Deliverables Documents, reports (17) Launch of website, Twitter, Research Gate, LinkedIn, Account and general project flyer/poster Launch of website, Twitter, Research Gate, LinkedIn, Account and general project flyer/poster (inlcuding description of web site contencts and management) Recruitment report update for “immune ageing in health and disease“ The report shall include an overview of recruited subjects by study site, potential recruiting problems and, if applicable, a detailed description of implemented and planned measures to compensate delays in the study subject recruitment. Report on status of posting results in the study registry(s) for “Research into Genetic variation AND Leucocyte Altered Function in health and disease (GANDALF)“ A report on the status of the result posting that includes timelines when final posting of results is scheduled after end of funding period. "Midterm recruitment report for ""RELENT bank of induced pluripotent stem cells""" The report shall include an overview of recruited subjects by study site potential recruiting problems and if applicable a detailed description of implemented and planned measures to compensate delays in the study subject recruitment All approvals package for “RELENT bank of induced pluripotent stem cells” The all approvals package should include all approvals from ethics committees and national competent authorities (if applicable) of all study sites once the last approval has been received. Recruitment report update for “AV-GWAS (Multi-Centre Genome-Wide Association Study of ANCA-associated vasculitis)” The report shall include an overview of recruited subjects by study site, potential recruiting problems and, if applicable, a detailed description of implemented and planned measures to compensate delays in the study subject recruitment. Report on status of posting results in the study registry(s) for “CD4+ T cells and immune ageing, major players and predictors for disease activity in giant cell arteritis” A report on the status of the result posting that includes timelines when final posting of results is scheduled after end of funding period. "First study subject approvals package for ""RELENT bank of induced pluripotent stem cells""" It will be provided a final version of study protocol as submitted to regulators ethics committees b registration number of CS in a WHO or ICMJE approved registry and c approvals ethics committees and national competent authority if applicable required for invitation enrolment of first subject in at least one clinical centre Report on status of posting results in the study registry(s) for “RELENT bank of induced pluripotent stem cells” A report on the status of the result posting that includes timelines when final posting of results is scheduled after end of funding period. Recruitment report update for “ANCA associated vasculitis is a relapsing disease; the role of regulatory B cells” The report shall include an overview of recruited subjects by study site, potential recruiting problems and, if applicable, a detailed description of implemented and planned measures to compensate delays in the study subject recruitment. Recruitment report update for “Cambridge Hinxton Centre for Translational Research in Autoimmune Disease 2 (CHIC TRIAD2)” The report shall include an overview of recruited subjects by study site, potential recruiting problems and, if applicable, a detailed description of implemented and planned measures to compensate delays in the study subject recruitment. Report on status of posting results in the study registry(s) for “immune ageing in health and disease“ A report on the status of the result posting that includes timelines when final posting of results is scheduled after end of funding period. Recruitment report update for “CD4+ T cells and immune ageing, major players and predictors for disease activity in giant cell arteritis” The report shall include an overview of recruited subjects by study site, potential recruiting problems and, if applicable, a detailed description of implemented and planned measures to compensate delays in the study subject recruitment. Report on status of posting results in the study registry(s) for “AV-GWAS (Multi-Centre Genome-Wide Association Study of ANCA-associated vasculitis)” A report on the status of the result posting that includes timelines when final posting of results is scheduled after end of funding period. Report on status of posting results in the study registry(s) for “Cambridge Hinxton Centre for Translational Research in Autoimmune Disease 2 (CHIC TRIAD2)” A report on the status of the result posting that includes timelines when final posting of results is scheduled after end of funding period. Recruitment report update for “Research into Genetic variation AND Leucocyte Altered Function in health and disease (GANDALF)“ The report shall include an overview of recruited subjects by study site, potential recruiting problems and, if applicable, a detailed description of implemented and planned measures to compensate delays in the study subject recruitment. Report on status of posting results in the study registry(s) for “ANCA associated vasculitis is a relapsing disease; the role of regulatory B cells” A report on the status of the result posting that includes timelines when final posting of results is scheduled after end of funding period. Websites, patent fillings, videos etc. (3) Individualized press release for every partner Individualized press release for every partner (including description of the partners, scope and expected impact of the project) Preparation of first bi-annual newsletter Preparation of first bi-annual newsletter (including achievements and report on impact) Report on dissemination and communication activities Report on dissemination and communication activities Publications Peer reviewed articles (50) ANCA-associated vasculitis Author(s): A. Richard Kitching, Hans-Joachim Anders, Neil Basu, Elisabeth Brouwer, Jennifer Gordon, David R. Jayne, Joyce Kullman, Paul A. Lyons, Peter A. Merkel, Caroline O. S. Savage, Ulrich Specks, Renate Kain Published in: Nature Reviews Disease Primers, Issue 6/1, 2020, ISSN 2056-676X Publisher: NATURE REVIEWS DOI: 10.1038/s41572-020-0204-y Toll-like receptors in lupus nephritis Author(s): Satish Kumar Devarapu, Hans-Joachim Anders Published in: Journal of Biomedical Science, Issue 25/1, 2018, ISSN 1423-0127 Publisher: Journal of Biomedical Science DOI: 10.1186/s12929-018-0436-2 CD27+CD38hi B Cell Frequency During Remission Predicts Relapsing Disease in Granulomatosis With Polyangiitis Patients Author(s): Anouk von Borstel, Judith Land, Wayel H. Abdulahad, Abraham Rutgers, Coen A. Stegeman, Arjan Diepstra, Peter Heeringa, Jan Stephan Sanders Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224 Publisher: Frontiers in Immunology DOI: 10.3389/fimmu.2019.02221 Processing and Maturation of Cathepsin C Zymogen: A Biochemical and Molecular Modeling Analysis Author(s): Anne-Sophie Lamort, Yveline Hamon, Cezary Czaplewski, Artur Gieldon, Seda Seren, Laurent Coquet, Fabien Lecaille, Adam Lesner, Gilles Lalmanach, Francis Gauthier, Dieter Jenne, Brice Korkmaz Published in: International Journal of Molecular Sciences, Issue 20/19, 2019, Page(s) 4747, ISSN 1422-0067 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ijms20194747 Increased miR-142-3p Expression Might Explain Reduced Regulatory T Cell Function in Granulomatosis With Polyangiitis Author(s): Gerjan J. Dekkema, Theo Bijma, Pytrick G. Jellema, Anke Van Den Berg, Bart-Jan Kroesen, Coen A. Stegeman, Peter Heeringa, Wayel H. Abdulahad, Jan-Stephan Sanders Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224 Publisher: Frontiers in Immunology DOI: 10.3389/fimmu.2019.02170 Prolonged IKKβ Inhibition Improves Ongoing CTL Antitumor Responses by Incapacitating Regulatory T Cells Author(s): Christoph Heuser, Janine Gotot, Eveline Christina Piotrowski, Marie-Sophie Philipp, Christina Johanna Felicia Courrèges, Martin Sylvester Otte, Linlin Guo, Jonathan Leo Schmid-Burgk, Veit Hornung, Annkristin Heine, Percy Alexander Knolle, Natalio Garbi, Edgar Serfling, César Evaristo, Friedrich Thaiss, Christian Kurts Published in: Cell Reports, Issue 21/3, 2017, Page(s) 578-586, ISSN 2211-1247 Publisher: Cell Press DOI: 10.1016/j.celrep.2017.09.082 Irf4 -dependent CD103 + CD11b + dendritic cells and the intestinal microbiome regulate monocyte and macrophage activation and intestinal peristalsis in postoperative ileus Author(s): Judith-Mira Pohl, Sebastian Gutweiler, Stephanie Thiebes, Julia K Volke, Ludger Klein-Hitpass, Denise Zwanziger, Matthias Gunzer, Steffen Jung, William W Agace, Christian Kurts, Daniel Robert Engel Published in: Gut, Issue 66/12, 2017, Page(s) 2110-2120, ISSN 0017-5749 Publisher: BMJ Publishing Group DOI: 10.1136/gutjnl-2017-313856 Exploiting the S4–S5 Specificity of Human Neutrophil Proteinase 3 to Improve the Potency of Peptidyl Di(chlorophenyl)-phosphonate Ester Inhibitors: A Kinetic and Molecular Modeling Analysis Author(s): Carla Guarino, Natalia Gruba, Renata Grzywa, Edyta Dyguda-Kazimierowicz, Yveline Hamon, Monika Łȩgowska, Marcin Skoreński, Sandrine Dallet-Choisy, Sylvain Marchand-Adam, Christine Kellenberger, Dieter E. Jenne, Marcin Sieńczyk, Adam Lesner, Francis Gauthier, Brice Korkmaz Published in: Journal of Medicinal Chemistry, Issue 61/5, 2018, Page(s) 1858-1870, ISSN 0022-2623 Publisher: American Chemical Society DOI: 10.1021/acs.jmedchem.7b01416 Lymphatic exosomes promote dendritic cell migration along guidance cues Author(s): Markus Brown, Louise A. Johnson, Dario A. Leone, Peter Majek, Kari Vaahtomeri, Daniel Senfter, Nora Bukosza, Helga Schachner, Gabriele Asfour, Brigitte Langer, Robert Hauschild, Katja Parapatics, Young-Kwon Hong, Keiryn L. Bennett, Renate Kain, Michael Detmar, Michael Sixt, David G. Jackson, Dontscho Kerjaschki Published in: The Journal of Cell Biology, 2018, Page(s) jcb.201612051, ISSN 0021-9525 Publisher: Rockefeller University Press DOI: 10.1083/jcb.201612051 Review: What Is the Current Evidence for Disease Subsets in Giant Cell Arteritis? Author(s): Kornelis S. M. van der Geest, Maria Sandovici, Yannick van Sleen, Jan-Stephan Sanders, Nicolaas A. Bos, Wayel H. Abdulahad, Coen A. Stegeman, Peter Heeringa, Abraham Rutgers, Cees G. M. Kallenberg, Annemieke M. H. Boots, Elisabeth Brouwer Published in: Arthritis & Rheumatology, Issue 70/9, 2018, Page(s) 1366-1376, ISSN 2326-5191 Publisher: Wiley DOI: 10.1002/art.40520 Urinary and serum soluble CD25 complements urinary soluble CD163 to detect active renal anti-neutrophil cytoplasmic autoantibody-associated vasculitis: a cohort study Author(s): Gerjan J Dekkema, Wayel H Abdulahad, Theo Bijma, Sarah M Moran, Louise Ryan, Mark A Little, Coen A Stegeman, Peter Heeringa, Jan Stephan Sanders Published in: Nephrology Dialysis Transplantation, Issue March 2018, 2018, ISSN 0931-0509 Publisher: Oxford University Press DOI: 10.1093/ndt/gfy018 Cellular immune regulation in the pathogenesis of ANCA-associated vasculitides Author(s): Anouk von Borstel, Jan Stephan Sanders, Abraham Rutgers, Coen A. Stegeman, Peter Heeringa, Wayel H. Abdulahad Published in: Autoimmunity Reviews, Issue 17/4, 2018, Page(s) 413-421, ISSN 1568-9972 Publisher: Elsevier BV DOI: 10.1016/j.autrev.2017.12.002 Checks and Balances in Autoimmune Vasculitis Author(s): Rebeca Hid Cadena, Wayel H. Abdulahad, G. A. P. Hospers, T. T. Wind, Annemieke M. H. Boots, Peter Heeringa, Elisabeth Brouwer Published in: Frontiers in Immunology, Issue 9, 2018, Page(s) 315, ISSN 1664-3224 Publisher: Frontiers Media DOI: 10.3389/fimmu.2018.00315 Comprehensive Proteoform Characterization of Plasma Complement Component C8αβγ by Hybrid Mass Spectrometry Approaches Author(s): Vojtech Franc, Jing Zhu, Albert J. R. Heck Published in: Journal of The American Society for Mass Spectrometry, Issue 29/6, 2018, Page(s) 1099-1110, ISSN 1044-0305 Publisher: Elsevier BV DOI: 10.1007/s13361-018-1901-6 Reprint of “Dual blockade of the pro-inflammatory chemokine CCL2 and the homeostatic chemokine CXCL12 is as effective as high dose cyclophosphamide in murine proliferative lupus nephritis” Author(s): Satish Kumar Devarapu, Santhosh Kumar VR, Khader Valli Rupanagudi, Onkar P. Kulkarni, Dirk Eulberg, Sven Klussmann, Hans-Joachim Anders Published in: Clinical Immunology, Issue 185, 2017, Page(s) 119-127, ISSN 1521-6616 Publisher: Academic Press DOI: 10.1016/j.clim.2017.10.011 Parsimonious Charge Deconvolution for Native Mass Spectrometry Author(s): Marshall Bern, Tomislav Caval, Yong J. Kil, Wilfred Tang, Christopher Becker, Eric Carlson, Doron Kletter, K. Ilker Sen, Nicolas Galy, Dominique Hagemans, Vojtech Franc, Albert J. R. Heck Published in: Journal of Proteome Research, Issue 17/3, 2018, Page(s) 1216-1226, ISSN 1535-3893 Publisher: American Chemical Society DOI: 10.1021/acs.jproteome.7b00839 Direct quality control of glycoengineered erythropoietin variants Author(s): Tomislav Čaval, Weihua Tian, Zhang Yang, Henrik Clausen, Albert J. R. Heck Published in: Nature Communications, Issue 9/1, 2018, Page(s) 3342, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/s41467-018-05536-3 Therapeutic targeting of cathepsin C: from pathophysiology to treatment Author(s): Brice Korkmaz, George H. Caughey, Iain Chapple, Francis Gauthier, Josefine Hirschfeld, Dieter E. Jenne, Ralph Kettritz, Gilles Lalmanach, Anne-Sophie Lamort, Conni Lauritzen, Monika Łȩgowska, Adam Lesner, Sylvain Marchand-Adam, Sarah J. McKaig, Celia Moss, John Pedersen, Helen Roberts, Adrian Schreiber, Seda Seren, Nalin S. Thakker Published in: Pharmacology & Therapeutics, Issue 190, 2018, Page(s) 202-236, ISSN 0163-7258 Publisher: Pergamon Press DOI: 10.1016/j.pharmthera.2018.05.011 Pathogenicity of human antibodies against myelin oligodendrocyte glycoprotein Author(s): Melania Spadaro, Stephan Winklmeier, Eduardo Beltrán, Caterina Macrini, Romana Höftberger, Elisabeth Schuh, Franziska S. Thaler, Lisa Ann Gerdes, Sarah Laurent, Ramona Gerhards, Simone Brändle, Klaus Dornmair, Constanze Breithaupt, Markus Krumbholz, Markus Moser, Gurumoorthy Krishnamoorthy, Frits Kamp, Dieter Jenne, Reinhard Hohlfeld, Tania Kümpfel, Hans Lassmann, Naoto Kawakami, Edgar Meinl Published in: Annals of Neurology, Issue 84/2, 2018, Page(s) 315-328, ISSN 0364-5134 Publisher: John Wiley & Sons Inc. DOI: 10.1002/ana.25291 Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis Author(s): Seda Seren, Maha Rashed Abouzaid, Claudia Eulenberg-Gustavus, Josefine Hirschfeld, Hala Nasr Soliman, Uwe Jerke, Koffi N'Guessan, Sandrine Dallet-Choisy, Adam Lesner, Conni Lauritzen, Beate Schacher, Peter Eickholz, Nikoletta Nagy, Marta Szell, Cécile Croix, Marie-Claude Viaud-Massuard, Abdullah Al Farraj Aldosari, Shivanna Ragunatha, Mostafa Ibrahim Mostafa, Francesca Giampieri, Maurizio Battino Published in: Journal of Biological Chemistry, Issue 293/32, 2018, Page(s) 12415-12428, ISSN 0021-9258 Publisher: American Society for Biochemistry and Molecular Biology Inc. DOI: 10.1074/jbc.RA118.001922 Extracellular traps in kidney disease Author(s): Daigo Nakazawa, Julian A. Marschner, Louise Platen, Hans-Joachim Anders Published in: Kidney International, Issue 94/6, 2018, Page(s) 1087-1098, ISSN 0085-2538 Publisher: Blackwell Publishing Inc. DOI: 10.1016/j.kint.2018.08.035 Dendritic cells and routing cargo into exosomes Author(s): Dario A Leone, Andrew J Rees, Renate Kain Published in: Immunology and Cell Biology, Issue 96/7, 2018, Page(s) 683-693, ISSN 0818-9641 Publisher: Blackwell Publishing Inc. DOI: 10.1111/imcb.12170 Circulating cathepsin-S levels correlate with GFR decline and sTNFR1 and sTNFR2 levels in mice and humans Author(s): Dominik Steubl, Santhosh V. Kumar, Maia Tato, Shrikant R. Mulay, Anders Larsson, Lars Lind, Ulf Risérus, Lutz Renders, Uwe Heemann, Axel C. Carlsson, Johan Ärnlöv, Hans-Joachim Anders Published in: Scientific Reports, Issue 7, 2017, Page(s) 43538, ISSN 2045-2322 Publisher: Nature Publishing Group DOI: 10.1038/srep43538 HLA and kidney disease: from associations to mechanisms Author(s): Kate J. Robson, Joshua D. Ooi, Stephen R. Holdsworth, Jamie Rossjohn, A. Richard Kitching Published in: Nature Reviews Nephrology, Issue 14/10, 2018, Page(s) 636-655, ISSN 1759-5061 Publisher: Nature Publishing Group DOI: 10.1038/s41581-018-0057-8 ANCA-Associated Vasculitis: Pathogenesis, Models, and Preclinical Testing Author(s): Holly L. Hutton, Stephen R. Holdsworth, A. Richard Kitching Published in: Seminars in Nephrology, Issue 37/5, 2017, Page(s) 418-435, ISSN 0270-9295 Publisher: W. B. Saunders Co., Ltd. DOI: 10.1016/j.semnephrol.2017.05.016 A Novel Role for GATA3 in Mesangial Cells in Glomerular Development and Injury Author(s): Irina V. Grigorieva, Andre Oszwald, Elena F. Grigorieva, Helga Schachner, Barbara Neudert, Tammo Ostendorf, Jürgen Floege, Maja T. Lindenmeyer, Clemens D. Cohen, Ulf Panzer, Christof Aigner, Alice Schmidt, Frank Grosveld, Rajesh V. Thakker, Andrew Jackson Rees, Renate Kain Published in: Journal of the American Society of Nephrology, Issue 30/9, 2019, Page(s) 1641-1658, ISSN 1046-6673 Publisher: Lippincott Williams & Wilkins Ltd. DOI: 10.1681/asn.2018111143 Decreased Expression of Negative Immune Checkpoint VISTA by CD4+ T Cells Facilitates T Helper 1, T Helper 17, and T Follicular Helper Lineage Differentiation in GCA Author(s): Rebeca Hid Cadena, Rosanne D. Reitsema, Minke G. Huitema, Yannick van Sleen, Kornelis S. M. van der Geest, Peter Heeringa, Annemieke M. H. Boots, Wayel H. Abdulahad, Elisabeth Brouwer Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224 Publisher: Frontiers in Immunology DOI: 10.3389/fimmu.2019.01638 Leukocyte Dynamics Reveal a Persistent Myeloid Dominance in Giant Cell Arteritis and Polymyalgia Rheumatica Author(s): Yannick van Sleen, Jacoba C. Graver, Wayel H. Abdulahad, Kornelis S. M. van der Geest, Annemieke M. H. Boots, Maria Sandovici, Elisabeth Brouwer Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224 Publisher: Frontiers in Immunology DOI: 10.3389/fimmu.2019.01981 The Glycosylation Site of Myelin Oligodendrocyte Glycoprotein Affects Autoantibody Recognition in a Large Proportion of Patients Author(s): Iris Marti Fernandez, Caterina Macrini, Markus Krumbholz, Paul J. Hensbergen, Agnes L. Hipgrave Ederveen, Stephan Winklmeier, Atay Vural, Asli Kurne, Dieter Jenne, Frits Kamp, Lisa Ann Gerdes, Reinhard Hohlfeld, Manfred Wuhrer, Tania Kümpfel, Edgar Meinl Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224 Publisher: Frontiers in Immunology DOI: 10.3389/fimmu.2019.01189 Premedication with a cathepsin C inhibitor alleviates early primary graft dysfunction in mouse recipients after lung transplantation Author(s): Salome R. T. Rehm, Natalia F. Smirnova, Carmela Morrone, Jessica Götzfried, Annette Feuchtinger, John Pedersen, Brice Korkmaz, Ali Önder Yildirim, Dieter E. Jenne Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322 Publisher: Nature Publishing Group DOI: 10.1038/s41598-019-46206-8 Prolonged pharmacological inhibition of cathepsin C results in elimination of neutrophil serine proteases Author(s): Carla Guarino, Yveline Hamon, C?cile Croix, Anne-Sophie Lamort, Sandrine Dallet-Choisy, Sylvain Marchand-Adam, Adam Lesner, Thomas Baranek, Marie-Claude Viaud-Massuard, Conni Lauritzen, John Pedersen, Nathalie Heuz?-Vourc'h, Mustapha Si-Tahar, Erhan F?ratl?, Dieter E. Jenne, Francis Gauthier, Marshall S. Horwitz, Niels Borregaard, Brice Korkmaz Published in: Biochemical Pharmacology, Issue 131, 2017, Page(s) 52-67, ISSN 0006-2952 Publisher: Elsevier BV DOI: 10.1016/j.bcp.2017.02.009 Common coding variant in SERPINA1 increases the risk for large artery stroke Author(s): Rainer Malik, Therese Dau, Maria Gonik, Anirudh Sivakumar, Daniel J. Deredge, Evgeniia V. Edeleva, Jessica G?tzfried, Sander W. van der Laan, Gerard Pasterkamp, Nathalie Beaufort, Susana Seixas, Steve Bevan, Lisa F. Lincz, Elizabeth G. Holliday, Annette I. Burgess, Kristiina Rannikm?e, Jens Minnerup, Jennifer Kriebel, Melanie Waldenberger, Martina M?ller-Nurasyid, Peter Lichtner, Danish Saleheen, Published in: Proceedings of the National Academy of Sciences, Issue 114/14, 2017, Page(s) 3613-3618, ISSN 0027-8424 Publisher: National Academy of Sciences DOI: 10.1073/pnas.1616301114 Regulated necrosis-related molecule mRNA expression in humans and mice and in murine acute tissue injury and systemic autoimmunity leading to progressive organ damage, and progressive fibrosis Author(s): M. Honarpisheh, J. Desai, J. A. Marschner, M. Weidenbusch, M. Lech, V. Vielhauer, H.-J. Anders, S. R. Mulay Published in: Bioscience Reports, Issue 36/6, 2016, Page(s) e00425-e00425, ISSN 0144-8463 Publisher: Kluwer Academic Publishers DOI: 10.1042/BSR20160336 Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases Author(s): Yveline Hamon, Monika Legowska, Virginie Hervé, Sandrine Dallet-Choisy, Sylvain Marchand-Adam, Lise Vanderlynden, Michèle Demonte, Rich Williams, Christopher J. Scott, Mustapha Si-Tahar, Nathalie Heuzé-Vourc'h, Gilles Lalmanach, Dieter E. Jenne, Adam Lesner, Francis Gauthier, Brice Korkmaz Published in: Journal of Biological Chemistry, Issue 291/16, 2016, Page(s) 8486-8499, ISSN 0021-9258 Publisher: American Society for Biochemistry and Molecular Biology Inc. DOI: 10.1074/jbc.M115.707109 Surface LAMP-2 Is an Endocytic Receptor That Diverts Antigen Internalized by Human Dendritic Cells into Highly Immunogenic Exosomes Author(s): Dario Armando Leone, Andrea Peschel, Markus Brown, Helga Schachner, Miriam J. Ball, Marianna Gyuraszova, Ulrike Salzer-Muhar, Minoru Fukuda, Caterina Vizzardelli, Barbara Bohle, Andrew J. Rees, Renate Kain Published in: The Journal of Immunology, 2017, Page(s) ji1601263, ISSN 0022-1767 Publisher: American Association of Immunologists DOI: 10.4049/jimmunol.1601263 Cellular and Molecular Mechanisms of Autoimmunity and Lupus Nephritis Author(s): S.K. Devarapu, G. Lorenz, O.P. Kulkarni, H.-J. Anders, S.R. Mulay Published in: International Review of Cell and Molecular Biology, 2017, Page(s) 43-154, ISSN 1937-6448 Publisher: Elsevier BV DOI: 10.1016/bs.ircmb.2016.12.001 Quantitative analysis of protease recognition by inhibitors in plasma using microscale thermophoresis Author(s): T. Dau, E. V. Edeleva, S. A. I. Seidel, R. A. Stockley, D. Braun, D. E. Jenne Published in: Scientific Reports, Issue 6/1, 2016, ISSN 2045-2322 Publisher: Nature Publishing Group DOI: 10.1038/srep35413 Animal Models of ANCA Associated Vasculitis Author(s): Lani Shochet, Stephen Holdsworth, A. Richard Kitching Published in: Frontiers in Immunology, Issue 11, 2020, ISSN 1664-3224 Publisher: Frontiers in Immunology DOI: 10.3389/fimmu.2020.00525 Proteoform Profile Mapping of the Human Serum Complement Component C9 Revealing Unexpected New Features of N -, O -, and C -Glycosylation Author(s): Vojtech Franc, Yang Yang, Albert J. R. Heck Published in: Analytical Chemistry, Issue 89/6, 2017, Page(s) 3483-3491, ISSN 0003-2700 Publisher: American Chemical Society DOI: 10.1021/acs.analchem.6b04527 Resolving the micro-heterogeneity and structural integrity of monoclonal antibodies by hybrid mass spectrometric approaches Author(s): Yang Yang, Guanbo Wang, Ting Song, Carlito B. Lebrilla, Albert J. R. Heck Published in: mAbs, Issue 9/4, 2017, Page(s) 638-645, ISSN 1942-0870 Publisher: Landes Bioscience DOI: 10.1080/19420862.2017.1290033 Preservation with α1-antitrypsin improves primary graft function of murine lung transplants Author(s): Jessica Götzfried, Natalia F. Smirnova, Carmela Morrone, Brice Korkmaz, Ali Önder Yildirim, Oliver Eickelberg, Dieter E. Jenne Published in: The Journal of Heart and Lung Transplantation, Issue 37/8, 2018, Page(s) 1021-1028, ISSN 1053-2498 Publisher: Elsevier BV DOI: 10.1016/j.healun.2018.03.015 Neutrophil myeloperoxidase harbors distinct site-specific peculiarities in its glycosylation Author(s): Karli R. Reiding, Vojtech Franc, Minke G. Huitema, Elisabeth Brouwer, Peter Heeringa, Albert J.R. Heck Published in: Journal of Biological Chemistry, Issue 294/52, 2019, Page(s) 20233-20245, ISSN 0021-9258 Publisher: American Society for Biochemistry and Molecular Biology Inc. DOI: 10.1074/jbc.ra119.011098 The glomerular crescent Author(s): Lidia Anguiano, Renate Kain, Hans-Joachim Anders Published in: Current Opinion in Nephrology and Hypertension, Issue 29/3, 2020, Page(s) 302-309, ISSN 1062-4821 Publisher: Lippincott Williams & Wilkins Ltd. DOI: 10.1097/mnh.0000000000000596 A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity Author(s): Joshua D. Ooi, Jhih-Hang Jiang, Peter J. Eggenhuizen, Ling L. Chua, Mirjan van Timmeren, Khai L. Loh, Kim M. O’Sullivan, Poh Y. Gan, Yong Zhong, Kirill Tsyganov, Lani R. Shochet, Jessica Ryan, Coen A. Stegeman, Lars Fugger, Hugh H. Reid, Jamie Rossjohn, Peter Heeringa, Stephen R. Holdsworth, Anton Y. Peleg, A. Richard Kitching Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/s41467-019-11255-0 Cathepsin S inhibition combines control of systemic and peripheral pathomechanisms of autoimmune tissue injury Author(s): Maia Tato, Santhosh V. Kumar, Yajuan Liu, Shrikant R. Mulay, Solange Moll, Bastian Popper, Jonathan N. Eberhard, Dana Thomasova, Arne Christian Rufer, Sabine Gruner, Wolfgang Haap, Guido Hartmann, Hans-Joachim Anders Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322 Publisher: Nature Publishing Group DOI: 10.1038/s41598-017-01894-y Chemokine receptor co-expression reveals aberrantly distributed TH effector memory cells in GPA patients Author(s): Lucas L. Lintermans, Abraham Rutgers, Coen A. Stegeman, Peter Heeringa, Wayel H. Abdulahad Published in: Arthritis Research & Therapy, Issue 19/1, 2017, Page(s) 136, ISSN 1478-6362 Publisher: BioMed Central DOI: 10.1186/s13075-017-1343-8 Towards precision medicine in ANCA-associated vasculitis Author(s): Kornelis S M van der Geest, Elisabeth Brouwer, Jan-Stephan Sanders, Maria Sandovici, Nicolaas A Bos, Annemieke M H Boots, Wayel H Abdulahad, Coen A Stegeman, Cees G M Kallenberg, Peter Heeringa, Abraham Rutgers Published in: Rheumatology, 2017, Page(s) 1332, ISSN 1462-0324 Publisher: Oxford University Press DOI: 10.1093/rheumatology/kex367 Kv1.3 Channel Blockade Modulates the Effector Function of B Cells in Granulomatosis with Polyangiitis Author(s): Judith Land, Lucas L. Lintermans, Coen A. Stegeman, Ernesto J. Muñoz-Elías, Eric J. Tarcha, Shawn P. Iadonato, Peter Heeringa, Abraham Rutgers, Wayel H. Abdulahad Published in: Frontiers in Immunology, Issue 8, 2017, Page(s) 1205, ISSN 1664-3224 Publisher: Frontiers Research Foundation DOI: 10.3389/fimmu.2017.01205 Remote Activation of a Latent Epitope in an Autoantigen Decoded with Simulated B-Factors Author(s): Yuan-Ping Pang; Marta Casal Moura; Gwen E. Thompson; Amber M. Hummel; Darlene R. Nelson; Dieter E. Jenne; Ulrich Specks Published in: Frontiers in Immunology, Issue 1, 2019, ISSN 1664-3224 Publisher: Frontiers in Immunology DOI: 10.1101/559963 Discovery and Quantification of Nonhuman Proteins in Human Milk Author(s): Jing Zhu, Luc Garrigues, Henk Van den Toorn, Bernd Stahl, Albert J. R. Heck Published in: Journal of Proteome Research, 2018, ISSN 1535-3893 Publisher: American Chemical Society DOI: 10.1021/acs.jproteome.8b00550 Other (4) Deviation of antigen presentation through (auto)antibodies Author(s): Kain R. Published in: Séminaire Hospitalo-Universitaire de Strasbourg, Issue 20/09/2018, 2018 Publisher: Université de Strasbourg Update on Immune Mechanisms in Systemic Lupus and Lupus Nephritis Author(s): Satish Kumar Devarapu, Hans-Joachim Anders, Khader Valli Rupanagudi Published in: 2016 Publisher: Omics International """RELENT""Less on Target - von molekularen Mechanismen zur Präzisionsmedizin" Author(s): Renate Kain Published in: Mitteilungen der Deutschen Gesellschaft für Nephrologie, Issue 2, 2016, Page(s) 20-23 Publisher: Deutschen Gesellschaft für Nephrologie Systemische Vaskulitiden verstehen Author(s): Renate Kain, Reno Barth Published in: Medical Tribune Online, 2016, Page(s) 1 Publisher: Medical Tribune Thesis dissertations (1) A new role of LAMP-2 in macroautophagy Author(s): Hubert V. Published in: Issue 14/11/2017, 2017 Publisher: Medical University Vienna Non-peer reviewed articles (1) ISN Nexus 2016 Symposia: Translational Immunology in Kidney Disease—The Berlin Roadmap Author(s): Hans-Joachim Anders, Brad Rovin, David Jayne, Paul Brunetta, Rosanna Coppo, Anne Davidson, Satish Kumar Devarapu, Dick de Zeeuw, Jeremy Duffield, Dirk Eulberg, Alberto Fierro, Jürgen Floege, Steffen Frese, Loïc Guillevin, Stephen Holdsworth, Jeremy Hughes, Ralph Kettritz, Malte Kluger, Christian Krebs, Larissa Lapteva, Adeera Levin, Jinhua Li, Liz Lightstone, Matthias Mack, Ladan Mansouri, Steph Published in: Kidney International Reports, Issue 1/4, 2016, Page(s) 327-339, ISSN 2468-0249 Publisher: Elsevier Inc. DOI: 10.1016/j.ekir.2016.06.009 Book chapters (1) The Role of Macroautophagy in T Cells Author(s): Wei Jia, Ian McLeod, Ming-Xiao He, You-Wen He Published in: Immunology, 2018, Page(s) 23-33, ISBN 9780-128098196 Publisher: Elsevier DOI: 10.1016/b978-0-12-809819-6.00003-4 Conference proceedings (1) Isolation of exosomes from body fluids by differential ultracentrifugation Author(s): Schulz S, Schachner H, Rees AJ, Kain R. Published in: Poster, 2019 Publisher: 15th YSA PhD Symposium Searching for OpenAIRE data... There was an error trying to search data from OpenAIRE No results available
