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Comorbid Conditions of Attention deficit / hyperactivity disorder

Objective

Understanding mechanisms underlying comorbid disorders poses a challenge for developing precision medicine tools. Psychiatric disorders are highly comorbid, and are among the last areas of medicine, where classification is driven by phenomenology rather than pathophysiology. We will study comorbidity between the most frequent psychiatric conditions, ADHD, mood/anxiety, and substance use disorders, and a highly prevalent somatic disease, obesity. ADHD, a childhood-onset disorder, forms the entry into a lifelong negative trajectory characterized by these comorbidities. Common mechanisms underlying this course are unknown, despite their relevance for early detection, prevention, and treatment. Our interdisciplinary team of experts will integrate epidemiologic/genetic approaches with experimental designs to address those issues. We will determine disease burden of comorbidity, calculate its socioeconomic impact, and reveal risk factors. We will study biological pathways of comorbidity and derive biomarkers, prioritizing two candidate mechanisms (circadian rhythm and dopaminergic neurotransmission), but also leveraging large existing data sets to identify new ones. A pilot clinical trial to study non-pharmacologic, dopamine-based and chronobiological treatments will be performed, employing innovative mHealth to monitor and support patients’ daily life. Integration of findings will lead to prediction algorithms enhancing early diagnosis and prevention of comorbidity. Finally, we will screen to repurpose existing pharmacological compounds. Integrating complementary approaches based on large-scale, existing data and innovative data collection, we maximize value for money in this project, leading to insight into the mechanisms underlying this comorbidity triad with its huge burden for healthcare, economy, and society. This will facilitate early detection and non-invasive, scalable, and low-cost treatment, creating opportunities for substantial and immediate societal impact.

Call for proposal

H2020-PHC-2015-two-stage
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN
Address
Theodor W Adorno Platz 1
60323 Frankfurt Am Main
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 991 897,50

Participants (16)

STICHTING KATHOLIEKE UNIVERSITEIT
Netherlands
EU contribution
€ 610 000
Address
Geert Grooteplein Noord 9
6525 EZ Nijmegen
Activity type
Higher or Secondary Education Establishments
ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands
EU contribution
€ 262 000
Address
Hanzeplein 1
9713 GZ Groningen
Activity type
Higher or Secondary Education Establishments
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 202 000
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
UNIVERSITAT DE BARCELONA
Spain
EU contribution
€ 252 391,25
Address
Gran Via De Les Corts Catalanes 585
08007 Barcelona
Activity type
Higher or Secondary Education Establishments
FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA
Spain
EU contribution
€ 326 996,25
Address
Passeig Vall D Hebron 119-129 Edificio De Recerca
08035 Barcelona
Activity type
Research Organisations
UNIVERSITATSMEDIZIN ROSTOCK
Germany
EU contribution
€ 240 000
Address
Schillingallee 35
18055 Rostock
Activity type
Higher or Secondary Education Establishments
KING'S COLLEGE LONDON
United Kingdom
EU contribution
€ 569 000
Address
Strand
WC2R 2LS London
Activity type
Higher or Secondary Education Establishments
UNIVERSITATSKLINIKUM HEIDELBERG
Germany
EU contribution
€ 339 657,50
Address
Im Neuenheimer Feld 672
69120 Heidelberg
Activity type
Higher or Secondary Education Establishments
TARTU ULIKOOL
Estonia
EU contribution
€ 147 000
Address
Ulikooli 18
51005 Tartu
Activity type
Higher or Secondary Education Establishments
KARLSRUHER INSTITUT FUER TECHNOLOGIE
Germany
EU contribution
€ 466 913
Address
Kaiserstrasse 12
76131 Karlsruhe
Activity type
Higher or Secondary Education Establishments
UNIVERSIDAD DE GRANADA
Spain
EU contribution
€ 105 000
Address
Cuesta Del Hospicio Sn
18071 Granada
Activity type
Higher or Secondary Education Establishments
UNIVERSITETET I BERGEN
Norway
EU contribution
€ 402 360
Address
Museplassen 1
5020 Bergen
Activity type
Higher or Secondary Education Establishments
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
United States
EU contribution
€ 312 000
Address
State Street 35
12201 Albany Ny
Activity type
Other
AARHUS UNIVERSITET
Denmark
EU contribution
€ 261 805
Address
Nordre Ringgade 1
8000 Aarhus C
Activity type
Higher or Secondary Education Establishments
HGC GESUNDHEITSCONSULT GMBH
Germany
EU contribution
€ 150 000
Address
Morsenbroicher Weg 200
40470 Dusseldorf
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Concentris Research Management GmbH
Germany
EU contribution
€ 360 000
Address
Ludwigstr. 4
D-82256 Fürstenfeldbruck
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)