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Advanced Regenerative and REStorative Therapies to combat corneal BLINDNESS

Deliverables

All approvals package for multicenter Phase II study

All approvals from ethics committees and national competent authorities (if applicable) of all study sites once the last approval has been received.

Classification of LSCD by in vivo confocal microscopy

Classification of LSCD by in vivo confocal microscopy in the first 5 enrolled patients at UZA. Also includes limbal stem cell imaging prior to biopsy in donors. Training of UZA personnel for in vivo confocal microscopy examination of patients.

Final report on minipig study results

Manuscript describing results of minipig study, suitable for publication.

First study approvals package for Phase I Biocornea study

First study subject approvals package includes (prior to enrolment of first study subject): a. Final version of study protocol as submitted to regulators / ethics committee(s) b. Registration number of clinical study in a WHO- or ICMJE- approved registry c. Approvals (ethics committees and national competent authority if applicable) required for invitation / enrolment of first subject

Project website and promotional materials

Project website to communicate project results externally and to communicate/share documents internally within the consortium.

Dissemination and Exploitation Strategy

Production and distribution of early project promotional materials, a communication strategy, and a dissemination strategy.

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Publications

A porous collagen-based hydrogel and implantation method for corneal stromal regeneration and sustained local drug delivery

Author(s): Maria Xeroudaki, Muthukumar Thangavelu, Anton Lennikov, Anjula Ratnayake, Jovana Bisevac, Goran Petrovski, Per Fagerholm, Mehrdad Rafat, Neil Lagali
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
DOI: 10.1038/s41598-020-73730-9

A method for quantifying limbal stem cell niches using OCT imaging

Author(s): Michel Haagdorens, Joséphine Behaegel, Jos Rozema, Veerle Van Gerwen, Sofie Michiels, Sorcha Ní Dhubhghaill, Marie-José Tassignon, Nadia Zakaria
Published in: British Journal of Ophthalmology, Issue 101/9, 2017, Page(s) 1250-1255, ISSN 0007-1161
DOI: 10.1136/bjophthalmol-2016-309549

Incidence and Clinical Course of Immune Reactions after Descemet Membrane Endothelial Keratoplasty

Author(s): Deniz Hos, Onur Tuac, Friederike Schaub, Tisha P. Stanzel, Silvia Schrittenlocher, Martin Hellmich, Björn O. Bachmann, Claus Cursiefen
Published in: Ophthalmology, Issue 124/4, 2017, Page(s) 512-518, ISSN 0161-6420
DOI: 10.1016/j.ophtha.2016.12.017

Improving the success rate of human corneal endothelial cell cultures from single donor corneas with stabilization medium

Author(s): D. Spinozzi, A. Miron, M. Bruinsma, J. T. Lie, I. Dapena, S. Oellerich, G. R. J. Melles
Published in: Cell and Tissue Banking, Issue 19/1, 2018, Page(s) 9-17, ISSN 1389-9333
DOI: 10.1007/s10561-017-9665-y

UV light-blocking contact lenses protect against short-term UVB-induced limbal stem cell niche damage and inflammation

Author(s): M. Notara, S. Behboudifard, M. A. Kluth, C. Maßlo, C. Ganss, M. H. Frank, B. Schumacher, C. Cursiefen
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
DOI: 10.1038/s41598-018-30021-8

Asymmetrical endothelial cell migration from in vitro Quarter-Descemet membrane endothelial keratoplasty grafts

Author(s): Alina Miron, Daniele Spinozzi, Marieke Bruinsma, Jessica T. Lie, Rénuka S. Birbal, Lamis Baydoun, Silke Oellerich, Gerrit R.J. Melles
Published in: Acta Ophthalmologica, Issue 96/8, 2018, Page(s) 828-833, ISSN 1755-375X
DOI: 10.1111/aos.13841

Oxygen Tension Strongly Influences Metabolic Parameters and the Release of Interleukin-6 of Human Amniotic Mesenchymal Stromal Cells In Vitro

Author(s): Asmita Banerjee, Andrea Lindenmair, Ralf Steinborn, Sergiu Dan Dumitrescu, Simone Hennerbichler, Andrey V. Kozlov, Heinz Redl, Susanne Wolbank, Adelheid Weidinger
Published in: Stem Cells International, Issue 2018, 2018, Page(s) 1-11, ISSN 1687-966X
DOI: 10.1155/2018/9502451

UV light crosslinking regresses mature corneal blood and lymphatic vessels and promotes subsequent high-risk corneal transplant survival

Author(s): Yanhong Hou, Viet Nhat Hung Le, Gábor Tóth, Sebastian Siebelmann, Jens Horstmann, Tim Gabriel, Felix Bock, Claus Cursiefen
Published in: American Journal of Transplantation, Issue 18/12, 2018, Page(s) 2873-2884, ISSN 1600-6135
DOI: 10.1111/ajt.14874

Fine Needle-Diathermy Regresses Pathological Corneal (Lymph)Angiogenesis and Promotes High-Risk Corneal Transplant Survival

Author(s): Viet Nhat Hung Le, Ann-Charlott Schneider, Rebecca Scholz, Felix Bock, Claus Cursiefen
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
DOI: 10.1038/s41598-018-24037-3

Label-Free In Vivo Imaging of Corneal Lymphatic Vessels Using Microscopic Optical Coherence Tomography

Author(s): Jens Horstmann, Hinnerk Schulz-Hildebrandt, Felix Bock, Sebastian Siebelmann, Eva Lankenau, Gereon Hüttmann, Philipp Steven, Claus Cursiefen
Published in: Investigative Opthalmology & Visual Science, Issue 58/13, 2017, Page(s) 5880, ISSN 1552-5783
DOI: 10.1167/iovs.17-22286

Novel Method to Detect Corneal Lymphatic Vessels In Vivo by Intrastromal Injection of Fluorescein

Author(s): Viet Nhat Hung Le, Yanhong Hou, Jens Horstmann, Felix Bock, Claus Cursiefen
Published in: Cornea, Issue 37/2, 2018, Page(s) 267-271, ISSN 0277-3740
DOI: 10.1097/ico.0000000000001444

Photodynamic Therapy Leads to Time-Dependent Regression of Pathologic Corneal (Lymph) Angiogenesis and Promotes High-Risk Corneal Allograft Survival

Author(s): Yanhong Hou, Viet Nhat Hung Le, Thomas Clahsen, Ann-Charlott Schneider, Felix Bock, Claus Cursiefen
Published in: Investigative Opthalmology & Visual Science, Issue 58/13, 2017, Page(s) 5862, ISSN 1552-5783
DOI: 10.1167/iovs.17-22904

Anterior segment optical coherence tomography for the diagnosis of corneal dystrophies according to the IC3D classification

Author(s): Sebastian Siebelmann, Paula Scholz, Simon Sonnenschein, Björn Bachmann, Mario Matthaei, Claus Cursiefen, Ludwig M. Heindl
Published in: Survey of Ophthalmology, Issue 63/3, 2018, Page(s) 365-380, ISSN 0039-6257
DOI: 10.1016/j.survophthal.2017.08.001

Functional and Morphologic Alterations in Mechanical, Polymodal, and Cold Sensory Nerve Fibers of the Cornea Following Photorefractive Keratectomy

Author(s): Federico Bech, Omar González-González, Enol Artime, Joana Serrano, Ignacio Alcalde, Juana Gallar, Jesús Merayo-Lloves, Carlos Belmonte
Published in: Investigative Opthalmology & Visual Science, Issue 59/6, 2018, Page(s) 2281, ISSN 1552-5783
DOI: 10.1167/iovs.18-24007

Evaluation of the Suitability of Biocompatible Carriers as Artificial Transplants Using Cultured Porcine Corneal Endothelial Cells

Author(s): Daniele Spinozzi, Alina Miron, Marieke Bruinsma, Isabel Dapena, Itay Lavy, Perry S. Binder, Mehrdad Rafat, Silke Oellerich, Gerrit R.J. Melles
Published in: Current Eye Research, 2018, Page(s) 1-7, ISSN 0271-3683
DOI: 10.1080/02713683.2018.1536215

Ethical issues in living-related corneal tissue transplantation

Author(s): Joséphine Behaegel, Sorcha Ní Dhubhghaill, Heather Draper
Published in: Journal of Medical Ethics, Issue 45/7, 2019, Page(s) 430-434, ISSN 0306-6800
DOI: 10.1136/MEDETHICS-2018-105146

Short- and Long-Term Results of Xenogeneic-Free Cultivated Autologous and Allogeneic Limbal Epithelial Stem Cell Transplantations

Author(s): Joséphine Behaegel, Nadia Zakaria, Marie-José Tassignon, Inge Leysen, Felix Bock, Carina Koppen, Sorcha Ní Dhubhghaill
Published in: Cornea, Issue 38/12, 2019, Page(s) 1543-1549, ISSN 0277-3740
DOI: 10.1097/ico.0000000000002153

Corneal Stromal Regeneration: Current Status and Future Therapeutic Potential

Author(s): Neil Lagali
Published in: Current Eye Research, 2019, Page(s) 1-13, ISSN 0271-3683
DOI: 10.1080/02713683.2019.1663874

Corneal epithelial restoration after penetrating keratoplasty in repeated failed cultivated limbal stem cell grafts

Author(s): Joséphine Behaegel, Carina Koppen, Veerle Van Gerwen, Marie-José Tassignon, Sorcha Ní Dhubhghaill
Published in: Journal of EuCornea, Issue 2, 2019, Page(s) 6-9, ISSN 2452-4034
DOI: 10.1016/j.xjec.2019.03.001

In vitro endothelial cell migration from limbal edge-modified Quarter-DMEK grafts

Author(s): Alina Miron, Daniele Spinozzi, Sorcha Ní Dhubhghaill, Jessica T. Lie, Silke Oellerich, Gerrit R. J. Melles
Published in: PLOS ONE, Issue 14/11, 2019, Page(s) e0225462, ISSN 1932-6203
DOI: 10.1371/journal.pone.0225462

Development and Validation of an Open-Source Grading Tool for Outcome Assessment in Limbal Stem Cell Treatment

Author(s): Joséphine Behaegel, Alejandra Consejo, Kristien Wouters, Carina Koppen, Joost De Cock, Sorcha Ní Dhubhghaill
Published in: Cornea, Issue 39/6, 2020, Page(s) 787-792, ISSN 0277-3740
DOI: 10.1097/ico.0000000000002282

Safety of Cultivated Limbal Epithelial Stem Cell Transplantation for Human Corneal Regeneration

Author(s): J. Behaegel, S. Ní Dhubhghaill, C. Koppen, N. Zakaria
Published in: Stem Cells International, Issue 2017, 2017, Page(s) 1-11, ISSN 1687-966X
DOI: 10.1155/2017/6978253

The Bigger Picture of Ex Vivo Limbal Epithelial Stem Cell Transplantation

Author(s): Joséphine Behaegel
Published in: PhD Dissertation, 2019

Cultivated Limbal Stem Cell Transplantation: Indications and Technique

Author(s): Joséphine Behaegel, Sorcha Ní Dhubhghaill, Marie-José Tassignon
Published in: Corneal Regeneration - Therapy and Surgery, Issue Jan 2019, 2019, Page(s) 277-290
DOI: 10.1007/978-3-030-01304-2_19

CORNEAL NEOVASCULARIZATION: UPDATE ON PATHOGENESIS AND ADVANCES IN TREATMENT STRATEGIES

Author(s): Joséphine Behaegel, Sorcha Ní Dhubhghaill, Carina Koppen, Nadia Zakaria
Published in: International Journal of Medical and Biological Frontiers;, Issue Vol 22, 2016, ISSN 1081-3829

Need for technologies in advanced corneal research, diagnosis, and transplantation

Author(s): Neil S. Lagali
Published in: Ophthalmic Technologies XXIX, 2019, Page(s) 82
DOI: 10.1117/12.2520656