Effect of ALlopurinol in addition to hypothermia for hypoxic-ischemic Brain Injury on Neurocognitive Outcome

Project Information

ALBINO

Grant agreement ID: 667224

DOI 10.3030/667224

EC signature date 9 December 2015

Start date 1 January 2016

End date 30 June 2025

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost € 6 307 599,50

EU contribution € 5 994 030,00

Coordinated by

EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany

Deliverables

Documents, reports (1)

D10.2 ISRCTN or NCT number

ISRCTN or NCT number

Publications

Peer reviewed articles (11)

Glomerular Filtration Rate in Asphyxiated Neonates Under Therapeutic Whole-Body Hypothermia, Quantified by Mannitol Clearance

Author(s): Neel Deferm, Kim V. Annink, Ruben Faelens, Michael Schroth, Christian A. Maiwald, Loubna el Bakkali, Frank van Bel, Manon J. N. L. Benders, Mirjam M. van Weissenbruch, Anja Hagen, Anne Smits, Pieter Annaert, Axel R. Franz, Karel Allegaert
Published in: Clinical Pharmacokinetics, 2021, ISSN 0312-5963
Publisher: Adis International Ltd.
DOI: 10.1007/s40262-021-00991-6

Mammillary body atrophy and other MRI correlates of school-age outcome following neonatal hypoxic-ischemic encephalopathy.

Author(s): Kim V. Annink; Linda S. de Vries; Floris Groenendaal; Rian M. J. C. Eijsermans; Manouk Mocking; Monique M. J. van Schooneveld; Jeroen Dudink; Henrica L. M. van Straaten; Manon J.N.L. Benders; Maarten H. Lequin; Niek E. van der Aa
Published in: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021), Issue 2, 2021, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-021-83982-8

Brain temperature of infants with neonatal encephalopathy following perinatal asphyxia calculated using magnetic resonance spectroscopy

Author(s): Kim V. Annink, Floris Groenendaal, Daan Cohen, Niek E. van der Aa, Thomas Alderliesten, Jeroen Dudink, Manon J. N. L. Benders, Jannie P. Wijnen
Published in: Pediatric Research, Issue 88/2, 2020, Page(s) 279-284, ISSN 0031-3998
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1038/s41390-019-0739-3

Semi-mechanistic Modeling of Hypoxanthine, Xanthine, and Uric Acid Metabolism in Asphyxiated Neonates

Author(s): Wan-Yu, Chu; Karel, Allegaert; Thomas P C, Dorlo; Alwin D R, Huitema; Roselinda, van der Vlugt-Meijer
Published in: Clincial Pharmacokinetics, Issue 1, 2022, Page(s) 1545–1558, ISSN 0312-5963
Publisher: Adis International Ltd.
DOI: 10.1007/s40262-022-01164-9

Allopurinol: Old Drug, New Indication in Neonates?

Author(s): Kim V. Annink, Axel R. Franz, Jan B. Derks, Mario Rüdiger, Frank van Bel, Manon J.N.L. Benders
Published in: Current Pharmaceutical Design, Issue 23/38, 2018, Page(s) 5935-5942, ISSN 1381-6128
Publisher: Bentham Science Publishers
DOI: 10.2174/1381612823666170918123307

Effect of allopurinol in addition to hypothermia treatment in neonates for hypoxic-ischemic brain injury on neurocognitive outcome (ALBINO): study protocol of a blinded randomized placebo-controlled parallel group multicenter trial for superiority (phase III)

Author(s): Christian A. Maiwald, Kim V. Annink, Mario Rüdiger, Manon J. N. L. Benders, Frank van Bel, Karel Allegaert, Gunnar Naulaers, Dirk Bassler, Katrin Klebermaß-Schrehof, Maximo Vento, Hercilia Guimarães, Tom Stiris, Luigi Cattarossi, Marjo Metsäranta, Sampsa Vanhatalo, Jan Mazela, Tuuli Metsvaht, Yannique Jacobs, Axel R. Franz
Published in: BMC Pediatrics, Issue 19/1, 2019, Page(s) 210, ISSN 1471-2431
Publisher: BioMed Central
DOI: 10.1186/s12887-019-1566-8

The development and validation of a cerebral ultrasound scoring system for infants with hypoxic-ischaemic encephalopathy

Author(s): Kim V. Annink, Linda S. de Vries, Floris Groenendaal, Daniel C. Vijlbrief, Lauren C. Weeke, Charles C. Roehr, Maarten Lequin, Irwin Reiss, Paul Govaert, Manon J. N. L. Benders, Jeroen Dudink
Published in: Pediatric Research, Issue 87/S1, 2020, Page(s) 59-66, ISSN 0031-3998
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1038/s41390-020-0782-0

Cerebellar injury in term neonates with hypoxic–ischemic encephalopathy is underestimated 

Author(s): Kim V. Annink, Lilly Meerts, Niek E. van der Aa, Thomas Alderliesten, Peter G. J. Nikkels, Cora H. A. Nijboer, Floris Groenendaal, Linda S. de Vries, Manon J. N. L. Benders, Freek E. Hoebeek, Jeroen Dudink
Published in: Pediatric Research, 2020, ISSN 0031-3998
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1038/s41390-020-01173-z

Pharmacokinetic/Pharmacodynamic Modelling of Allopurinol, its Active Metabolite Oxypurinol, and Biomarkers Hypoxanthine, Xanthine and Uric Acid in Hypoxic-Ischemic Encephalopathy Neonates

Author(s): Wan-Yu Chu, Kim V Annink, A Laura Nijstad, Christian A Maiwald, Michael Schroth, Loubna El Bakkali, Frank van Bel, Manon J N L Benders, Mirjam M van Weissenbruch, Anja Hagen, Axel R Franz, Thomas P C Dorlo, Karel Allegaert, Alwin D R Huitema; ALBINO Study Group
Published in: Clinical Pharmakokinetics, 2022, Page(s) 321-333, ISSN 0312-5963
Publisher: Adis International Ltd.
DOI: 10.1007/s40262-021-01068-0

Parental perspectives about information and deferred versus two-stage consent in studies of neonatal asphyxia

Author(s): Christian A Maiwald, Charlotte Rovers, Annie Janvier, Heidrun Sturm, Martina Michaelis, Georg Marckmann, Hans-Joerg Ehni, Christian F Poets, Mario Rüdiger, Axel R Franz
Published in: Archives of Disease in Childhood - Fetal and Neonatal Edition, 2023, ISSN 1359-2998
Publisher: BMJ Publishing Group
DOI: 10.1136/archdischild-2023-325900

Introduction of Ultra-High-Field MR Imaging in Infants: Preparations and Feasibility

Author(s): K.V. Annink, N.E. van der Aa, J. Dudink, T. Alderliesten, F. Groenendaal, M. Lequin, F.E. Jansen, K.S. Rhebergen, P. Luijten, J. Hendrikse, H.J.M. Hoogduin, E.R. Huijing, E. Versteeg, F. Visser, A.J.E. Raaijmakers, E.C. Wiegers, D.W.J. Klomp, J.P. Wijnen, M.J.N.L. Benders
Published in: American Journal of Neuroradiology, Issue 41/8, 2020, Page(s) 1532-1537, ISSN 0195-6108
Publisher: American Society of Neuoradiology
DOI: 10.3174/ajnr.a6702