Project description
Gut microbiota: therapeutic target for alcohol liver fibrosis?
Heavy consumption of alcohol may lead to fat accumulation in the liver, inflammation and damage, which cause alcohol-related liver disease. If detected and treated early, alcoholic liver fibrosis can be reversed. The EU-funded GALAXY project will work under the hypothesis that the interaction between the gut microbiome and the liver plays a crucial role in the development and progression of alcoholic liver fibrosis. Researchers will investigate the complex interplay between gut microbiota and liver, identify biomarkers and develop personalised healthcare strategies for individuals at risk. The goal is to modulate the gut microbiota for prevention and mitigation of alcohol liver fibrosis, with obvious socio economic benefits.
Objective
Alcohol overuse is an important societal challenge with annual healthcare costs of over €22 billion in Europe. Alcohol is the main cause of liver cirrhosis, which is the 5th and 7th most common cause of life years lost in respectively Eastern and Western Europe. Cirrhosis is considered irreversible but its precursor, liver fibrosis, is reversible when detected before disease progression. GALAXY proposes that crosstalk between the gut microbiome and the liver influences the development and progression of alcoholic liver fibrosis. Here, a ‘dysbiotic’ microbiome in susceptible individuals leads to progressive liver fibrosis in combination with alcohol overuse. Therefore, interventions aiming to restore a healthy gut microbiome will reduce disease development. We will use state-of-the-art systems medicine tools to improve understanding of the complex interplay present during alcoholic liver fibrosis, to identify at-risk individuals in time and to develop personalised healthcare strategies for alcohol over-users (20% of the EU population >15 years old). GALAXY brings together partners with unique research competences in clinical hepatology, microbiome, multi-omics, biomarkers and bioinformatics. Our aim is to develop novel systems medicine tools which integrate clinical, multi-omics and lifestyle information from alcohol over-users at various stages of the disease and healthy individuals in order to: 1) identify signatures of host-microbial cross-talk during disease development and progression, 2) translate this into biomarkers for diagnosis, stratification and treatment monitoring in alcohol over users, and 3) evaluate new interventions to modulate gut microbiota towards prevention and mitigation of the disease in at-risk individuals. We will also study societal and economic impact of GALAXY biomarkers and treatments to accelerate future development. The GALAXY consortium includes strong SME partners who will enable the results to be exploited commercially.
Fields of science
Programme(s)
Funding Scheme
RIA - Research and Innovation actionCoordinator
5230 Odense M
Denmark