Advanced Regenerative and REStorative Therapies to combat corneal BLINDNESS

Livrables

All approvals package for multicenter Phase II study

All approvals from ethics committees and national competent authorities (if applicable) of all study sites once the last approval has been received.

Identification of the best location for cell harvesting

Identification of the best location for cell harvesting and optimal cell culture conditions, for human corneal endothelial cells.

Classification of LSCD by in vivo confocal microscopy

Classification of LSCD by in vivo confocal microscopy in the first 5 enrolled patients at UZA. Also includes limbal stem cell imaging prior to biopsy in donors. Training of UZA personnel for in vivo confocal microscopy examination of patients.

Final report on minipig study results

Manuscript describing results of minipig study, suitable for publication.

Report on feasibility of reducing antigenicity

Results of in vitro experiments with human cultured epithelial and endothelial cells from beneficiary LUMC. Cells obtained from UZA and NIIOS.

First study approvals package for Phase I Biocornea study

First study subject approvals package includes (prior to enrolment of first study subject): a. Final version of study protocol as submitted to regulators / ethics committee(s) b. Registration number of clinical study in a WHO- or ICMJE- approved registry c. Approvals (ethics committees and national competent authority if applicable) required for invitation / enrolment of first subject

Identification of an optimum carrier for porcine cells

Identification of an optimum carrier material based on porcine endothelial cell expansion, adhesion, and biomechanical test data.

Project website and promotional materials

Project website to communicate project results externally and to communicate/share documents internally within the consortium.

CE certified ologen™ Biocornea

Certificate of granted CE-mark to the Biocornea from the appropriate regulatory body.

Dissemination and Exploitation Strategy

Production and distribution of early project promotional materials, a communication strategy, and a dissemination strategy.

Marketing and business plan and final symposium

By the final year of the project, a market analysis and business plan will be delivered, and final conference symposium and communications report will be delivered.

Publications

VEGF Trap R1R2 Suspended in the Semifluorinated Alkane F6H8 Inhibits Inflammatory Corneal Hem- and Lymphangiogenesis

Auteurs: Viet Nhat Hung Le, Deniz Hos, Yanhong Hou, Madlen Witt, Mikhail Barkovskiy, Felix Bock, Claus Cursiefen
Publié dans: Translational Vision Science & Technology, Numéro 9/11, 2020, Page(s) 15, ISSN 2164-2591
Éditeur: ARVO
DOI: 10.1167/tvst.9.11.15

Risk of Corneal Graft Rejection After High-risk Keratoplasty Following Fine-needle Vessel Coagulation of Corneal Neovascularization Combined With Bevacizumab: A Pilot Study

Auteurs: Deniz Hos, Viet Nhat Hung Le, Martin Hellmich, Sebastian Siebelmann, Sigrid Roters, Bjoern O. Bachmann, Claus Cursiefen
Publié dans: Transplantation Direct, Numéro 5/5, 2019, Page(s) e452, ISSN 2373-8731
Éditeur: The Transplantation Society
DOI: 10.1097/txd.0000000000000894

New developments in corneal endothelial cell replacement

Auteurs: Daniele Spinozzi, Alina Miron, Marieke Bruinsma, Isabel Dapena, Viridiana Kocaba, Martine J. Jager, Gerrit R. J. Melles, Sorcha Ni Dhubhghaill, Silke Oellerich
Publié dans: Acta Ophthalmologica, 2021, ISSN 1755-375X
Éditeur: Wiley-Blackwell
DOI: 10.1111/aos.14722

A porous collagen-based hydrogel and implantation method for corneal stromal regeneration and sustained local drug delivery

Auteurs: Maria Xeroudaki, Muthukumar Thangavelu, Anton Lennikov, Anjula Ratnayake, Jovana Bisevac, Goran Petrovski, Per Fagerholm, Mehrdad Rafat, Neil Lagali
Publié dans: Scientific Reports, Numéro 10/1, 2020, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-020-73730-9

Göttingen Minipig is not a Suitable Animal Model for in Vivo Testing of Tissue-Engineered Corneal Endothelial Cell-Carrier Sheets and for Endothelial Keratoplasty

Auteurs: Niklas Telinius, Daniele Spinozzi, Dusan Rasic, Isabel Dapena, Ulrik Baandrup, Alina Miron, Silke Oellerich, Jesper Hjortdal
Publié dans: Current Eye Research, Numéro 45/8, 2020, Page(s) 945-949, ISSN 0271-3683
Éditeur: Swets & Zeitlinger
DOI: 10.1080/02713683.2019.1706747

Supplemental Anti Vegf A-Therapy Prevents Rebound Neovascularisation After Fine Needle Diathermy Treatment to Regress Pathological Corneal (LYMPH)Angiogenesis

Auteurs: Viet Nhat Hung Le, Yanhong Hou, Felix Bock, Claus Cursiefen
Publié dans: Scientific Reports, Numéro 10/1, 2020, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-020-60705-z

A method for quantifying limbal stem cell niches using OCT imaging

Auteurs: Michel Haagdorens, Joséphine Behaegel, Jos Rozema, Veerle Van Gerwen, Sofie Michiels, Sorcha Ní Dhubhghaill, Marie-José Tassignon, Nadia Zakaria
Publié dans: British Journal of Ophthalmology, Numéro 101/9, 2017, Page(s) 1250-1255, ISSN 0007-1161
Éditeur: BMJ Publishing Group
DOI: 10.1136/bjophthalmol-2016-309549

Incidence and Clinical Course of Immune Reactions after Descemet Membrane Endothelial Keratoplasty

Auteurs: Deniz Hos, Onur Tuac, Friederike Schaub, Tisha P. Stanzel, Silvia Schrittenlocher, Martin Hellmich, Björn O. Bachmann, Claus Cursiefen
Publié dans: Ophthalmology, Numéro 124/4, 2017, Page(s) 512-518, ISSN 0161-6420
Éditeur: Elsevier BV
DOI: 10.1016/j.ophtha.2016.12.017

Improving the success rate of human corneal endothelial cell cultures from single donor corneas with stabilization medium

Auteurs: D. Spinozzi, A. Miron, M. Bruinsma, J. T. Lie, I. Dapena, S. Oellerich, G. R. J. Melles
Publié dans: Cell and Tissue Banking, Numéro 19/1, 2018, Page(s) 9-17, ISSN 1389-9333
Éditeur: Kluwer Academic Publishers
DOI: 10.1007/s10561-017-9665-y

UV light-blocking contact lenses protect against short-term UVB-induced limbal stem cell niche damage and inflammation

Auteurs: M. Notara, S. Behboudifard, M. A. Kluth, C. Maßlo, C. Ganss, M. H. Frank, B. Schumacher, C. Cursiefen
Publié dans: Scientific Reports, Numéro 8/1, 2018, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-018-30021-8

Asymmetrical endothelial cell migration from in vitro Quarter-Descemet membrane endothelial keratoplasty grafts

Auteurs: Alina Miron, Daniele Spinozzi, Marieke Bruinsma, Jessica T. Lie, Rénuka S. Birbal, Lamis Baydoun, Silke Oellerich, Gerrit R.J. Melles
Publié dans: Acta Ophthalmologica, Numéro 96/8, 2018, Page(s) 828-833, ISSN 1755-375X
Éditeur: Wiley-Blackwell
DOI: 10.1111/aos.13841

Oxygen Tension Strongly Influences Metabolic Parameters and the Release of Interleukin-6 of Human Amniotic Mesenchymal Stromal Cells In Vitro

Auteurs: Asmita Banerjee, Andrea Lindenmair, Ralf Steinborn, Sergiu Dan Dumitrescu, Simone Hennerbichler, Andrey V. Kozlov, Heinz Redl, Susanne Wolbank, Adelheid Weidinger
Publié dans: Stem Cells International, Numéro 2018, 2018, Page(s) 1-11, ISSN 1687-966X
Éditeur: Hindawi
DOI: 10.1155/2018/9502451

UV light crosslinking regresses mature corneal blood and lymphatic vessels and promotes subsequent high-risk corneal transplant survival

Auteurs: Yanhong Hou, Viet Nhat Hung Le, Gábor Tóth, Sebastian Siebelmann, Jens Horstmann, Tim Gabriel, Felix Bock, Claus Cursiefen
Publié dans: American Journal of Transplantation, Numéro 18/12, 2018, Page(s) 2873-2884, ISSN 1600-6135
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/ajt.14874

Fine Needle-Diathermy Regresses Pathological Corneal (Lymph)Angiogenesis and Promotes High-Risk Corneal Transplant Survival

Auteurs: Viet Nhat Hung Le, Ann-Charlott Schneider, Rebecca Scholz, Felix Bock, Claus Cursiefen
Publié dans: Scientific Reports, Numéro 8/1, 2018, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-018-24037-3

Label-Free In Vivo Imaging of Corneal Lymphatic Vessels Using Microscopic Optical Coherence Tomography

Auteurs: Jens Horstmann, Hinnerk Schulz-Hildebrandt, Felix Bock, Sebastian Siebelmann, Eva Lankenau, Gereon Hüttmann, Philipp Steven, Claus Cursiefen
Publié dans: Investigative Opthalmology & Visual Science, Numéro 58/13, 2017, Page(s) 5880, ISSN 1552-5783
Éditeur: ARVO
DOI: 10.1167/iovs.17-22286

Novel Method to Detect Corneal Lymphatic Vessels In Vivo by Intrastromal Injection of Fluorescein

Auteurs: Viet Nhat Hung Le, Yanhong Hou, Jens Horstmann, Felix Bock, Claus Cursiefen
Publié dans: Cornea, Numéro 37/2, 2018, Page(s) 267-271, ISSN 0277-3740
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/ico.0000000000001444

Photodynamic Therapy Leads to Time-Dependent Regression of Pathologic Corneal (Lymph) Angiogenesis and Promotes High-Risk Corneal Allograft Survival

Auteurs: Yanhong Hou, Viet Nhat Hung Le, Thomas Clahsen, Ann-Charlott Schneider, Felix Bock, Claus Cursiefen
Publié dans: Investigative Opthalmology & Visual Science, Numéro 58/13, 2017, Page(s) 5862, ISSN 1552-5783
Éditeur: ARVO
DOI: 10.1167/iovs.17-22904

Anterior segment optical coherence tomography for the diagnosis of corneal dystrophies according to the IC3D classification

Auteurs: Sebastian Siebelmann, Paula Scholz, Simon Sonnenschein, Björn Bachmann, Mario Matthaei, Claus Cursiefen, Ludwig M. Heindl
Publié dans: Survey of Ophthalmology, Numéro 63/3, 2018, Page(s) 365-380, ISSN 0039-6257
Éditeur: Elsevier BV
DOI: 10.1016/j.survophthal.2017.08.001

Functional and Morphologic Alterations in Mechanical, Polymodal, and Cold Sensory Nerve Fibers of the Cornea Following Photorefractive Keratectomy

Auteurs: Federico Bech, Omar González-González, Enol Artime, Joana Serrano, Ignacio Alcalde, Juana Gallar, Jesús Merayo-Lloves, Carlos Belmonte
Publié dans: Investigative Opthalmology & Visual Science, Numéro 59/6, 2018, Page(s) 2281, ISSN 1552-5783
Éditeur: ARVO
DOI: 10.1167/iovs.18-24007

Evaluation of the Suitability of Biocompatible Carriers as Artificial Transplants Using Cultured Porcine Corneal Endothelial Cells

Auteurs: Daniele Spinozzi, Alina Miron, Marieke Bruinsma, Isabel Dapena, Itay Lavy, Perry S. Binder, Mehrdad Rafat, Silke Oellerich, Gerrit R.J. Melles
Publié dans: Current Eye Research, 2018, Page(s) 1-7, ISSN 0271-3683
Éditeur: Swets & Zeitlinger
DOI: 10.1080/02713683.2018.1536215

Ethical issues in living-related corneal tissue transplantation

Auteurs: Joséphine Behaegel, Sorcha Ní Dhubhghaill, Heather Draper
Publié dans: Journal of Medical Ethics, Numéro 45/7, 2019, Page(s) 430-434, ISSN 0306-6800
Éditeur: BMJ Publishing Group
DOI: 10.1136/MEDETHICS-2018-105146

Short- and Long-Term Results of Xenogeneic-Free Cultivated Autologous and Allogeneic Limbal Epithelial Stem Cell Transplantations

Auteurs: Joséphine Behaegel, Nadia Zakaria, Marie-José Tassignon, Inge Leysen, Felix Bock, Carina Koppen, Sorcha Ní Dhubhghaill
Publié dans: Cornea, Numéro 38/12, 2019, Page(s) 1543-1549, ISSN 0277-3740
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/ico.0000000000002153

Corneal Stromal Regeneration: Current Status and Future Therapeutic Potential

Auteurs: Neil Lagali
Publié dans: Current Eye Research, 2019, Page(s) 1-13, ISSN 0271-3683
Éditeur: Swets & Zeitlinger
DOI: 10.1080/02713683.2019.1663874

Corneal epithelial restoration after penetrating keratoplasty in repeated failed cultivated limbal stem cell grafts

Auteurs: Joséphine Behaegel, Carina Koppen, Veerle Van Gerwen, Marie-José Tassignon, Sorcha Ní Dhubhghaill
Publié dans: Journal of EuCornea, Numéro 2, 2019, Page(s) 6-9, ISSN 2452-4034
Éditeur: Elsevier
DOI: 10.1016/j.xjec.2019.03.001

In vitro endothelial cell migration from limbal edge-modified Quarter-DMEK grafts

Auteurs: Alina Miron, Daniele Spinozzi, Sorcha Ní Dhubhghaill, Jessica T. Lie, Silke Oellerich, Gerrit R. J. Melles
Publié dans: PLOS ONE, Numéro 14/11, 2019, Page(s) e0225462, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0225462

Development and Validation of an Open-Source Grading Tool for Outcome Assessment in Limbal Stem Cell Treatment

Auteurs: Joséphine Behaegel, Alejandra Consejo, Kristien Wouters, Carina Koppen, Joost De Cock, Sorcha Ní Dhubhghaill
Publié dans: Cornea, Numéro 39/6, 2020, Page(s) 787-792, ISSN 0277-3740
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/ico.0000000000002282

Safety of Cultivated Limbal Epithelial Stem Cell Transplantation for Human Corneal Regeneration

Auteurs: J. Behaegel, S. Ní Dhubhghaill, C. Koppen, N. Zakaria
Publié dans: Stem Cells International, Numéro 2017, 2017, Page(s) 1-11, ISSN 1687-966X
Éditeur: Hindawi Limited
DOI: 10.1155/2017/6978253

In Vitro Evaluation and Transplantation of Human Corneal Endothelial Cells Cultured on Biocompatible Carriers

Auteurs: Daniele Spinozzi, Alina Miron, Jessica T. Lie, Mehrdad Rafat, Neil Lagali, Gerrit R.J. Melles, Sorcha Ni Dhubhghaill, Isabel Dapena, Silke Oellerich
Publié dans: Cell Transplantation, Numéro 29, 2020, Page(s) 096368972092357, ISSN 0963-6897
Éditeur: Cognizant Communication Corp.
DOI: 10.1177/0963689720923577

Corneal Crosslinking to Regress Pathologic Corneal Neovascularization Before High-Risk Keratoplasty

Auteurs: Friederike Schaub, Yanhong Hou, Wei Zhang, Felix Bock, Deniz Hos, Claus Cursiefen
Publié dans: Cornea, Numéro 40/2, 2021, Page(s) 147-155, ISSN 0277-3740
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/ico.0000000000002406

Outcomes of Human Leukocyte Antigen–Matched Allogeneic Cultivated Limbal Epithelial Transplantation in Aniridia-Associated Keratopathy—A Single-Center Retrospective Analysis

Auteurs: Joséphine Behaegel, Marie-José Tassignon, Neil Lagali, Alejandra Consejo, Carina Koppen, Sorcha Ní Dhubhghaill
Publié dans: Cornea, Numéro Publish Ahead of Print, 2021, ISSN 0277-3740
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/ico.0000000000002729

The Bigger Picture of Ex Vivo Limbal Epithelial Stem Cell Transplantation

Auteurs: Joséphine Behaegel
Publié dans: PhD Dissertation, 2019
Éditeur: Academic and Scientific Publishers

Cultivated Limbal Stem Cell Transplantation: Indications and Technique

Auteurs: Joséphine Behaegel, Sorcha Ní Dhubhghaill, Marie-José Tassignon
Publié dans: Corneal Regeneration - Therapy and Surgery, Numéro Jan 2019, 2019, Page(s) 277-290, ISBN 978-3-030-01303-5
Éditeur: Springer International Publishing
DOI: 10.1007/978-3-030-01304-2_19

CORNEAL NEOVASCULARIZATION: UPDATE ON PATHOGENESIS AND ADVANCES IN TREATMENT STRATEGIES

Auteurs: Joséphine Behaegel, Sorcha Ní Dhubhghaill, Carina Koppen, Nadia Zakaria
Publié dans: International Journal of Medical and Biological Frontiers;, Numéro Vol 22, 2016, ISSN 1081-3829
Éditeur: Nova Science Publishers

Need for technologies in advanced corneal research, diagnosis, and transplantation

Auteurs: Neil S. Lagali
Publié dans: Ophthalmic Technologies XXIX, 2019, Page(s) 82, ISBN 9781-510623590
Éditeur: SPIE
DOI: 10.1117/12.2520656

Droits de propriété intellectuelle

COMPOSITIONS AND METHODS FOR THE TREATMENT OF OCULAR NEOVASCULARIZATION

Numéro de demande/publication: 20 20053405
Date: 2020-02-11
Demandeur(s): NOVALIQ GMBH

COMPOSITIONS AND METHODS FOR THE TREATMENT OF OCULAR NEOVASCULARIZATION

Numéro de demande/publication: 20 20053405
Date: 2020-02-11

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