Deliverables
All approvals from ethics committees and national competent authorities (if applicable) of all study sites once the last approval has been received.
Identification of the best location for cell harvesting and optimal cell culture conditions, for human corneal endothelial cells.
Classification of LSCD by in vivo confocal microscopy in the first 5 enrolled patients at UZA. Also includes limbal stem cell imaging prior to biopsy in donors. Training of UZA personnel for in vivo confocal microscopy examination of patients.
Manuscript describing results of minipig study, suitable for publication.
Results of in vitro experiments with human cultured epithelial and endothelial cells from beneficiary LUMC. Cells obtained from UZA and NIIOS.
First study subject approvals package includes (prior to enrolment of first study subject): a. Final version of study protocol as submitted to regulators / ethics committee(s) b. Registration number of clinical study in a WHO- or ICMJE- approved registry c. Approvals (ethics committees and national competent authority if applicable) required for invitation / enrolment of first subject
Identification of an optimum carrier material based on porcine endothelial cell expansion, adhesion, and biomechanical test data.
Project website to communicate project results externally and to communicate/share documents internally within the consortium.
Certificate of granted CE-mark to the Biocornea from the appropriate regulatory body.
Production and distribution of early project promotional materials, a communication strategy, and a dissemination strategy.
By the final year of the project, a market analysis and business plan will be delivered, and final conference symposium and communications report will be delivered.
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Publications
Author(s): Viet Nhat Hung Le, Deniz Hos, Yanhong Hou, Madlen Witt, Mikhail Barkovskiy, Felix Bock, Claus Cursiefen
Published in: Translational Vision Science & Technology, 9/11, 2020, Page(s) 15, ISSN 2164-2591
Publisher: ARVO
DOI: 10.1167/tvst.9.11.15
Author(s): Deniz Hos, Viet Nhat Hung Le, Martin Hellmich, Sebastian Siebelmann, Sigrid Roters, Bjoern O. Bachmann, Claus Cursiefen
Published in: Transplantation Direct, 5/5, 2019, Page(s) e452, ISSN 2373-8731
Publisher: The Transplantation Society
DOI: 10.1097/txd.0000000000000894
Author(s): Daniele Spinozzi, Alina Miron, Marieke Bruinsma, Isabel Dapena, Viridiana Kocaba, Martine J. Jager, Gerrit R. J. Melles, Sorcha Ni Dhubhghaill, Silke Oellerich
Published in: Acta Ophthalmologica, 2021, ISSN 1755-375X
Publisher: Wiley-Blackwell
DOI: 10.1111/aos.14722
Author(s): Maria Xeroudaki, Muthukumar Thangavelu, Anton Lennikov, Anjula Ratnayake, Jovana Bisevac, Goran Petrovski, Per Fagerholm, Mehrdad Rafat, Neil Lagali
Published in: Scientific Reports, 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-73730-9
Author(s): Niklas Telinius, Daniele Spinozzi, Dusan Rasic, Isabel Dapena, Ulrik Baandrup, Alina Miron, Silke Oellerich, Jesper Hjortdal
Published in: Current Eye Research, 45/8, 2020, Page(s) 945-949, ISSN 0271-3683
Publisher: Swets & Zeitlinger
DOI: 10.1080/02713683.2019.1706747
Author(s): Viet Nhat Hung Le, Yanhong Hou, Felix Bock, Claus Cursiefen
Published in: Scientific Reports, 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-60705-z
Author(s): Michel Haagdorens, Joséphine Behaegel, Jos Rozema, Veerle Van Gerwen, Sofie Michiels, Sorcha Ní Dhubhghaill, Marie-José Tassignon, Nadia Zakaria
Published in: British Journal of Ophthalmology, 101/9, 2017, Page(s) 1250-1255, ISSN 0007-1161
Publisher: BMJ Publishing Group
DOI: 10.1136/bjophthalmol-2016-309549
Author(s): Deniz Hos, Onur Tuac, Friederike Schaub, Tisha P. Stanzel, Silvia Schrittenlocher, Martin Hellmich, Björn O. Bachmann, Claus Cursiefen
Published in: Ophthalmology, 124/4, 2017, Page(s) 512-518, ISSN 0161-6420
Publisher: Elsevier BV
DOI: 10.1016/j.ophtha.2016.12.017
Author(s): D. Spinozzi, A. Miron, M. Bruinsma, J. T. Lie, I. Dapena, S. Oellerich, G. R. J. Melles
Published in: Cell and Tissue Banking, 19/1, 2018, Page(s) 9-17, ISSN 1389-9333
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10561-017-9665-y
Author(s): M. Notara, S. Behboudifard, M. A. Kluth, C. Maßlo, C. Ganss, M. H. Frank, B. Schumacher, C. Cursiefen
Published in: Scientific Reports, 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-30021-8
Author(s): Alina Miron, Daniele Spinozzi, Marieke Bruinsma, Jessica T. Lie, Rénuka S. Birbal, Lamis Baydoun, Silke Oellerich, Gerrit R.J. Melles
Published in: Acta Ophthalmologica, 96/8, 2018, Page(s) 828-833, ISSN 1755-375X
Publisher: Wiley-Blackwell
DOI: 10.1111/aos.13841
Author(s): Asmita Banerjee, Andrea Lindenmair, Ralf Steinborn, Sergiu Dan Dumitrescu, Simone Hennerbichler, Andrey V. Kozlov, Heinz Redl, Susanne Wolbank, Adelheid Weidinger
Published in: Stem Cells International, 2018, 2018, Page(s) 1-11, ISSN 1687-966X
Publisher: Hindawi
DOI: 10.1155/2018/9502451
Author(s): Yanhong Hou, Viet Nhat Hung Le, Gábor Tóth, Sebastian Siebelmann, Jens Horstmann, Tim Gabriel, Felix Bock, Claus Cursiefen
Published in: American Journal of Transplantation, 18/12, 2018, Page(s) 2873-2884, ISSN 1600-6135
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/ajt.14874
Author(s): Viet Nhat Hung Le, Ann-Charlott Schneider, Rebecca Scholz, Felix Bock, Claus Cursiefen
Published in: Scientific Reports, 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-24037-3
Author(s): Jens Horstmann, Hinnerk Schulz-Hildebrandt, Felix Bock, Sebastian Siebelmann, Eva Lankenau, Gereon Hüttmann, Philipp Steven, Claus Cursiefen
Published in: Investigative Opthalmology & Visual Science, 58/13, 2017, Page(s) 5880, ISSN 1552-5783
Publisher: ARVO
DOI: 10.1167/iovs.17-22286
Author(s): Viet Nhat Hung Le, Yanhong Hou, Jens Horstmann, Felix Bock, Claus Cursiefen
Published in: Cornea, 37/2, 2018, Page(s) 267-271, ISSN 0277-3740
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/ico.0000000000001444
Author(s): Yanhong Hou, Viet Nhat Hung Le, Thomas Clahsen, Ann-Charlott Schneider, Felix Bock, Claus Cursiefen
Published in: Investigative Opthalmology & Visual Science, 58/13, 2017, Page(s) 5862, ISSN 1552-5783
Publisher: ARVO
DOI: 10.1167/iovs.17-22904
Author(s): Sebastian Siebelmann, Paula Scholz, Simon Sonnenschein, Björn Bachmann, Mario Matthaei, Claus Cursiefen, Ludwig M. Heindl
Published in: Survey of Ophthalmology, 63/3, 2018, Page(s) 365-380, ISSN 0039-6257
Publisher: Elsevier BV
DOI: 10.1016/j.survophthal.2017.08.001
Author(s): Federico Bech, Omar González-González, Enol Artime, Joana Serrano, Ignacio Alcalde, Juana Gallar, Jesús Merayo-Lloves, Carlos Belmonte
Published in: Investigative Opthalmology & Visual Science, 59/6, 2018, Page(s) 2281, ISSN 1552-5783
Publisher: ARVO
DOI: 10.1167/iovs.18-24007
Author(s): Daniele Spinozzi, Alina Miron, Marieke Bruinsma, Isabel Dapena, Itay Lavy, Perry S. Binder, Mehrdad Rafat, Silke Oellerich, Gerrit R.J. Melles
Published in: Current Eye Research, 2018, Page(s) 1-7, ISSN 0271-3683
Publisher: Swets & Zeitlinger
DOI: 10.1080/02713683.2018.1536215
Author(s): Joséphine Behaegel, Sorcha Ní Dhubhghaill, Heather Draper
Published in: Journal of Medical Ethics, 45/7, 2019, Page(s) 430-434, ISSN 0306-6800
Publisher: BMJ Publishing Group
DOI: 10.1136/MEDETHICS-2018-105146
Author(s): Joséphine Behaegel, Nadia Zakaria, Marie-José Tassignon, Inge Leysen, Felix Bock, Carina Koppen, Sorcha Ní Dhubhghaill
Published in: Cornea, 38/12, 2019, Page(s) 1543-1549, ISSN 0277-3740
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/ico.0000000000002153
Author(s): Neil Lagali
Published in: Current Eye Research, 2019, Page(s) 1-13, ISSN 0271-3683
Publisher: Swets & Zeitlinger
DOI: 10.1080/02713683.2019.1663874
Author(s): Joséphine Behaegel, Carina Koppen, Veerle Van Gerwen, Marie-José Tassignon, Sorcha Ní Dhubhghaill
Published in: Journal of EuCornea, 2, 2019, Page(s) 6-9, ISSN 2452-4034
Publisher: Elsevier
DOI: 10.1016/j.xjec.2019.03.001
Author(s): Alina Miron, Daniele Spinozzi, Sorcha Ní Dhubhghaill, Jessica T. Lie, Silke Oellerich, Gerrit R. J. Melles
Published in: PLOS ONE, 14/11, 2019, Page(s) e0225462, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0225462
Author(s): Joséphine Behaegel, Alejandra Consejo, Kristien Wouters, Carina Koppen, Joost De Cock, Sorcha Ní Dhubhghaill
Published in: Cornea, 39/6, 2020, Page(s) 787-792, ISSN 0277-3740
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/ico.0000000000002282
Author(s): J. Behaegel, S. Ní Dhubhghaill, C. Koppen, N. Zakaria
Published in: Stem Cells International, 2017, 2017, Page(s) 1-11, ISSN 1687-966X
Publisher: Hindawi Limited
DOI: 10.1155/2017/6978253
Author(s): Daniele Spinozzi, Alina Miron, Jessica T. Lie, Mehrdad Rafat, Neil Lagali, Gerrit R.J. Melles, Sorcha Ni Dhubhghaill, Isabel Dapena, Silke Oellerich
Published in: Cell Transplantation, 29, 2020, Page(s) 096368972092357, ISSN 0963-6897
Publisher: Cognizant Communication Corp.
DOI: 10.1177/0963689720923577
Author(s): Friederike Schaub, Yanhong Hou, Wei Zhang, Felix Bock, Deniz Hos, Claus Cursiefen
Published in: Cornea, 40/2, 2021, Page(s) 147-155, ISSN 0277-3740
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/ico.0000000000002406
Author(s): Joséphine Behaegel, Marie-José Tassignon, Neil Lagali, Alejandra Consejo, Carina Koppen, Sorcha Ní Dhubhghaill
Published in: Cornea, Publish Ahead of Print, 2021, ISSN 0277-3740
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/ico.0000000000002729
Author(s): Joséphine Behaegel
Published in: PhD Dissertation, 2019
Publisher: Academic and Scientific Publishers
Author(s): Joséphine Behaegel, Sorcha Ní Dhubhghaill, Marie-José Tassignon
Published in: Corneal Regeneration - Therapy and Surgery, Jan 2019, 2019, Page(s) 277-290, ISBN 978-3-030-01303-5
Publisher: Springer International Publishing
DOI: 10.1007/978-3-030-01304-2_19
Author(s): Joséphine Behaegel, Sorcha Ní Dhubhghaill, Carina Koppen, Nadia Zakaria
Published in: International Journal of Medical and Biological Frontiers;, Vol 22, 2016, ISSN 1081-3829
Publisher: Nova Science Publishers
Author(s): Neil S. Lagali
Published in: Ophthalmic Technologies XXIX, 2019, Page(s) 82, ISBN 9781-510623590
Publisher: SPIE
DOI: 10.1117/12.2520656