Argmann, Eric Schadt, Philippe Ravas
Pubblicato in: Cell Metabolism, Numero 25/2, 2017, Pagina/e 400-411, ISSN 1550-4131
Editore: Cell Press
DOI: 10.1016/j.cmet.2016.11.016

Checks and Balances—The Limits of β-Cell Endurance to ER Stress

Autori: Decio L. Eizirik, Alexandra Coomans de Brachène
Pubblicato in: Diabetes, Numero 66/6, 2017, Pagina/e 1467-1469, ISSN 0012-1797
Editore: American Diabetes Association
DOI: 10.2337/dbi17-0018

The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes

Autori: Tania Quesada-López, Rubén Cereijo, Jean-Valery Turatsinze, Anna Planavila, Montserrat Cairó, Aleix Gavaldà-Navarro, Marion Peyrou, Ricardo Moure, Roser Iglesias, Marta Giralt, Decio L. Eizirik, Francesc Villarroya
Pubblicato in: Nature Communications, Numero 7, 2016, Pagina/e 13479, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/ncomms13479

Co-localization of acinar markers and insulin in pancreatic cells of subjects with type 2 diabetes

Autori: Matilde Masini, Lorella Marselli, Eddy Himpe, Luisa Martino, Marco Bugliani, Mara Suleiman, Ugo Boggi, Franco Filipponi, Margherita Occhipinti, Luc Bouwens, Vincenzo De Tata, Piero Marchetti
Pubblicato in: PLOS ONE, Numero 12/6, 2017, Pagina/e e0179398, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0179398

High Prevalence of Diabetes-Predisposing Variants in MODY Genes Among Danish Women With Gestational Diabetes Mellitus

Autori: Anette P. Gjesing, Gao Rui, Jeannet Lauenborg, Christian Theil Have, Mette Hollensted, Ehm Andersson, Niels Grarup, Jihua Sun, Shi Quan, Ivan Brandslund, Peter Damm, Oluf Pedersen, Jun Wang, Torben Hansen
Pubblicato in: Journal of the Endocrine Society, Numero 1/6, 2017, Pagina/e 681-690, ISSN 2472-1972
Editore: Journal of the Endocrine Society, Oxford University Press
DOI: 10.1210/js.2017-00040

Guanabenz Sensitizes Pancreatic β Cells to Lipotoxic Endoplasmic Reticulum Stress and Apoptosis

Autori: Baroj Abdulkarim, Miriam Hernangomez, Mariana Igoillo-Esteve, Daniel A. Cunha, Lorella Marselli, Piero Marchetti, Laurence Ladriere, Miriam Cnop
Pubblicato in: Endocrinology, Numero 158/6, 2017, Pagina/e 1659-1670, ISSN 0013-7227
Editore: The Endocrine Society
DOI: 10.1210/en.2016-1773

Protective role of complement C3 against cytokine-mediated β-cell apoptosis

Autori: Reinaldo S. Dos Santos, Laura Marroqui, Fabio A. Grieco, Lorella Marselli, Mara Suleiman, Stefan R. Henz, Piero Marchetti, Rasmus Wernersson, Decio L. Eizirik
Pubblicato in: Endocrinology, 2017, ISSN 0013-7227
Editore: The Endocrine Society
DOI: 10.1210/en.2017-00104

High-throughput screening and bioinformatic analysis to ascertain compounds that prevent saturated fatty acid-induced β-cell apoptosis

Autori: Seung-Hee Lee, Daniel Cunha, Carlo Piermarocchi, Giovanni Paternostro, Anthony Pinkerton, Laurence Ladriere, Piero Marchetti, Decio L. Eizirik, Miriam Cnop, Fred Levine
Pubblicato in: Biochemical Pharmacology, Numero 138, 2017, Pagina/e 140-149, ISSN 0006-2952
Editore: Elsevier BV
DOI: 10.1016/j.bcp.2017.05.007

Interferon-α mediates human beta cell HLA class I overexpression, endoplasmic reticulum stress and apoptosis, three hallmarks of early human type 1 diabetes

Autori: Laura Marroqui, Reinaldo S. Dos Santos, Anne Op de beeck, Alexandra Coomans de Brachène, Lorella Marselli, Piero Marchetti, Decio L. Eizirik
Pubblicato in: Diabetologia, Numero 60/4, 2017, Pagina/e 656-667, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-016-4201-3

MicroRNAs miR-23a-3p, miR-23b-3p, and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic β-Cells

Autori: Fabio Arturo Grieco, Guido Sebastiani, Jonas Juan-Mateu, Olatz Villate, Laura Marroqui, Laurence Ladrière, Ksenya Tugay, Romano Regazzi, Marco Bugliani, Piero Marchetti, Francesco Dotta, Décio L. Eizirik
Pubblicato in: Diabetes, Numero 66/1, 2016, Pagina/e 100-112, ISSN 0012-1797
Editore: American Diabetes Association
DOI: 10.2337/db16-0592

Neuron-enriched RNA-binding Proteins Regulate Pancreatic Beta Cell Function and Survival

Autori: Jonàs Juan-Mateu, Tatiana H. Rech, Olatz Villate, Esther Lizarraga-Mollinedo, Anna Wendt, Jean-Valery Turatsinze, Letícia A. Brondani, Tarlliza R. Nardelli, Tatiane C. Nogueira, Jonathan L. S. Esguerra, Maria Inês Alvelos, Piero Marchetti, Lena Eliasson, Décio L. Eizirik
Pubblicato in: Journal of Biological Chemistry, Numero 292/8, 2017, Pagina/e 3466-3480, ISSN 0021-9258
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.M116.748335

Perturbed Mitochondrial Metabolism in Islets from Donors with Type-2 Diabetes

Autori: Jiangming Sun, Ruchi Jain, Lotta E. Andersson, Anya Medina, Petter Storm, Peter Spegel, Hindrik Mulder
Pubblicato in: Bio RXiv, 2017
Editore: Cold Spring Harbour Laboratory
DOI: 10.1101/212548

Developing a network view of type 2 diabetes risk pathways through integration of genetic, genomic and functional data

Autori: Juan Fernandez-Tajes, Kyle J Gaulton, Martijn van de Bunt, Jason Torres, Mathias Turner, Anubha Mahajan, Anna L Gloyn, Kasper Lage, Mark I McCarthy
Pubblicato in: bioRxiv, 2018
Editore: Cold Spring Harbour Laboratories
DOI: 10.1101/350181

Developing a network view of type 2 diabetes risk pathways through integration of genetic, genomic and functional data

Autori: Fernandez-Tajes, Juan; Gaulton, Kyle J; van de Bunt, Martijn; Torres, Jason; Turner, Mathias; Mahajan, Anubha; Gloyn, Anna L; Lage, Kasper; McCarthy, Mark I
Pubblicato in: bioRxiv - biorxiv;350181v2, Numero 7, 2018
Editore: Cold Spring Harbour Laboratory
DOI: 10.1101/350181

Perturbed Mitochondrial Metabolism in Islets from Donors with Type-2 Diabetes

Autori: Sun, Jiangming; Jain, Ruchi; Andersson, Lotta E.; Medina, Anya; Storm, Petter; Spegel, Peter; Mulder, Hindrik
Pubblicato in: bioRxiv - biorxiv;212548v1, Numero 8, 2017
Editore: Cold Spring Harbour Laboratory
DOI: 10.1101/212548

Unsupervised clustering of missense variants in the HNF1A gene using multidimensional functional data aids clinical interpretation

Autori: Sara Althari, Laeya A. Najmi, Amanda J. Bennett, Ingvild Aukrust, Jana K. Rundle, Kevin Colclough, Janne Molnes, Alba Kaci, Sameena Nawaz, Timme van der Lugt, Neelam Hassanali, Anders Molven, Sian Ellard, Mark I. McCarthy, Lise Bjorkhaug, Pal Rasmus Njolstad, Anna L Gloyn
Pubblicato in: medRxiv, 2019
Editore: Cold Spring Harbour Laboratory
DOI: 10.1101/19010900

Influence of genetic variants on gene expression in human pancreatic islets – implications for type 2 diabetes

Autori: Viñuela, A., Varshney A., van de Bunt M., Prasad R.B., Asplund O., Bennett A., Boehnke M, Brown A, Erdos M.R., Fadista J., Hansson O, Hatem G, Howald C, Iyengar A.K., Johnson P., Krus U, MacDonald P.E., Mahajan A, Manning Fox J., Narisu J., Nylander N., Orchard P., Oskolkov N., Panousis N.I., Payne A., Stitzel M.L., Vadlamudi S., Welch R., Collins F.S., Mohlke K.L., Gloyn AL, Scott L.E, Dermitzak
Pubblicato in: bioRxiv, 2019
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/655670

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