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In Vivo Spectral Photon Counting CT Molecular Imaging in Cardio- and Neuro-Vascular Diseases

Deliverables

Project handbook and internal platform

Project handbook and internal platform

Preliminary exploitation strategy

Preliminary exploitation strategy based on mid-term results

Identification of the sensitivity threshold for the preparation of SPCCT contrast agents

Identification of the sensitivity threshold for the preparation of SPCCT contrast agents

Selection of the most promising nanoparticles to be used as contrast agents for SPCCT

Selection of the most promising nanoparticles to be used as contrast agents for SPCCT

Report of results on small animals

Report of results of SPCCT and selected contrast agents for Atherosclerotic Plaque Characterization and Thrombus, Stroke and Myocardial Infarction morphological and functional evaluation in small animals

Functionalization of the nanoparticles for targeting relevant biomarkers

Functionalization of the nanoparticles for targeting relevant biomarkers in the diseases of interest in the project. Main cellular and in vivo tests

Ethics report on pre-clinical studies

Ethics report and documents (including due authorisations) on pre-clinical studies

Communication plan and dissemination strategy

Communication plan and dissemination strategy towards all the identified stakeholder

management report 1

management report, detailing and monitoring all management/internal coordination activities of the first period

Comprehensive overview of current care of imaging atherosclerotic patients in four major European countries

Comprehensive overview of current care of imaging atherosclerotic patients in four major European countries

Mid-term open Workshop

Mid-term open Workshop on results of project phase 1, announcing project phase 2

Press release 1

Press release 1, announcing the start of the project

Press release 2

Press release 2 – results at mid-term

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Publications

Experimental feasibility of spectral photon-counting computed tomography with two contrast agents for the detection of endoleaks following endovascular aortic repair

Author(s): Julia Dangelmaier, Daniel Bar-Ness, Heiner Daerr, Daniela Muenzel, Salim Si-Mohamed, Sebastian Ehn, Alexander A. Fingerle, Melanie A. Kimm, Felix K. Kopp, Loic Boussel, Ewald Roessl, Franz Pfeiffer, Ernst J. Rummeny, Roland Proksa, Philippe Douek, Peter B. Noël
Published in: European Radiology, Issue 28/8, 2018, Page(s) 3318-3325, ISSN 0938-7994
DOI: 10.1007/s00330-017-5252-7

Synthesis of High Relaxivity Gadolinium AAZTA Tetramers as Building Blocks for Bioconjugation

Author(s): Martina Tripepi, Federico Capuana, Eliana Gianolio, Flávio Vinicius Crizóstomo Kock, Amerigo Pagoto, Rachele Stefania, Giuseppe Digilio, Silvio Aime
Published in: Bioconjugate Chemistry, Issue 29/4, 2018, Page(s) 1428-1437, ISSN 1043-1802
DOI: 10.1021/acs.bioconjchem.8b00120

Nonlinear material decomposition using a regularized iterative scheme based on the Bregman distance

Author(s): J F P J Abascal, N Ducros, F Peyrin
Published in: Inverse Problems, Issue 34/12, 2018, Page(s) 124003, ISSN 0266-5611
DOI: 10.1088/1361-6420/aae1e7

Hybrid Nano-GdF3 contrast media allows pre-clinical in vivo element-specific K-edge imaging and quantification

Author(s): Niki Halttunen, Frederic Lerouge, Frederic Chaput, Marc Vandamme, Szilvia Karpati, Salim Si-Mohamed, Monica Sigovan, Loic Boussel, Emmanuel Chereul, Philippe Douek, Stephane Parola
Published in: Scientific Reports, Issue 9/1, 2019, Page(s) Sci Rep 9, 12090 (2019), ISSN 2045-2322
DOI: 10.1038/s41598-019-48641-z

Evaluation of a preclinical photon-counting CT prototype for pulmonary imaging

Author(s): Felix K. Kopp, Heiner Daerr, Salim Si-Mohamed, Andreas P. Sauter, Sebastian Ehn, Alexander A. Fingerle, Bernhard Brendel, Franz Pfeiffer, Ewald Roessl, Ernst J. Rummeny, Daniela Pfeiffer, Roland Proksa, Philippe Douek, Peter B. Noël
Published in: Scientific Reports, Issue 8/1, 2018, Page(s) 2018; 8: 17386., ISSN 2045-2322
DOI: 10.1038/s41598-018-35888-1

Simultaneous dual-contrast multi-phase liver imaging using spectral photon-counting computed tomography: a proof-of-concept study

Author(s): Daniela Muenzel, Heiner Daerr, Roland Proksa, Alexander A. Fingerle, Felix K. Kopp, Philippe Douek, Julia Herzen, Franz Pfeiffer, Ernst J. Rummeny, Peter B. Noël
Published in: European Radiology Experimental, Issue 1/1, 2017, Page(s) 2017;1(1):25., ISSN 2509-9280
DOI: 10.1186/s41747-017-0030-5

Differentiation between blood and iodine in a bovine brain—Initial experience with Spectral Photon-Counting Computed Tomography (SPCCT)

Author(s): Isabelle Riederer, Salim Si-Mohamed, Sebastian Ehn, Daniel Bar-Ness, Peter B. Noël, Alexander A. Fingerle, Franz Pfeiffer, Ernst J. Rummeny, Philippe Douek, Daniela Pfeiffer
Published in: PLOS ONE, Issue 14/2, 2019, Page(s) e0212679, ISSN 1932-6203
DOI: 10.1371/journal.pone.0212679

Liquid Embolic Agents in Spectral X-Ray Photon-Counting Computed Tomography using Tantalum K-Edge Imaging

Author(s): Isabelle Riederer, Daniel Bar-Ness, Melanie A. Kimm, Salim Si-Mohamed, Peter B. Noël, Ernst J. Rummeny, Philippe Douek, Daniela Pfeiffer
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
DOI: 10.1038/s41598-019-41737-6

Tomodensitométrie spectrale : de la double énergie à la multiénergie

Author(s): S.A. Si-Mohamed, P.C. Douek, L. Boussel
Published in: Journal d'imagerie diagnostique et interventionnelle, Issue 2/1, 2019, Page(s) 32-45, ISSN 2543-3431
DOI: 10.1016/j.jidi.2018.11.004

Effect of Gold Nanoparticle Size on Their Properties as Contrast Agents for Computed Tomography

Author(s): Yuxi C. Dong, Maryam Hajfathalian, Portia S. N. Maidment, Jessica C. Hsu, Pratap C. Naha, Salim Si-Mohamed, Marine Breuilly, Johoon Kim, Peter Chhour, Philippe Douek, Harold I. Litt, David P. Cormode
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
DOI: 10.1038/s41598-019-50332-8

Spectral Photon-Counting Computed Tomography for Coronary Stent Imaging


Published in: ISSN 0020-9996
DOI: 10.1097/rli.0000000000000610

Spectral Photon-Counting Computed Tomography (SPCCT): in-vivo single-acquisition multi-phase liver imaging with a dual contrast agent protocol

Author(s): Salim Si-Mohamed, Valérie Tatard-Leitman, Alexis Laugerette, Monica Sigovan, Daniela Pfeiffer, Ernst J. Rummeny, Philippe Coulon, Yoad Yagil, Philippe Douek, Loic Boussel, Peter B. Noël
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
DOI: 10.1038/s41598-019-44821-z

Spectral Photon-counting CT: Initial Experience with Dual–Contrast Agent K-Edge Colonography

Author(s): Daniela Muenzel, Daniel Bar-Ness, Ewald Roessl, Ira Blevis, Matthias Bartels, Alexander A. Fingerle, Stefan Ruschke, Philippe Coulon, Heiner Daerr, Felix K. Kopp, Bernhard Brendel, Axel Thran, Michal Rokni, Julia Herzen, Loic Boussel, Franz Pfeiffer, Roland Proksa, Ernst J. Rummeny, Philippe Douek, Peter B. Noël
Published in: Radiology, Issue 283/3, 2017, Page(s) 723-728, ISSN 0033-8419
DOI: 10.1148/radiol.2016160890

ChromAIX2: A large area, high count-rate energy-resolving photon counting ASIC for a Spectral CT Prototype

Author(s): Roger Steadman, Christoph Herrmann, Amir Livne
Published in: Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Issue 862, 2017, Page(s) 18-24, ISSN 0168-9002
DOI: 10.1016/j.nima.2017.05.010

Evaluation of spectral photon counting computed tomography K-edge imaging for determination of gold nanoparticle biodistribution in vivo

Author(s): Salim Si-Mohamed, David P. Cormode, Daniel Bar-Ness, Monica Sigovan, Pratap C. Naha, Jean-Baptiste Langlois, Lara Chalabreysse, Philippe Coulon, Ira Blevis, Ewald Roessl, Klaus Erhard, Loic Boussel, Philippe Douek
Published in: Nanoscale, 2017, ISSN 2040-3364
DOI: 10.1039/C7NR01153A

Multicolor spectral photon-counting computed tomography: in vivo dual contrast imaging with a high count rate scanner

Author(s): David P. Cormode, Salim Si-Mohamed, Daniel Bar-Ness, Monica Sigovan, Pratap C. Naha, Joelle Balegamire, Franck Lavenne, Philippe Coulon, Ewald Roessl, Matthias Bartels, Michal Rokni, Ira Blevis, Loic Boussel, Philippe Douek
Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
DOI: 10.1038/s41598-017-04659-9

Review of an initial experience with an experimental spectral photon-counting computed tomography system

Author(s): Salim Si-Mohamed, Daniel Bar-Ness, Monica Sigovan, David P. Cormode, Philippe Coulon, Emmanuel Coche, Alain Vlassenbroek, Gabrielle Normand, Loic Boussel, Philippe Douek
Published in: Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2017, ISSN 0168-9002
DOI: 10.1016/j.nima.2017.04.014

Experimental evaluation of the influence of scattered radiation on quantitative spectral CT imaging

Author(s): Klaus Erhard, Artur Sossin, Axel Thran, Michal Rokni, Bernhard Brendel, Heiner Daerr
Published in: Medical Imaging 2018: Physics of Medical Imaging, 2018, Page(s) 46
DOI: 10.1117/12.2293476

A sparse and prior based method for 3D image denoising

Author(s): J. F. P. J. Abascal, S. Si-Mohamed, P. Douek, C. Chappard, F. Peyrin
Published in: 2019 27th European Signal Processing Conference (EUSIPCO), 2019, Page(s) 1-5
DOI: 10.23919/eusipco.2019.8902564

Human Knee Phantom for Spectral CT: Validation of a Material Decomposition Algorithm

Author(s): S. Bussod, J.F.P.J. Abascal, N. Ducros, C. Olivier, S. Si-Mohamed, P. Douek, C. Chappard, F. Peyrin
Published in: 2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI 2019), 2019, Page(s) 1170-1173
DOI: 10.1109/isbi.2019.8759192

Experimental feasibility of dual contrast agent based spectral photon-counting computed tomografy for detection of endoleaks following EVAR

Author(s): J Dangelmaier, D Bar-Ness, D Münzel, H Daerr, F Pfeiffer, R Proksa, E Rummeny, P Douek, P Noël
Published in: RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, Issue 189/S 01, 2017, Page(s) S1-S124
DOI: 10.1055/s-0037-1600231

Assessment of candidate elements for development of spectral photon-counting CT specific contrast agents

Author(s): Johoon Kim, Daniel Bar-Ness, Salim Si-Mohamed, Philippe Coulon, Ira Blevis, Philippe Douek, David P. Cormode
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
DOI: 10.1038/s41598-018-30570-y

Comparison of five one-step reconstruction algorithms for spectral CT


Published in: ISSN 1361-6560
DOI: 10.1088/1361-6560/aaeaf2