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RELapses prevENTion in chronic autoimmune disease: common mechanisms and co-morbidities

Deliverables

Launch of website, Twitter, Research Gate, LinkedIn, Account and general project flyer/poster

Launch of website, Twitter, Research Gate, LinkedIn, Account and general project flyer/poster (inlcuding description of web site contencts and management)

Recruitment report update for “immune ageing in health and disease“

The report shall include an overview of recruited subjects by study site, potential recruiting problems and, if applicable, a detailed description of implemented and planned measures to compensate delays in the study subject recruitment.

Report on status of posting results in the study registry(s) for “Research into Genetic variation AND Leucocyte Altered Function in health and disease (GANDALF)“

A report on the status of the result posting that includes timelines when final posting of results is scheduled after end of funding period.

"Midterm recruitment report for ""RELENT bank of induced pluripotent stem cells"""

The report shall include an overview of recruited subjects by study site potential recruiting problems and if applicable a detailed description of implemented and planned measures to compensate delays in the study subject recruitment

All approvals package for “RELENT bank of induced pluripotent stem cells”

The all approvals package should include all approvals from ethics committees and national competent authorities (if applicable) of all study sites once the last approval has been received.

Recruitment report update for “AV-GWAS (Multi-Centre Genome-Wide Association Study of ANCA-associated vasculitis)”

The report shall include an overview of recruited subjects by study site, potential recruiting problems and, if applicable, a detailed description of implemented and planned measures to compensate delays in the study subject recruitment.

Report on status of posting results in the study registry(s) for “CD4+ T cells and immune ageing, major players and predictors for disease activity in giant cell arteritis”

A report on the status of the result posting that includes timelines when final posting of results is scheduled after end of funding period.

"First study subject approvals package for ""RELENT bank of induced pluripotent stem cells"""

It will be provided a final version of study protocol as submitted to regulators ethics committees b registration number of CS in a WHO or ICMJE approved registry and c approvals ethics committees and national competent authority if applicable required for invitation enrolment of first subject in at least one clinical centre

Report on status of posting results in the study registry(s) for “RELENT bank of induced pluripotent stem cells”

A report on the status of the result posting that includes timelines when final posting of results is scheduled after end of funding period.

Recruitment report update for “ANCA associated vasculitis is a relapsing disease; the role of regulatory B cells”

The report shall include an overview of recruited subjects by study site, potential recruiting problems and, if applicable, a detailed description of implemented and planned measures to compensate delays in the study subject recruitment.

Recruitment report update for “Cambridge Hinxton Centre for Translational Research in Autoimmune Disease 2 (CHIC TRIAD2)”

The report shall include an overview of recruited subjects by study site, potential recruiting problems and, if applicable, a detailed description of implemented and planned measures to compensate delays in the study subject recruitment.

Report on status of posting results in the study registry(s) for “immune ageing in health and disease“

A report on the status of the result posting that includes timelines when final posting of results is scheduled after end of funding period.

Recruitment report update for “CD4+ T cells and immune ageing, major players and predictors for disease activity in giant cell arteritis”

The report shall include an overview of recruited subjects by study site, potential recruiting problems and, if applicable, a detailed description of implemented and planned measures to compensate delays in the study subject recruitment.

Report on status of posting results in the study registry(s) for “AV-GWAS (Multi-Centre Genome-Wide Association Study of ANCA-associated vasculitis)”

A report on the status of the result posting that includes timelines when final posting of results is scheduled after end of funding period.

Report on status of posting results in the study registry(s) for “Cambridge Hinxton Centre for Translational Research in Autoimmune Disease 2 (CHIC TRIAD2)”

A report on the status of the result posting that includes timelines when final posting of results is scheduled after end of funding period.

Recruitment report update for “Research into Genetic variation AND Leucocyte Altered Function in health and disease (GANDALF)“

The report shall include an overview of recruited subjects by study site, potential recruiting problems and, if applicable, a detailed description of implemented and planned measures to compensate delays in the study subject recruitment.

Report on status of posting results in the study registry(s) for “ANCA associated vasculitis is a relapsing disease; the role of regulatory B cells”

A report on the status of the result posting that includes timelines when final posting of results is scheduled after end of funding period.

Individualized press release for every partner

Individualized press release for every partner (including description of the partners, scope and expected impact of the project)

Preparation of first bi-annual newsletter

Preparation of first bi-annual newsletter (including achievements and report on impact)

Report on dissemination and communication activities

Report on dissemination and communication activities

Searching for OpenAIRE data...

Publications

ANCA-associated vasculitis

Author(s): A. Richard Kitching, Hans-Joachim Anders, Neil Basu, Elisabeth Brouwer, Jennifer Gordon, David R. Jayne, Joyce Kullman, Paul A. Lyons, Peter A. Merkel, Caroline O. S. Savage, Ulrich Specks, Renate Kain
Published in: Nature Reviews Disease Primers, 6/1, 2020, ISSN 2056-676X
Publisher: NATURE REVIEWS
DOI: 10.1038/s41572-020-0204-y

Toll-like receptors in lupus nephritis

Author(s): Satish Kumar Devarapu, Hans-Joachim Anders
Published in: Journal of Biomedical Science, 25/1, 2018, ISSN 1423-0127
Publisher: Journal of Biomedical Science
DOI: 10.1186/s12929-018-0436-2

CD27+CD38hi B Cell Frequency During Remission Predicts Relapsing Disease in Granulomatosis With Polyangiitis Patients

Author(s): Anouk von Borstel, Judith Land, Wayel H. Abdulahad, Abraham Rutgers, Coen A. Stegeman, Arjan Diepstra, Peter Heeringa, Jan Stephan Sanders
Published in: Frontiers in Immunology, 10, 2019, ISSN 1664-3224
Publisher: Frontiers in Immunology
DOI: 10.3389/fimmu.2019.02221

Processing and Maturation of Cathepsin C Zymogen: A Biochemical and Molecular Modeling Analysis

Author(s): Anne-Sophie Lamort, Yveline Hamon, Cezary Czaplewski, Artur Gieldon, Seda Seren, Laurent Coquet, Fabien Lecaille, Adam Lesner, Gilles Lalmanach, Francis Gauthier, Dieter Jenne, Brice Korkmaz
Published in: International Journal of Molecular Sciences, 20/19, 2019, Page(s) 4747, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20194747

Increased miR-142-3p Expression Might Explain Reduced Regulatory T Cell Function in Granulomatosis With Polyangiitis

Author(s): Gerjan J. Dekkema, Theo Bijma, Pytrick G. Jellema, Anke Van Den Berg, Bart-Jan Kroesen, Coen A. Stegeman, Peter Heeringa, Wayel H. Abdulahad, Jan-Stephan Sanders
Published in: Frontiers in Immunology, 10, 2019, ISSN 1664-3224
Publisher: Frontiers in Immunology
DOI: 10.3389/fimmu.2019.02170

Prolonged IKKβ Inhibition Improves Ongoing CTL Antitumor Responses by Incapacitating Regulatory T Cells

Author(s): Christoph Heuser, Janine Gotot, Eveline Christina Piotrowski, Marie-Sophie Philipp, Christina Johanna Felicia Courrèges, Martin Sylvester Otte, Linlin Guo, Jonathan Leo Schmid-Burgk, Veit Hornung, Annkristin Heine, Percy Alexander Knolle, Natalio Garbi, Edgar Serfling, César Evaristo, Friedrich Thaiss, Christian Kurts
Published in: Cell Reports, 21/3, 2017, Page(s) 578-586, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2017.09.082

Irf4 -dependent CD103 + CD11b + dendritic cells and the intestinal microbiome regulate monocyte and macrophage activation and intestinal peristalsis in postoperative ileus

Author(s): Judith-Mira Pohl, Sebastian Gutweiler, Stephanie Thiebes, Julia K Volke, Ludger Klein-Hitpass, Denise Zwanziger, Matthias Gunzer, Steffen Jung, William W Agace, Christian Kurts, Daniel Robert Engel
Published in: Gut, 66/12, 2017, Page(s) 2110-2120, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2017-313856

Exploiting the S4–S5 Specificity of Human Neutrophil Proteinase 3 to Improve the Potency of Peptidyl Di(chlorophenyl)-phosphonate Ester Inhibitors: A Kinetic and Molecular Modeling Analysis

Author(s): Carla Guarino, Natalia Gruba, Renata Grzywa, Edyta Dyguda-Kazimierowicz, Yveline Hamon, Monika Łȩgowska, Marcin Skoreński, Sandrine Dallet-Choisy, Sylvain Marchand-Adam, Christine Kellenberger, Dieter E. Jenne, Marcin Sieńczyk, Adam Lesner, Francis Gauthier, Brice Korkmaz
Published in: Journal of Medicinal Chemistry, 61/5, 2018, Page(s) 1858-1870, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.7b01416

Lymphatic exosomes promote dendritic cell migration along guidance cues

Author(s): Markus Brown, Louise A. Johnson, Dario A. Leone, Peter Majek, Kari Vaahtomeri, Daniel Senfter, Nora Bukosza, Helga Schachner, Gabriele Asfour, Brigitte Langer, Robert Hauschild, Katja Parapatics, Young-Kwon Hong, Keiryn L. Bennett, Renate Kain, Michael Detmar, Michael Sixt, David G. Jackson, Dontscho Kerjaschki
Published in: The Journal of Cell Biology, 2018, Page(s) jcb.201612051, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.201612051

Review: What Is the Current Evidence for Disease Subsets in Giant Cell Arteritis?

Author(s): Kornelis S. M. van der Geest, Maria Sandovici, Yannick van Sleen, Jan-Stephan Sanders, Nicolaas A. Bos, Wayel H. Abdulahad, Coen A. Stegeman, Peter Heeringa, Abraham Rutgers, Cees G. M. Kallenberg, Annemieke M. H. Boots, Elisabeth Brouwer
Published in: Arthritis & Rheumatology, 70/9, 2018, Page(s) 1366-1376, ISSN 2326-5191
Publisher: Wiley
DOI: 10.1002/art.40520

Urinary and serum soluble CD25 complements urinary soluble CD163 to detect active renal anti-neutrophil cytoplasmic autoantibody-associated vasculitis: a cohort study

Author(s): Gerjan J Dekkema, Wayel H Abdulahad, Theo Bijma, Sarah M Moran, Louise Ryan, Mark A Little, Coen A Stegeman, Peter Heeringa, Jan Stephan Sanders
Published in: Nephrology Dialysis Transplantation, March 2018, 2018, ISSN 0931-0509
Publisher: Oxford University Press
DOI: 10.1093/ndt/gfy018

Cellular immune regulation in the pathogenesis of ANCA-associated vasculitides

Author(s): Anouk von Borstel, Jan Stephan Sanders, Abraham Rutgers, Coen A. Stegeman, Peter Heeringa, Wayel H. Abdulahad
Published in: Autoimmunity Reviews, 17/4, 2018, Page(s) 413-421, ISSN 1568-9972
Publisher: Elsevier BV
DOI: 10.1016/j.autrev.2017.12.002

Checks and Balances in Autoimmune Vasculitis

Author(s): Rebeca Hid Cadena, Wayel H. Abdulahad, G. A. P. Hospers, T. T. Wind, Annemieke M. H. Boots, Peter Heeringa, Elisabeth Brouwer
Published in: Frontiers in Immunology, 9, 2018, Page(s) 315, ISSN 1664-3224
Publisher: Frontiers Media
DOI: 10.3389/fimmu.2018.00315

Comprehensive Proteoform Characterization of Plasma Complement Component C8αβγ by Hybrid Mass Spectrometry Approaches

Author(s): Vojtech Franc, Jing Zhu, Albert J. R. Heck
Published in: Journal of The American Society for Mass Spectrometry, 29/6, 2018, Page(s) 1099-1110, ISSN 1044-0305
Publisher: Elsevier BV
DOI: 10.1007/s13361-018-1901-6

Reprint of “Dual blockade of the pro-inflammatory chemokine CCL2 and the homeostatic chemokine CXCL12 is as effective as high dose cyclophosphamide in murine proliferative lupus nephritis”

Author(s): Satish Kumar Devarapu, Santhosh Kumar VR, Khader Valli Rupanagudi, Onkar P. Kulkarni, Dirk Eulberg, Sven Klussmann, Hans-Joachim Anders
Published in: Clinical Immunology, 185, 2017, Page(s) 119-127, ISSN 1521-6616
Publisher: Academic Press
DOI: 10.1016/j.clim.2017.10.011

Parsimonious Charge Deconvolution for Native Mass Spectrometry

Author(s): Marshall Bern, Tomislav Caval, Yong J. Kil, Wilfred Tang, Christopher Becker, Eric Carlson, Doron Kletter, K. Ilker Sen, Nicolas Galy, Dominique Hagemans, Vojtech Franc, Albert J. R. Heck
Published in: Journal of Proteome Research, 17/3, 2018, Page(s) 1216-1226, ISSN 1535-3893
Publisher: American Chemical Society
DOI: 10.1021/acs.jproteome.7b00839

Direct quality control of glycoengineered erythropoietin variants

Author(s): Tomislav Čaval, Weihua Tian, Zhang Yang, Henrik Clausen, Albert J. R. Heck
Published in: Nature Communications, 9/1, 2018, Page(s) 3342, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-05536-3

Therapeutic targeting of cathepsin C: from pathophysiology to treatment

Author(s): Brice Korkmaz, George H. Caughey, Iain Chapple, Francis Gauthier, Josefine Hirschfeld, Dieter E. Jenne, Ralph Kettritz, Gilles Lalmanach, Anne-Sophie Lamort, Conni Lauritzen, Monika Łȩgowska, Adam Lesner, Sylvain Marchand-Adam, Sarah J. McKaig, Celia Moss, John Pedersen, Helen Roberts, Adrian Schreiber, Seda Seren, Nalin S. Thakker
Published in: Pharmacology & Therapeutics, 190, 2018, Page(s) 202-236, ISSN 0163-7258
Publisher: Pergamon Press
DOI: 10.1016/j.pharmthera.2018.05.011

Pathogenicity of human antibodies against myelin oligodendrocyte glycoprotein

Author(s): Melania Spadaro, Stephan Winklmeier, Eduardo Beltrán, Caterina Macrini, Romana Höftberger, Elisabeth Schuh, Franziska S. Thaler, Lisa Ann Gerdes, Sarah Laurent, Ramona Gerhards, Simone Brändle, Klaus Dornmair, Constanze Breithaupt, Markus Krumbholz, Markus Moser, Gurumoorthy Krishnamoorthy, Frits Kamp, Dieter Jenne, Reinhard Hohlfeld, Tania Kümpfel, Hans Lassmann, Naoto Kawakami, Edgar Meinl
Published in: Annals of Neurology, 84/2, 2018, Page(s) 315-328, ISSN 0364-5134
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/ana.25291

Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis

Author(s): Seda Seren, Maha Rashed Abouzaid, Claudia Eulenberg-Gustavus, Josefine Hirschfeld, Hala Nasr Soliman, Uwe Jerke, Koffi N'Guessan, Sandrine Dallet-Choisy, Adam Lesner, Conni Lauritzen, Beate Schacher, Peter Eickholz, Nikoletta Nagy, Marta Szell, Cécile Croix, Marie-Claude Viaud-Massuard, Abdullah Al Farraj Aldosari, Shivanna Ragunatha, Mostafa Ibrahim Mostafa, Francesca Giampieri, Maurizio Battino
Published in: Journal of Biological Chemistry, 293/32, 2018, Page(s) 12415-12428, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.RA118.001922

Extracellular traps in kidney disease

Author(s): Daigo Nakazawa, Julian A. Marschner, Louise Platen, Hans-Joachim Anders
Published in: Kidney International, 94/6, 2018, Page(s) 1087-1098, ISSN 0085-2538
Publisher: Blackwell Publishing Inc.
DOI: 10.1016/j.kint.2018.08.035

Dendritic cells and routing cargo into exosomes

Author(s): Dario A Leone, Andrew J Rees, Renate Kain
Published in: Immunology and Cell Biology, 96/7, 2018, Page(s) 683-693, ISSN 0818-9641
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/imcb.12170

Circulating cathepsin-S levels correlate with GFR decline and sTNFR1 and sTNFR2 levels in mice and humans

Author(s): Dominik Steubl, Santhosh V. Kumar, Maia Tato, Shrikant R. Mulay, Anders Larsson, Lars Lind, Ulf Risérus, Lutz Renders, Uwe Heemann, Axel C. Carlsson, Johan Ärnlöv, Hans-Joachim Anders
Published in: Scientific Reports, 7, 2017, Page(s) 43538, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/srep43538

HLA and kidney disease: from associations to mechanisms

Author(s): Kate J. Robson, Joshua D. Ooi, Stephen R. Holdsworth, Jamie Rossjohn, A. Richard Kitching
Published in: Nature Reviews Nephrology, 14/10, 2018, Page(s) 636-655, ISSN 1759-5061
Publisher: Nature Publishing Group
DOI: 10.1038/s41581-018-0057-8

ANCA-Associated Vasculitis: Pathogenesis, Models, and Preclinical Testing

Author(s): Holly L. Hutton, Stephen R. Holdsworth, A. Richard Kitching
Published in: Seminars in Nephrology, 37/5, 2017, Page(s) 418-435, ISSN 0270-9295
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.semnephrol.2017.05.016

A Novel Role for GATA3 in Mesangial Cells in Glomerular Development and Injury

Author(s): Irina V. Grigorieva, Andre Oszwald, Elena F. Grigorieva, Helga Schachner, Barbara Neudert, Tammo Ostendorf, Jürgen Floege, Maja T. Lindenmeyer, Clemens D. Cohen, Ulf Panzer, Christof Aigner, Alice Schmidt, Frank Grosveld, Rajesh V. Thakker, Andrew Jackson Rees, Renate Kain
Published in: Journal of the American Society of Nephrology, 30/9, 2019, Page(s) 1641-1658, ISSN 1046-6673
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1681/asn.2018111143

Decreased Expression of Negative Immune Checkpoint VISTA by CD4+ T Cells Facilitates T Helper 1, T Helper 17, and T Follicular Helper Lineage Differentiation in GCA

Author(s): Rebeca Hid Cadena, Rosanne D. Reitsema, Minke G. Huitema, Yannick van Sleen, Kornelis S. M. van der Geest, Peter Heeringa, Annemieke M. H. Boots, Wayel H. Abdulahad, Elisabeth Brouwer
Published in: Frontiers in Immunology, 10, 2019, ISSN 1664-3224
Publisher: Frontiers in Immunology
DOI: 10.3389/fimmu.2019.01638

Leukocyte Dynamics Reveal a Persistent Myeloid Dominance in Giant Cell Arteritis and Polymyalgia Rheumatica

Author(s): Yannick van Sleen, Jacoba C. Graver, Wayel H. Abdulahad, Kornelis S. M. van der Geest, Annemieke M. H. Boots, Maria Sandovici, Elisabeth Brouwer
Published in: Frontiers in Immunology, 10, 2019, ISSN 1664-3224
Publisher: Frontiers in Immunology
DOI: 10.3389/fimmu.2019.01981

The Glycosylation Site of Myelin Oligodendrocyte Glycoprotein Affects Autoantibody Recognition in a Large Proportion of Patients

Author(s): Iris Marti Fernandez, Caterina Macrini, Markus Krumbholz, Paul J. Hensbergen, Agnes L. Hipgrave Ederveen, Stephan Winklmeier, Atay Vural, Asli Kurne, Dieter Jenne, Frits Kamp, Lisa Ann Gerdes, Reinhard Hohlfeld, Manfred Wuhrer, Tania Kümpfel, Edgar Meinl
Published in: Frontiers in Immunology, 10, 2019, ISSN 1664-3224
Publisher: Frontiers in Immunology
DOI: 10.3389/fimmu.2019.01189

Premedication with a cathepsin C inhibitor alleviates early primary graft dysfunction in mouse recipients after lung transplantation

Author(s): Salome R. T. Rehm, Natalia F. Smirnova, Carmela Morrone, Jessica Götzfried, Annette Feuchtinger, John Pedersen, Brice Korkmaz, Ali Önder Yildirim, Dieter E. Jenne
Published in: Scientific Reports, 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-46206-8

Prolonged pharmacological inhibition of cathepsin C results in elimination of neutrophil serine proteases

Author(s): Carla Guarino, Yveline Hamon, C?cile Croix, Anne-Sophie Lamort, Sandrine Dallet-Choisy, Sylvain Marchand-Adam, Adam Lesner, Thomas Baranek, Marie-Claude Viaud-Massuard, Conni Lauritzen, John Pedersen, Nathalie Heuz?-Vourc'h, Mustapha Si-Tahar, Erhan F?ratl?, Dieter E. Jenne, Francis Gauthier, Marshall S. Horwitz, Niels Borregaard, Brice Korkmaz
Published in: Biochemical Pharmacology, 131, 2017, Page(s) 52-67, ISSN 0006-2952
Publisher: Elsevier BV
DOI: 10.1016/j.bcp.2017.02.009

Common coding variant in SERPINA1 increases the risk for large artery stroke

Author(s): Rainer Malik, Therese Dau, Maria Gonik, Anirudh Sivakumar, Daniel J. Deredge, Evgeniia V. Edeleva, Jessica G?tzfried, Sander W. van der Laan, Gerard Pasterkamp, Nathalie Beaufort, Susana Seixas, Steve Bevan, Lisa F. Lincz, Elizabeth G. Holliday, Annette I. Burgess, Kristiina Rannikm?e, Jens Minnerup, Jennifer Kriebel, Melanie Waldenberger, Martina M?ller-Nurasyid, Peter Lichtner, Danish Saleheen,
Published in: Proceedings of the National Academy of Sciences, 114/14, 2017, Page(s) 3613-3618, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1616301114

Regulated necrosis-related molecule mRNA expression in humans and mice and in murine acute tissue injury and systemic autoimmunity leading to progressive organ damage, and progressive fibrosis

Author(s): M. Honarpisheh, J. Desai, J. A. Marschner, M. Weidenbusch, M. Lech, V. Vielhauer, H.-J. Anders, S. R. Mulay
Published in: Bioscience Reports, 36/6, 2016, Page(s) e00425-e00425, ISSN 0144-8463
Publisher: Kluwer Academic Publishers
DOI: 10.1042/BSR20160336

Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases

Author(s): Yveline Hamon, Monika Legowska, Virginie Hervé, Sandrine Dallet-Choisy, Sylvain Marchand-Adam, Lise Vanderlynden, Michèle Demonte, Rich Williams, Christopher J. Scott, Mustapha Si-Tahar, Nathalie Heuzé-Vourc'h, Gilles Lalmanach, Dieter E. Jenne, Adam Lesner, Francis Gauthier, Brice Korkmaz
Published in: Journal of Biological Chemistry, 291/16, 2016, Page(s) 8486-8499, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.M115.707109

Surface LAMP-2 Is an Endocytic Receptor That Diverts Antigen Internalized by Human Dendritic Cells into Highly Immunogenic Exosomes

Author(s): Dario Armando Leone, Andrea Peschel, Markus Brown, Helga Schachner, Miriam J. Ball, Marianna Gyuraszova, Ulrike Salzer-Muhar, Minoru Fukuda, Caterina Vizzardelli, Barbara Bohle, Andrew J. Rees, Renate Kain
Published in: The Journal of Immunology, 2017, Page(s) ji1601263, ISSN 0022-1767
Publisher: American Association of Immunologists
DOI: 10.4049/jimmunol.1601263

Cellular and Molecular Mechanisms of Autoimmunity and Lupus Nephritis

Author(s): S.K. Devarapu, G. Lorenz, O.P. Kulkarni, H.-J. Anders, S.R. Mulay
Published in: International Review of Cell and Molecular Biology, 2017, Page(s) 43-154, ISSN 1937-6448
Publisher: Elsevier BV
DOI: 10.1016/bs.ircmb.2016.12.001

Quantitative analysis of protease recognition by inhibitors in plasma using microscale thermophoresis

Author(s): T. Dau, E. V. Edeleva, S. A. I. Seidel, R. A. Stockley, D. Braun, D. E. Jenne
Published in: Scientific Reports, 6/1, 2016, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/srep35413

Animal Models of ANCA Associated Vasculitis

Author(s): Lani Shochet, Stephen Holdsworth, A. Richard Kitching
Published in: Frontiers in Immunology, 11, 2020, ISSN 1664-3224
Publisher: Frontiers in Immunology
DOI: 10.3389/fimmu.2020.00525

Proteoform Profile Mapping of the Human Serum Complement Component C9 Revealing Unexpected New Features of N -, O -, and C -Glycosylation

Author(s): Vojtech Franc, Yang Yang, Albert J. R. Heck
Published in: Analytical Chemistry, 89/6, 2017, Page(s) 3483-3491, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.6b04527

Resolving the micro-heterogeneity and structural integrity of monoclonal antibodies by hybrid mass spectrometric approaches

Author(s): Yang Yang, Guanbo Wang, Ting Song, Carlito B. Lebrilla, Albert J. R. Heck
Published in: mAbs, 9/4, 2017, Page(s) 638-645, ISSN 1942-0870
Publisher: Landes Bioscience
DOI: 10.1080/19420862.2017.1290033

Preservation with α1-antitrypsin improves primary graft function of murine lung transplants

Author(s): Jessica Götzfried, Natalia F. Smirnova, Carmela Morrone, Brice Korkmaz, Ali Önder Yildirim, Oliver Eickelberg, Dieter E. Jenne
Published in: The Journal of Heart and Lung Transplantation, 37/8, 2018, Page(s) 1021-1028, ISSN 1053-2498
Publisher: Elsevier BV
DOI: 10.1016/j.healun.2018.03.015

Neutrophil myeloperoxidase harbors distinct site-specific peculiarities in its glycosylation

Author(s): Karli R. Reiding, Vojtech Franc, Minke G. Huitema, Elisabeth Brouwer, Peter Heeringa, Albert J.R. Heck
Published in: Journal of Biological Chemistry, 294/52, 2019, Page(s) 20233-20245, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra119.011098

The glomerular crescent

Author(s): Lidia Anguiano, Renate Kain, Hans-Joachim Anders
Published in: Current Opinion in Nephrology and Hypertension, 29/3, 2020, Page(s) 302-309, ISSN 1062-4821
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/mnh.0000000000000596

A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity

Author(s): Joshua D. Ooi, Jhih-Hang Jiang, Peter J. Eggenhuizen, Ling L. Chua, Mirjan van Timmeren, Khai L. Loh, Kim M. O’Sullivan, Poh Y. Gan, Yong Zhong, Kirill Tsyganov, Lani R. Shochet, Jessica Ryan, Coen A. Stegeman, Lars Fugger, Hugh H. Reid, Jamie Rossjohn, Peter Heeringa, Stephen R. Holdsworth, Anton Y. Peleg, A. Richard Kitching
Published in: Nature Communications, 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-11255-0

Cathepsin S inhibition combines control of systemic and peripheral pathomechanisms of autoimmune tissue injury

Author(s): Maia Tato, Santhosh V. Kumar, Yajuan Liu, Shrikant R. Mulay, Solange Moll, Bastian Popper, Jonathan N. Eberhard, Dana Thomasova, Arne Christian Rufer, Sabine Gruner, Wolfgang Haap, Guido Hartmann, Hans-Joachim Anders
Published in: Scientific Reports, 7/1, 2017, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-017-01894-y

Chemokine receptor co-expression reveals aberrantly distributed TH effector memory cells in GPA patients

Author(s): Lucas L. Lintermans, Abraham Rutgers, Coen A. Stegeman, Peter Heeringa, Wayel H. Abdulahad
Published in: Arthritis Research & Therapy, 19/1, 2017, Page(s) 136, ISSN 1478-6362
Publisher: BioMed Central
DOI: 10.1186/s13075-017-1343-8

Towards precision medicine in ANCA-associated vasculitis

Author(s): Kornelis S M van der Geest, Elisabeth Brouwer, Jan-Stephan Sanders, Maria Sandovici, Nicolaas A Bos, Annemieke M H Boots, Wayel H Abdulahad, Coen A Stegeman, Cees G M Kallenberg, Peter Heeringa, Abraham Rutgers
Published in: Rheumatology, 2017, Page(s) 1332, ISSN 1462-0324
Publisher: Oxford University Press
DOI: 10.1093/rheumatology/kex367

Kv1.3 Channel Blockade Modulates the Effector Function of B Cells in Granulomatosis with Polyangiitis

Author(s): Judith Land, Lucas L. Lintermans, Coen A. Stegeman, Ernesto J. Muñoz-Elías, Eric J. Tarcha, Shawn P. Iadonato, Peter Heeringa, Abraham Rutgers, Wayel H. Abdulahad
Published in: Frontiers in Immunology, 8, 2017, Page(s) 1205, ISSN 1664-3224
Publisher: Frontiers Research Foundation
DOI: 10.3389/fimmu.2017.01205

Remote Activation of a Latent Epitope in an Autoantigen Decoded with Simulated B-Factors

Author(s): Yuan-Ping Pang; Marta Casal Moura; Gwen E. Thompson; Amber M. Hummel; Darlene R. Nelson; Dieter E. Jenne; Ulrich Specks
Published in: Frontiers in Immunology, 1, 2019, ISSN 1664-3224
Publisher: Frontiers in Immunology
DOI: 10.1101/559963

Discovery and Quantification of Nonhuman Proteins in Human Milk

Author(s): Jing Zhu, Luc Garrigues, Henk Van den Toorn, Bernd Stahl, Albert J. R. Heck
Published in: Journal of Proteome Research, 2018, ISSN 1535-3893
Publisher: American Chemical Society
DOI: 10.1021/acs.jproteome.8b00550

Deviation of antigen presentation through (auto)antibodies

Author(s): Kain R.
Published in: Séminaire Hospitalo-Universitaire de Strasbourg, 20/09/2018, 2018
Publisher: Université de Strasbourg

Update on Immune Mechanisms in Systemic Lupus and Lupus Nephritis

Author(s): Satish Kumar Devarapu, Hans-Joachim Anders, Khader Valli Rupanagudi
Published in: 2016
Publisher: Omics International

"""RELENT""Less on Target - von molekularen Mechanismen zur Präzisionsmedizin"

Author(s): Renate Kain
Published in: Mitteilungen der Deutschen Gesellschaft für Nephrologie, 2, 2016, Page(s) 20-23
Publisher: Deutschen Gesellschaft für Nephrologie

Systemische Vaskulitiden verstehen

Author(s): Renate Kain, Reno Barth
Published in: Medical Tribune Online, 2016, Page(s) 1
Publisher: Medical Tribune

A new role of LAMP-2 in macroautophagy

Author(s): Hubert V.
Published in: 14/11/2017, 2017
Publisher: Medical University Vienna

ISN Nexus 2016 Symposia: Translational Immunology in Kidney Disease—The Berlin Roadmap

Author(s): Hans-Joachim Anders, Brad Rovin, David Jayne, Paul Brunetta, Rosanna Coppo, Anne Davidson, Satish Kumar Devarapu, Dick de Zeeuw, Jeremy Duffield, Dirk Eulberg, Alberto Fierro, Jürgen Floege, Steffen Frese, Loïc Guillevin, Stephen Holdsworth, Jeremy Hughes, Ralph Kettritz, Malte Kluger, Christian Krebs, Larissa Lapteva, Adeera Levin, Jinhua Li, Liz Lightstone, Matthias Mack, Ladan Mansouri, Steph
Published in: Kidney International Reports, 1/4, 2016, Page(s) 327-339, ISSN 2468-0249
Publisher: Elsevier Inc.
DOI: 10.1016/j.ekir.2016.06.009

The Role of Macroautophagy in T Cells

Author(s): Wei Jia, Ian McLeod, Ming-Xiao He, You-Wen He
Published in: Immunology, 2018, Page(s) 23-33, ISBN 9780-128098196
Publisher: Elsevier
DOI: 10.1016/b978-0-12-809819-6.00003-4

Isolation of exosomes from body fluids by differential ultracentrifugation

Author(s): Schulz S, Schachner H, Rees AJ, Kain R.
Published in: Poster, 2019
Publisher: 15th YSA PhD Symposium