Effect of ALlopurinol in addition to hypothermia for hypoxic-ischemic Brain Injury on Neurocognitive Outcome

Informazioni relative al progetto

ALBINO

ID dell’accordo di sovvenzione: 667224

DOI

10.3030/667224

Progetto chiuso

Data della firma CE 9 Dicembre 2015

Data di avvio 1 Gennaio 2016

Data di completamento 30 Giugno 2025

Finanziato da

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Costo totale

€ 6 307 599,50

Contributo UE

€ 5 994 030,00

Coordinato da

EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (1)

D10.2 ISRCTN or NCT number

ISRCTN or NCT number

Pubblicazioni

Peer reviewed articles (13)

Glomerular Filtration Rate in Asphyxiated Neonates Under Therapeutic Whole-Body Hypothermia, Quantified by Mannitol Clearance

Autori: Neel Deferm, Kim V. Annink, Ruben Faelens, Michael Schroth, Christian A. Maiwald, Loubna el Bakkali, Frank van Bel, Manon J. N. L. Benders, Mirjam M. van Weissenbruch, Anja Hagen, Anne Smits, Pieter Annaert, Axel R. Franz, Karel Allegaert
Pubblicato in: Clinical Pharmacokinetics, 2021, ISSN 0312-5963
Editore: Adis International Ltd.
DOI: 10.1007/s40262-021-00991-6

Detailed statistical analysis plan for ALBINO: effect of Allopurinol in addition to hypothermia for hypoxic-ischemic Brain Injury on Neurocognitive Outcome — a blinded randomized placebo-controlled parallel group multicenter trial for superiority (phase III)

Autori: Corinna Engel; Mario Rüdiger; Manon J. N. L. Benders; Frank van Bel; Karel Allegaert; Gunnar Naulaers; Dirk Bassler; Katrin Klebermaß-Schrehof; Maximo Vento; Ana Vilan; Mari Falck; Isabella Mauro; Marjo Metsäranta; Sampsa Vanhatalo; Jan Mazela; Tuuli Metsvaht; Roselinda van der Vlught; Axel R. Franz; Christian F. Poets; Hercilia Guimarães; Tom Stiri; Luigi Cattarossi; Cees K. W. van Veldhuizen
Pubblicato in: Trials, Vol 25, Iss 1, Pp 1-13 (2024), Numero 2, 2024, ISSN 1745-6215
Editore: BioMed Central
DOI: 10.1186/s13063-023-07828-6

Early outcome-prediction with an automated EEG background trend in hypothermia-treated newborns with encephalopathy

Autori: Karla Gonzalez-Tamez, Saeed Montazeri, Johan Ågren, Sampsa Vanhatalo, Lena Hellström-Westas
Pubblicato in: Pediatric Research, 2025, ISSN 0031-3998
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1038/s41390-025-04193-9

Mammillary body atrophy and other MRI correlates of school-age outcome following neonatal hypoxic-ischemic encephalopathy.

Autori: Kim V. Annink; Linda S. de Vries; Floris Groenendaal; Rian M. J. C. Eijsermans; Manouk Mocking; Monique M. J. van Schooneveld; Jeroen Dudink; Henrica L. M. van Straaten; Manon J.N.L. Benders; Maarten H. Lequin; Niek E. van der Aa
Pubblicato in: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021), Numero 2, 2021, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-021-83982-8

Brain temperature of infants with neonatal encephalopathy following perinatal asphyxia calculated using magnetic resonance spectroscopy

Autori: Kim V. Annink, Floris Groenendaal, Daan Cohen, Niek E. van der Aa, Thomas Alderliesten, Jeroen Dudink, Manon J. N. L. Benders, Jannie P. Wijnen
Pubblicato in: Pediatric Research, Numero 88/2, 2020, Pagina/e 279-284, ISSN 0031-3998
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1038/s41390-019-0739-3

Semi-mechanistic Modeling of Hypoxanthine, Xanthine, and Uric Acid Metabolism in Asphyxiated Neonates

Autori: Wan-Yu, Chu; Karel, Allegaert; Thomas P C, Dorlo; Alwin D R, Huitema; Roselinda, van der Vlugt-Meijer
Pubblicato in: Clincial Pharmacokinetics, Numero 1, 2022, Pagina/e 1545–1558, ISSN 0312-5963
Editore: Adis International Ltd.
DOI: 10.1007/s40262-022-01164-9

Allopurinol: Old Drug, New Indication in Neonates?

Autori: Kim V. Annink, Axel R. Franz, Jan B. Derks, Mario Rüdiger, Frank van Bel, Manon J.N.L. Benders
Pubblicato in: Current Pharmaceutical Design, Numero 23/38, 2018, Pagina/e 5935-5942, ISSN 1381-6128
Editore: Bentham Science Publishers
DOI: 10.2174/1381612823666170918123307

Effect of allopurinol in addition to hypothermia treatment in neonates for hypoxic-ischemic brain injury on neurocognitive outcome (ALBINO): study protocol of a blinded randomized placebo-controlled parallel group multicenter trial for superiority (phase III)

Autori: Christian A. Maiwald, Kim V. Annink, Mario Rüdiger, Manon J. N. L. Benders, Frank van Bel, Karel Allegaert, Gunnar Naulaers, Dirk Bassler, Katrin Klebermaß-Schrehof, Maximo Vento, Hercilia Guimarães, Tom Stiris, Luigi Cattarossi, Marjo Metsäranta, Sampsa Vanhatalo, Jan Mazela, Tuuli Metsvaht, Yannique Jacobs, Axel R. Franz
Pubblicato in: BMC Pediatrics, Numero 19/1, 2019, Pagina/e 210, ISSN 1471-2431
Editore: BioMed Central
DOI: 10.1186/s12887-019-1566-8

The development and validation of a cerebral ultrasound scoring system for infants with hypoxic-ischaemic encephalopathy

Autori: Kim V. Annink, Linda S. de Vries, Floris Groenendaal, Daniel C. Vijlbrief, Lauren C. Weeke, Charles C. Roehr, Maarten Lequin, Irwin Reiss, Paul Govaert, Manon J. N. L. Benders, Jeroen Dudink
Pubblicato in: Pediatric Research, Numero 87/S1, 2020, Pagina/e 59-66, ISSN 0031-3998
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1038/s41390-020-0782-0

Cerebellar injury in term neonates with hypoxic–ischemic encephalopathy is underestimated 

Autori: Kim V. Annink, Lilly Meerts, Niek E. van der Aa, Thomas Alderliesten, Peter G. J. Nikkels, Cora H. A. Nijboer, Floris Groenendaal, Linda S. de Vries, Manon J. N. L. Benders, Freek E. Hoebeek, Jeroen Dudink
Pubblicato in: Pediatric Research, 2020, ISSN 0031-3998
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1038/s41390-020-01173-z

Pharmacokinetic/Pharmacodynamic Modelling of Allopurinol, its Active Metabolite Oxypurinol, and Biomarkers Hypoxanthine, Xanthine and Uric Acid in Hypoxic-Ischemic Encephalopathy Neonates

Autori: Wan-Yu Chu, Kim V Annink, A Laura Nijstad, Christian A Maiwald, Michael Schroth, Loubna El Bakkali, Frank van Bel, Manon J N L Benders, Mirjam M van Weissenbruch, Anja Hagen, Axel R Franz, Thomas P C Dorlo, Karel Allegaert, Alwin D R Huitema; ALBINO Study Group
Pubblicato in: Clinical Pharmakokinetics, 2022, Pagina/e 321-333, ISSN 0312-5963
Editore: Adis International Ltd.
DOI: 10.1007/s40262-021-01068-0

Parental perspectives about information and deferred versus two-stage consent in studies of neonatal asphyxia

Autori: Christian A Maiwald, Charlotte Rovers, Annie Janvier, Heidrun Sturm, Martina Michaelis, Georg Marckmann, Hans-Joerg Ehni, Christian F Poets, Mario Rüdiger, Axel R Franz
Pubblicato in: Archives of Disease in Childhood - Fetal and Neonatal Edition, 2023, ISSN 1359-2998
Editore: BMJ Publishing Group
DOI: 10.1136/archdischild-2023-325900

Introduction of Ultra-High-Field MR Imaging in Infants: Preparations and Feasibility

Autori: K.V. Annink, N.E. van der Aa, J. Dudink, T. Alderliesten, F. Groenendaal, M. Lequin, F.E. Jansen, K.S. Rhebergen, P. Luijten, J. Hendrikse, H.J.M. Hoogduin, E.R. Huijing, E. Versteeg, F. Visser, A.J.E. Raaijmakers, E.C. Wiegers, D.W.J. Klomp, J.P. Wijnen, M.J.N.L. Benders
Pubblicato in: American Journal of Neuroradiology, Numero 41/8, 2020, Pagina/e 1532-1537, ISSN 0195-6108
Editore: American Society of Neuoradiology
DOI: 10.3174/ajnr.a6702