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GALAXY: Gut-and-liver axis in alcoholic liver fibrosis

Objective

Alcohol overuse is an important societal challenge with annual healthcare costs of over €22 billion in Europe. Alcohol is the main cause of liver cirrhosis, which is the 5th and 7th most common cause of life years lost in respectively Eastern and Western Europe. Cirrhosis is considered irreversible but its precursor, liver fibrosis, is reversible when detected before disease progression. GALAXY proposes that crosstalk between the gut microbiome and the liver influences the development and progression of alcoholic liver fibrosis. Here, a ‘dysbiotic’ microbiome in susceptible individuals leads to progressive liver fibrosis in combination with alcohol overuse. Therefore, interventions aiming to restore a healthy gut microbiome will reduce disease development. We will use state-of-the-art systems medicine tools to improve understanding of the complex interplay present during alcoholic liver fibrosis, to identify at-risk individuals in time and to develop personalised healthcare strategies for alcohol over-users (20% of the EU population >15 years old). GALAXY brings together partners with unique research competences in clinical hepatology, microbiome, multi-omics, biomarkers and bioinformatics. Our aim is to develop novel systems medicine tools which integrate clinical, multi-omics and lifestyle information from alcohol over-users at various stages of the disease and healthy individuals in order to: 1) identify signatures of host-microbial cross-talk during disease development and progression, 2) translate this into biomarkers for diagnosis, stratification and treatment monitoring in alcohol over users, and 3) evaluate new interventions to modulate gut microbiota towards prevention and mitigation of the disease in at-risk individuals. We will also study societal and economic impact of GALAXY biomarkers and treatments to accelerate future development. The GALAXY consortium includes strong SME partners who will enable the results to be exploited commercially.

Field of science

  • /medical and health sciences/clinical medicine/hepatology

Call for proposal

H2020-PHC-2015-two-stage
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

SYDDANSK UNIVERSITET
Address
Campusvej 55
5230 Odense M
Denmark
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 639 843

Participants (12)

EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
EU contribution
€ 1 387 000
Address
Meyerhofstrasse 1
69117 Heidelberg
Activity type
Research Organisations
KOBENHAVNS UNIVERSITET
Denmark
EU contribution
€ 928 752
Address
Norregade 10
1165 Kobenhavn
Activity type
Higher or Secondary Education Establishments
IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON
Greece
EU contribution
€ 427 987
Address
Soranou Efesiou 4
115 27 Athina
Activity type
Research Organisations
UNIVERSITATSKLINIKUM BONN

Participation ended

Germany
EU contribution
€ 353 240,87
Address
Venusberg-campus 1
53127 Bonn
Activity type
Higher or Secondary Education Establishments
NOVO NORDISK INVEST 4 A/S

Participation ended

Denmark
EU contribution
€ 130 279,24
Address
Novo Alle 1
2880 Bagsvaerd
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
NORDIC BIOSCIENCE A/S
Denmark
EU contribution
€ 301 381
Address
Herlev Hovedgade 205-207
2730 Herlev
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
NORDISK REBALANCE AS
Denmark
EU contribution
€ 178 907
Address
M D Madsensvej 14 16 1St Floor
3450 Allerd
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITETET I OSLO
Norway
EU contribution
€ 195 127
Address
Problemveien 5-7
0313 Oslo
Activity type
Higher or Secondary Education Establishments
REGION SYDDANMARK
Denmark
EU contribution
€ 1 187 082
Address
Damhaven 12
7100 Vejle
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
NORGINE BV
Netherlands
EU contribution
€ 0
Address
Hogehilweg 7
1101 CA Amsterdam
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
REGION HOVEDSTADEN
Denmark
EU contribution
€ 328 685,76
Address
Kongens Vaenge 2
3400 Hillerod
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN
Germany
EU contribution
€ 247 369,13
Address
Theodor W Adorno Platz 1
60323 Frankfurt Am Main
Activity type
Higher or Secondary Education Establishments