Skip to main content

GALAXY: Gut-and-liver axis in alcoholic liver fibrosis

Deliverables

Data management plan

Data management described: GALAXY will create an extensive research data warehouse containing clinical and experimental data. The partners University of Southern Denmark, Odense University Hospital, EMBL, University of Copenhagen, University of Oslo and Steno Diabetes Centre will be responsible and be involved in data management. The data management plan will be in five sections: a) Data generation and collection b) Standards used c) Data preservation d) Data security e) Data exploitation

Approvals obtained for SYN-ALD

1. Written study protocol to be used for study execution and applications to the GCP unit, ethics committee and Danish data protection agency. 2. Approvals in writing from the GCP unit, ethics committee and Danish data protection agency.

Exploitation plan and updates

Strategies to protect and exploit the results from GALAXY described: A detailed exploitation strategy will be developed at the start of the project and updated every year, including IP protection.

Project infrastructure established

1. Consortium agreement written and signed by all partners: Administration of contracts including the Grant Agreement and any future amendments, establishment and maintenance of a Consortium Agreement, handling of legal issues, coordination of activities to ensure and monitor respect of ethical rules and gender equity. Also includes IP contracts. 2. Project management plan described, including detailed description of project management structure, coordination, communication, organisational structure, decision-making mechanisms and detailed project management activities. This includes: a) Developing project management and quality assurance plans which describe the plan for project management and collaboration and coordination tools of the project. It will be created as a support to the consortium with the main goal to facilitate the collaboration between partners and ensure that EC requirements are respected. b) Standars for handling of the project correspondence and the day-to-day requests from partners and external bodies. c) Implementing and maintaining the project infrastructure and the internal collaborative website as a platform for secured internal information exchange and project documents archive (not to be confused with the public website). d) Plans for running and hosting of project meetings at months 1, 18, 36, 54 and 72: Planning, organising, executing and post-processing of major project meetings such as Annual meetings, Executive board and Work Group meetings and meetings with the Supervisory board. 3. Provided templates and standard procedures for internal progress reporting and monitoring systems and procedures. Includes progress reports, the results and the necessary changes to the work plan as a result of those findings, according to project milestones and indicators. 4. Coordinated and planned the periodic technical and financial reporting: Designing and maintaining partner-specific templates for collecting input to the required EU documents, coordination of financial and administrative issues: establish and maintain financial records, co-ordinate financial statements submission by all project partners and audit certificates as needed, follow-up of EC payments, calculate partner shares according to rules agreed in the Consortium Agreement. 6. Developed detailed communication and dissemination plan: a) Outlined the target audiences including development of tailored key messages and dissemination material (logo, templates, press releases, website, leaflets, social media, public engagement exercises etc.). b) Development of a corporate style including logos and standard templates will be developed to create and maintain a consistent and recognisable ‘corporate image’ of the network. c) Plan for dissemination activities to enable external stakeholders to become aware of, learn from and implement project results. Includes creating and maintaining links and communications on behalf of the consortium with partners and potential future collaborators within Europe and globally by e.g. newsletters, brochures, digital media platforms. d) Plan for online presence e) Plan for communication of the research results with international relevant societies and with research and public health entities (WHO) in order to secure translation into clinical practise in every or specific regions of the world. f) Organisation of conference to present the results to international press and other relevant European and international stakeholders.

Future exploitation strategy described

The exploitation plan will present options for long-term sustainability of the consortium and network after the official end of the project.

Included first 300 (75%) patients in GALA-ALD

Identified eligible patients with current or prior alcohol overuse and alcoholic liver fibrosis along the entire spectrum of disease. Eligible patients are recruited from alcohol abuse centres, outpatient liver clinics, emergency rooms and family physicians in Region of Southern Denmark and via national web adverts. Collected informed consent, tissue samples and clinical data for first 300 GALA-ALD patients. After consent a one-day inclusion visit are scheduled. We will perform: (i) liver biopsy, (ii) collection of venous fasting blood, faeces, urine and saliva, (iii) physical examinations including anthropometric data, abdominal ultrasonography, heart rate and blood pressure, (iv) non-invasive assessment of liver fibrosis using transient elastography, real-time shear-wave elastography and serum markers, (v) questionnaires evaluating alcohol use, alcohol dependency, demographic data, medicine use, comorbidity and health-related quality of life.

Tool developed for integrative metagenomics-based metatranscriptomics data analysis

1. Results from deliverable 4.1 extended by incorporating host-derived omics data (host transcriptomics, liver microRNA, blood readouts, etc.) to investigate the cross-talk between the gut microbial communities and host liver. 2. Novel algorithms developed to identify associations between gut taxonomic and/or gene functional composition and liver transcriptional activity and/or microRNA abundance.

Treated and evaluated patients in SYN-ALD

1 Profermin and matching placebo produced and labelled for central randomisation Due to the perishable nature of the intervention active drug and placebo will be produced continuously2 Fourty patients treated followed and evaluated at endoftreatmentTreat with Profermin or placebo The mixtures are provided by Nordic Rebalance Patients are investigated at day 0 and seen again at four visits until month 6 A project nurse registers compliance sideeffects alcohol use and adverse events NR will gather clinical data during treatment in parallel with the participating hospital Undertake endoftreatment investigations All investigations will be performed as described in 12 including a liver biopsy

Identified and included 100 healthy controls in GALA-HP

1. Written study protocol to be used for study execution and applications to the ethics committee and data protection agency. 2. Age- and gender-matched healthy controls identified: 100 matched controls without prior or current alcohol overuse and no malignancy, diabetes or liver-, cardiovascular-, renal- and autoimmune-related comorbidities. Controls will be recruited from libraries, train stations, emergency rooms, outpatient clinics and family physicians in Region of Southern Denmark and via national web adverts. 3. Onehundred healthy controls included: Collect informed consent, tissue samples and clinical data. Other than liver biopsy, all investigations will be performed as described in GALA-ALD.

Identified and included 40 patients in SYN-ALD

1 Patients identified with current or prior alcohol overuse and alcoholic liver fibrosis based on the current available stateoftheart noninvasive biomarkers Inclusion criteria also includes a dysbiotic microbiome as defined by WP4 Eligible patients are recruited from alcohol abuse centres outpatient liver clinics emergency rooms and family physicians in Region of Southern Denmark and via national web adverts2 Eighty patients included Collect informed consent After consent patients will be randomised in a 11 doubleblind manner Randomisation stratifies according to drinking status and degree of fibrosis After randomisation all investigations will be performed as described in 12 except liver biopsy

Included, treated and evaluated 136 patients in GAB-ALD

1 Patients identified from GALAALD with established liver disease based on liver histology fibrosis degree F03 The study will include both ongoing alcohol abusers and nondrinkers to elucidate the impact of alcohol on the microbiome2 Onehundredthirty six patients included in GABALD Collect informed consent After consent patients will be randomised in a doubleblind manner Randomisation stratifies according to drinking status and degree of fibrosis After randomisation all investigations will be performed as described in 12 except liver biopsyPatients treated followed and evaluated at endoftreatment Treat with Rifaximin or placebo The tablets are provided by Norgine Patients are investigated at day 0 and seen again at month 1 2 4 6 8 10 12 14 16 and 18 A project nurse registers compliance sideeffects alcohol use and adverse events Undertake endoftreatment investigations All investigations will be performed as described in 12 including a liver biopsy

Collaborative website ready to use

Developed, hosted and ensured continued maintenance of a public website. Includes gathering content based on partner contributions, designing the site and ensure the technical implementation

Publications

Preemptive‐TIPS Improves Outcome in High‐Risk Variceal Bleeding: An Observational Study

Author(s): Virginia Hernández‐Gea, Bogdan Procopet, Álvaro Giráldez, Lucio Amitrano, Candid Villanueva, Dominique Thabut, Luis Ibañez‐Samaniego, Gilberto Silva‐Junior, Javier Martinez, Joan Genescà, Christophe Bureau, Jonel Trebicka, Elba Llop, Wim Laleman, Jose Maria Palazon, Jose Castellote, Susana Rodrigues, Lise L. Gluud, Carlos Noronha Ferreira, Rafael Barcelo, Nuria Cañete, Manuel Rodrígue
Published in: Hepatology, 2018, ISSN 0270-9139
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/hep.30182

Cost‐Effectiveness of Noninvasive Screening for Alcohol‐Related Liver Fibrosis

Author(s): Lars Asphaug, Maja Thiele, Aleksander Krag, Hans Olav Melberg
Published in: Hepatology, 71/6, 2020, Page(s) 2093-2104, ISSN 0270-9139
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/hep.30979

Variceal bleeding has increased mortality compared to nonvariceal bleeding only in males

Author(s): Erasmus, Hans-Peter; Bektas, Rukiye; Orland, Katharina; Trifonova, Svetlozara; Gu, Wen-Yi; Uschner, Frank Erharda; Brol, Maximilian J.; Chang, Johannes; Praktiknjo, Michael; Strassburg, Christian P.; Trebicka, Jonel; Jansen, Christian
Published in: European Journal of Gastroenterology and Hepatology, 2021, ISSN 1473-5687
Publisher: Wolters Kluwer Health, Inc.
DOI: 10.1097/meg.0000000000001964

Stage-dependent expression of fibrogenic markers in alcohol-related liver disease

Author(s): Mia Dahl Sørensen, Maja Thiele, Aleksander Krag, Samuel Joseph Daniels, Diana Julie Leeming, Morten Karsdal, Sönke Detlefsen
Published in: Pathology - Research and Practice, 2022, ISSN 0344-0338
Publisher: Elsevier BV
DOI: 10.1016/j.prp.2022.153798

β-Arrestin2 is increased in liver fibrosis in humans and rodents

Author(s): Robert Schierwagen; Peter Dietrich; Sabine Klein; Frank Erhard Uschner; Cristina Ortiz; Olaf Tyc; Sandra Torres; Claus Hellerbrand; Tilman Sauerbruch; Jonel Trebicka
Published in: PNAS, 1, 2020, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2014337117

Controlled underdilation using novel VIATORR® controlled expansion stents improves survival after transjugular intrahepatic portosystemic shunt implantation

Author(s): MichaelPraktiknjo, JasminAbu-Omar, JohannesChang, DanielThomas2ChristianJansen, PatrickKupczyk2FilippoSchepis3Juan CarlosGarcia-Pagan, ManuelaMerli, CarstenMeyer, Christian P.Strassburg, Claus C.Pieper, JonelTrebicka
Published in: JHEP Reports, 2021, ISSN 2589-5559
Publisher: Elsevier
DOI: 10.1016/j.jhepr.2021.100264.

Differential inflammasome activation predisposes to acute-on-chronic liver failure in human and experimental cirrhosis with and without previous decompensation

Author(s): Sofia Monteiro, Josephine Grandt, Frank Erhard Uschner, Nina Kimer, Jan Lysgård Madsen, Robert Schierwagen, Sabine Klein, Christoph Welsch, Liliana Schäfer, Christian Jansen, Joan Claria, José Alcaraz-Quiles, Vicente Arroyo, Richard Moreau, Javier Fernandez, Flemming Bendtsen, Gautam Mehta, Lise Lotte Gluud, Søren Møller, Michael Praktiknjo, Jonel Trebicka
Published in: Gut, 2020, Page(s) gutjnl-2019-320170, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2019-320170

Extrahepatic Surgery in Cirrhosis Significantly Increases Portal Pressure in Preclinical Animal Models

Author(s): Johannes Chang, Jonathan Meinke, Moritz Geck, Marc Hebest, Nina Böhling, Ramona Dolscheid-Pommerich, Birgit Stoffel-Wagner, Glen Kristiansen, Marcus Overhaus, Leon O. Peyman, Sabine Klein, Frank E. Uschner, Maximilian J. Brol, Tim O. Vilz, Philipp Lingohr, Jörg C. Kalff, Christian Jansen, Christian P. Strassburg, Sven Wehner, Jonel Trebicka, and Michael Praktiknjo
Published in: Frontiers in Physiology, 2021, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2021.720898.

The Development and Outcome of Acute‐on‐Chronic Liver Failure After Surgical Interventions

Author(s): Leah Maria Klein, Johannes Chang, Wenyi Gu, Steffen Manekeller, Christian Jansen, Philipp Lingohr, Michael Praktiknjo, Jörg C. Kalf, Martin Schulz, Ulrich Spengler, Christian Strassburg, Andrés Cárdenas, Vicente Arroyo, Jonel Trebicka
Published in: Liver Transplantation, 26/2, 2019, Page(s) 227-237, ISSN 1527-6465
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/lt.25675

TGR(mREN2)27 rats develop non-alcoholic fatty liver disease-associated portal hypertension responsive to modulations of Janus-kinase 2 and Mas receptor

Author(s): Sabine Klein, Carola-Ellen Kleine, Andrea Pieper, Michaela Granzow, Sebastian Gautsch, Mimoun Himmit, Katharina Kahrmann, Robert Schierwagen, Frank Erhard Uschner, Fernando Magdaleno, Maria Eleni Naoum, Glen Kristiansen, Thomas Walther, Michael Bader, Tilman Sauerbruch, Jonel Trebicka
Published in: Scientific Reports, 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-48024-4

Combination of CCl 4 with alcoholic and metabolic injuries mimics human liver fibrosis

Author(s): Maximilian Joseph Brol, Felicitas Rösch, Robert Schierwagen, Fernando Magdaleno, Frank Erhard Uschner, Steffen Manekeller, Alexander Queck, Katharina Schwarzkopf, Margarete Odenthal, Uta Drebber, Maja Thiele, Philipp Lingohr, Andreas Plamper, Glen Kristiansen, Sophie Lotersztajn, Aleksander Krag, Sabine Klein, Karl P. Rheinwalt, Jonel Trebicka
Published in: American Journal of Physiology-Gastrointestinal and Liver Physiology, 317/2, 2019, Page(s) G182-G194, ISSN 0193-1857
Publisher: American Physiological Society
DOI: 10.1152/ajpgi.00361.2018

Follistatin-controlled activin-HNF4α-coagulation factor axis in liver progenitor cells determines outcome of acute liver failure

Author(s): Tao Lin,Shanshan Wang,Stefan Munker,Kyounghwa Jung,Ricardo U. Macías-Rodríguez,Astrid Ruiz-Margáin,Robert Schierwagen,Hui Liu,Chen Shao,Chunlei Fan,Rilu Feng,Xiaodong Yuan,Sai Wang,Franziska Wandrer,Christoph Meyer,Ralf Wimmer,Roman Liebe,Jens Kroll,Long Zhang,Tobias Schiergens,Peter ten Dijke,Andreas Teufel,Alexander Marx,Peter R. Mertens,Hua Wang,Matthias P.A. Ebert,Heike Bantel,Enrico N. De
Published in: Hepatology, 2021, ISSN 0270-9139
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/hep.32119.

Prognostic performance of 7 biomarkers compared to liver biopsy in early alcohol-related liver disease

Author(s): Ditlev Nytoft Rasmussen; Ditlev Nytoft Rasmussen; Maja Thiele; Maja Thiele; Stine Johansen; Stine Johansen; Maria Kjærgaard; Katrine Lindvig; Katrine Lindvig; Mads Israelsen; Steen Antonsen; Steen Antonsen; Sönke Detlefsen; Sönke Detlefsen; Aleksander Krag; Aleksander Krag; Ema Anastasiadou; Manimozhian Arumugam; Peer Bork; Torben Hansen; Christina Hartoft; Hans Israelsen; Morten A. Karsdal; Cr
Published in: Journal of Hepatology, 2, 2021, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2021.05.037

Prediction of liver fibrosis severity in alcoholic liver disease by human microfibrillar‐associated protein 4

Author(s): Bjørn S. Madsen, Maja Thiele, Sönke Detlefsen, Mia D. Sørensen, Maria Kjærgaard, Linda S. Møller, Ditlev N. Rasmussen, Anders Schlosser, Uffe Holmskov, Jonel Trebicka, Grith L. Sorensen, Aleksander Krag
Published in: Liver International, 40/7, 2020, Page(s) 1701-1712, ISSN 1478-3223
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/liv.14491

Elective Surgery but not Transjugular Intrahepatic Portosystemic Shunt Precipitates Acute-On-Chronic Liver Failure

Author(s): Johannes Chang; Avend Bamarni; Nina Böhling; Xin Zhou; Leah-Marie Klein; Jonathan Meinke; Georg D. Duerr; Philipp Lingohr; Sven Wehner; Maximilian J. Brol; Jürgen K. Rockstroh; Jörg C. Kalff; Steffen Manekeller; Carsten H. Meyer; Ulrich Spengler; Christian Jansen; Vicente Arroyo; Christian P. Strassburg; Jonel Trebicka; Michael Praktiknjo
Published in: Hepatology Communications, 2021, ISSN 2471-254X
Publisher: Wiley
DOI: 10.1002/hep4.1712

Impact of transjugular intrahepatic portosystemic shunt creation on the central lymphatic system in liver cirrhosis

Author(s): Claus Christian Pieper, Andreas Feißt, Carsten Meyer, Julian Luetkens, Michael Praktiknjo, Jonel Trebicka, Ulrike Attenberger & Christian Jansen
Published in: Scientific Reports, 2021, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-021-86006-7

A Dynamic Aspartate-to-Alanine Aminotransferase Ratio Provides Valid Predictions of Incident Severe Liver Disease.

Author(s): Fredrik Åberg; Fredrik Åberg; Christopher J. Danford; Maja Thiele; Maja Thiele; Mats Talbäck; Ditlev Nytoft Rasmussen; Z. Gordon Jiang; Niklas Hammar; Patrik Nasr; Mattias Ekstedt; Anna But; Pauli Puukka; Aleksander Krag; Aleksander Krag; Jouko Sundvall; Iris Erlund; Veikko Salomaa; Per Stål; Per Stål; Stergios Kechagias; Rolf Hultcrantz; Michelle Lai; Nezam H. Afdhal; Antti Jula; Satu Männi
Published in: Hepatology communications, 2, 2021, ISSN 2471-254X
Publisher: Wiley Open Access
DOI: 10.1002/hep4.1700

The Role of Macrophage-Inducible C-Type Lectin in Different Stages of Chronic Liver Disease.

Author(s): Robert Schierwagen; Frank E. Uschner; Cristina Ortiz; Sandra Torres; Max J. Brol; Olaf Tyc; Wenyi Gu; Christian Grimm; Stefan Zeuzem; Andreas Plamper; Philipp Pfeifer; Sebastian Zimmer; Christoph Welsch; Liliana Schaefer; Karl P. Rheinwalt; Joan Clària; Vicente Arroyo; Jonel Trebicka; Jonel Trebicka; Jonel Trebicka; Jonel Trebicka; Sabine Klein
Published in: Frontiers in Immunology, 1, 2020, ISSN 1664-3224
Publisher: Frontiers Media
DOI: 10.3389/fimmu.2020.01352

Acute Decompensation and Acute-on-Chronic Liver Failure

Author(s): Philip Ferstl Dr med and Jonel Trebicka Dr med, PhD
Published in: Clinics in Liver Disease, 2021, ISSN 1089-3261
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.cld.2021.01.009

Preemptive-TIPS Improves Outcome in High-Risk Variceal Bleeding: An Observational Study

Author(s): Virginia Hernández-Gea,Bogdan Procopet,Álvaro Giráldez,Lucio Amitrano,Candid Villanueva,Dominique Thabut,Luis Ibañez-Samaniego,Gilberto Silva-Junior,Javier Martinez,Joan Genescà,Christophe Bureau,Jonel Trebicka,Elba Llop,Wim Laleman,Jose Maria Palazon,Jose Castellote,Susana Rodrigues,Lise L. Gluud,Carlos Noronha Ferreira,Rafael Barcelo,Nuria Cañete,Manuel Rodríguez,Arnulf Ferlitsch,Jose Lui
Published in: Hepatology, 2018, ISSN 0270-9139
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/hep.30182.epub2018dec10.

Transient elastography for screening of liver fibrosis: Cost-effectiveness analysis from six prospective cohorts in Europe and Asia

Author(s): Miquel Serra-Burriel, Isabel Graupera, Pere Torán, Maja Thiele, Dominique Roulot, Vincent Wai-Sun Wong, Indra Neil Guha, Núria Fabrellas, Anita Arslanow, Carmen Expósito, Rosario Hernández, Grace Lai-Hung Wong, David Harman, Sarwa Darwish Murad, Aleksander Krag, Guillem Pera, Paolo Angeli, Peter Galle, Guruprasad P. Aithal, Llorenç Caballeria, Laurent Castera, Pere Ginès, Frank Lammert
Published in: Journal of Hepatology, 71/6, 2019, Page(s) 1141-1151, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2019.08.019

Recent Advances in Practical Methods for Liver Cell Biology: A Short Overview

Author(s): Sandra Torres, Zeinab Abdullah, Maximilian J Brol, Claus Hellerbrand, Mercedes Fernandez, Romina Fiorotto, Sabine Klein, Philipp Königshofer, Christian Liedtke, Sophie Lotersztajn, Yulia A. Nevzorova, Robert Schierwagen, Thomas Reiberger, Frank Erhard Uschner, Frank Tacke, Ralf Weiskirchen, Jonel Trebicka
Published in: International Journal of Molecular Sciences, 21/6, 2020, Page(s) 2027, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21062027

Role of circulating angiogenin levels in portal hypertension and TIPS

Author(s): Alexander Queck, Frank E. Uschner, Philip G. Ferstl, Martin Schulz, Maximilian J. Brol, Michael Praktiknjo, Robert Schierwagen, Sabine Klein, Christian P. Strassburg, Carsten Meyer, Christian Jansen , Marie-Luise Berres , Jonel Trebicka
Published in: PLOS ONE, 2021, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0256473.

PRO-C3 and ADAPT algorithm accurately identify patients with advanced fibrosis due to alcohol-related liver disease.

Author(s): Bjørn Stæhr Madsen; Maja Thiele; Sönke Detlefsen; Sönke Detlefsen; Maria Kjærgaard; Linda Maria Sevelsted Møller; Jonel Trebicka; Mette Juul Nielsen; Natasja Stæhr Gudmann; Diana Julie Leeming; Morten A. Karsdal; Aleksander Krag
Published in: Alimentary Pharmacology and Therapeutics, 2, 2021, ISSN 1365-2036
Publisher: John Wiley & Sons Ltd
DOI: 10.1111/apt.16513

Portal hypertension in cirrhosis: Pathophysiological mechanisms and therapy

Author(s): YasukoIwakiri, JonelTrebicka
Published in: JHEP Reports, 2021, ISSN 2589-5559
Publisher: Elsevier
DOI: 10.1016/j.jhepr.2021.100316

Additional file 1: of Antifibrotic and molecular aspects of rifaximin in alcoholic liver disease: study protocol for a randomized controlled trial

Author(s): BjøRn Madsen; Jonel Trebicka; Thiele, Maja; Israelsen, Mads; Manimozhiyan Arumugan; Havelund, Troels; Krag, Aleksander
Published in: Trials, 2, 2018, ISSN 1745-6215
Publisher: BioMed Central
DOI: 10.6084/m9.figshare.5927761

Total area of spontaneous portosystemic shunts independently predicts hepatic encephalopathy and mortality in liver cirrhosis

Author(s): Michael Praktiknjo, Macarena Simón-Talero, Julia Römer, Davide Roccarina, Javier Martínez, Katharina Lampichler, Anna Baiges, Gavin Low, Elba Llop, Martin H. Maurer, Alexander Zipprich, Michela Triolo, Geert Maleux, Annette Dam Fialla, Claus Dam, Judit Vidal-González, Avik Majumdar, Carmen Picón, Daniel Toth, Anna Darnell, Juan G. Abraldes, Marta López, Christian Jansen, Johannes Chang, Robe
Published in: Journal of Hepatology, 72/6, 2020, Page(s) 1140-1150, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2019.12.021

2D shear wave liver elastography by Aixplorer to detect portal hypertension in cirrhosis: An individual patient data meta‐analysis

Author(s): Maja Thiele, Mie B. Hugger, Yongsoo Kim, Pierre‐Emmanuel Rautou, Laure Elkrief, Christian Jansen, Wim Verlinden, Giulia Allegretti, Mads Israelsen, Horia Stefanescu, Fabio Piscaglia, Juan C. García‐Pagán, Sven Franque, Annalisa Berzigotti, Laurent Castera, Woo K. Jeong, Jonel Trebicka, Aleksander Krag
Published in: Liver International, 40/6, 2020, Page(s) 1435-1446, ISSN 1478-3223
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/liv.14439

Effect of sarcopenia on survival in patients with cirrhosis: A meta-analysis

Author(s): Xinxing Tantai, Yi Liu, Yee Hui Yeo, Michael Praktiknjo, Ezequiel Mauro, Yuhei Hamaguchi, Cornelius Engelmann, Peng Zhang, Jae Yoon Jeong, Jeroen Laurens Ad van Vugt, Huijuan Xiao, Huan Deng, Xu Gao, Qing Ye, Jiayuan Zhang, Longbao Yang, Yaqin Cai, Yixin Liu, Na Liu, Zongfang Li, Tao Han, Toshimi Kaido, Joo Hyun Sohn, Christian Strassburg, Thomas Berg, Jonel Trebicka, Yao-Chun Hsu, Jan Nicolaas Ma
Published in: Journal of Hepatology, 2022, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2021.11.006.

Stratifying the risk of NAFLD in patients with HIV under combination antiretroviral therapy (cART)

Author(s): Jenny Bischoffa, Wenyi Gu, Carolynne Schwarze-Zander, Christoph BoeseckeacJan-Christian Wasmuth, Kathrinvan Bremen, Leona Dold, Jürgen K Rockstrohac, JonelTrebicka
Published in: E Clinical Medicine part of the LANCET Discovery Science, 2021, ISSN 2589-5370
Publisher: Elsevier
DOI: 10.1016/j.eclinm.2021.101116.

From the Argonauts Mythological Sailors to the Argonautes RNA-Silencing Navigators: Their Emerging Roles in Human-Cell Pathologies

Author(s): Vasiliki I. Pantazopoulou, Stella Georgiou, Panos Kakoulidis, Stavroula N. Giannakopoulou, Sofia Tseleni, Dimitrios J. Stravopodis, Ema Anastasiadou
Published in: International Journal of Molecular Sciences, 21/11, 2020, Page(s) 4007, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21114007

Communications via the Small Leucine-rich Proteoglycans: Molecular Specificity in Inflammation and Autoimmune Diseases

Author(s): Jinyang Zeng-Brouwers, Sony Pandey, Jonel Trebicka, Malgorzata Wygrecka, Liliana Schaefer
Published in: Journal of Histochemistry & Cytochemistry, 2020, ISSN 0022-1554
Publisher: Histochemical Society
DOI: 10.1369/0022155420930303

Acute-on-chronic liver failure: a global disease

Author(s): Martin Schulz, Jonel Trebicka
Published in: GUT, 2021, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2020-323973

Granulocyte-colony stimulating factor (G-CSF) to treat acute-on-chronic liver failure: A multicenter randomized trial (GRAFT study)

Author(s): Cornelius Engelmann, Adam Herber, Annegret Franke, Tony Bruns, Philipp Reuken, Ingolf Schiefke, Alexander Zipprich, Stefan Zeuzem, Tobias Goeser, Ali Canbay, Christoph Berg, Jonel Trebicka, Frank E. Uschner, Johannes Chang, Tobias Mueller, Niklas Aehling, Moritz Schmelzle, Katrin Splith, Frank Lammert, Christian M. Lange, Christoph Sarrazin, Christian Trautwein, Michael Manns, Dieter Häussinger,
Published in: Journal of Hepatology, 2021, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2021.07.033.

Alteration of contrast enhanced ultrasound (CEUS) of hepatocellular carcinoma in patients with cirrhosis and transjugular intrahepatic portosystemic shunt (TIPS).

Author(s): Johannes Chang; Alexia Dumitrache; N Böhling; J Abu-Omar; Carsten Meyer; Deike Strobel; Julian A. Luetkens; Andreas Minh Luu; Jürgen K. Rockstroh; Christian P. Strassburg; Jonel Trebicka; Maria A. Gonzalez-Carmona; Milka Marinova; Michael Praktiknjo
Published in: Scientific Reports, 2, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-77801-9

AGO2 localizes to cytokinetic protrusions in a p38-dependent manner and is needed for accurate cell division.

Author(s): Vasiliki I. Pantazopoulou; Anastasios D Delis; Stella Georgiou; Stamatis N. Pagakis; Vicky Filippa; Eleni Dragona; Ismini Kloukina; Elias Chatzitheodoridis; Jonel Trebicka; Athanassios D. Velentzas; Maja Thiele; Sarantis Gagos; Dimitris Thanos; Sofia Tseleni-Balafouta; Dimitrios J. Stravopodis; Ema Anastasiadou
Published in: Communications Biology, 1, 2021, ISSN 2399-3642
Publisher: Nature Publishing Group
DOI: 10.1038/s42003-021-02130-0

Combination of phosphodiesterase‐5‐inhibitors and beta blockers improves experimental portal hypertension and erectile dysfunction

Author(s): Frank E. Uschner, Kathleen Glückert, Rafael Paternostro, Thorsten Gnad, Robert Schierwagen, Mattias Mandorfer, Fernando Magdaleno, Cristina Ortiz, Katharina Schwarzkopf, Patrick S. Kamath, Carlo Alessandria, Christoph Boesecke, Alexander Pfeifer, Thomas Reiberger, Wolfgang Kreisel, Tilman Sauerbruch, Arnulf Ferlitsch, Jonel Trebicka, Sabine Klein
Published in: Liver International, 40/9, 2020, Page(s) 2228-2241, ISSN 1478-3223
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/liv.14586

Profiling circulating microRNAs in patients with cirrhosis and acute-on-chronic liver failure

Author(s): Delia Blaya, Elisa Pose, Mar Coll123Juan JoséLozano2IsabelGraupera123RobertSchierwagen4ChristianJansen8PedroCastro9SaraFernandez9JuliaSidorova10MariucaVasa-Nicotera4ElsaSolà123JoanCaballería123JonelTrebicka4567PereGinès123PauSancho-Bru12
Published in: JHEP Reports, 2021, ISSN 2589-5559
Publisher: Elsevier
DOI: 10.1016/j.jhepr.2021.100233

Metabolic and Genetic Risk Factors Are the Strongest Predictors of Severity of Alcohol-Related Liver Fibrosis

Author(s): Mads Israelsen, Helene Bæk Juel, Sönke Detlefsen, Bjørn Stæhr Madsen, Ditlev Nytoft Rasmussen, Trine R. Larsen, Maria Kjærgaard, Mary Jo Fernandes Jensen, Stefan Stender, Torben Hansen, Aleksander Krag and Maja Thiele
Published in: Clinical Gastroenterology and Hepatology, 2020, ISSN 2575-7733
Publisher: Elsevier
DOI: 10.1016/j.cgh.2020.11.038

settingsOpen AccessReviewThe Role of Diagnostic Biomarkers, Omics Strategies, and Single-Cell Sequencing for Nonalcoholic Fatty Liver Disease in Severely Obese Patients

Author(s): Charlotte W. Wernberg, Kim Ravnskjaer, Mette M. Lauridsen and Maja Thiele
Published in: Journal of Clinical Medicine, 2021, ISSN 2077-0383
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm10050930

Role of portal venous platelet activation in patients with decompensated cirrhosis and TIPS

Author(s): Alexander Queck, Roberto Carnevale, Frank Erhard Uschner, Robert Schierwagen, Sabine Klein, Christian Jansen, Carsten Meyer, Michael Praktiknjo, Daniel Thomas, Christian Strassburg, Stefan Zeuzem, Francesco Violi, Jonel Trebicka
Published in: Gut, 69/8, 2020, Page(s) 1535-1536, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2019-319044

Progressive alcohol-related liver fibrosis is characterised by imbalanced collagen formation and degradation.

Author(s): Maja Thiele; Maja Thiele; Stine Johansen; Natasja Stæhr Gudmann; Bjørn Stæhr Madsen; Maria Kjærgaard; Mette Juul Nielsen; Diana Julie Leeming; Suganya Jacobsen; Flemming Bendtsen; Søren Møller; Søren Møller; Sönke Detlefsen; Sönke Detlefsen; Morten A. Karsdal; Aleksander Krag; Aleksander Krag
Published in: Alimentary Pharmacology and Therapeutics, 5, 2021, ISSN 1365-2036
Publisher: John Wiley & Sons Ltd
DOI: 10.1111/apt.16567

Liver Transplantation for Acute‐on‐Chronic Liver Failure: Science or Fiction?

Author(s): Jonel Trebicka, Vinay Sundaram, Richard Moreau, Rajiv Jalan, Vicente Arroyo
Published in: Liver Transplantation, 26/7, 2020, Page(s) 906-915, ISSN 1527-6465
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/lt.25788

Two-dimensional shear wave elastography predicts survival in advanced chronic liver disease.

Author(s): Jonel Trebicka; Wenyi Gu; Victor de Ledinghen; Christophe Aubé; Aleksander Krag; Michael Praktiknjo; Laurent Castera; Jérôme Dumortier; David Bauer; Mireen Friedrich-Rust; Stanislas Pol; Ivica Grgurević; Rongqin Zheng; Sven Francque; Halima Gottfriedová; Sanda Mustapic; Ioan Sporea; Annalisa Berzigotti; Frank Erhard Uschner; Benedikt Simbrunner; Maxime Ronot; Christophe Cassinotto; Maria Kjæ
Published in: Gut, 1, 2021, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2020-323419

High-Throughput UHPLC-MS to Screen Metabolites in Feces for Gut Metabolic Health

Author(s): Andressa de Zawadzki, Maja Thiele, Tommi Suvitaival, Asger Wretlind, Min Kim, Mina Ali, Annette F. Bjerre, Karin Stahr, Ismo Mattila, Torben Hansen, Aleksander Krag and Cristina Legido-Quigley
Published in: Metabolites, 2022, ISSN 2218-1989
Publisher: MDPI
DOI: 10.3390/metabo12030211

Activation of the Alternate Renin-Angiotensin System Correlates with the Clinical Status in Human Cirrhosis and Corrects Post Liver Transplantation

Author(s): Stephen Casey, Robert Schierwagen, Kai Mak, Sabine Klein, Frank Uschner, Christian Jansen, Michael Praktiknjo, Carsten Meyer, Daniel Thomas, Chandana Herath, Robert Jones, Jonel Trebicka, Peter Angus
Published in: Journal of Clinical Medicine, 8/4, 2019, Page(s) 419, ISSN 2077-0383
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm8040419

Rebleeding and mortality risk are increased by ACLF but reduced by pre-emptive TIPS

Author(s): Jonel Trebicka, Wenyi Gu, Luis Ibáñez-Samaniego, Virginia Hernández-Gea, Carla Pitarch, Elisabet Garcia, Bogdan Procopet, Álvaro Giráldez, Lucio Amitrano, Candid Villanueva, Dominique Thabut, Gilberto Silva-Junior, Javier Martinez, Joan Genescà, Cristophe Bureau, Elba Llop, Wim Laleman, Jose Maria Palazon, Jose Castellote, Susanag Rodrigues, Liselotte Gluud, Carlos Noronha Ferreira, Rafael B
Published in: Journal of Hepatology, 2020, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2020.04.024

The rs429358 Locus in Apolipoprotein E Is Associated With Hepatocellular Carcinoma in Patients With Cirrhosis

Author(s): Hamish Innes,Hans Dieter Nischalke,Indra Neil Guha,Karl Heinz Weiss,Will Irving,Daniel Gotthardt,Eleanor Barnes,Janett Fischer,M. Azim Ansari,Jonas Rosendahl,Shang-Kuan Lin,Astrid Marot,Vincent Pedergnana,Markus Casper,Jennifer Benselin,Frank Lammert,John McLauchlan,Philip L. Lutz,Victoria Hamill,Sebastian Mueller,Joanne R. Morling,Georg Semmler,Florian Eyer,Johann von Felden,Alexander Link,Arndt
Published in: Hepatology Communications, 2021, ISSN 2471-254X
Publisher: John Wiley
DOI: 10.1002/hep4.1886.

Antifibrotic and molecular aspects of rifaximin in alcoholic liver disease: study protocol for a randomized controlled trial

Author(s): Bjørn Stæhr Madsen, Jonel Trebicka, Maja Thiele, Mads Israelsen, Manimozhiyan Arumugan, Troels Havelund, Aleksander Krag
Published in: Trials, 19/1, 2018, ISSN 1745-6215
Publisher: BioMed Central
DOI: 10.1186/s13063-018-2523-9

The soluble guanylate cyclase stimulator riociguat reduces fibrogenesis and portal pressure in cirrhotic rats

Author(s): Philipp Schwabl, Ksenia Brusilovskaya, Paul Supper, David Bauer, Philipp Königshofer, Florian Riedl, Hubert Hayden, Claudia Daniela Fuchs, Judith Stift, Georg Oberhuber, Stefan Aschauer, Diana Bonderman, Thorsten Gnad, Alexander Pfeifer, Frank Erhard Uschner, Jonel Trebicka, Nataliya Rohr-Udilova, Bruno Karl Podesser, Markus Peck-Radosavljevic, Michael Trauner, Thomas Reiberger
Published in: Scientific Reports, 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-27656-y

Left Ventricular Longitudinal Contractility Predicts Acute-on-Chronic Liver Failure Development and Mortality After Transjugular Intrahepatic Portosystemic Shunt

Author(s): Christian Jansen, Anna Schröder, Robert Schueler, Jennifer Lehmann, Michael Praktiknjo, Frank E. Uschner, Robert Schierwagen, Daniel Thomas, Sofia Monteiro, Georg Nickenig, Christian P. Strassburg, Carsten Meyer, Vicente Arroyo, Christoph Hammerstingl, Jonel Trebicka
Published in: Hepatology Communications, 2019, ISSN 2471-254X
Publisher: John Wiley and Sons Inc.
DOI: 10.1002/hep4.1308

Acute decompensation boosts hepatic collagen type III deposition and deteriorates experimental and human cirrhosis

Author(s): Michael Praktiknjo, Jennifer Lehmann, Mette J. Nielsen, Robert Schierwagen, Frank E. Uschner, Carsten Meyer, Daniel Thomas, Christian P. Strassburg, Flemming Bendtsen, Søren Møller, Aleksander Krag, Morten A. Karsdal, Diana J. Leeming, Jonel Trebicka
Published in: Hepatology Communications, 2/2, 2018, Page(s) 211-222, ISSN 2471-254X
Publisher: John Wiley and Sons Inc.
DOI: 10.1002/hep4.1135

Accuracy of the Enhanced Liver Fibrosis Test vs FibroTest, Elastography, and Indirect Markers in Detection of Advanced Fibrosis in Patients With Alcoholic Liver Disease

Author(s): Maja Thiele, Bjørn Stæhr Madsen, Janne Fuglsang Hansen, Sönke Detlefsen, Steen Antonsen, Aleksander Krag
Published in: Gastroenterology, 154/5, 2018, Page(s) 1369-1379, ISSN 0016-5085
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2018.01.005

MicroRNA-155 is upregulated in ascites in patients with spontaneous bacterial peritonitis

Author(s): Philipp Lutz, Mohamed M´haimid, Alessandra Pohlmann, Jennifer Lehmann, Christian Jansen, Robert Schierwagen, Sabine Klein, Christian P. Strassburg, Ulrich Spengler, Jonel Trebicka
Published in: Scientific Reports, 7/1, 2017, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/srep40556

γ-Glutamyl Transferase Is an Independent Biomarker of Splanchnic Thrombosis in Patients With Myeloproliferative Neoplasm

Author(s): Görtzen, Jan; Hunka, Lena M.; Vonnahme, Maria; Praktiknjo, Michael; Kaifie, Andrea; Fimmers, Rolf; Jansen, Christian; Heine, Annkristin; Lehmann, Jennifer; Goethert, Joachim R.; Gattermann, Norbert; Goekkurt, Eray; Platzbecker, Uwe; Brossart, Peter; Strassburg, Christian P.; Brummendorf, Tim H.; Koschmieder, Steffen; Wolf, Dominik; Trebicka, Jonel
Published in: Medicine, 6, 2016, ISSN 0025-7974
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.18154/RWTH-CONV-211209

Evolution of nodule stiffness might predict response to local ablative therapy: A series of patients with hepatocellular carcinoma

Author(s): Michael Praktiknjo, Viktoria Krabbe, Alessandra Pohlmann, Matthias Sampels, Christian Jansen, Carsten Meyer, Christian P. Strassburg, Jonel Trebicka, Maria A. Gonzalez Carmona
Published in: PLOS ONE, 13/2, 2018, Page(s) e0192897, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0192897

Compartmentalization of Immune Response and Microbial Translocation in Decompensated Cirrhosis

Author(s): Camila Alvarez-Silva, Robert Schierwagen, Alessandra Pohlmann, Fernando Magdaleno, Frank E. Uschner, Patrick Ryan, Maria J. G. T. Vehreschild, Joan Claria, Eicke Latz, Benjamin Lelouvier, Manimozhiyan Arumugam, Jonel Trebicka
Published in: Frontiers in Immunology, 10, 2019, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/fimmu.2019.00069

Collagen type IV remodeling gender-specifically predicts mortality in decompensated liver cirrhosis

Author(s): Jennifer Lehmann, Michael Praktiknjo, Mette Juul Nielsen, Robert Schierwagen, Carsten Meyer, Daniel Thomas, Francesco Violi, Christian P. Strassburg, Flemming Bendtsen, Søren Møller, Aleksander Krag, Morten Asser Karsdal, Diana Julie Leeming, Jonel Trebicka
Published in: Liver International, 2019, ISSN 1478-3223
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/liv.14070

Rho-kinase inhibitor coupled to peptide-modified albumin carrier reduces portal pressure and increases renal perfusion in cirrhotic rats

Author(s): Sabine Klein, Franziska Frohn, Fernando Magdaleno, Catharina Reker-Smit, Robert Schierwagen, Irela Schierwagen, Frank Erhard Uschner, Fransien van Dijk, Dieter O. Fürst, Sonja Djudjaj, Peter Boor, Klaas Poelstra, Leonie Beljaars, Jonel Trebicka
Published in: Scientific Reports, 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-38678-5

Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis

Author(s): M. Welz, S. Eickhoff, Z. Abdullah, J. Trebicka, K. H. Gartlan, J. A. Spicer, A. J. Demetris, H. Akhlaghi, M. Anton, K. Manske, D. Zehn, B. Nieswandt, C. Kurts, J. A. Trapani, P. Knolle, D. Wohlleber, W. Kastenmüller
Published in: Nature Communications, 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-07213-x

Fast Genome-Wide Functional Annotation through Orthology Assignment by eggNOG-Mapper

Author(s): Jaime Huerta-Cepas, Kristoffer Forslund, Luis Pedro Coelho, Damian Szklarczyk, Lars Juhl Jensen, Christian von Mering, Peer Bork
Published in: Molecular Biology and Evolution, 34/8, 2017, Page(s) 2115-2122, ISSN 0737-4038
Publisher: Oxford University Press
DOI: 10.1093/molbev/msx148

proGenomes: a resource for consistent functional and taxonomic annotations of prokaryotic genomes

Author(s): Daniel R. Mende, Ivica Letunic, Jaime Huerta-Cepas, Simone S. Li, Kristoffer Forslund, Shinichi Sunagawa, Peer Bork
Published in: Nucleic Acids Research, 45/D1, 2017, Page(s) D529-D534, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkw989

Managing portal hypertension in patients with liver cirrhosis

Author(s): Tilman Sauerbruch, Robert Schierwagen, Jonel Trebicka
Published in: F1000Research, 7, 2018, Page(s) 533, ISSN 2046-1402
Publisher: F1000 Research Ltd.
DOI: 10.12688/f1000research.13943.1

Controlled attenuation parameter and alcoholic hepatic steatosis: Diagnostic accuracy and role of alcohol detoxification

Author(s): Maja Thiele, Vanessa Rausch, Gabriele Fluhr, Maria Kjærgaard, Felix Piecha, Johannes Mueller, Beate Katharina Straub, Monica Lupșor-Platon, Victor De-Ledinghen, Helmut Karl Seitz, Sönke Detlefsen, Bjørn Madsen, Aleksander Krag, Sebastian Mueller
Published in: Journal of Hepatology, 68/5, 2018, Page(s) 1025-1032, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2017.12.029

Describing the fecal metabolome in cryogenically collected samples from healthy participants

Author(s): Kajetan Trošt, Linda Ahonen, Tommi Suvitaival, Nina Christiansen, Trine Nielsen, Maja Thiele, Suganya Jacobsen, Aleksander Krag, Peter Rossing, Torben Hansen, Lars Ove Dragsted, Cristina Legido-Quigley
Published in: Scientific Reports, 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-57888-w

The Use of Rifaximin in Patients With Cirrhosis

Author(s): Paolo Caraceni,Victor Vargas,Elsa Solà,Carlo Alessandria,Koos de Wit,Jonel Trebicka,Paolo Angeli,Rajeshwar P. Mookerjee,François Durand,Elisa Pose,Aleksander Krag,Jasmohan S. Bajaj,Ulrich Beuers,Pere Ginès
Published in: Hepatology, 2021, ISSN 0270-9139
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/hep.31708

The Specific NLRP3 Antagonist IFM-514 Decreases Fibrosis and Inflammation in Experimental Murine Non-Alcoholic Steatohepatitis

Author(s): Sandra Torres; Maximilian J Brol; Fernando Magdaleno; Robert Schierwagen; Frank E. Uschner; Sabine Klein; Cristina Ortiz; Olaf Tyc; Nadine Bachtler; James Stunden; Damien Bertheloot; Damien Bertheloot; Ana Kitanovic; Brian Sanchez; Jacob Schrum; William R. Roush; Luigi Franchi; Kate Byth; Eicke Latz; Eicke Latz; Jonel Trebicka; Jonel Trebicka
Published in: Frontiers in Molecular Biosciences, 3, 2021, ISSN 2296-889x
Publisher: Frontiers Media
DOI: 10.18154/rwth-2021-09761

Effects of Ethanol Feeding in Early-Stage NAFLD Mice Induced by Western Diet

Author(s): Maximilian J. Brol; Stella Georgiou; Ditlev Nytoft Rasmussen; Cristina Ortiz; Sabine D. Klein; Robert Schierwagen; Frank Erhard Uschner; Larissa Eberle; Sönke Detlefsen; Vasiliki I. Pantazopoulou; Maja Thiele; Vasiliki Filippa; Sandra Torres; Ema Anastasiadou; Aleksander Krag; Jonel Trebicka
Published in: Livers, 2021, ISSN 2673-4389
Publisher: MDPI
DOI: 10.3390/livers1010003

Baseline Presence of NAFLD Predicts Weight Loss after Gastric Bypass Surgery for Morbid Obesity

Author(s): Karl Peter Rheinwalt, Uta Drebber, Robert Schierwagen, Sabine Klein, Ulf Peter Neumann, Tom Florian Ulmer, Andreas Plamper, Andreas Kroh, Sandra Schipper, Margarete Odenthal, Frank Erhard Uschner, Philipp Lingohr, Jonel Trebicka and Maximilian Joseph Brol
Published in: Journal of Clinical Medicine, 2020, ISSN 2077-0383
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm9113430

The microbiota in cirrhosis and its role in hepatic decompensation

Author(s): JonelTrebicka, Jane Macnaughtan, Bernd Schnabl, Debbie L. Shawcross, Jasmohan S. Bajaj
Published in: Journal of Hepatology, 2021, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2020.11.013

The Role of Decorin and Biglycan Signaling in Tumorigenesis

Author(s): Valentina Diehl, Lisa Sophie Huber, Jonel Trebicka, Malgorzata Wygrecka, Renato V. Iozzo and Liliana Schaefer
Published in: Frontiers in Oncology, 2021, ISSN 2234-943X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fonc.2021.801801.

Sarcopenia Is Associated With Development of Acute-on-Chronic Liver Failure in Decompensated Liver Cirrhosis Receiving Transjugular Intrahepatic Portosystemic Shunt

Author(s): Michael Praktiknjo, Caroline Clees, Alessandra Pigliacelli, Stefan Fischer, Christian Jansen, Jennifer Lehmann, Alessandra Pohlmann, Barbara Lattanzi, Viktoria Katharina Krabbe, Christian P. Strassburg, Vicente Arroyo, Manuela Merli, Carsten Meyer, Jonel Trebicka
Published in: Clinical and Translational Gastroenterology, 10/4, 2019, Page(s) e00025, ISSN 2155-384X
Publisher: Nature Publishing Group
DOI: 10.14309/ctg.0000000000000025

Diagnostic accuracy of routine liver function tests to identify patients with significant and advanced alcohol-related liver fibrosis

Author(s): Katrine P. Lindvig, Thor L. Hansen, Bjørn S. Madsen, Maria Kjaergaard, Linda Møller, Sönke Detlefsen, Aleksander Krag and Maja Thiele
Published in: Scandinavian Journal of Gastroenterology, 2021, ISSN 0036-5521
Publisher: Taylor & Francis
DOI: 10.1080/00365521.2021.1929450

Alcoholic liver disease: A registry view on comorbidities and disease prediction

Author(s): Dhouha Grissa, Ditlev Nytoft Rasmussen, Aleksander Krag, Søren Brunak, Lars Juhl Jensen
Published in: PLOS Computational Biology, 2020, ISSN 1553-7358
Publisher: Public Library of Science
DOI: 10.1371/journal.pcbi.1008244

Systemic MCP-1 Levels Derive Mainly From Injured Liver and Are Associated With Complications in Cirrhosis

Author(s): Alexander Queck, Hannah Bode, Frank E. Uschner, Maximilian J. Brol, Christiana Graf, Martin Schulz, Christian Jansen, Michael Praktiknjo, Robert Schierwagen, Sabine Klein, Christian Trautwein, Hermann E. Wasmuth, Marie-Luise Berres, Jonel Trebicka, Jennifer Lehmann
Published in: Frontiers in Immunology, 11, 2020, ISSN 1664-3224
Publisher: Frontiers in Immunology
DOI: 10.3389/fimmu.2020.00354

Early transplantation maximizes survival in severe acute-on-chronic liver failure: Results of a Markov decision process model

Author(s): Suyanpeng Zhang, Sze-ChuanSuen, Cynthia L.Gong, JessicaPham, JonelTrebicka, Christophe Duvoux, Andrew S.Klein, Tiffany Wu, Rajiv Jalan, Vinay Sundaram
Published in: JHEP Reports, 2021, ISSN 2589-5559
Publisher: Elsevier
DOI: 10.1016/j.jhepr.2021.100367.

Pathophysiological role of prostanoids in coagulation of the portal venous system in liver cirrhosis

Author(s): Alexander Queck, Dominique Thomas, Christian Jansen, Yannick Schreiber, Sabrina Rüschenbaum, Michael Praktiknjo, Katharina Maria Schwarzkopf, Marcus Maximilian Mücke, Robert Schierwagen, Frank Erhard Uschner, Carsten Meyer, Joan Clària, Stefan Zeuzem, Gerd Geisslinger, Jonel Trebicka, Christian Markus Lange
Published in: PLOS ONE, 14/10, 2019, Page(s) e0222840, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0222840

Statins: Old drugs as new therapy for liver diseases?

Author(s): Elisa Pose, Jonel Trebicka, Rajeshwar P Mookerjee, Paolo Angeli, Pere Ginès
Published in: Journal of Hepatology, 70/1, 2019, Page(s) 194-202, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2018.07.019

Serum levels of bone sialoprotein correlate with portal pressure in patients with liver cirrhosis

Author(s): Fabian Benz, Andreas Bogen, Michael Praktiknjo, Christian Jansen, Carsten Meyer, Alexander Wree, Muenevver Demir, Sven Loosen, Mihael Vucur, Robert Schierwagen, Frank Tacke, Jonel Trebicka, Christoph Roderburg
Published in: PLOS ONE, 15/4, 2020, Page(s) e0231701, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0231701

Prognostic Value of the CLIF-C AD Score in Patients With Implantation of Transjugular Intrahepatic Portosystemic Shunt

Author(s): Lukas Sturm, Michael Praktiknjo, Dominik Bettinger, Jan P. Huber, Lara Volkwein, Arthur Schmidt,Rafael Kaeser, Johannes Chang, Christian Jansen, Carsten Meyer, Daniel Thomas,Robert Thimme, Jonel Trebicka, Michael Schultheiß
Published in: Hepatology Communications, 2021, ISSN 2471-254X
Publisher: Wiley
DOI: 10.1002/hep4.1654

Bile Acids, Liver Cirrhosis, and Extrahepatic Vascular Dysfunction

Author(s): Tilman Sauerbruch, Martin Hennenberg, Jonel Trebicka and Ulrich Beuers
Published in: Frontiers in Physiology, 2021, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2021.718783.

Short-Term Western Diet Aggravates Non-Alcoholic Fatty Liver Disease (NAFLD) With Portal Hypertension in TGR(mREN2)27 Rats

Author(s): Carla Cremonese, Robert Schierwagen, Frank Erhard Uschner, Sandra Torres, Olaf Tyc, Cristina Ortiz, Martin Schulz, Alexander Queck, Glen Kristiansen, Michael Bader, Tilman Sauerbruch, Ralf Weiskirchen, Thomas Walther, Jonel Trebicka, Sabine Klein
Published in: International Journal of Molecular Sciences, 21/9, 2020, Page(s) 3308, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21093308

Serologically assessed heat shock protein 47 is related to fibrosis stage in early compensated alcohol-related liver disease

Author(s): Ida Lønsmanna, Natasja Stæhr Gudmanna, Tina Manon-Jensen, MajaThiele, Ydalina Maria Morenoa, Lasse Løcke Langholm, Mette Juul Nielsena, Sönke Detlefsen, Morten Asser Karsdal, Aleksander AhmKrag, Diana Julie Leeming
Published in: Clinical Biochemistry, 2021, ISSN 0009-9120
Publisher: Elsevier BV
DOI: 10.1016/j.clinbiochem.2021.12.008

Dicing the Disease with Dicer: The Implications of Dicer Ribonuclease in Human Pathologies.

Author(s): Eleni I. Theotoki; Eleni I. Theotoki; Vasiliki I. Pantazopoulou; Stella Georgiou; Panos Kakoulidis; Vicky Filippa; Dimitrios J. Stravopodis; Ema Anastasiadou
Published in: International Journal of Molecular Sciences, 1, 2020, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21197223

The Human Gut-Liver-Axis in Health and Disease

Author(s): Aleksander KragTorben Hansen
Published in: The Human Gut-Liver-Axis in Health and Disease, 2019, ISBN 978-3-662-30830-1
Publisher: Springer
DOI: 10.1007/978-3-319-98890-0

Reply to: “Definition of SPSS: we need to speak the same language”: Computer-assisted image processing for better quantification

Author(s): Michael Praktiknjo, JordiTorner, Macarena Simón-Talero, Wenyi Gu, Antoni Perez-Poch, Cristina de laTorre6Inés delVal, Francisco Alpiste, Joan Genescà, Jonel Trebicka
Published in: Journal of Hepatology, 2020, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2020.04.012

Interleukin-22 in acute-on-chronic liver failure: A matter of ineffective levels, receptor dysregulation or defective signalling?

Author(s): Katharina Maria Schwarzkopf, Larissa Eberle, Frank Erhard Uschner, Sabine Klein, RobertSchierwagen, Marcus Maximilian Mücke, Liliana Schaefer, Joan Clària, Stefan Zeuzem, Edith Hintermann, Urs Christen, Christian Markus Lange, JonelTrebicka, ChristophWelsch
Published in: Journal of Hepatology, 2020, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2020.05.012

The Role of microRNAs in the Gut-Liver Axis

Author(s): S. Georgiou, V. Pantazopoulou, Ema Anastasiadou
Published in: The Human Gut-Liver-Axis in Health and Disease, 2019, Page(s) 207-234, ISBN 978-3-319-98889-4
Publisher: Springer International Publishing
DOI: 10.1007/978-3-319-98890-0_13

Collagen proportionate area predicts clinical outcomes in patients with alcohol-related liver disease

Author(s): Mads Israelsen,Marta Guerrero Misas,Anastasios Koutsoumourakis,Yi Huang,Maja Thiele,Andrew Hall,Ditlev Rasmussen,Claudia Covelli,Elena Buzzetti,Laura Iogna Prat,Davide Roccarina,Sönke Detlefsen,Tu Vinh Luong,Alberto Quaglia,Aleksander Krag,Gary Jeffrey,Massimo Pinzani,Emmanuel A. Tsochatzis
Published in: Alimentary Pharmacology and Therapeutics, 2020, ISSN 1365-2036
Publisher: John Wiley & Sons Ltd
DOI: 10.1111/apt.16111

Datasets

AGO2 localises to cytokinetic protrusions in a p38 dependent manner and is needed for accurate cell division.

Author(s): Pantazopoulou, I. Vasiliki; Delis, D. Anastasios; Georgiou, Styliani; Pagakis, N. Stamatis; Filippa, Vasiliki; Dragona, Eleni; Kloukina, Ismini; Chatzitheodoridis, Elias; Trebicka, Jonel; Velentzas, D. Athanasios; Thiele, Maja; Gagos, Sarantis; Thanos, Dimitris; Tseleni-Balafouta, Sofia; Stravopodis, J. Dimitrios; Anastasiadou, Ema
Published in: Zenodo

A novel Argonaute 2-Niche at the midzone is essential for Cell-division integrity

Author(s): Pantazopoulou, I. Vasiliki; Delis, D. Anastasios; Georgiou, Styliani; Pagakis, N. Stamatis; Filippa, Vasiliki; Dragona, Eleni; Kloukina, Ismini; Chatzitheodoridis, Elias; Trebicka, Jonel; Velentzas, D. Athanasios; Thiele, Maja; Gagos, Sarantis; Thanos, Dimitris; Tseleni-Balafouta, Sofia; Stravopodis, J. Dimitrios; Anastasiadou, Ema
Published in: Zenodo