GALAXY: Gut-and-liver axis in alcoholic liver fibrosis

Resultado final

Data management described: GALAXY will create an extensive research data warehouse containing clinical and experimental data. The partners University of Southern Denmark, Odense University Hospital, EMBL, University of Copenhagen, University of Oslo and Steno Diabetes Centre will be responsible and be involved in data management. The data management plan will be in five sections: a) Data generation and collection b) Standards used c) Data preservation d) Data security e) Data exploitation

Approvals obtained for SYN-ALD

1. Written study protocol to be used for study execution and applications to the GCP unit, ethics committee and Danish data protection agency. 2. Approvals in writing from the GCP unit, ethics committee and Danish data protection agency.

Exploitation plan and updates

Strategies to protect and exploit the results from GALAXY described: A detailed exploitation strategy will be developed at the start of the project and updated every year, including IP protection.

Project infrastructure established

1. Consortium agreement written and signed by all partners: Administration of contracts including the Grant Agreement and any future amendments, establishment and maintenance of a Consortium Agreement, handling of legal issues, coordination of activities to ensure and monitor respect of ethical rules and gender equity. Also includes IP contracts. 2. Project management plan described, including detailed description of project management structure, coordination, communication, organisational structure, decision-making mechanisms and detailed project management activities. This includes: a) Developing project management and quality assurance plans which describe the plan for project management and collaboration and coordination tools of the project. It will be created as a support to the consortium with the main goal to facilitate the collaboration between partners and ensure that EC requirements are respected. b) Standars for handling of the project correspondence and the day-to-day requests from partners and external bodies. c) Implementing and maintaining the project infrastructure and the internal collaborative website as a platform for secured internal information exchange and project documents archive (not to be confused with the public website). d) Plans for running and hosting of project meetings at months 1, 18, 36, 54 and 72: Planning, organising, executing and post-processing of major project meetings such as Annual meetings, Executive board and Work Group meetings and meetings with the Supervisory board. 3. Provided templates and standard procedures for internal progress reporting and monitoring systems and procedures. Includes progress reports, the results and the necessary changes to the work plan as a result of those findings, according to project milestones and indicators. 4. Coordinated and planned the periodic technical and financial reporting: Designing and maintaining partner-specific templates for collecting input to the required EU documents, coordination of financial and administrative issues: establish and maintain financial records, co-ordinate financial statements submission by all project partners and audit certificates as needed, follow-up of EC payments, calculate partner shares according to rules agreed in the Consortium Agreement. 6. Developed detailed communication and dissemination plan: a) Outlined the target audiences including development of tailored key messages and dissemination material (logo, templates, press releases, website, leaflets, social media, public engagement exercises etc.). b) Development of a corporate style including logos and standard templates will be developed to create and maintain a consistent and recognisable ‘corporate image’ of the network. c) Plan for dissemination activities to enable external stakeholders to become aware of, learn from and implement project results. Includes creating and maintaining links and communications on behalf of the consortium with partners and potential future collaborators within Europe and globally by e.g. newsletters, brochures, digital media platforms. d) Plan for online presence e) Plan for communication of the research results with international relevant societies and with research and public health entities (WHO) in order to secure translation into clinical practise in every or specific regions of the world. f) Organisation of conference to present the results to international press and other relevant European and international stakeholders.

Results disseminated: Submitted article to an international journal on the costs and benefits of the treatments, made final results available online, co-organised conference to disseminate results

1 Wider social and economic costs and benefits of the treatments analysed in costbenefit modelIn order to quantify not only the medical impact of the treatments but also their wider social and economic costs and benefits we will perform a costbenefit analysis of the interventions These benefits include reduced need for long term care reduced health care spending and will be estimated using the average costs of these services in the different countries Based on both the medical and social costs and benefits we will calculate the net benefit of the treatment using a Markov model approach Finally we will quantify the uncertainty using probabilistic sensitivity analysis derive the probability that the interventions will be profitable at different thresholds acceptability curves and identify the most important factors driving the results2 Submitted article to an international journal on the costs and benefits of the treatments3 Final results made available on the web4 Coorganized a conference to disseminate the results to policymakers and commercial interests

Future exploitation strategy described

The exploitation plan will present options for long-term sustainability of the consortium and network after the official end of the project.

Included first 300 (75%) patients in GALA-ALD

Identified eligible patients with current or prior alcohol overuse and alcoholic liver fibrosis along the entire spectrum of disease. Eligible patients are recruited from alcohol abuse centres, outpatient liver clinics, emergency rooms and family physicians in Region of Southern Denmark and via national web adverts. Collected informed consent, tissue samples and clinical data for first 300 GALA-ALD patients. After consent a one-day inclusion visit are scheduled. We will perform: (i) liver biopsy, (ii) collection of venous fasting blood, faeces, urine and saliva, (iii) physical examinations including anthropometric data, abdominal ultrasonography, heart rate and blood pressure, (iv) non-invasive assessment of liver fibrosis using transient elastography, real-time shear-wave elastography and serum markers, (v) questionnaires evaluating alcohol use, alcohol dependency, demographic data, medicine use, comorbidity and health-related quality of life.

Tool developed for integrative metagenomics-based metatranscriptomics data analysis

1. Results from deliverable 4.1 extended by incorporating host-derived omics data (host transcriptomics, liver microRNA, blood readouts, etc.) to investigate the cross-talk between the gut microbial communities and host liver. 2. Novel algorithms developed to identify associations between gut taxonomic and/or gene functional composition and liver transcriptional activity and/or microRNA abundance.

Treated and evaluated patients in SYN-ALD

1 Profermin and matching placebo produced and labelled for central randomisation Due to the perishable nature of the intervention active drug and placebo will be produced continuously2 Fourty patients treated followed and evaluated at endoftreatmentTreat with Profermin or placebo The mixtures are provided by Nordic Rebalance Patients are investigated at day 0 and seen again at four visits until month 6 A project nurse registers compliance sideeffects alcohol use and adverse events NR will gather clinical data during treatment in parallel with the participating hospital Undertake endoftreatment investigations All investigations will be performed as described in 12 including a liver biopsy

Identified and included 100 healthy controls in GALA-HP

1. Written study protocol to be used for study execution and applications to the ethics committee and data protection agency. 2. Age- and gender-matched healthy controls identified: 100 matched controls without prior or current alcohol overuse and no malignancy, diabetes or liver-, cardiovascular-, renal- and autoimmune-related comorbidities. Controls will be recruited from libraries, train stations, emergency rooms, outpatient clinics and family physicians in Region of Southern Denmark and via national web adverts. 3. Onehundred healthy controls included: Collect informed consent, tissue samples and clinical data. Other than liver biopsy, all investigations will be performed as described in GALA-ALD.

Identified and included 40 patients in SYN-ALD

1 Patients identified with current or prior alcohol overuse and alcoholic liver fibrosis based on the current available stateoftheart noninvasive biomarkers Inclusion criteria also includes a dysbiotic microbiome as defined by WP4 Eligible patients are recruited from alcohol abuse centres outpatient liver clinics emergency rooms and family physicians in Region of Southern Denmark and via national web adverts2 Eighty patients included Collect informed consent After consent patients will be randomised in a 11 doubleblind manner Randomisation stratifies according to drinking status and degree of fibrosis After randomisation all investigations will be performed as described in 12 except liver biopsy

Included, treated and evaluated 136 patients in GAB-ALD

1 Patients identified from GALAALD with established liver disease based on liver histology fibrosis degree F03 The study will include both ongoing alcohol abusers and nondrinkers to elucidate the impact of alcohol on the microbiome2 Onehundredthirty six patients included in GABALD Collect informed consent After consent patients will be randomised in a doubleblind manner Randomisation stratifies according to drinking status and degree of fibrosis After randomisation all investigations will be performed as described in 12 except liver biopsyPatients treated followed and evaluated at endoftreatment Treat with Rifaximin or placebo The tablets are provided by Norgine Patients are investigated at day 0 and seen again at month 1 2 4 6 8 10 12 14 16 and 18 A project nurse registers compliance sideeffects alcohol use and adverse events Undertake endoftreatment investigations All investigations will be performed as described in 12 including a liver biopsy

Collaborative website ready to use

Developed, hosted and ensured continued maintenance of a public website. Includes gathering content based on partner contributions, designing the site and ensure the technical implementation

Publicaciones

Preemptive‐TIPS Improves Outcome in High‐Risk Variceal Bleeding: An Observational Study

Autores: Virginia Hernández‐Gea, Bogdan Procopet, Álvaro Giráldez, Lucio Amitrano, Candid Villanueva, Dominique Thabut, Luis Ibañez‐Samaniego, Gilberto Silva‐Junior, Javier Martinez, Joan Genescà, Christophe Bureau, Jonel Trebicka, Elba Llop, Wim Laleman, Jose Maria Palazon, Jose Castellote, Susana Rodrigues, Lise L. Gluud, Carlos Noronha Ferreira, Rafael Barcelo, Nuria Cañete, Manuel Rodrígue
Publicado en: Hepatology, 2018, ISSN 0270-9139
Editor: John Wiley & Sons Inc.
DOI: 10.1002/hep.30182

Cost‐Effectiveness of Noninvasive Screening for Alcohol‐Related Liver Fibrosis

Autores: Lars Asphaug, Maja Thiele, Aleksander Krag, Hans Olav Melberg
Publicado en: Hepatology, Edición 71/6, 2020, Página(s) 2093-2104, ISSN 0270-9139
Editor: John Wiley & Sons Inc.
DOI: 10.1002/hep.30979

A Previously Undescribed Highly Prevalent Phage Identified in a Danish Entric Virome Catalog

Autores: Lore Van Espen; Emilie Glad Bak; Leen Beller; Lila Close; Ward Deboutte; Helene Bæk Juel; Trine Nielsen; Deniz Sinar; Lander De Coninck; Christine Frithioff-Bøjsøe; Cilius Esmann Fonvig; Suganya Jacobsen; Maria Kjærgaard; Maja Thiele; Anthony Fullam; Michael Kuhn; Jens-Christian Holm; Peer Bork; Aleksander Krag; Torben Hansen; Manimozhiyan Arumugam and Jelle Matthijnssens
Publicado en: mSystems, 2021, ISSN 2379-5077
Editor: mSystems
DOI: 10.1128/msystems.00382-21

Stage-dependent expression of fibrogenic markers in alcohol-related liver disease

Autores: Mia Dahl Sørensen, Maja Thiele, Aleksander Krag, Samuel Joseph Daniels, Diana Julie Leeming, Morten Karsdal, Sönke Detlefsen
Publicado en: Pathology - Research and Practice, 2022, ISSN 0344-0338
Editor: Elsevier BV
DOI: 10.1016/j.prp.2022.153798

Validation of scores of PRO-C3 to predict liver-related events in alcohol-related liver disease

Autores: Stine Johansen; Mads Israelsen; Ida F Villesen; Nikolaj Torp; Mette J Nielsen; Maria Kjaergaard; Katrine P Lindvig; Camilla D Hansen; Peter Andersen; Ditlev N Rasmussen; Sönke Detlefsen; Diana J Leeming; Maja Thiele; Morten Karsdal and Aleksander Krag
Publicado en: Liver International, 2023, ISSN 1478-3223
Editor: Blackwell Publishing Inc.
DOI: 10.1111/liv.15595

β-Arrestin2 is increased in liver fibrosis in humans and rodents

Autores: Robert Schierwagen; Peter Dietrich; Sabine Klein; Frank Erhard Uschner; Cristina Ortiz; Olaf Tyc; Sandra Torres; Claus Hellerbrand; Tilman Sauerbruch; Jonel Trebicka
Publicado en: PNAS, Edición 1, 2020, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2014337117

Controlled underdilation using novel VIATORR® controlled expansion stents improves survival after transjugular intrahepatic portosystemic shunt implantation

Autores: MichaelPraktiknjo, JasminAbu-Omar, JohannesChang, DanielThomas2ChristianJansen, PatrickKupczyk2FilippoSchepis3Juan CarlosGarcia-Pagan, ManuelaMerli, CarstenMeyer, Christian P.Strassburg, Claus C.Pieper, JonelTrebicka
Publicado en: JHEP Reports, 2021, ISSN 2589-5559
Editor: Elsevier
DOI: 10.1016/j.jhepr.2021.100264.

Differential inflammasome activation predisposes to acute-on-chronic liver failure in human and experimental cirrhosis with and without previous decompensation

Autores: Sofia Monteiro, Josephine Grandt, Frank Erhard Uschner, Nina Kimer, Jan Lysgård Madsen, Robert Schierwagen, Sabine Klein, Christoph Welsch, Liliana Schäfer, Christian Jansen, Joan Claria, José Alcaraz-Quiles, Vicente Arroyo, Richard Moreau, Javier Fernandez, Flemming Bendtsen, Gautam Mehta, Lise Lotte Gluud, Søren Møller, Michael Praktiknjo, Jonel Trebicka
Publicado en: Gut, 2020, Página(s) gutjnl-2019-320170, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2019-320170

Extrahepatic Surgery in Cirrhosis Significantly Increases Portal Pressure in Preclinical Animal Models

Autores: Johannes Chang, Jonathan Meinke, Moritz Geck, Marc Hebest, Nina Böhling, Ramona Dolscheid-Pommerich, Birgit Stoffel-Wagner, Glen Kristiansen, Marcus Overhaus, Leon O. Peyman, Sabine Klein, Frank E. Uschner, Maximilian J. Brol, Tim O. Vilz, Philipp Lingohr, Jörg C. Kalff, Christian Jansen, Christian P. Strassburg, Sven Wehner, Jonel Trebicka, and Michael Praktiknjo
Publicado en: Frontiers in Physiology, 2021, ISSN 1664-042X
Editor: Frontiers Research Foundation
DOI: 10.3389/fphys.2021.720898.

The Development and Outcome of Acute‐on‐Chronic Liver Failure After Surgical Interventions

Autores: Leah Maria Klein, Johannes Chang, Wenyi Gu, Steffen Manekeller, Christian Jansen, Philipp Lingohr, Michael Praktiknjo, Jörg C. Kalf, Martin Schulz, Ulrich Spengler, Christian Strassburg, Andrés Cárdenas, Vicente Arroyo, Jonel Trebicka
Publicado en: Liver Transplantation, Edición 26/2, 2019, Página(s) 227-237, ISSN 1527-6465
Editor: John Wiley & Sons Inc.
DOI: 10.1002/lt.25675

TGR(mREN2)27 rats develop non-alcoholic fatty liver disease-associated portal hypertension responsive to modulations of Janus-kinase 2 and Mas receptor

Autores: Sabine Klein, Carola-Ellen Kleine, Andrea Pieper, Michaela Granzow, Sebastian Gautsch, Mimoun Himmit, Katharina Kahrmann, Robert Schierwagen, Frank Erhard Uschner, Fernando Magdaleno, Maria Eleni Naoum, Glen Kristiansen, Thomas Walther, Michael Bader, Tilman Sauerbruch, Jonel Trebicka
Publicado en: Scientific Reports, Edición 9/1, 2019, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-019-48024-4

Combination of CCl 4 with alcoholic and metabolic injuries mimics human liver fibrosis

Autores: Maximilian Joseph Brol, Felicitas Rösch, Robert Schierwagen, Fernando Magdaleno, Frank Erhard Uschner, Steffen Manekeller, Alexander Queck, Katharina Schwarzkopf, Margarete Odenthal, Uta Drebber, Maja Thiele, Philipp Lingohr, Andreas Plamper, Glen Kristiansen, Sophie Lotersztajn, Aleksander Krag, Sabine Klein, Karl P. Rheinwalt, Jonel Trebicka
Publicado en: American Journal of Physiology-Gastrointestinal and Liver Physiology, Edición 317/2, 2019, Página(s) G182-G194, ISSN 0193-1857
Editor: American Physiological Society
DOI: 10.1152/ajpgi.00361.2018

Follistatin-controlled activin-HNF4α-coagulation factor axis in liver progenitor cells determines outcome of acute liver failure

Autores: Tao Lin,Shanshan Wang,Stefan Munker,Kyounghwa Jung,Ricardo U. Macías-Rodríguez,Astrid Ruiz-Margáin,Robert Schierwagen,Hui Liu,Chen Shao,Chunlei Fan,Rilu Feng,Xiaodong Yuan,Sai Wang,Franziska Wandrer,Christoph Meyer,Ralf Wimmer,Roman Liebe,Jens Kroll,Long Zhang,Tobias Schiergens,Peter ten Dijke,Andreas Teufel,Alexander Marx,Peter R. Mertens,Hua Wang,Matthias P.A. Ebert,Heike Bantel,Enrico N. De
Publicado en: Hepatology, 2021, ISSN 0270-9139
Editor: John Wiley & Sons Inc.
DOI: 10.1002/hep.32119.

Prognostic performance of 7 biomarkers compared to liver biopsy in early alcohol-related liver disease

Autores: Ditlev Nytoft Rasmussen; Ditlev Nytoft Rasmussen; Maja Thiele; Maja Thiele; Stine Johansen; Stine Johansen; Maria Kjærgaard; Katrine Lindvig; Katrine Lindvig; Mads Israelsen; Steen Antonsen; Steen Antonsen; Sönke Detlefsen; Sönke Detlefsen; Aleksander Krag; Aleksander Krag; Ema Anastasiadou; Manimozhian Arumugam; Peer Bork; Torben Hansen; Christina Hartoft; Hans Israelsen; Morten A. Karsdal; Cr
Publicado en: Journal of Hepatology, Edición 2, 2021, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2021.05.037

Sphingolipids are depleted in alcohol-related liver fibrosis

Autores: Maja Thiele; Tommi Suvitaival; Kajetan Trošt; Min Kim; Andressa de Zawadzki; Maria Kjaergaard; Ditlev Nytoft Rasmussen; Katrine Prier Lindvig; Mads Israelsen; Sönke Detlefsen; Peter Andersen; Helene Bæk Juel; Trine Nielsen; Stella Georgiou; Vicky Filippa; Michael Kuhn; Suguru Nishijima; Lucas Moitinho-Silva; Peter Rossing; Jonel Trebicka; Ema Anastasiadou; Peer Bork; Torben Hansen; Cristina Leg
Publicado en: Gastroenterology, 2023, ISSN 0016-5085
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2023.02.023

Prediction of liver fibrosis severity in alcoholic liver disease by human microfibrillar‐associated protein 4

Autores: Bjørn S. Madsen, Maja Thiele, Sönke Detlefsen, Mia D. Sørensen, Maria Kjærgaard, Linda S. Møller, Ditlev N. Rasmussen, Anders Schlosser, Uffe Holmskov, Jonel Trebicka, Grith L. Sorensen, Aleksander Krag
Publicado en: Liver International, Edición 40/7, 2020, Página(s) 1701-1712, ISSN 1478-3223
Editor: Blackwell Publishing Inc.
DOI: 10.1111/liv.14491

Elective Surgery but not Transjugular Intrahepatic Portosystemic Shunt Precipitates Acute-On-Chronic Liver Failure

Autores: Johannes Chang; Avend Bamarni; Nina Böhling; Xin Zhou; Leah-Marie Klein; Jonathan Meinke; Georg D. Duerr; Philipp Lingohr; Sven Wehner; Maximilian J. Brol; Jürgen K. Rockstroh; Jörg C. Kalff; Steffen Manekeller; Carsten H. Meyer; Ulrich Spengler; Christian Jansen; Vicente Arroyo; Christian P. Strassburg; Jonel Trebicka; Michael Praktiknjo
Publicado en: Hepatology Communications, 2021, ISSN 2471-254X
Editor: Wiley
DOI: 10.1002/hep4.1712

Impact of transjugular intrahepatic portosystemic shunt creation on the central lymphatic system in liver cirrhosis

Autores: Claus Christian Pieper, Andreas Feißt, Carsten Meyer, Julian Luetkens, Michael Praktiknjo, Jonel Trebicka, Ulrike Attenberger & Christian Jansen
Publicado en: Scientific Reports, 2021, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-021-86006-7

A Dynamic Aspartate-to-Alanine Aminotransferase Ratio Provides Valid Predictions of Incident Severe Liver Disease.

Autores: Fredrik Åberg; Fredrik Åberg; Christopher J. Danford; Maja Thiele; Maja Thiele; Mats Talbäck; Ditlev Nytoft Rasmussen; Z. Gordon Jiang; Niklas Hammar; Patrik Nasr; Mattias Ekstedt; Anna But; Pauli Puukka; Aleksander Krag; Aleksander Krag; Jouko Sundvall; Iris Erlund; Veikko Salomaa; Per Stål; Per Stål; Stergios Kechagias; Rolf Hultcrantz; Michelle Lai; Nezam H. Afdhal; Antti Jula; Satu Männi
Publicado en: Hepatology communications, Edición 2, 2021, ISSN 2471-254X
Editor: Wiley Open Access
DOI: 10.1002/hep4.1700

The Role of Macrophage-Inducible C-Type Lectin in Different Stages of Chronic Liver Disease.

Autores: Robert Schierwagen; Frank E. Uschner; Cristina Ortiz; Sandra Torres; Max J. Brol; Olaf Tyc; Wenyi Gu; Christian Grimm; Stefan Zeuzem; Andreas Plamper; Philipp Pfeifer; Sebastian Zimmer; Christoph Welsch; Liliana Schaefer; Karl P. Rheinwalt; Joan Clària; Vicente Arroyo; Jonel Trebicka; Jonel Trebicka; Jonel Trebicka; Jonel Trebicka; Sabine Klein
Publicado en: Frontiers in Immunology, Edición 1, 2020, ISSN 1664-3224
Editor: Frontiers Media
DOI: 10.3389/fimmu.2020.01352

Acute Decompensation and Acute-on-Chronic Liver Failure

Autores: Philip Ferstl Dr med and Jonel Trebicka Dr med, PhD
Publicado en: Clinics in Liver Disease, 2021, ISSN 1089-3261
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.cld.2021.01.009

Transient elastography for screening of liver fibrosis: Cost-effectiveness analysis from six prospective cohorts in Europe and Asia

Autores: Miquel Serra-Burriel, Isabel Graupera, Pere Torán, Maja Thiele, Dominique Roulot, Vincent Wai-Sun Wong, Indra Neil Guha, Núria Fabrellas, Anita Arslanow, Carmen Expósito, Rosario Hernández, Grace Lai-Hung Wong, David Harman, Sarwa Darwish Murad, Aleksander Krag, Guillem Pera, Paolo Angeli, Peter Galle, Guruprasad P. Aithal, Llorenç Caballeria, Laurent Castera, Pere Ginès, Frank Lammert
Publicado en: Journal of Hepatology, Edición 71/6, 2019, Página(s) 1141-1151, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2019.08.019

Recent Advances in Practical Methods for Liver Cell Biology: A Short Overview

Autores: Sandra Torres, Zeinab Abdullah, Maximilian J Brol, Claus Hellerbrand, Mercedes Fernandez, Romina Fiorotto, Sabine Klein, Philipp Königshofer, Christian Liedtke, Sophie Lotersztajn, Yulia A. Nevzorova, Robert Schierwagen, Thomas Reiberger, Frank Erhard Uschner, Frank Tacke, Ralf Weiskirchen, Jonel Trebicka
Publicado en: International Journal of Molecular Sciences, Edición 21/6, 2020, Página(s) 2027, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21062027

Role of circulating angiogenin levels in portal hypertension and TIPS

Autores: Alexander Queck, Frank E. Uschner, Philip G. Ferstl, Martin Schulz, Maximilian J. Brol, Michael Praktiknjo, Robert Schierwagen, Sabine Klein, Christian P. Strassburg, Carsten Meyer, Christian Jansen , Marie-Luise Berres , Jonel Trebicka
Publicado en: PLOS ONE, 2021, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0256473.

Tidlig opsporing af alkoholrelateret leversygdom

Autores: Katrine Prier Lindvig; Aleksander Krag; Maja Thiele
Publicado en: Ugeskrift for Laeger, Edición 3, 2021, ISSN 0041-5782
Editor: Danish Medical Association

PRO-C3 and ADAPT algorithm accurately identify patients with advanced fibrosis due to alcohol-related liver disease.

Autores: Bjørn Stæhr Madsen; Maja Thiele; Sönke Detlefsen; Sönke Detlefsen; Maria Kjærgaard; Linda Maria Sevelsted Møller; Jonel Trebicka; Mette Juul Nielsen; Natasja Stæhr Gudmann; Diana Julie Leeming; Morten A. Karsdal; Aleksander Krag
Publicado en: Alimentary Pharmacology and Therapeutics, Edición 2, 2021, ISSN 1365-2036
Editor: John Wiley & Sons Ltd
DOI: 10.1111/apt.16513

Portal hypertension in cirrhosis: Pathophysiological mechanisms and therapy

Autores: YasukoIwakiri, JonelTrebicka
Publicado en: JHEP Reports, 2021, ISSN 2589-5559
Editor: Elsevier
DOI: 10.1016/j.jhepr.2021.100316

Additional file 1: of Antifibrotic and molecular aspects of rifaximin in alcoholic liver disease: study protocol for a randomized controlled trial

Autores: BjĂ¸Rn Madsen; Jonel Trebicka; Thiele, Maja; Israelsen, Mads; Manimozhiyan Arumugan; Havelund, Troels; Krag, Aleksander
Publicado en: Trials, Edición 2, 2018, ISSN 1745-6215
Editor: BioMed Central
DOI: 10.6084/m9.figshare.5927761

Total area of spontaneous portosystemic shunts independently predicts hepatic encephalopathy and mortality in liver cirrhosis

Autores: Michael Praktiknjo, Macarena Simón-Talero, Julia Römer, Davide Roccarina, Javier Martínez, Katharina Lampichler, Anna Baiges, Gavin Low, Elba Llop, Martin H. Maurer, Alexander Zipprich, Michela Triolo, Geert Maleux, Annette Dam Fialla, Claus Dam, Judit Vidal-González, Avik Majumdar, Carmen Picón, Daniel Toth, Anna Darnell, Juan G. Abraldes, Marta López, Christian Jansen, Johannes Chang, Robe
Publicado en: Journal of Hepatology, Edición 72/6, 2020, Página(s) 1140-1150, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2019.12.021

Noninvasive proteomic biomarkers for alcohol-related liver disease

Autores: Lili Niu; Maja Thiele; Philipp E. Geyer; Ditlev Nytoft Rasmussen; Henry Emanuel Webel; Alberto Santos; Rajat Gupta; Florian Meier; Maximilian Strauss; Maria Kjaergaard; Katrine Lindvig; Suganya Jacobsen; Simon Rasmussen; Torben Hansen; Aleksander Krag; Matthias Mann
Publicado en: Nature Medicine, Edición 6, 2022, ISSN 1078-8956
Editor: Nature Publishing Group
DOI: 10.1038/s41591-022-01850-y

2D shear wave liver elastography by Aixplorer to detect portal hypertension in cirrhosis: An individual patient data meta‐analysis

Autores: Maja Thiele, Mie B. Hugger, Yongsoo Kim, Pierre‐Emmanuel Rautou, Laure Elkrief, Christian Jansen, Wim Verlinden, Giulia Allegretti, Mads Israelsen, Horia Stefanescu, Fabio Piscaglia, Juan C. García‐Pagán, Sven Franque, Annalisa Berzigotti, Laurent Castera, Woo K. Jeong, Jonel Trebicka, Aleksander Krag
Publicado en: Liver International, Edición 40/6, 2020, Página(s) 1435-1446, ISSN 1478-3223
Editor: Blackwell Publishing Inc.
DOI: 10.1111/liv.14439

Effect of sarcopenia on survival in patients with cirrhosis: A meta-analysis

Autores: Xinxing Tantai, Yi Liu, Yee Hui Yeo, Michael Praktiknjo, Ezequiel Mauro, Yuhei Hamaguchi, Cornelius Engelmann, Peng Zhang, Jae Yoon Jeong, Jeroen Laurens Ad van Vugt, Huijuan Xiao, Huan Deng, Xu Gao, Qing Ye, Jiayuan Zhang, Longbao Yang, Yaqin Cai, Yixin Liu, Na Liu, Zongfang Li, Tao Han, Toshimi Kaido, Joo Hyun Sohn, Christian Strassburg, Thomas Berg, Jonel Trebicka, Yao-Chun Hsu, Jan Nicolaas Ma
Publicado en: Journal of Hepatology, 2022, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2021.11.006.

Stratifying the risk of NAFLD in patients with HIV under combination antiretroviral therapy (cART)

Autores: Jenny Bischoffa, Wenyi Gu, Carolynne Schwarze-Zander, Christoph BoeseckeacJan-Christian Wasmuth, Kathrinvan Bremen, Leona Dold, Jürgen K Rockstrohac, JonelTrebicka
Publicado en: E Clinical Medicine part of the LANCET Discovery Science, 2021, ISSN 2589-5370
Editor: Elsevier
DOI: 10.1016/j.eclinm.2021.101116.

From the Argonauts Mythological Sailors to the Argonautes RNA-Silencing Navigators: Their Emerging Roles in Human-Cell Pathologies

Autores: Vasiliki I. Pantazopoulou, Stella Georgiou, Panos Kakoulidis, Stavroula N. Giannakopoulou, Sofia Tseleni, Dimitrios J. Stravopodis, Ema Anastasiadou
Publicado en: International Journal of Molecular Sciences, Edición 21/11, 2020, Página(s) 4007, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21114007

Communications via the Small Leucine-rich Proteoglycans: Molecular Specificity in Inflammation and Autoimmune Diseases

Autores: Jinyang Zeng-Brouwers, Sony Pandey, Jonel Trebicka, Malgorzata Wygrecka, Liliana Schaefer
Publicado en: Journal of Histochemistry & Cytochemistry, 2020, ISSN 0022-1554
Editor: Histochemical Society
DOI: 10.1369/0022155420930303

Impact of acute alcohol consumption on circulating microbiome in asymptomatic alcohol-related liver disease

Autores: Mads Israelsen; Camila Alvarez-Silva; Bjørn Stæhr Madsen; Camilla Dalby Hansen; Nikolaj Christian Torp; Stine Johansen; Johanne Kragh Hansen; Katrine Prier Lindvig; Jeanlouis Insonere; Virginie Riviere; Helene Bæk Juel; Asker Brejnrod; Lars Juhl Jensen; Maja Thiele; Benjamin Lelouvier; Torben Hansen; Manimozhiyan Arumugam and Aleksander Krag
Publicado en: Gut, 2023, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2023-330360

Acute-on-chronic liver failure: a global disease

Autores: Martin Schulz, Jonel Trebicka
Publicado en: GUT, 2021, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2020-323973

Granulocyte-colony stimulating factor (G-CSF) to treat acute-on-chronic liver failure: A multicenter randomized trial (GRAFT study)

Autores: Cornelius Engelmann, Adam Herber, Annegret Franke, Tony Bruns, Philipp Reuken, Ingolf Schiefke, Alexander Zipprich, Stefan Zeuzem, Tobias Goeser, Ali Canbay, Christoph Berg, Jonel Trebicka, Frank E. Uschner, Johannes Chang, Tobias Mueller, Niklas Aehling, Moritz Schmelzle, Katrin Splith, Frank Lammert, Christian M. Lange, Christoph Sarrazin, Christian Trautwein, Michael Manns, Dieter Häussinger,
Publicado en: Journal of Hepatology, 2021, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2021.07.033.

Alteration of contrast enhanced ultrasound (CEUS) of hepatocellular carcinoma in patients with cirrhosis and transjugular intrahepatic portosystemic shunt (TIPS).

Autores: Johannes Chang; Alexia Dumitrache; N Böhling; J Abu-Omar; Carsten Meyer; Deike Strobel; Julian A. Luetkens; Andreas Minh Luu; Jürgen K. Rockstroh; Christian P. Strassburg; Jonel Trebicka; Maria A. Gonzalez-Carmona; Milka Marinova; Michael Praktiknjo
Publicado en: Scientific Reports, Edición 2, 2020, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-020-77801-9

AGO2 localizes to cytokinetic protrusions in a p38-dependent manner and is needed for accurate cell division.

Autores: Vasiliki I. Pantazopoulou; Anastasios D Delis; Stella Georgiou; Stamatis N. Pagakis; Vicky Filippa; Eleni Dragona; Ismini Kloukina; Elias Chatzitheodoridis; Jonel Trebicka; Athanassios D. Velentzas; Maja Thiele; Sarantis Gagos; Dimitris Thanos; Sofia Tseleni-Balafouta; Dimitrios J. Stravopodis; Ema Anastasiadou
Publicado en: Communications Biology, Edición 1, 2021, ISSN 2399-3642
Editor: Nature Publishing Group
DOI: 10.1038/s42003-021-02130-0

Combination of phosphodiesterase‐5‐inhibitors and beta blockers improves experimental portal hypertension and erectile dysfunction

Autores: Frank E. Uschner, Kathleen Glückert, Rafael Paternostro, Thorsten Gnad, Robert Schierwagen, Mattias Mandorfer, Fernando Magdaleno, Cristina Ortiz, Katharina Schwarzkopf, Patrick S. Kamath, Carlo Alessandria, Christoph Boesecke, Alexander Pfeifer, Thomas Reiberger, Wolfgang Kreisel, Tilman Sauerbruch, Arnulf Ferlitsch, Jonel Trebicka, Sabine Klein
Publicado en: Liver International, Edición 40/9, 2020, Página(s) 2228-2241, ISSN 1478-3223
Editor: Blackwell Publishing Inc.
DOI: 10.1111/liv.14586

Profiling circulating microRNAs in patients with cirrhosis and acute-on-chronic liver failure

Autores: Delia Blaya, Elisa Pose, Mar Coll123Juan JoséLozano2IsabelGraupera123RobertSchierwagen4ChristianJansen8PedroCastro9SaraFernandez9JuliaSidorova10MariucaVasa-Nicotera4ElsaSolà123JoanCaballería123JonelTrebicka4567PereGinès123PauSancho-Bru12
Publicado en: JHEP Reports, 2021, ISSN 2589-5559
Editor: Elsevier
DOI: 10.1016/j.jhepr.2021.100233

Metabolic and Genetic Risk Factors Are the Strongest Predictors of Severity of Alcohol-Related Liver Fibrosis

Autores: Mads Israelsen, Helene Bæk Juel, Sönke Detlefsen, Bjørn Stæhr Madsen, Ditlev Nytoft Rasmussen, Trine R. Larsen, Maria Kjærgaard, Mary Jo Fernandes Jensen, Stefan Stender, Torben Hansen, Aleksander Krag and Maja Thiele
Publicado en: Clinical Gastroenterology and Hepatology, 2020, ISSN 2575-7733
Editor: Elsevier
DOI: 10.1016/j.cgh.2020.11.038

settingsOpen AccessReviewThe Role of Diagnostic Biomarkers, Omics Strategies, and Single-Cell Sequencing for Nonalcoholic Fatty Liver Disease in Severely Obese Patients

Autores: Charlotte W. Wernberg, Kim Ravnskjaer, Mette M. Lauridsen and Maja Thiele
Publicado en: Journal of Clinical Medicine, 2021, ISSN 2077-0383
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm10050930

Role of portal venous platelet activation in patients with decompensated cirrhosis and TIPS

Autores: Alexander Queck, Roberto Carnevale, Frank Erhard Uschner, Robert Schierwagen, Sabine Klein, Christian Jansen, Carsten Meyer, Michael Praktiknjo, Daniel Thomas, Christian Strassburg, Stefan Zeuzem, Francesco Violi, Jonel Trebicka
Publicado en: Gut, Edición 69/8, 2020, Página(s) 1535-1536, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2019-319044

Progressive alcohol-related liver fibrosis is characterised by imbalanced collagen formation and degradation.

Autores: Maja Thiele; Maja Thiele; Stine Johansen; Natasja Stæhr Gudmann; Bjørn Stæhr Madsen; Maria Kjærgaard; Mette Juul Nielsen; Diana Julie Leeming; Suganya Jacobsen; Flemming Bendtsen; Søren Møller; Søren Møller; Sönke Detlefsen; Sönke Detlefsen; Morten A. Karsdal; Aleksander Krag; Aleksander Krag
Publicado en: Alimentary Pharmacology and Therapeutics, Edición 5, 2021, ISSN 1365-2036
Editor: John Wiley & Sons Ltd
DOI: 10.1111/apt.16567

Liver Transplantation for Acute‐on‐Chronic Liver Failure: Science or Fiction?

Autores: Jonel Trebicka, Vinay Sundaram, Richard Moreau, Rajiv Jalan, Vicente Arroyo
Publicado en: Liver Transplantation, Edición 26/7, 2020, Página(s) 906-915, ISSN 1527-6465
Editor: John Wiley & Sons Inc.
DOI: 10.1002/lt.25788

Two-dimensional shear wave elastography predicts survival in advanced chronic liver disease.

Autores: Jonel Trebicka; Wenyi Gu; Victor de Ledinghen; Christophe Aubé; Aleksander Krag; Michael Praktiknjo; Laurent Castera; Jérôme Dumortier; David Bauer; Mireen Friedrich-Rust; Stanislas Pol; Ivica Grgurević; Rongqin Zheng; Sven Francque; Halima Gottfriedová; Sanda Mustapic; Ioan Sporea; Annalisa Berzigotti; Frank Erhard Uschner; Benedikt Simbrunner; Maxime Ronot; Christophe Cassinotto; Maria Kjæ
Publicado en: Gut, Edición 1, 2021, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2020-323419

High-Throughput UHPLC-MS to Screen Metabolites in Feces for Gut Metabolic Health

Autores: Andressa de Zawadzki, Maja Thiele, Tommi Suvitaival, Asger Wretlind, Min Kim, Mina Ali, Annette F. Bjerre, Karin Stahr, Ismo Mattila, Torben Hansen, Aleksander Krag and Cristina Legido-Quigley
Publicado en: Metabolites, 2022, ISSN 2218-1989
Editor: MDPI
DOI: 10.3390/metabo12030211

Activation of the Alternate Renin-Angiotensin System Correlates with the Clinical Status in Human Cirrhosis and Corrects Post Liver Transplantation

Autores: Stephen Casey, Robert Schierwagen, Kai Mak, Sabine Klein, Frank Uschner, Christian Jansen, Michael Praktiknjo, Carsten Meyer, Daniel Thomas, Chandana Herath, Robert Jones, Jonel Trebicka, Peter Angus
Publicado en: Journal of Clinical Medicine, Edición 8/4, 2019, Página(s) 419, ISSN 2077-0383
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm8040419

Rebleeding and mortality risk are increased by ACLF but reduced by pre-emptive TIPS

Autores: Jonel Trebicka, Wenyi Gu, Luis Ibáñez-Samaniego, Virginia Hernández-Gea, Carla Pitarch, Elisabet Garcia, Bogdan Procopet, Álvaro Giráldez, Lucio Amitrano, Candid Villanueva, Dominique Thabut, Gilberto Silva-Junior, Javier Martinez, Joan Genescà, Cristophe Bureau, Elba Llop, Wim Laleman, Jose Maria Palazon, Jose Castellote, Susanag Rodrigues, Liselotte Gluud, Carlos Noronha Ferreira, Rafael B
Publicado en: Journal of Hepatology, 2020, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2020.04.024

The rs429358 Locus in Apolipoprotein E Is Associated With Hepatocellular Carcinoma in Patients With Cirrhosis

Autores: Hamish Innes,Hans Dieter Nischalke,Indra Neil Guha,Karl Heinz Weiss,Will Irving,Daniel Gotthardt,Eleanor Barnes,Janett Fischer,M. Azim Ansari,Jonas Rosendahl,Shang-Kuan Lin,Astrid Marot,Vincent Pedergnana,Markus Casper,Jennifer Benselin,Frank Lammert,John McLauchlan,Philip L. Lutz,Victoria Hamill,Sebastian Mueller,Joanne R. Morling,Georg Semmler,Florian Eyer,Johann von Felden,Alexander Link,Arndt
Publicado en: Hepatology Communications, 2021, ISSN 2471-254X
Editor: John Wiley
DOI: 10.1002/hep4.1886.

Antifibrotic and molecular aspects of rifaximin in alcoholic liver disease: study protocol for a randomized controlled trial

Autores: Bjørn Stæhr Madsen, Jonel Trebicka, Maja Thiele, Mads Israelsen, Manimozhiyan Arumugan, Troels Havelund, Aleksander Krag
Publicado en: Trials, Edición 19/1, 2018, ISSN 1745-6215
Editor: BioMed Central
DOI: 10.1186/s13063-018-2523-9

The soluble guanylate cyclase stimulator riociguat reduces fibrogenesis and portal pressure in cirrhotic rats

Autores: Philipp Schwabl, Ksenia Brusilovskaya, Paul Supper, David Bauer, Philipp Königshofer, Florian Riedl, Hubert Hayden, Claudia Daniela Fuchs, Judith Stift, Georg Oberhuber, Stefan Aschauer, Diana Bonderman, Thorsten Gnad, Alexander Pfeifer, Frank Erhard Uschner, Jonel Trebicka, Nataliya Rohr-Udilova, Bruno Karl Podesser, Markus Peck-Radosavljevic, Michael Trauner, Thomas Reiberger
Publicado en: Scientific Reports, Edición 8/1, 2018, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-018-27656-y

Left Ventricular Longitudinal Contractility Predicts Acute-on-Chronic Liver Failure Development and Mortality After Transjugular Intrahepatic Portosystemic Shunt

Autores: Christian Jansen, Anna Schröder, Robert Schueler, Jennifer Lehmann, Michael Praktiknjo, Frank E. Uschner, Robert Schierwagen, Daniel Thomas, Sofia Monteiro, Georg Nickenig, Christian P. Strassburg, Carsten Meyer, Vicente Arroyo, Christoph Hammerstingl, Jonel Trebicka
Publicado en: Hepatology Communications, 2019, ISSN 2471-254X
Editor: John Wiley and Sons Inc.
DOI: 10.1002/hep4.1308

Acute decompensation boosts hepatic collagen type III deposition and deteriorates experimental and human cirrhosis

Autores: Michael Praktiknjo, Jennifer Lehmann, Mette J. Nielsen, Robert Schierwagen, Frank E. Uschner, Carsten Meyer, Daniel Thomas, Christian P. Strassburg, Flemming Bendtsen, Søren Møller, Aleksander Krag, Morten A. Karsdal, Diana J. Leeming, Jonel Trebicka
Publicado en: Hepatology Communications, Edición 2/2, 2018, Página(s) 211-222, ISSN 2471-254X
Editor: John Wiley and Sons Inc.
DOI: 10.1002/hep4.1135

Accuracy of the Enhanced Liver Fibrosis Test vs FibroTest, Elastography, and Indirect Markers in Detection of Advanced Fibrosis in Patients With Alcoholic Liver Disease

Autores: Maja Thiele, Bjørn Stæhr Madsen, Janne Fuglsang Hansen, Sönke Detlefsen, Steen Antonsen, Aleksander Krag
Publicado en: Gastroenterology, Edición 154/5, 2018, Página(s) 1369-1379, ISSN 0016-5085
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2018.01.005

MicroRNA-155 is upregulated in ascites in patients with spontaneous bacterial peritonitis

Autores: Philipp Lutz, Mohamed M´haimid, Alessandra Pohlmann, Jennifer Lehmann, Christian Jansen, Robert Schierwagen, Sabine Klein, Christian P. Strassburg, Ulrich Spengler, Jonel Trebicka
Publicado en: Scientific Reports, Edición 7/1, 2017, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/srep40556

γ-Glutamyl Transferase Is an Independent Biomarker of Splanchnic Thrombosis in Patients With Myeloproliferative Neoplasm

Autores: Görtzen, Jan; Hunka, Lena M.; Vonnahme, Maria; Praktiknjo, Michael; Kaifie, Andrea; Fimmers, Rolf; Jansen, Christian; Heine, Annkristin; Lehmann, Jennifer; Goethert, Joachim R.; Gattermann, Norbert; Goekkurt, Eray; Platzbecker, Uwe; Brossart, Peter; Strassburg, Christian P.; Brummendorf, Tim H.; Koschmieder, Steffen; Wolf, Dominik; Trebicka, Jonel
Publicado en: Medicine, Edición 6, 2016, ISSN 0025-7974
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.18154/RWTH-CONV-211209

Evolution of nodule stiffness might predict response to local ablative therapy: A series of patients with hepatocellular carcinoma

Autores: Michael Praktiknjo, Viktoria Krabbe, Alessandra Pohlmann, Matthias Sampels, Christian Jansen, Carsten Meyer, Christian P. Strassburg, Jonel Trebicka, Maria A. Gonzalez Carmona
Publicado en: PLOS ONE, Edición 13/2, 2018, Página(s) e0192897, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0192897

Compartmentalization of Immune Response and Microbial Translocation in Decompensated Cirrhosis

Autores: Camila Alvarez-Silva, Robert Schierwagen, Alessandra Pohlmann, Fernando Magdaleno, Frank E. Uschner, Patrick Ryan, Maria J. G. T. Vehreschild, Joan Claria, Eicke Latz, Benjamin Lelouvier, Manimozhiyan Arumugam, Jonel Trebicka
Publicado en: Frontiers in Immunology, Edición 10, 2019, ISSN 1664-3224
Editor: Frontiers Media SA
DOI: 10.3389/fimmu.2019.00069

Collagen type IV remodeling gender-specifically predicts mortality in decompensated liver cirrhosis

Autores: Jennifer Lehmann, Michael Praktiknjo, Mette Juul Nielsen, Robert Schierwagen, Carsten Meyer, Daniel Thomas, Francesco Violi, Christian P. Strassburg, Flemming Bendtsen, Søren Møller, Aleksander Krag, Morten Asser Karsdal, Diana Julie Leeming, Jonel Trebicka
Publicado en: Liver International, 2019, ISSN 1478-3223
Editor: Blackwell Publishing Inc.
DOI: 10.1111/liv.14070

Rho-kinase inhibitor coupled to peptide-modified albumin carrier reduces portal pressure and increases renal perfusion in cirrhotic rats

Autores: Sabine Klein, Franziska Frohn, Fernando Magdaleno, Catharina Reker-Smit, Robert Schierwagen, Irela Schierwagen, Frank Erhard Uschner, Fransien van Dijk, Dieter O. Fürst, Sonja Djudjaj, Peter Boor, Klaas Poelstra, Leonie Beljaars, Jonel Trebicka
Publicado en: Scientific Reports, Edición 9/1, 2019, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-019-38678-5

Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis

Autores: M. Welz, S. Eickhoff, Z. Abdullah, J. Trebicka, K. H. Gartlan, J. A. Spicer, A. J. Demetris, H. Akhlaghi, M. Anton, K. Manske, D. Zehn, B. Nieswandt, C. Kurts, J. A. Trapani, P. Knolle, D. Wohlleber, W. Kastenmüller
Publicado en: Nature Communications, Edición 9/1, 2018, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-018-07213-x

Fast Genome-Wide Functional Annotation through Orthology Assignment by eggNOG-Mapper

Autores: Jaime Huerta-Cepas, Kristoffer Forslund, Luis Pedro Coelho, Damian Szklarczyk, Lars Juhl Jensen, Christian von Mering, Peer Bork
Publicado en: Molecular Biology and Evolution, Edición 34/8, 2017, Página(s) 2115-2122, ISSN 0737-4038
Editor: Oxford University Press
DOI: 10.1093/molbev/msx148

proGenomes: a resource for consistent functional and taxonomic annotations of prokaryotic genomes

Autores: Daniel R. Mende, Ivica Letunic, Jaime Huerta-Cepas, Simone S. Li, Kristoffer Forslund, Shinichi Sunagawa, Peer Bork
Publicado en: Nucleic Acids Research, Edición 45/D1, 2017, Página(s) D529-D534, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkw989

Managing portal hypertension in patients with liver cirrhosis

Autores: Tilman Sauerbruch, Robert Schierwagen, Jonel Trebicka
Publicado en: F1000Research, Edición 7, 2018, Página(s) 533, ISSN 2046-1402
Editor: F1000 Research Ltd.
DOI: 10.12688/f1000research.13943.1

Controlled attenuation parameter and alcoholic hepatic steatosis: Diagnostic accuracy and role of alcohol detoxification

Autores: Maja Thiele, Vanessa Rausch, Gabriele Fluhr, Maria Kjærgaard, Felix Piecha, Johannes Mueller, Beate Katharina Straub, Monica Lupșor-Platon, Victor De-Ledinghen, Helmut Karl Seitz, Sönke Detlefsen, Bjørn Madsen, Aleksander Krag, Sebastian Mueller
Publicado en: Journal of Hepatology, Edición 68/5, 2018, Página(s) 1025-1032, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2017.12.029

Describing the fecal metabolome in cryogenically collected samples from healthy participants

Autores: Kajetan Trošt, Linda Ahonen, Tommi Suvitaival, Nina Christiansen, Trine Nielsen, Maja Thiele, Suganya Jacobsen, Aleksander Krag, Peter Rossing, Torben Hansen, Lars Ove Dragsted, Cristina Legido-Quigley
Publicado en: Scientific Reports, Edición 10/1, 2020, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-020-57888-w

The Use of Rifaximin in Patients With Cirrhosis

Autores: Paolo Caraceni,Victor Vargas,Elsa Solà,Carlo Alessandria,Koos de Wit,Jonel Trebicka,Paolo Angeli,Rajeshwar P. Mookerjee,François Durand,Elisa Pose,Aleksander Krag,Jasmohan S. Bajaj,Ulrich Beuers,Pere Ginès
Publicado en: Hepatology, 2021, ISSN 0270-9139
Editor: John Wiley & Sons Inc.
DOI: 10.1002/hep.31708

The Specific NLRP3 Antagonist IFM-514 Decreases Fibrosis and Inflammation in Experimental Murine Non-Alcoholic Steatohepatitis

Autores: Sandra Torres; Maximilian J Brol; Fernando Magdaleno; Robert Schierwagen; Frank E. Uschner; Sabine Klein; Cristina Ortiz; Olaf Tyc; Nadine Bachtler; James Stunden; Damien Bertheloot; Damien Bertheloot; Ana Kitanovic; Brian Sanchez; Jacob Schrum; William R. Roush; Luigi Franchi; Kate Byth; Eicke Latz; Eicke Latz; Jonel Trebicka; Jonel Trebicka
Publicado en: Frontiers in Molecular Biosciences, Edición 3, 2021, ISSN 2296-889x
Editor: Frontiers Media
DOI: 10.18154/rwth-2021-09761

Validation of the new nomenclature of steatotic liver disease in patients with a history of excessive alcohol intake: an analysis of data from a prospective cohort study

Autores: Mads Israelsen, Nikolaj Torp, Stine Johansen, Camilla Dalby Hansen, Emil Deleuran Hansen, Katrine Thorhauge, Johanne Kragh Hansen, Ida Villesen, Katrine Bech, Charlotte Wernberg, Peter Andersen, Katrine Prier Lindvig, Emmanuel A Tsochatzis, Maja Thiele, Mary E Rinella and Aleksander Krag
Publicado en: Lancet Gastroenterol Hepatol, 2024, ISSN 0140-6736
Editor: The Lancet Publishing Group
DOI: 10.1016/s2468-1253(23)00443-0

Effects of Ethanol Feeding in Early-Stage NAFLD Mice Induced by Western Diet

Autores: Maximilian J. Brol; Stella Georgiou; Ditlev Nytoft Rasmussen; Cristina Ortiz; Sabine D. Klein; Robert Schierwagen; Frank Erhard Uschner; Larissa Eberle; Sönke Detlefsen; Vasiliki I. Pantazopoulou; Maja Thiele; Vasiliki Filippa; Sandra Torres; Ema Anastasiadou; Aleksander Krag; Jonel Trebicka
Publicado en: Livers, 2021, ISSN 2673-4389
Editor: MDPI
DOI: 10.3390/livers1010003

Baseline Presence of NAFLD Predicts Weight Loss after Gastric Bypass Surgery for Morbid Obesity

Autores: Karl Peter Rheinwalt, Uta Drebber, Robert Schierwagen, Sabine Klein, Ulf Peter Neumann, Tom Florian Ulmer, Andreas Plamper, Andreas Kroh, Sandra Schipper, Margarete Odenthal, Frank Erhard Uschner, Philipp Lingohr, Jonel Trebicka and Maximilian Joseph Brol
Publicado en: Journal of Clinical Medicine, 2020, ISSN 2077-0383
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm9113430

The microbiota in cirrhosis and its role in hepatic decompensation

Autores: JonelTrebicka, Jane Macnaughtan, Bernd Schnabl, Debbie L. Shawcross, Jasmohan S. Bajaj
Publicado en: Journal of Hepatology, 2021, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2020.11.013

The Role of Decorin and Biglycan Signaling in Tumorigenesis

Autores: Valentina Diehl, Lisa Sophie Huber, Jonel Trebicka, Malgorzata Wygrecka, Renato V. Iozzo and Liliana Schaefer
Publicado en: Frontiers in Oncology, 2021, ISSN 2234-943X
Editor: Frontiers Media S. A.
DOI: 10.3389/fonc.2021.801801.

Sarcopenia Is Associated With Development of Acute-on-Chronic Liver Failure in Decompensated Liver Cirrhosis Receiving Transjugular Intrahepatic Portosystemic Shunt

Autores: Michael Praktiknjo, Caroline Clees, Alessandra Pigliacelli, Stefan Fischer, Christian Jansen, Jennifer Lehmann, Alessandra Pohlmann, Barbara Lattanzi, Viktoria Katharina Krabbe, Christian P. Strassburg, Vicente Arroyo, Manuela Merli, Carsten Meyer, Jonel Trebicka
Publicado en: Clinical and Translational Gastroenterology, Edición 10/4, 2019, Página(s) e00025, ISSN 2155-384X
Editor: Nature Publishing Group
DOI: 10.14309/ctg.0000000000000025

Diagnostic accuracy of routine liver function tests to identify patients with significant and advanced alcohol-related liver fibrosis

Autores: Katrine P. Lindvig, Thor L. Hansen, Bjørn S. Madsen, Maria Kjaergaard, Linda Møller, Sönke Detlefsen, Aleksander Krag and Maja Thiele
Publicado en: Scandinavian Journal of Gastroenterology, 2021, ISSN 0036-5521
Editor: Taylor & Francis
DOI: 10.1080/00365521.2021.1929450

Alcoholic liver disease: A registry view on comorbidities and disease prediction

Autores: Dhouha Grissa, Ditlev Nytoft Rasmussen, Aleksander Krag, Søren Brunak, Lars Juhl Jensen
Publicado en: PLOS Computational Biology, 2020, ISSN 1553-7358
Editor: Public Library of Science
DOI: 10.1371/journal.pcbi.1008244

Systemic MCP-1 Levels Derive Mainly From Injured Liver and Are Associated With Complications in Cirrhosis

Autores: Alexander Queck, Hannah Bode, Frank E. Uschner, Maximilian J. Brol, Christiana Graf, Martin Schulz, Christian Jansen, Michael Praktiknjo, Robert Schierwagen, Sabine Klein, Christian Trautwein, Hermann E. Wasmuth, Marie-Luise Berres, Jonel Trebicka, Jennifer Lehmann
Publicado en: Frontiers in Immunology, Edición 11, 2020, ISSN 1664-3224
Editor: Frontiers in Immunology
DOI: 10.3389/fimmu.2020.00354

Early transplantation maximizes survival in severe acute-on-chronic liver failure: Results of a Markov decision process model

Autores: Suyanpeng Zhang, Sze-ChuanSuen, Cynthia L.Gong, JessicaPham, JonelTrebicka, Christophe Duvoux, Andrew S.Klein, Tiffany Wu, Rajiv Jalan, Vinay Sundaram
Publicado en: JHEP Reports, 2021, ISSN 2589-5559
Editor: Elsevier
DOI: 10.1016/j.jhepr.2021.100367.

Pathophysiological role of prostanoids in coagulation of the portal venous system in liver cirrhosis

Autores: Alexander Queck, Dominique Thomas, Christian Jansen, Yannick Schreiber, Sabrina Rüschenbaum, Michael Praktiknjo, Katharina Maria Schwarzkopf, Marcus Maximilian Mücke, Robert Schierwagen, Frank Erhard Uschner, Carsten Meyer, Joan Clària, Stefan Zeuzem, Gerd Geisslinger, Jonel Trebicka, Christian Markus Lange
Publicado en: PLOS ONE, Edición 14/10, 2019, Página(s) e0222840, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0222840

Statins: Old drugs as new therapy for liver diseases?

Autores: Elisa Pose, Jonel Trebicka, Rajeshwar P Mookerjee, Paolo Angeli, Pere Ginès
Publicado en: Journal of Hepatology, Edición 70/1, 2019, Página(s) 194-202, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2018.07.019

Serum levels of bone sialoprotein correlate with portal pressure in patients with liver cirrhosis

Autores: Fabian Benz, Andreas Bogen, Michael Praktiknjo, Christian Jansen, Carsten Meyer, Alexander Wree, Muenevver Demir, Sven Loosen, Mihael Vucur, Robert Schierwagen, Frank Tacke, Jonel Trebicka, Christoph Roderburg
Publicado en: PLOS ONE, Edición 15/4, 2020, Página(s) e0231701, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0231701

Prognostic Value of the CLIF-C AD Score in Patients With Implantation of Transjugular Intrahepatic Portosystemic Shunt

Autores: Lukas Sturm, Michael Praktiknjo, Dominik Bettinger, Jan P. Huber, Lara Volkwein, Arthur Schmidt,Rafael Kaeser, Johannes Chang, Christian Jansen, Carsten Meyer, Daniel Thomas,Robert Thimme, Jonel Trebicka, Michael Schultheiß
Publicado en: Hepatology Communications, 2021, ISSN 2471-254X
Editor: Wiley
DOI: 10.1002/hep4.1654

Bile Acids, Liver Cirrhosis, and Extrahepatic Vascular Dysfunction

Autores: Tilman Sauerbruch, Martin Hennenberg, Jonel Trebicka and Ulrich Beuers
Publicado en: Frontiers in Physiology, 2021, ISSN 1664-042X
Editor: Frontiers Research Foundation
DOI: 10.3389/fphys.2021.718783.

Short-Term Western Diet Aggravates Non-Alcoholic Fatty Liver Disease (NAFLD) With Portal Hypertension in TGR(mREN2)27 Rats

Autores: Carla Cremonese, Robert Schierwagen, Frank Erhard Uschner, Sandra Torres, Olaf Tyc, Cristina Ortiz, Martin Schulz, Alexander Queck, Glen Kristiansen, Michael Bader, Tilman Sauerbruch, Ralf Weiskirchen, Thomas Walther, Jonel Trebicka, Sabine Klein
Publicado en: International Journal of Molecular Sciences, Edición 21/9, 2020, Página(s) 3308, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21093308

Serologically assessed heat shock protein 47 is related to fibrosis stage in early compensated alcohol-related liver disease

Autores: Ida Lønsmanna, Natasja Stæhr Gudmanna, Tina Manon-Jensen, MajaThiele, Ydalina Maria Morenoa, Lasse Løcke Langholm, Mette Juul Nielsena, Sönke Detlefsen, Morten Asser Karsdal, Aleksander AhmKrag, Diana Julie Leeming
Publicado en: Clinical Biochemistry, 2021, ISSN 0009-9120
Editor: Elsevier BV
DOI: 10.1016/j.clinbiochem.2021.12.008

Dicing the Disease with Dicer: The Implications of Dicer Ribonuclease in Human Pathologies.

Autores: Eleni I. Theotoki; Eleni I. Theotoki; Vasiliki I. Pantazopoulou; Stella Georgiou; Panos Kakoulidis; Vicky Filippa; Dimitrios J. Stravopodis; Ema Anastasiadou
Publicado en: International Journal of Molecular Sciences, Edición 1, 2020, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21197223

Rifaximin-a for liver fibrosis in patients with alcohol-related liver disease (GALA-RIF): a randomised, double-blind, placebo-controlled, phase 2 trial

Autores: Mads Israelsen; Bjørn Stæhr Madsen; Nikolaj Torp; Stine Johansen; Camilla Dalby Hansen; Sönke Detlefsen; Peter Andersen; Johanne Kragh Hansen; Katrine Prier Lindvig; Ditlev Nytoft Rasmussen; Katrine Holtz Thorhauge; Maria Kjærgaard; Morten Karsdal; Torben Hansen; Manimozhiyan Arumugam; Jonel Trebicka; Maja Thiele and Aleksander Krag
Publicado en: Lancet Gastroenterol Hepatol, 2023, ISSN 0140-6736
Editor: The Lancet Publishing Group
DOI: 10.1016/s2468-1253(23)00010-9

The Human Gut-Liver-Axis in Health and Disease

Autores: Aleksander KragTorben Hansen
Publicado en: The Human Gut-Liver-Axis in Health and Disease, 2019, ISBN 978-3-662-30830-1
Editor: Springer
DOI: 10.1007/978-3-319-98890-0

Reply to: “Definition of SPSS: we need to speak the same language”: Computer-assisted image processing for better quantification

Autores: Michael Praktiknjo, JordiTorner, Macarena Simón-Talero, Wenyi Gu, Antoni Perez-Poch, Cristina de laTorre6Inés delVal, Francisco Alpiste, Joan Genescà, Jonel Trebicka
Publicado en: Journal of Hepatology, 2020, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2020.04.012

Interleukin-22 in acute-on-chronic liver failure: A matter of ineffective levels, receptor dysregulation or defective signalling?

Autores: Katharina Maria Schwarzkopf, Larissa Eberle, Frank Erhard Uschner, Sabine Klein, RobertSchierwagen, Marcus Maximilian Mücke, Liliana Schaefer, Joan Clària, Stefan Zeuzem, Edith Hintermann, Urs Christen, Christian Markus Lange, JonelTrebicka, ChristophWelsch
Publicado en: Journal of Hepatology, 2020, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2020.05.012

Reply to: Rifaximin-a for liver fibrosis in patients with alcohol-related liver disease - Authors' reply

Autores: Mads Israelsen; Nikolaj Torp; Stine Johansen; Maja Thiele and Aleksander Krag
Publicado en: Lancet Gastroenterol Hepatol, 2023
Editor: Lancet
DOI: 10.1016/s2468-1253(23)00155-3

The Role of microRNAs in the Gut-Liver Axis

Autores: S. Georgiou, V. Pantazopoulou, Ema Anastasiadou
Publicado en: The Human Gut-Liver-Axis in Health and Disease, 2019, Página(s) 207-234, ISBN 978-3-319-98889-4
Editor: Springer International Publishing
DOI: 10.1007/978-3-319-98890-0_13

Collagen proportionate area predicts clinical outcomes in patients with alcohol-related liver disease

Autores: Mads Israelsen,Marta Guerrero Misas,Anastasios Koutsoumourakis,Yi Huang,Maja Thiele,Andrew Hall,Ditlev Rasmussen,Claudia Covelli,Elena Buzzetti,Laura Iogna Prat,Davide Roccarina,Sönke Detlefsen,Tu Vinh Luong,Alberto Quaglia,Aleksander Krag,Gary Jeffrey,Massimo Pinzani,Emmanuel A. Tsochatzis
Publicado en: Alimentary Pharmacology and Therapeutics, 2020, ISSN 1365-2036
Editor: John Wiley & Sons Ltd
DOI: 10.1111/apt.16111

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