RELapses prevENTion in chronic autoimmune disease: common mechanisms and co-morbidities

Resultado final

Launch of website, Twitter, Research Gate, LinkedIn, Account and general project flyer/poster

Launch of website, Twitter, Research Gate, LinkedIn, Account and general project flyer/poster (inlcuding description of web site contencts and management)

Recruitment report update for “immune ageing in health and disease“

The report shall include an overview of recruited subjects by study site, potential recruiting problems and, if applicable, a detailed description of implemented and planned measures to compensate delays in the study subject recruitment.

Report on status of posting results in the study registry(s) for “Research into Genetic variation AND Leucocyte Altered Function in health and disease (GANDALF)“

A report on the status of the result posting that includes timelines when final posting of results is scheduled after end of funding period.

"Midterm recruitment report for ""RELENT bank of induced pluripotent stem cells"""

The report shall include an overview of recruited subjects by study site potential recruiting problems and if applicable a detailed description of implemented and planned measures to compensate delays in the study subject recruitment

All approvals package for “RELENT bank of induced pluripotent stem cells”

The all approvals package should include all approvals from ethics committees and national competent authorities (if applicable) of all study sites once the last approval has been received.

Recruitment report update for “AV-GWAS (Multi-Centre Genome-Wide Association Study of ANCA-associated vasculitis)”

Report on status of posting results in the study registry(s) for “CD4+ T cells and immune ageing, major players and predictors for disease activity in giant cell arteritis”

A report on the status of the result posting that includes timelines when final posting of results is scheduled after end of funding period.

"First study subject approvals package for ""RELENT bank of induced pluripotent stem cells"""

It will be provided a final version of study protocol as submitted to regulators ethics committees b registration number of CS in a WHO or ICMJE approved registry and c approvals ethics committees and national competent authority if applicable required for invitation enrolment of first subject in at least one clinical centre

Report on status of posting results in the study registry(s) for “RELENT bank of induced pluripotent stem cells”

A report on the status of the result posting that includes timelines when final posting of results is scheduled after end of funding period.

Recruitment report update for “ANCA associated vasculitis is a relapsing disease; the role of regulatory B cells”

Recruitment report update for “Cambridge Hinxton Centre for Translational Research in Autoimmune Disease 2 (CHIC TRIAD2)”

Report on status of posting results in the study registry(s) for “immune ageing in health and disease“

A report on the status of the result posting that includes timelines when final posting of results is scheduled after end of funding period.

Recruitment report update for “CD4+ T cells and immune ageing, major players and predictors for disease activity in giant cell arteritis”

Report on status of posting results in the study registry(s) for “AV-GWAS (Multi-Centre Genome-Wide Association Study of ANCA-associated vasculitis)”

A report on the status of the result posting that includes timelines when final posting of results is scheduled after end of funding period.

Report on status of posting results in the study registry(s) for “Cambridge Hinxton Centre for Translational Research in Autoimmune Disease 2 (CHIC TRIAD2)”

A report on the status of the result posting that includes timelines when final posting of results is scheduled after end of funding period.

Recruitment report update for “Research into Genetic variation AND Leucocyte Altered Function in health and disease (GANDALF)“

Report on status of posting results in the study registry(s) for “ANCA associated vasculitis is a relapsing disease; the role of regulatory B cells”

A report on the status of the result posting that includes timelines when final posting of results is scheduled after end of funding period.

Individualized press release for every partner

Individualized press release for every partner (including description of the partners, scope and expected impact of the project)

Preparation of first bi-annual newsletter

Preparation of first bi-annual newsletter (including achievements and report on impact)

Report on dissemination and communication activities

Publicaciones

ANCA-associated vasculitis

Autores: A. Richard Kitching, Hans-Joachim Anders, Neil Basu, Elisabeth Brouwer, Jennifer Gordon, David R. Jayne, Joyce Kullman, Paul A. Lyons, Peter A. Merkel, Caroline O. S. Savage, Ulrich Specks, Renate Kain
Publicado en: Nature Reviews Disease Primers, Edición 6/1, 2020, ISSN 2056-676X
Editor: NATURE REVIEWS
DOI: 10.1038/s41572-020-0204-y

Toll-like receptors in lupus nephritis

Autores: Satish Kumar Devarapu, Hans-Joachim Anders
Publicado en: Journal of Biomedical Science, Edición 25/1, 2018, ISSN 1423-0127
Editor: Journal of Biomedical Science
DOI: 10.1186/s12929-018-0436-2

CD27+CD38hi B Cell Frequency During Remission Predicts Relapsing Disease in Granulomatosis With Polyangiitis Patients

Autores: Anouk von Borstel, Judith Land, Wayel H. Abdulahad, Abraham Rutgers, Coen A. Stegeman, Arjan Diepstra, Peter Heeringa, Jan Stephan Sanders
Publicado en: Frontiers in Immunology, Edición 10, 2019, ISSN 1664-3224
Editor: Frontiers in Immunology
DOI: 10.3389/fimmu.2019.02221

Processing and Maturation of Cathepsin C Zymogen: A Biochemical and Molecular Modeling Analysis

Autores: Anne-Sophie Lamort, Yveline Hamon, Cezary Czaplewski, Artur Gieldon, Seda Seren, Laurent Coquet, Fabien Lecaille, Adam Lesner, Gilles Lalmanach, Francis Gauthier, Dieter Jenne, Brice Korkmaz
Publicado en: International Journal of Molecular Sciences, Edición 20/19, 2019, Página(s) 4747, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20194747

Increased miR-142-3p Expression Might Explain Reduced Regulatory T Cell Function in Granulomatosis With Polyangiitis

Autores: Gerjan J. Dekkema, Theo Bijma, Pytrick G. Jellema, Anke Van Den Berg, Bart-Jan Kroesen, Coen A. Stegeman, Peter Heeringa, Wayel H. Abdulahad, Jan-Stephan Sanders
Publicado en: Frontiers in Immunology, Edición 10, 2019, ISSN 1664-3224
Editor: Frontiers in Immunology
DOI: 10.3389/fimmu.2019.02170

Prolonged IKKβ Inhibition Improves Ongoing CTL Antitumor Responses by Incapacitating Regulatory T Cells

Autores: Christoph Heuser, Janine Gotot, Eveline Christina Piotrowski, Marie-Sophie Philipp, Christina Johanna Felicia Courrèges, Martin Sylvester Otte, Linlin Guo, Jonathan Leo Schmid-Burgk, Veit Hornung, Annkristin Heine, Percy Alexander Knolle, Natalio Garbi, Edgar Serfling, César Evaristo, Friedrich Thaiss, Christian Kurts
Publicado en: Cell Reports, Edición 21/3, 2017, Página(s) 578-586, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2017.09.082

Irf4 -dependent CD103 + CD11b + dendritic cells and the intestinal microbiome regulate monocyte and macrophage activation and intestinal peristalsis in postoperative ileus

Autores: Judith-Mira Pohl, Sebastian Gutweiler, Stephanie Thiebes, Julia K Volke, Ludger Klein-Hitpass, Denise Zwanziger, Matthias Gunzer, Steffen Jung, William W Agace, Christian Kurts, Daniel Robert Engel
Publicado en: Gut, Edición 66/12, 2017, Página(s) 2110-2120, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2017-313856

Exploiting the S4–S5 Specificity of Human Neutrophil Proteinase 3 to Improve the Potency of Peptidyl Di(chlorophenyl)-phosphonate Ester Inhibitors: A Kinetic and Molecular Modeling Analysis

Autores: Carla Guarino, Natalia Gruba, Renata Grzywa, Edyta Dyguda-Kazimierowicz, Yveline Hamon, Monika Łȩgowska, Marcin Skoreński, Sandrine Dallet-Choisy, Sylvain Marchand-Adam, Christine Kellenberger, Dieter E. Jenne, Marcin Sieńczyk, Adam Lesner, Francis Gauthier, Brice Korkmaz
Publicado en: Journal of Medicinal Chemistry, Edición 61/5, 2018, Página(s) 1858-1870, ISSN 0022-2623
Editor: American Chemical Society
DOI: 10.1021/acs.jmedchem.7b01416

Lymphatic exosomes promote dendritic cell migration along guidance cues

Autores: Markus Brown, Louise A. Johnson, Dario A. Leone, Peter Majek, Kari Vaahtomeri, Daniel Senfter, Nora Bukosza, Helga Schachner, Gabriele Asfour, Brigitte Langer, Robert Hauschild, Katja Parapatics, Young-Kwon Hong, Keiryn L. Bennett, Renate Kain, Michael Detmar, Michael Sixt, David G. Jackson, Dontscho Kerjaschki
Publicado en: The Journal of Cell Biology, 2018, Página(s) jcb.201612051, ISSN 0021-9525
Editor: Rockefeller University Press
DOI: 10.1083/jcb.201612051

Review: What Is the Current Evidence for Disease Subsets in Giant Cell Arteritis?

Autores: Kornelis S. M. van der Geest, Maria Sandovici, Yannick van Sleen, Jan-Stephan Sanders, Nicolaas A. Bos, Wayel H. Abdulahad, Coen A. Stegeman, Peter Heeringa, Abraham Rutgers, Cees G. M. Kallenberg, Annemieke M. H. Boots, Elisabeth Brouwer
Publicado en: Arthritis & Rheumatology, Edición 70/9, 2018, Página(s) 1366-1376, ISSN 2326-5191
Editor: Wiley
DOI: 10.1002/art.40520

Urinary and serum soluble CD25 complements urinary soluble CD163 to detect active renal anti-neutrophil cytoplasmic autoantibody-associated vasculitis: a cohort study

Autores: Gerjan J Dekkema, Wayel H Abdulahad, Theo Bijma, Sarah M Moran, Louise Ryan, Mark A Little, Coen A Stegeman, Peter Heeringa, Jan Stephan Sanders
Publicado en: Nephrology Dialysis Transplantation, Edición March 2018, 2018, ISSN 0931-0509
Editor: Oxford University Press
DOI: 10.1093/ndt/gfy018

Cellular immune regulation in the pathogenesis of ANCA-associated vasculitides

Autores: Anouk von Borstel, Jan Stephan Sanders, Abraham Rutgers, Coen A. Stegeman, Peter Heeringa, Wayel H. Abdulahad
Publicado en: Autoimmunity Reviews, Edición 17/4, 2018, Página(s) 413-421, ISSN 1568-9972
Editor: Elsevier BV
DOI: 10.1016/j.autrev.2017.12.002

Checks and Balances in Autoimmune Vasculitis

Autores: Rebeca Hid Cadena, Wayel H. Abdulahad, G. A. P. Hospers, T. T. Wind, Annemieke M. H. Boots, Peter Heeringa, Elisabeth Brouwer
Publicado en: Frontiers in Immunology, Edición 9, 2018, Página(s) 315, ISSN 1664-3224
Editor: Frontiers Media
DOI: 10.3389/fimmu.2018.00315

Comprehensive Proteoform Characterization of Plasma Complement Component C8αβγ by Hybrid Mass Spectrometry Approaches

Autores: Vojtech Franc, Jing Zhu, Albert J. R. Heck
Publicado en: Journal of The American Society for Mass Spectrometry, Edición 29/6, 2018, Página(s) 1099-1110, ISSN 1044-0305
Editor: Elsevier BV
DOI: 10.1007/s13361-018-1901-6

Reprint of “Dual blockade of the pro-inflammatory chemokine CCL2 and the homeostatic chemokine CXCL12 is as effective as high dose cyclophosphamide in murine proliferative lupus nephritis”

Autores: Satish Kumar Devarapu, Santhosh Kumar VR, Khader Valli Rupanagudi, Onkar P. Kulkarni, Dirk Eulberg, Sven Klussmann, Hans-Joachim Anders
Publicado en: Clinical Immunology, Edición 185, 2017, Página(s) 119-127, ISSN 1521-6616
Editor: Academic Press
DOI: 10.1016/j.clim.2017.10.011

Parsimonious Charge Deconvolution for Native Mass Spectrometry

Autores: Marshall Bern, Tomislav Caval, Yong J. Kil, Wilfred Tang, Christopher Becker, Eric Carlson, Doron Kletter, K. Ilker Sen, Nicolas Galy, Dominique Hagemans, Vojtech Franc, Albert J. R. Heck
Publicado en: Journal of Proteome Research, Edición 17/3, 2018, Página(s) 1216-1226, ISSN 1535-3893
Editor: American Chemical Society
DOI: 10.1021/acs.jproteome.7b00839

Direct quality control of glycoengineered erythropoietin variants

Autores: Tomislav Čaval, Weihua Tian, Zhang Yang, Henrik Clausen, Albert J. R. Heck
Publicado en: Nature Communications, Edición 9/1, 2018, Página(s) 3342, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-018-05536-3

Therapeutic targeting of cathepsin C: from pathophysiology to treatment

Autores: Brice Korkmaz, George H. Caughey, Iain Chapple, Francis Gauthier, Josefine Hirschfeld, Dieter E. Jenne, Ralph Kettritz, Gilles Lalmanach, Anne-Sophie Lamort, Conni Lauritzen, Monika Łȩgowska, Adam Lesner, Sylvain Marchand-Adam, Sarah J. McKaig, Celia Moss, John Pedersen, Helen Roberts, Adrian Schreiber, Seda Seren, Nalin S. Thakker
Publicado en: Pharmacology & Therapeutics, Edición 190, 2018, Página(s) 202-236, ISSN 0163-7258
Editor: Pergamon Press
DOI: 10.1016/j.pharmthera.2018.05.011

Pathogenicity of human antibodies against myelin oligodendrocyte glycoprotein

Autores: Melania Spadaro, Stephan Winklmeier, Eduardo Beltrán, Caterina Macrini, Romana Höftberger, Elisabeth Schuh, Franziska S. Thaler, Lisa Ann Gerdes, Sarah Laurent, Ramona Gerhards, Simone Brändle, Klaus Dornmair, Constanze Breithaupt, Markus Krumbholz, Markus Moser, Gurumoorthy Krishnamoorthy, Frits Kamp, Dieter Jenne, Reinhard Hohlfeld, Tania Kümpfel, Hans Lassmann, Naoto Kawakami, Edgar Meinl
Publicado en: Annals of Neurology, Edición 84/2, 2018, Página(s) 315-328, ISSN 0364-5134
Editor: John Wiley & Sons Inc.
DOI: 10.1002/ana.25291

Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis

Autores: Seda Seren, Maha Rashed Abouzaid, Claudia Eulenberg-Gustavus, Josefine Hirschfeld, Hala Nasr Soliman, Uwe Jerke, Koffi N'Guessan, Sandrine Dallet-Choisy, Adam Lesner, Conni Lauritzen, Beate Schacher, Peter Eickholz, Nikoletta Nagy, Marta Szell, Cécile Croix, Marie-Claude Viaud-Massuard, Abdullah Al Farraj Aldosari, Shivanna Ragunatha, Mostafa Ibrahim Mostafa, Francesca Giampieri, Maurizio Battino
Publicado en: Journal of Biological Chemistry, Edición 293/32, 2018, Página(s) 12415-12428, ISSN 0021-9258
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.RA118.001922

Extracellular traps in kidney disease

Autores: Daigo Nakazawa, Julian A. Marschner, Louise Platen, Hans-Joachim Anders
Publicado en: Kidney International, Edición 94/6, 2018, Página(s) 1087-1098, ISSN 0085-2538
Editor: Blackwell Publishing Inc.
DOI: 10.1016/j.kint.2018.08.035

Dendritic cells and routing cargo into exosomes

Autores: Dario A Leone, Andrew J Rees, Renate Kain
Publicado en: Immunology and Cell Biology, Edición 96/7, 2018, Página(s) 683-693, ISSN 0818-9641
Editor: Blackwell Publishing Inc.
DOI: 10.1111/imcb.12170

Circulating cathepsin-S levels correlate with GFR decline and sTNFR1 and sTNFR2 levels in mice and humans

Autores: Dominik Steubl, Santhosh V. Kumar, Maia Tato, Shrikant R. Mulay, Anders Larsson, Lars Lind, Ulf Risérus, Lutz Renders, Uwe Heemann, Axel C. Carlsson, Johan Ärnlöv, Hans-Joachim Anders
Publicado en: Scientific Reports, Edición 7, 2017, Página(s) 43538, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/srep43538

HLA and kidney disease: from associations to mechanisms

Autores: Kate J. Robson, Joshua D. Ooi, Stephen R. Holdsworth, Jamie Rossjohn, A. Richard Kitching
Publicado en: Nature Reviews Nephrology, Edición 14/10, 2018, Página(s) 636-655, ISSN 1759-5061
Editor: Nature Publishing Group
DOI: 10.1038/s41581-018-0057-8

ANCA-Associated Vasculitis: Pathogenesis, Models, and Preclinical Testing

Autores: Holly L. Hutton, Stephen R. Holdsworth, A. Richard Kitching
Publicado en: Seminars in Nephrology, Edición 37/5, 2017, Página(s) 418-435, ISSN 0270-9295
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.semnephrol.2017.05.016

A Novel Role for GATA3 in Mesangial Cells in Glomerular Development and Injury

Autores: Irina V. Grigorieva, Andre Oszwald, Elena F. Grigorieva, Helga Schachner, Barbara Neudert, Tammo Ostendorf, Jürgen Floege, Maja T. Lindenmeyer, Clemens D. Cohen, Ulf Panzer, Christof Aigner, Alice Schmidt, Frank Grosveld, Rajesh V. Thakker, Andrew Jackson Rees, Renate Kain
Publicado en: Journal of the American Society of Nephrology, Edición 30/9, 2019, Página(s) 1641-1658, ISSN 1046-6673
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1681/asn.2018111143

Decreased Expression of Negative Immune Checkpoint VISTA by CD4+ T Cells Facilitates T Helper 1, T Helper 17, and T Follicular Helper Lineage Differentiation in GCA

Autores: Rebeca Hid Cadena, Rosanne D. Reitsema, Minke G. Huitema, Yannick van Sleen, Kornelis S. M. van der Geest, Peter Heeringa, Annemieke M. H. Boots, Wayel H. Abdulahad, Elisabeth Brouwer
Publicado en: Frontiers in Immunology, Edición 10, 2019, ISSN 1664-3224
Editor: Frontiers in Immunology
DOI: 10.3389/fimmu.2019.01638

Leukocyte Dynamics Reveal a Persistent Myeloid Dominance in Giant Cell Arteritis and Polymyalgia Rheumatica

Autores: Yannick van Sleen, Jacoba C. Graver, Wayel H. Abdulahad, Kornelis S. M. van der Geest, Annemieke M. H. Boots, Maria Sandovici, Elisabeth Brouwer
Publicado en: Frontiers in Immunology, Edición 10, 2019, ISSN 1664-3224
Editor: Frontiers in Immunology
DOI: 10.3389/fimmu.2019.01981

The Glycosylation Site of Myelin Oligodendrocyte Glycoprotein Affects Autoantibody Recognition in a Large Proportion of Patients

Autores: Iris Marti Fernandez, Caterina Macrini, Markus Krumbholz, Paul J. Hensbergen, Agnes L. Hipgrave Ederveen, Stephan Winklmeier, Atay Vural, Asli Kurne, Dieter Jenne, Frits Kamp, Lisa Ann Gerdes, Reinhard Hohlfeld, Manfred Wuhrer, Tania Kümpfel, Edgar Meinl
Publicado en: Frontiers in Immunology, Edición 10, 2019, ISSN 1664-3224
Editor: Frontiers in Immunology
DOI: 10.3389/fimmu.2019.01189

Premedication with a cathepsin C inhibitor alleviates early primary graft dysfunction in mouse recipients after lung transplantation

Autores: Salome R. T. Rehm, Natalia F. Smirnova, Carmela Morrone, Jessica Götzfried, Annette Feuchtinger, John Pedersen, Brice Korkmaz, Ali Önder Yildirim, Dieter E. Jenne
Publicado en: Scientific Reports, Edición 9/1, 2019, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-019-46206-8

Prolonged pharmacological inhibition of cathepsin C results in elimination of neutrophil serine proteases

Autores: Carla Guarino, Yveline Hamon, C?cile Croix, Anne-Sophie Lamort, Sandrine Dallet-Choisy, Sylvain Marchand-Adam, Adam Lesner, Thomas Baranek, Marie-Claude Viaud-Massuard, Conni Lauritzen, John Pedersen, Nathalie Heuz?-Vourc'h, Mustapha Si-Tahar, Erhan F?ratl?, Dieter E. Jenne, Francis Gauthier, Marshall S. Horwitz, Niels Borregaard, Brice Korkmaz
Publicado en: Biochemical Pharmacology, Edición 131, 2017, Página(s) 52-67, ISSN 0006-2952
Editor: Elsevier BV
DOI: 10.1016/j.bcp.2017.02.009

Common coding variant in SERPINA1 increases the risk for large artery stroke

Autores: Rainer Malik, Therese Dau, Maria Gonik, Anirudh Sivakumar, Daniel J. Deredge, Evgeniia V. Edeleva, Jessica G?tzfried, Sander W. van der Laan, Gerard Pasterkamp, Nathalie Beaufort, Susana Seixas, Steve Bevan, Lisa F. Lincz, Elizabeth G. Holliday, Annette I. Burgess, Kristiina Rannikm?e, Jens Minnerup, Jennifer Kriebel, Melanie Waldenberger, Martina M?ller-Nurasyid, Peter Lichtner, Danish Saleheen,
Publicado en: Proceedings of the National Academy of Sciences, Edición 114/14, 2017, Página(s) 3613-3618, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1616301114

Regulated necrosis-related molecule mRNA expression in humans and mice and in murine acute tissue injury and systemic autoimmunity leading to progressive organ damage, and progressive fibrosis

Autores: M. Honarpisheh, J. Desai, J. A. Marschner, M. Weidenbusch, M. Lech, V. Vielhauer, H.-J. Anders, S. R. Mulay
Publicado en: Bioscience Reports, Edición 36/6, 2016, Página(s) e00425-e00425, ISSN 0144-8463
Editor: Kluwer Academic Publishers
DOI: 10.1042/BSR20160336

Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases

Autores: Yveline Hamon, Monika Legowska, Virginie Hervé, Sandrine Dallet-Choisy, Sylvain Marchand-Adam, Lise Vanderlynden, Michèle Demonte, Rich Williams, Christopher J. Scott, Mustapha Si-Tahar, Nathalie Heuzé-Vourc'h, Gilles Lalmanach, Dieter E. Jenne, Adam Lesner, Francis Gauthier, Brice Korkmaz
Publicado en: Journal of Biological Chemistry, Edición 291/16, 2016, Página(s) 8486-8499, ISSN 0021-9258
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.M115.707109

Surface LAMP-2 Is an Endocytic Receptor That Diverts Antigen Internalized by Human Dendritic Cells into Highly Immunogenic Exosomes

Autores: Dario Armando Leone, Andrea Peschel, Markus Brown, Helga Schachner, Miriam J. Ball, Marianna Gyuraszova, Ulrike Salzer-Muhar, Minoru Fukuda, Caterina Vizzardelli, Barbara Bohle, Andrew J. Rees, Renate Kain
Publicado en: The Journal of Immunology, 2017, Página(s) ji1601263, ISSN 0022-1767
Editor: American Association of Immunologists
DOI: 10.4049/jimmunol.1601263

Cellular and Molecular Mechanisms of Autoimmunity and Lupus Nephritis

Autores: S.K. Devarapu, G. Lorenz, O.P. Kulkarni, H.-J. Anders, S.R. Mulay
Publicado en: International Review of Cell and Molecular Biology, 2017, Página(s) 43-154, ISSN 1937-6448
Editor: Elsevier BV
DOI: 10.1016/bs.ircmb.2016.12.001

Quantitative analysis of protease recognition by inhibitors in plasma using microscale thermophoresis

Autores: T. Dau, E. V. Edeleva, S. A. I. Seidel, R. A. Stockley, D. Braun, D. E. Jenne
Publicado en: Scientific Reports, Edición 6/1, 2016, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/srep35413

Animal Models of ANCA Associated Vasculitis

Autores: Lani Shochet, Stephen Holdsworth, A. Richard Kitching
Publicado en: Frontiers in Immunology, Edición 11, 2020, ISSN 1664-3224
Editor: Frontiers in Immunology
DOI: 10.3389/fimmu.2020.00525

Proteoform Profile Mapping of the Human Serum Complement Component C9 Revealing Unexpected New Features of N -, O -, and C -Glycosylation

Autores: Vojtech Franc, Yang Yang, Albert J. R. Heck
Publicado en: Analytical Chemistry, Edición 89/6, 2017, Página(s) 3483-3491, ISSN 0003-2700
Editor: American Chemical Society
DOI: 10.1021/acs.analchem.6b04527

Resolving the micro-heterogeneity and structural integrity of monoclonal antibodies by hybrid mass spectrometric approaches

Autores: Yang Yang, Guanbo Wang, Ting Song, Carlito B. Lebrilla, Albert J. R. Heck
Publicado en: mAbs, Edición 9/4, 2017, Página(s) 638-645, ISSN 1942-0870
Editor: Landes Bioscience
DOI: 10.1080/19420862.2017.1290033

Preservation with α1-antitrypsin improves primary graft function of murine lung transplants

Autores: Jessica Götzfried, Natalia F. Smirnova, Carmela Morrone, Brice Korkmaz, Ali Önder Yildirim, Oliver Eickelberg, Dieter E. Jenne
Publicado en: The Journal of Heart and Lung Transplantation, Edición 37/8, 2018, Página(s) 1021-1028, ISSN 1053-2498
Editor: Elsevier BV
DOI: 10.1016/j.healun.2018.03.015

Neutrophil myeloperoxidase harbors distinct site-specific peculiarities in its glycosylation

Autores: Karli R. Reiding, Vojtech Franc, Minke G. Huitema, Elisabeth Brouwer, Peter Heeringa, Albert J.R. Heck
Publicado en: Journal of Biological Chemistry, Edición 294/52, 2019, Página(s) 20233-20245, ISSN 0021-9258
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra119.011098

The glomerular crescent

Autores: Lidia Anguiano, Renate Kain, Hans-Joachim Anders
Publicado en: Current Opinion in Nephrology and Hypertension, Edición 29/3, 2020, Página(s) 302-309, ISSN 1062-4821
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/mnh.0000000000000596

A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity

Autores: Joshua D. Ooi, Jhih-Hang Jiang, Peter J. Eggenhuizen, Ling L. Chua, Mirjan van Timmeren, Khai L. Loh, Kim M. O’Sullivan, Poh Y. Gan, Yong Zhong, Kirill Tsyganov, Lani R. Shochet, Jessica Ryan, Coen A. Stegeman, Lars Fugger, Hugh H. Reid, Jamie Rossjohn, Peter Heeringa, Stephen R. Holdsworth, Anton Y. Peleg, A. Richard Kitching
Publicado en: Nature Communications, Edición 10/1, 2019, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-019-11255-0

Cathepsin S inhibition combines control of systemic and peripheral pathomechanisms of autoimmune tissue injury

Autores: Maia Tato, Santhosh V. Kumar, Yajuan Liu, Shrikant R. Mulay, Solange Moll, Bastian Popper, Jonathan N. Eberhard, Dana Thomasova, Arne Christian Rufer, Sabine Gruner, Wolfgang Haap, Guido Hartmann, Hans-Joachim Anders
Publicado en: Scientific Reports, Edición 7/1, 2017, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-017-01894-y

Chemokine receptor co-expression reveals aberrantly distributed TH effector memory cells in GPA patients

Autores: Lucas L. Lintermans, Abraham Rutgers, Coen A. Stegeman, Peter Heeringa, Wayel H. Abdulahad
Publicado en: Arthritis Research & Therapy, Edición 19/1, 2017, Página(s) 136, ISSN 1478-6362
Editor: BioMed Central
DOI: 10.1186/s13075-017-1343-8

Towards precision medicine in ANCA-associated vasculitis

Autores: Kornelis S M van der Geest, Elisabeth Brouwer, Jan-Stephan Sanders, Maria Sandovici, Nicolaas A Bos, Annemieke M H Boots, Wayel H Abdulahad, Coen A Stegeman, Cees G M Kallenberg, Peter Heeringa, Abraham Rutgers
Publicado en: Rheumatology, 2017, Página(s) 1332, ISSN 1462-0324
Editor: Oxford University Press
DOI: 10.1093/rheumatology/kex367

Kv1.3 Channel Blockade Modulates the Effector Function of B Cells in Granulomatosis with Polyangiitis

Autores: Judith Land, Lucas L. Lintermans, Coen A. Stegeman, Ernesto J. Muñoz-Elías, Eric J. Tarcha, Shawn P. Iadonato, Peter Heeringa, Abraham Rutgers, Wayel H. Abdulahad
Publicado en: Frontiers in Immunology, Edición 8, 2017, Página(s) 1205, ISSN 1664-3224
Editor: Frontiers Research Foundation
DOI: 10.3389/fimmu.2017.01205

Remote Activation of a Latent Epitope in an Autoantigen Decoded with Simulated B-Factors

Autores: Yuan-Ping Pang; Marta Casal Moura; Gwen E. Thompson; Amber M. Hummel; Darlene R. Nelson; Dieter E. Jenne; Ulrich Specks
Publicado en: Frontiers in Immunology, Edición 1, 2019, ISSN 1664-3224
Editor: Frontiers in Immunology
DOI: 10.1101/559963

Discovery and Quantification of Nonhuman Proteins in Human Milk

Autores: Jing Zhu, Luc Garrigues, Henk Van den Toorn, Bernd Stahl, Albert J. R. Heck
Publicado en: Journal of Proteome Research, 2018, ISSN 1535-3893
Editor: American Chemical Society
DOI: 10.1021/acs.jproteome.8b00550

Deviation of antigen presentation through (auto)antibodies

Autores: Kain R.
Publicado en: Séminaire Hospitalo-Universitaire de Strasbourg, Edición 20/09/2018, 2018
Editor: Université de Strasbourg

Update on Immune Mechanisms in Systemic Lupus and Lupus Nephritis

Autores: Satish Kumar Devarapu, Hans-Joachim Anders, Khader Valli Rupanagudi
Publicado en: 2016
Editor: Omics International

"""RELENT""Less on Target - von molekularen Mechanismen zur Präzisionsmedizin"

Autores: Renate Kain
Publicado en: Mitteilungen der Deutschen Gesellschaft für Nephrologie, Edición 2, 2016, Página(s) 20-23
Editor: Deutschen Gesellschaft für Nephrologie

Systemische Vaskulitiden verstehen

Autores: Renate Kain, Reno Barth
Publicado en: Medical Tribune Online, 2016, Página(s) 1
Editor: Medical Tribune

A new role of LAMP-2 in macroautophagy

Autores: Hubert V.
Publicado en: Edición 14/11/2017, 2017
Editor: Medical University Vienna

ISN Nexus 2016 Symposia: Translational Immunology in Kidney Disease—The Berlin Roadmap

Autores: Hans-Joachim Anders, Brad Rovin, David Jayne, Paul Brunetta, Rosanna Coppo, Anne Davidson, Satish Kumar Devarapu, Dick de Zeeuw, Jeremy Duffield, Dirk Eulberg, Alberto Fierro, Jürgen Floege, Steffen Frese, Loïc Guillevin, Stephen Holdsworth, Jeremy Hughes, Ralph Kettritz, Malte Kluger, Christian Krebs, Larissa Lapteva, Adeera Levin, Jinhua Li, Liz Lightstone, Matthias Mack, Ladan Mansouri, Steph
Publicado en: Kidney International Reports, Edición 1/4, 2016, Página(s) 327-339, ISSN 2468-0249
Editor: Elsevier Inc.
DOI: 10.1016/j.ekir.2016.06.009

The Role of Macroautophagy in T Cells

Autores: Wei Jia, Ian McLeod, Ming-Xiao He, You-Wen He
Publicado en: Immunology, 2018, Página(s) 23-33, ISBN 9780-128098196
Editor: Elsevier
DOI: 10.1016/b978-0-12-809819-6.00003-4

Isolation of exosomes from body fluids by differential ultracentrifugation

Autores: Schulz S, Schachner H, Rees AJ, Kain R.
Publicado en: Poster, 2019
Editor: 15th YSA PhD Symposium

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