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GALAXY: Gut-and-liver axis in alcoholic liver fibrosis

Deliverables

Data management plan

Data management described: GALAXY will create an extensive research data warehouse containing clinical and experimental data. The partners University of Southern Denmark, Odense University Hospital, EMBL, University of Copenhagen, University of Oslo and Steno Diabetes Centre will be responsible and be involved in data management. The data management plan will be in five sections: a) Data generation and collection b) Standards used c) Data preservation d) Data security e) Data exploitation

Approvals obtained for SYN-ALD

1. Written study protocol to be used for study execution and applications to the GCP unit, ethics committee and Danish data protection agency. 2. Approvals in writing from the GCP unit, ethics committee and Danish data protection agency.

Exploitation plan and updates

Strategies to protect and exploit the results from GALAXY described: A detailed exploitation strategy will be developed at the start of the project and updated every year, including IP protection.

Project infrastructure established

1. Consortium agreement written and signed by all partners: Administration of contracts including the Grant Agreement and any future amendments, establishment and maintenance of a Consortium Agreement, handling of legal issues, coordination of activities to ensure and monitor respect of ethical rules and gender equity. Also includes IP contracts. 2. Project management plan described, including detailed description of project management structure, coordination, communication, organisational structure, decision-making mechanisms and detailed project management activities. This includes: a) Developing project management and quality assurance plans which describe the plan for project management and collaboration and coordination tools of the project. It will be created as a support to the consortium with the main goal to facilitate the collaboration between partners and ensure that EC requirements are respected. b) Standars for handling of the project correspondence and the day-to-day requests from partners and external bodies. c) Implementing and maintaining the project infrastructure and the internal collaborative website as a platform for secured internal information exchange and project documents archive (not to be confused with the public website). d) Plans for running and hosting of project meetings at months 1, 18, 36, 54 and 72: Planning, organising, executing and post-processing of major project meetings such as Annual meetings, Executive board and Work Group meetings and meetings with the Supervisory board. 3. Provided templates and standard procedures for internal progress reporting and monitoring systems and procedures. Includes progress reports, the results and the necessary changes to the work plan as a result of those findings, according to project milestones and indicators. 4. Coordinated and planned the periodic technical and financial reporting: Designing and maintaining partner-specific templates for collecting input to the required EU documents, coordination of financial and administrative issues: establish and maintain financial records, co-ordinate financial statements submission by all project partners and audit certificates as needed, follow-up of EC payments, calculate partner shares according to rules agreed in the Consortium Agreement. 6. Developed detailed communication and dissemination plan: a) Outlined the target audiences including development of tailored key messages and dissemination material (logo, templates, press releases, website, leaflets, social media, public engagement exercises etc.). b) Development of a corporate style including logos and standard templates will be developed to create and maintain a consistent and recognisable ‘corporate image’ of the network. c) Plan for dissemination activities to enable external stakeholders to become aware of, learn from and implement project results. Includes creating and maintaining links and communications on behalf of the consortium with partners and potential future collaborators within Europe and globally by e.g. newsletters, brochures, digital media platforms. d) Plan for online presence e) Plan for communication of the research results with international relevant societies and with research and public health entities (WHO) in order to secure translation into clinical practise in every or specific regions of the world. f) Organisation of conference to present the results to international press and other relevant European and international stakeholders.

Future exploitation strategy described

The exploitation plan will present options for long-term sustainability of the consortium and network after the official end of the project.

Included first 300 (75%) patients in GALA-ALD

Identified eligible patients with current or prior alcohol overuse and alcoholic liver fibrosis along the entire spectrum of disease. Eligible patients are recruited from alcohol abuse centres, outpatient liver clinics, emergency rooms and family physicians in Region of Southern Denmark and via national web adverts. Collected informed consent, tissue samples and clinical data for first 300 GALA-ALD patients. After consent a one-day inclusion visit are scheduled. We will perform: (i) liver biopsy, (ii) collection of venous fasting blood, faeces, urine and saliva, (iii) physical examinations including anthropometric data, abdominal ultrasonography, heart rate and blood pressure, (iv) non-invasive assessment of liver fibrosis using transient elastography, real-time shear-wave elastography and serum markers, (v) questionnaires evaluating alcohol use, alcohol dependency, demographic data, medicine use, comorbidity and health-related quality of life.

Tool developed for integrative metagenomics-based metatranscriptomics data analysis

1. Results from deliverable 4.1 extended by incorporating host-derived omics data (host transcriptomics, liver microRNA, blood readouts, etc.) to investigate the cross-talk between the gut microbial communities and host liver. 2. Novel algorithms developed to identify associations between gut taxonomic and/or gene functional composition and liver transcriptional activity and/or microRNA abundance.

Identified and included 100 healthy controls in GALA-HP

1. Written study protocol to be used for study execution and applications to the ethics committee and data protection agency. 2. Age- and gender-matched healthy controls identified: 100 matched controls without prior or current alcohol overuse and no malignancy, diabetes or liver-, cardiovascular-, renal- and autoimmune-related comorbidities. Controls will be recruited from libraries, train stations, emergency rooms, outpatient clinics and family physicians in Region of Southern Denmark and via national web adverts. 3. Onehundred healthy controls included: Collect informed consent, tissue samples and clinical data. Other than liver biopsy, all investigations will be performed as described in GALA-ALD.

Collaborative website ready to use

Developed, hosted and ensured continued maintenance of a public website. Includes gathering content based on partner contributions, designing the site and ensure the technical implementation

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Publications

Preemptive‐TIPS Improves Outcome in High‐Risk Variceal Bleeding: An Observational Study

Author(s): Virginia Hernández‐Gea, Bogdan Procopet, Álvaro Giráldez, Lucio Amitrano, Candid Villanueva, Dominique Thabut, Luis Ibañez‐Samaniego, Gilberto Silva‐Junior, Javier Martinez, Joan Genescà, Christophe Bureau, Jonel Trebicka, Elba Llop, Wim Laleman, Jose Maria Palazon, Jose Castellote, Susana Rodrigues, Lise L. Gluud, Carlos Noronha Ferreira, Rafael Barcelo, Nuria Cañete, Manuel Rodrígue
Published in: Hepatology, 2018, ISSN 0270-9139
DOI: 10.1002/hep.30182

Cost‐Effectiveness of Noninvasive Screening for Alcohol‐Related Liver Fibrosis

Author(s): Lars Asphaug, Maja Thiele, Aleksander Krag, Hans Olav Melberg
Published in: Hepatology, Issue 71/6, 2020, Page(s) 2093-2104, ISSN 0270-9139
DOI: 10.1002/hep.30979

Differential inflammasome activation predisposes to acute-on-chronic liver failure in human and experimental cirrhosis with and without previous decompensation

Author(s): Sofia Monteiro, Josephine Grandt, Frank Erhard Uschner, Nina Kimer, Jan Lysgård Madsen, Robert Schierwagen, Sabine Klein, Christoph Welsch, Liliana Schäfer, Christian Jansen, Joan Claria, José Alcaraz-Quiles, Vicente Arroyo, Richard Moreau, Javier Fernandez, Flemming Bendtsen, Gautam Mehta, Lise Lotte Gluud, Søren Møller, Michael Praktiknjo, Jonel Trebicka
Published in: Gut, 2020, Page(s) gutjnl-2019-320170, ISSN 0017-5749
DOI: 10.1136/gutjnl-2019-320170

The Development and Outcome of Acute‐on‐Chronic Liver Failure After Surgical Interventions

Author(s): Leah Maria Klein, Johannes Chang, Wenyi Gu, Steffen Manekeller, Christian Jansen, Philipp Lingohr, Michael Praktiknjo, Jörg C. Kalf, Martin Schulz, Ulrich Spengler, Christian Strassburg, Andrés Cárdenas, Vicente Arroyo, Jonel Trebicka
Published in: Liver Transplantation, Issue 26/2, 2019, Page(s) 227-237, ISSN 1527-6465
DOI: 10.1002/lt.25675

TGR(mREN2)27 rats develop non-alcoholic fatty liver disease-associated portal hypertension responsive to modulations of Janus-kinase 2 and Mas receptor

Author(s): Sabine Klein, Carola-Ellen Kleine, Andrea Pieper, Michaela Granzow, Sebastian Gautsch, Mimoun Himmit, Katharina Kahrmann, Robert Schierwagen, Frank Erhard Uschner, Fernando Magdaleno, Maria Eleni Naoum, Glen Kristiansen, Thomas Walther, Michael Bader, Tilman Sauerbruch, Jonel Trebicka
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
DOI: 10.1038/s41598-019-48024-4

Combination of CCl 4 with alcoholic and metabolic injuries mimics human liver fibrosis

Author(s): Maximilian Joseph Brol, Felicitas Rösch, Robert Schierwagen, Fernando Magdaleno, Frank Erhard Uschner, Steffen Manekeller, Alexander Queck, Katharina Schwarzkopf, Margarete Odenthal, Uta Drebber, Maja Thiele, Philipp Lingohr, Andreas Plamper, Glen Kristiansen, Sophie Lotersztajn, Aleksander Krag, Sabine Klein, Karl P. Rheinwalt, Jonel Trebicka
Published in: American Journal of Physiology-Gastrointestinal and Liver Physiology, Issue 317/2, 2019, Page(s) G182-G194, ISSN 0193-1857
DOI: 10.1152/ajpgi.00361.2018

Prediction of liver fibrosis severity in alcoholic liver disease by human microfibrillar‐associated protein 4

Author(s): Bjørn S. Madsen, Maja Thiele, Sönke Detlefsen, Mia D. Sørensen, Maria Kjærgaard, Linda S. Møller, Ditlev N. Rasmussen, Anders Schlosser, Uffe Holmskov, Jonel Trebicka, Grith L. Sorensen, Aleksander Krag
Published in: Liver International, Issue 40/7, 2020, Page(s) 1701-1712, ISSN 1478-3223
DOI: 10.1111/liv.14491

Transient elastography for screening of liver fibrosis: Cost-effectiveness analysis from six prospective cohorts in Europe and Asia

Author(s): Miquel Serra-Burriel, Isabel Graupera, Pere Torán, Maja Thiele, Dominique Roulot, Vincent Wai-Sun Wong, Indra Neil Guha, Núria Fabrellas, Anita Arslanow, Carmen Expósito, Rosario Hernández, Grace Lai-Hung Wong, David Harman, Sarwa Darwish Murad, Aleksander Krag, Guillem Pera, Paolo Angeli, Peter Galle, Guruprasad P. Aithal, Llorenç Caballeria, Laurent Castera, Pere Ginès, Frank Lammert
Published in: Journal of Hepatology, Issue 71/6, 2019, Page(s) 1141-1151, ISSN 0168-8278
DOI: 10.1016/j.jhep.2019.08.019

Recent Advances in Practical Methods for Liver Cell Biology: A Short Overview

Author(s): Sandra Torres, Zeinab Abdullah, Maximilian J Brol, Claus Hellerbrand, Mercedes Fernandez, Romina Fiorotto, Sabine Klein, Philipp Königshofer, Christian Liedtke, Sophie Lotersztajn, Yulia A. Nevzorova, Robert Schierwagen, Thomas Reiberger, Frank Erhard Uschner, Frank Tacke, Ralf Weiskirchen, Jonel Trebicka
Published in: International Journal of Molecular Sciences, Issue 21/6, 2020, Page(s) 2027, ISSN 1422-0067
DOI: 10.3390/ijms21062027

Total area of spontaneous portosystemic shunts independently predicts hepatic encephalopathy and mortality in liver cirrhosis

Author(s): Michael Praktiknjo, Macarena Simón-Talero, Julia Römer, Davide Roccarina, Javier Martínez, Katharina Lampichler, Anna Baiges, Gavin Low, Elba Llop, Martin H. Maurer, Alexander Zipprich, Michela Triolo, Geert Maleux, Annette Dam Fialla, Claus Dam, Judit Vidal-González, Avik Majumdar, Carmen Picón, Daniel Toth, Anna Darnell, Juan G. Abraldes, Marta López, Christian Jansen, Johannes Chang, Robe
Published in: Journal of Hepatology, Issue 72/6, 2020, Page(s) 1140-1150, ISSN 0168-8278
DOI: 10.1016/j.jhep.2019.12.021

2D shear wave liver elastography by Aixplorer to detect portal hypertension in cirrhosis: An individual patient data meta‐analysis

Author(s): Maja Thiele, Mie B. Hugger, Yongsoo Kim, Pierre‐Emmanuel Rautou, Laure Elkrief, Christian Jansen, Wim Verlinden, Giulia Allegretti, Mads Israelsen, Horia Stefanescu, Fabio Piscaglia, Juan C. García‐Pagán, Sven Franque, Annalisa Berzigotti, Laurent Castera, Woo K. Jeong, Jonel Trebicka, Aleksander Krag
Published in: Liver International, Issue 40/6, 2020, Page(s) 1435-1446, ISSN 1478-3223
DOI: 10.1111/liv.14439

From the Argonauts Mythological Sailors to the Argonautes RNA-Silencing Navigators: Their Emerging Roles in Human-Cell Pathologies

Author(s): Vasiliki I. Pantazopoulou, Stella Georgiou, Panos Kakoulidis, Stavroula N. Giannakopoulou, Sofia Tseleni, Dimitrios J. Stravopodis, Ema Anastasiadou
Published in: International Journal of Molecular Sciences, Issue 21/11, 2020, Page(s) 4007, ISSN 1422-0067
DOI: 10.3390/ijms21114007

Combination of phosphodiesterase‐5‐inhibitors and beta blockers improves experimental portal hypertension and erectile dysfunction

Author(s): Frank E. Uschner, Kathleen Glückert, Rafael Paternostro, Thorsten Gnad, Robert Schierwagen, Mattias Mandorfer, Fernando Magdaleno, Cristina Ortiz, Katharina Schwarzkopf, Patrick S. Kamath, Carlo Alessandria, Christoph Boesecke, Alexander Pfeifer, Thomas Reiberger, Wolfgang Kreisel, Tilman Sauerbruch, Arnulf Ferlitsch, Jonel Trebicka, Sabine Klein
Published in: Liver International, Issue 40/9, 2020, Page(s) 2228-2241, ISSN 1478-3223
DOI: 10.1111/liv.14586

Role of portal venous platelet activation in patients with decompensated cirrhosis and TIPS

Author(s): Alexander Queck, Roberto Carnevale, Frank Erhard Uschner, Robert Schierwagen, Sabine Klein, Christian Jansen, Carsten Meyer, Michael Praktiknjo, Daniel Thomas, Christian Strassburg, Stefan Zeuzem, Francesco Violi, Jonel Trebicka
Published in: Gut, Issue 69/8, 2020, Page(s) 1535-1536, ISSN 0017-5749
DOI: 10.1136/gutjnl-2019-319044

Liver Transplantation for Acute‐on‐Chronic Liver Failure: Science or Fiction?

Author(s): Jonel Trebicka, Vinay Sundaram, Richard Moreau, Rajiv Jalan, Vicente Arroyo
Published in: Liver Transplantation, Issue 26/7, 2020, Page(s) 906-915, ISSN 1527-6465
DOI: 10.1002/lt.25788

Activation of the Alternate Renin-Angiotensin System Correlates with the Clinical Status in Human Cirrhosis and Corrects Post Liver Transplantation

Author(s): Stephen Casey, Robert Schierwagen, Kai Mak, Sabine Klein, Frank Uschner, Christian Jansen, Michael Praktiknjo, Carsten Meyer, Daniel Thomas, Chandana Herath, Robert Jones, Jonel Trebicka, Peter Angus
Published in: Journal of Clinical Medicine, Issue 8/4, 2019, Page(s) 419, ISSN 2077-0383
DOI: 10.3390/jcm8040419

Rebleeding and mortality risk are increased by ACLF but reduced by pre-emptive TIPS

Author(s): Jonel Trebicka, Wenyi Gu, Luis Ibáñez-Samaniego, Virginia Hernández-Gea, Carla Pitarch, Elisabet Garcia, Bogdan Procopet, Álvaro Giráldez, Lucio Amitrano, Candid Villanueva, Dominique Thabut, Gilberto Silva-Junior, Javier Martinez, Joan Genescà, Cristophe Bureau, Elba Llop, Wim Laleman, Jose Maria Palazon, Jose Castellote, Susanag Rodrigues, Liselotte Gluud, Carlos Noronha Ferreira, Rafael B
Published in: Journal of Hepatology, 2020, ISSN 0168-8278
DOI: 10.1016/j.jhep.2020.04.024

Antifibrotic and molecular aspects of rifaximin in alcoholic liver disease: study protocol for a randomized controlled trial

Author(s): Bjørn Stæhr Madsen, Jonel Trebicka, Maja Thiele, Mads Israelsen, Manimozhiyan Arumugan, Troels Havelund, Aleksander Krag
Published in: Trials, Issue 19/1, 2018, ISSN 1745-6215
DOI: 10.1186/s13063-018-2523-9

The soluble guanylate cyclase stimulator riociguat reduces fibrogenesis and portal pressure in cirrhotic rats

Author(s): Philipp Schwabl, Ksenia Brusilovskaya, Paul Supper, David Bauer, Philipp Königshofer, Florian Riedl, Hubert Hayden, Claudia Daniela Fuchs, Judith Stift, Georg Oberhuber, Stefan Aschauer, Diana Bonderman, Thorsten Gnad, Alexander Pfeifer, Frank Erhard Uschner, Jonel Trebicka, Nataliya Rohr-Udilova, Bruno Karl Podesser, Markus Peck-Radosavljevic, Michael Trauner, Thomas Reiberger
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
DOI: 10.1038/s41598-018-27656-y

Left Ventricular Longitudinal Contractility Predicts Acute-on-Chronic Liver Failure Development and Mortality After Transjugular Intrahepatic Portosystemic Shunt

Author(s): Christian Jansen, Anna Schröder, Robert Schueler, Jennifer Lehmann, Michael Praktiknjo, Frank E. Uschner, Robert Schierwagen, Daniel Thomas, Sofia Monteiro, Georg Nickenig, Christian P. Strassburg, Carsten Meyer, Vicente Arroyo, Christoph Hammerstingl, Jonel Trebicka
Published in: Hepatology Communications, 2019, ISSN 2471-254X
DOI: 10.1002/hep4.1308

Acute decompensation boosts hepatic collagen type III deposition and deteriorates experimental and human cirrhosis

Author(s): Michael Praktiknjo, Jennifer Lehmann, Mette J. Nielsen, Robert Schierwagen, Frank E. Uschner, Carsten Meyer, Daniel Thomas, Christian P. Strassburg, Flemming Bendtsen, Søren Møller, Aleksander Krag, Morten A. Karsdal, Diana J. Leeming, Jonel Trebicka
Published in: Hepatology Communications, Issue 2/2, 2018, Page(s) 211-222, ISSN 2471-254X
DOI: 10.1002/hep4.1135

Accuracy of the Enhanced Liver Fibrosis Test vs FibroTest, Elastography, and Indirect Markers in Detection of Advanced Fibrosis in Patients With Alcoholic Liver Disease

Author(s): Maja Thiele, Bjørn Stæhr Madsen, Janne Fuglsang Hansen, Sönke Detlefsen, Steen Antonsen, Aleksander Krag
Published in: Gastroenterology, Issue 154/5, 2018, Page(s) 1369-1379, ISSN 0016-5085
DOI: 10.1053/j.gastro.2018.01.005

MicroRNA-155 is upregulated in ascites in patients with spontaneous bacterial peritonitis

Author(s): Philipp Lutz, Mohamed M´haimid, Alessandra Pohlmann, Jennifer Lehmann, Christian Jansen, Robert Schierwagen, Sabine Klein, Christian P. Strassburg, Ulrich Spengler, Jonel Trebicka
Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
DOI: 10.1038/srep40556

γ-Glutamyl Transferase Is an Independent Biomarker of Splanchnic Thrombosis in Patients With Myeloproliferative Neoplasm

Author(s): Görtzen, Jan; Hunka, Lena M.; Vonnahme, Maria; Praktiknjo, Michael; Kaifie, Andrea; Fimmers, Rolf; Jansen, Christian; Heine, Annkristin; Lehmann, Jennifer; Goethert, Joachim R.; Gattermann, Norbert; Goekkurt, Eray; Platzbecker, Uwe; Brossart, Peter; Strassburg, Christian P.; Brummendorf, Tim H.; Koschmieder, Steffen; Wolf, Dominik; Trebicka, Jonel
Published in: Medicine 95(20), e3355 (2016). doi:10.18154/RWTH-CONV-211209, Issue 6, 2016, ISSN 0025-7974
DOI: 10.18154/RWTH-CONV-211209

Evolution of nodule stiffness might predict response to local ablative therapy: A series of patients with hepatocellular carcinoma

Author(s): Michael Praktiknjo, Viktoria Krabbe, Alessandra Pohlmann, Matthias Sampels, Christian Jansen, Carsten Meyer, Christian P. Strassburg, Jonel Trebicka, Maria A. Gonzalez Carmona
Published in: PLOS ONE, Issue 13/2, 2018, Page(s) e0192897, ISSN 1932-6203
DOI: 10.1371/journal.pone.0192897

Compartmentalization of Immune Response and Microbial Translocation in Decompensated Cirrhosis

Author(s): Camila Alvarez-Silva, Robert Schierwagen, Alessandra Pohlmann, Fernando Magdaleno, Frank E. Uschner, Patrick Ryan, Maria J. G. T. Vehreschild, Joan Claria, Eicke Latz, Benjamin Lelouvier, Manimozhiyan Arumugam, Jonel Trebicka
Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224
DOI: 10.3389/fimmu.2019.00069

Collagen type IV remodeling gender-specifically predicts mortality in decompensated liver cirrhosis

Author(s): Jennifer Lehmann, Michael Praktiknjo, Mette Juul Nielsen, Robert Schierwagen, Carsten Meyer, Daniel Thomas, Francesco Violi, Christian P. Strassburg, Flemming Bendtsen, Søren Møller, Aleksander Krag, Morten Asser Karsdal, Diana Julie Leeming, Jonel Trebicka
Published in: Liver International, 2019, ISSN 1478-3223
DOI: 10.1111/liv.14070

Rho-kinase inhibitor coupled to peptide-modified albumin carrier reduces portal pressure and increases renal perfusion in cirrhotic rats

Author(s): Sabine Klein, Franziska Frohn, Fernando Magdaleno, Catharina Reker-Smit, Robert Schierwagen, Irela Schierwagen, Frank Erhard Uschner, Fransien van Dijk, Dieter O. Fürst, Sonja Djudjaj, Peter Boor, Klaas Poelstra, Leonie Beljaars, Jonel Trebicka
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
DOI: 10.1038/s41598-019-38678-5

Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis

Author(s): M. Welz, S. Eickhoff, Z. Abdullah, J. Trebicka, K. H. Gartlan, J. A. Spicer, A. J. Demetris, H. Akhlaghi, M. Anton, K. Manske, D. Zehn, B. Nieswandt, C. Kurts, J. A. Trapani, P. Knolle, D. Wohlleber, W. Kastenmüller
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
DOI: 10.1038/s41467-018-07213-x

Fast Genome-Wide Functional Annotation through Orthology Assignment by eggNOG-Mapper

Author(s): Jaime Huerta-Cepas, Kristoffer Forslund, Luis Pedro Coelho, Damian Szklarczyk, Lars Juhl Jensen, Christian von Mering, Peer Bork
Published in: Molecular Biology and Evolution, Issue 34/8, 2017, Page(s) 2115-2122, ISSN 0737-4038
DOI: 10.1093/molbev/msx148

proGenomes: a resource for consistent functional and taxonomic annotations of prokaryotic genomes

Author(s): Daniel R. Mende, Ivica Letunic, Jaime Huerta-Cepas, Simone S. Li, Kristoffer Forslund, Shinichi Sunagawa, Peer Bork
Published in: Nucleic Acids Research, Issue 45/D1, 2017, Page(s) D529-D534, ISSN 0305-1048
DOI: 10.1093/nar/gkw989

Managing portal hypertension in patients with liver cirrhosis

Author(s): Tilman Sauerbruch, Robert Schierwagen, Jonel Trebicka
Published in: F1000Research, Issue 7, 2018, Page(s) 533, ISSN 2046-1402
DOI: 10.12688/f1000research.13943.1

Controlled attenuation parameter and alcoholic hepatic steatosis: Diagnostic accuracy and role of alcohol detoxification

Author(s): Maja Thiele, Vanessa Rausch, Gabriele Fluhr, Maria Kjærgaard, Felix Piecha, Johannes Mueller, Beate Katharina Straub, Monica Lupșor-Platon, Victor De-Ledinghen, Helmut Karl Seitz, Sönke Detlefsen, Bjørn Madsen, Aleksander Krag, Sebastian Mueller
Published in: Journal of Hepatology, Issue 68/5, 2018, Page(s) 1025-1032, ISSN 0168-8278
DOI: 10.1016/j.jhep.2017.12.029

Describing the fecal metabolome in cryogenically collected samples from healthy participants

Author(s): Kajetan Trošt, Linda Ahonen, Tommi Suvitaival, Nina Christiansen, Trine Nielsen, Maja Thiele, Suganya Jacobsen, Aleksander Krag, Peter Rossing, Torben Hansen, Lars Ove Dragsted, Cristina Legido-Quigley
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
DOI: 10.1038/s41598-020-57888-w

Sarcopenia Is Associated With Development of Acute-on-Chronic Liver Failure in Decompensated Liver Cirrhosis Receiving Transjugular Intrahepatic Portosystemic Shunt

Author(s): Michael Praktiknjo, Caroline Clees, Alessandra Pigliacelli, Stefan Fischer, Christian Jansen, Jennifer Lehmann, Alessandra Pohlmann, Barbara Lattanzi, Viktoria Katharina Krabbe, Christian P. Strassburg, Vicente Arroyo, Manuela Merli, Carsten Meyer, Jonel Trebicka
Published in: Clinical and Translational Gastroenterology, Issue 10/4, 2019, Page(s) e00025, ISSN 2155-384X
DOI: 10.14309/ctg.0000000000000025

Systemic MCP-1 Levels Derive Mainly From Injured Liver and Are Associated With Complications in Cirrhosis

Author(s): Alexander Queck, Hannah Bode, Frank E. Uschner, Maximilian J. Brol, Christiana Graf, Martin Schulz, Christian Jansen, Michael Praktiknjo, Robert Schierwagen, Sabine Klein, Christian Trautwein, Hermann E. Wasmuth, Marie-Luise Berres, Jonel Trebicka, Jennifer Lehmann
Published in: Frontiers in Immunology, Issue 11, 2020, ISSN 1664-3224
DOI: 10.3389/fimmu.2020.00354

Pathophysiological role of prostanoids in coagulation of the portal venous system in liver cirrhosis

Author(s): Alexander Queck, Dominique Thomas, Christian Jansen, Yannick Schreiber, Sabrina Rüschenbaum, Michael Praktiknjo, Katharina Maria Schwarzkopf, Marcus Maximilian Mücke, Robert Schierwagen, Frank Erhard Uschner, Carsten Meyer, Joan Clària, Stefan Zeuzem, Gerd Geisslinger, Jonel Trebicka, Christian Markus Lange
Published in: PLOS ONE, Issue 14/10, 2019, Page(s) e0222840, ISSN 1932-6203
DOI: 10.1371/journal.pone.0222840

Statins: Old drugs as new therapy for liver diseases?

Author(s): Elisa Pose, Jonel Trebicka, Rajeshwar P Mookerjee, Paolo Angeli, Pere Ginès
Published in: Journal of Hepatology, Issue 70/1, 2019, Page(s) 194-202, ISSN 0168-8278
DOI: 10.1016/j.jhep.2018.07.019

Serum levels of bone sialoprotein correlate with portal pressure in patients with liver cirrhosis

Author(s): Fabian Benz, Andreas Bogen, Michael Praktiknjo, Christian Jansen, Carsten Meyer, Alexander Wree, Muenevver Demir, Sven Loosen, Mihael Vucur, Robert Schierwagen, Frank Tacke, Jonel Trebicka, Christoph Roderburg
Published in: PLOS ONE, Issue 15/4, 2020, Page(s) e0231701, ISSN 1932-6203
DOI: 10.1371/journal.pone.0231701

Short-Term Western Diet Aggravates Non-Alcoholic Fatty Liver Disease (NAFLD) With Portal Hypertension in TGR(mREN2)27 Rats

Author(s): Carla Cremonese, Robert Schierwagen, Frank Erhard Uschner, Sandra Torres, Olaf Tyc, Cristina Ortiz, Martin Schulz, Alexander Queck, Glen Kristiansen, Michael Bader, Tilman Sauerbruch, Ralf Weiskirchen, Thomas Walther, Jonel Trebicka, Sabine Klein
Published in: International Journal of Molecular Sciences, Issue 21/9, 2020, Page(s) 3308, ISSN 1422-0067
DOI: 10.3390/ijms21093308

The Role of microRNAs in the Gut-Liver Axis

Author(s): S. Georgiou, V. Pantazopoulou, Ema Anastasiadou
Published in: The Human Gut-Liver-Axis in Health and Disease, 2019, Page(s) 207-234
DOI: 10.1007/978-3-319-98890-0_13