In Vivo Spectral Photon Counting CT Molecular Imaging in Cardio- and Neuro-Vascular Diseases

Livrables

Project handbook and internal platform
Contrast agent particles leads optimization and upscale development
Preliminary exploitation strategy

Preliminary exploitation strategy based on midterm results

Identification of the sensitivity threshold for the preparation of SPCCT contrast agents
Final exploitation strategy report
Selection of the most promising nanoparticles to be used as contrast agents for SPCCT
Report of results on small animals

Report of results of SPCCT and selected contrast agents for Atherosclerotic Plaque Characterization and Thrombus, Stroke and Myocardial Infarction morphological and functional evaluation in small animals

Report of results on large animals

Report of results of SPCCT and selected contrast agents for Atherosclerotic Plaque Characterization and Thrombus Stroke and Myocardial Infarction morphological and functional evaluation in large animals

Functionalization of the nanoparticles for targeting relevant biomarkers

Functionalization of the nanoparticles for targeting relevant biomarkers in the diseases of interest in the project. Main cellular and in vivo tests

Ethics report on pre-clinical studies

Ethics report and documents (including due authorisations) on pre-clinical studies

Communication plan and dissemination strategy

Communication plan and dissemination strategy towards all the identified stakeholder

management report 1

management report, detailing and monitoring all management/internal coordination activities of the first period

Biodistribution of the contrast agent with active targeting to tropoelastin

Upscale synthesis and biodistribution profile of a selected tropoelastin-targeted contrast agent, and assessment of its potential for further clinical/industrial translation

Report of preliminary results in human

Report of preliminary results on SPCCT capabilities in human for carotid arteries (lumen and plaque) and stroke analysis

Comprehensive overview of current care of imaging atherosclerotic patients in four major European countries

Mid-term open Workshop

Mid-term open Workshop on results of project phase 1, announcing project phase 2

Press release 1

Press release 1, announcing the start of the project

Final press release
Press release 2

Press release 2 – results at mid-term

Project website

Publications

Multicolor spectral photon counting CT monitors and quantifies therapeutic cells and their encapsulating scaffold in a model of brain damage

Auteurs: Elisa Cuccione, Peter Chhour, Salim Si-Mohamed, Chloé Dumot, Johoon Kim, Violaine Hubert, Claire Crola Da Silva, Marc Vandamme, Emmanuel Chereul, Joëlle Balegamire, Yves Chevalier, Yves Berthezène, Loïc Boussel, Philippe Douek, David P. Cormode, Marlène Wiart
Publié dans: Nanotheranostics, Numéro 4/3, 2020, Page(s) 129-141, ISSN 2206-7418
Éditeur: Nanotheranostics
DOI: 10.7150/ntno.45354

Tropoelastin

Auteurs: Alkystis Phinikaridou, Sara Lacerda, Begoña Lavin, Marcelo E. Andia, Alberto Smith, Prakash Saha, René M. Botnar
Publié dans: Circulation: Cardiovascular Imaging, Numéro 11/8, 2018, ISSN 1941-9651
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circimaging.117.007303

European survey on acute coronary syndrome diagnosis and revascularisation treatment: Assessing differences in reported clinical practice with a focus on strategies for specific patient cases

Auteurs: Anne‐Claire Peultier, Dimitrios Venetsanos, Imran Rashid, Johan L. Severens, William K. Redekop
Publié dans: Journal of Evaluation in Clinical Practice, Numéro 26/5, 2020, Page(s) 1457-1466, ISSN 1356-1294
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/jep.13333

Spectral photon-counting CT imaging of colorectal peritoneal metastases: initial experience in rats

Auteurs: Arnaud Thivolet, Salim Si-Mohamed, Pierre-Emmanuel Bonnot, Christophe Blanchet, Vahan Képénékian, Loïc Boussel, Philippe Douek, Pascal Rousset
Publié dans: Scientific Reports, Numéro 10/1, 2020, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-020-70282-w

Iodinated polymer nanoparticles as contrast agent for spectral photon counting computed tomography

Auteurs: Joëlle Balegamire, Marc Vandamme, Emmanuel Chereul, Salim Si-Mohamed, Samira Azzouz Maache, Eyad Almouazen, Laurent Ettouati, Hatem Fessi, Loïc Boussel, Philippe Douek, Yves Chevalier
Publié dans: Biomaterials Science, Numéro 8/20, 2020, Page(s) 5715-5728, ISSN 2047-4830
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d0bm01046d

Feasibility of lung imaging with a large field-of-view spectral photon-counting CT system

Auteurs: Salim Si-Mohamed, Sara Boccalini, Pierre-Antoine Rodesch, Riham Dessouky, Elias Lahoud, Thomas Broussaud, Monica Sigovan, Delphine Gamondes, Philippe Coulon, Yoad Yagil, Loïc Boussel, Philippe Douek
Publié dans: Diagnostic and Interventional Imaging, Numéro 102/5, 2021, Page(s) 305-312, ISSN 2211-5684
Éditeur: Elsevier Masson
DOI: 10.1016/j.diii.2021.01.001

Material Decomposition in Spectral CT Using Deep Learning: A Sim2Real Transfer Approach

Auteurs: Juan F. P. J. Abascal, Nicolas Ducros, Valeriya Pronina, Simon Rit, Pierre-Antoine Rodesch, Thomas Broussaud, Suzanne Bussod, Philippe C. Douek, Andreas Hauptmann, Simon Arridge, Francoise Peyrin
Publié dans: IEEE Access, Numéro 9, 2021, Page(s) 25632-25647, ISSN 2169-3536
Éditeur: Institute of Electrical and Electronics Engineers Inc.
DOI: 10.1109/access.2021.3056150

What are the images used to diagnose and assess suspected strokes?: A systematic literature review of care in four European countries

Auteurs: Anne-Claire Peultier, Ken Redekop, Emmanuel Coche, Johan L Severens
Publié dans: Expert Review of Pharmacoeconomics & Outcomes Research, Numéro 18/2, 2017, Page(s) 177-189, ISSN 1473-7167
Éditeur: Future Drugs Ltd.
DOI: 10.1080/14737167.2018.1429270

Experimental feasibility of spectral photon-counting computed tomography with two contrast agents for the detection of endoleaks following endovascular aortic repair

Auteurs: Julia Dangelmaier, Daniel Bar-Ness, Heiner Daerr, Daniela Muenzel, Salim Si-Mohamed, Sebastian Ehn, Alexander A. Fingerle, Melanie A. Kimm, Felix K. Kopp, Loic Boussel, Ewald Roessl, Franz Pfeiffer, Ernst J. Rummeny, Roland Proksa, Philippe Douek, Peter B. Noël
Publié dans: European Radiology, Numéro 28/8, 2018, Page(s) 3318-3325, ISSN 0938-7994
Éditeur: Springer Verlag
DOI: 10.1007/s00330-017-5252-7

Synthesis of High Relaxivity Gadolinium AAZTA Tetramers as Building Blocks for Bioconjugation

Auteurs: Martina Tripepi, Federico Capuana, Eliana Gianolio, Flávio Vinicius Crizóstomo Kock, Amerigo Pagoto, Rachele Stefania, Giuseppe Digilio, Silvio Aime
Publié dans: Bioconjugate Chemistry, Numéro 29/4, 2018, Page(s) 1428-1437, ISSN 1043-1802
Éditeur: American Chemical Society
DOI: 10.1021/acs.bioconjchem.8b00120

Nonlinear material decomposition using a regularized iterative scheme based on the Bregman distance

Auteurs: J F P J Abascal, N Ducros, F Peyrin
Publié dans: Inverse Problems, Numéro 34/12, 2018, Page(s) 124003, ISSN 0266-5611
Éditeur: Institute of Physics Publishing
DOI: 10.1088/1361-6420/aae1e7

Assessment of candidate elements for development of spectral photon-counting CT specific contrast agents

Auteurs: Johoon Kim, Daniel Bar-Ness, Salim Si-Mohamed, Philippe Coulon, Ira Blevis, Philippe Douek, David P. Cormode
Publié dans: Scientific Reports, Numéro 8/1, 2018, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-018-30570-y

Hybrid Nano-GdF3 contrast media allows pre-clinical in vivo element-specific K-edge imaging and quantification

Auteurs: Niki Halttunen, Frederic Lerouge, Frederic Chaput, Marc Vandamme, Szilvia Karpati, Salim Si-Mohamed, Monica Sigovan, Loic Boussel, Emmanuel Chereul, Philippe Douek, Stephane Parola
Publié dans: Scientific Reports, Numéro 9/1, 2019, Page(s) Sci Rep 9, 12090 (2019), ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-019-48641-z

Evaluation of a preclinical photon-counting CT prototype for pulmonary imaging

Auteurs: Felix K. Kopp, Heiner Daerr, Salim Si-Mohamed, Andreas P. Sauter, Sebastian Ehn, Alexander A. Fingerle, Bernhard Brendel, Franz Pfeiffer, Ewald Roessl, Ernst J. Rummeny, Daniela Pfeiffer, Roland Proksa, Philippe Douek, Peter B. Noël
Publié dans: Scientific Reports, Numéro 8/1, 2018, Page(s) 2018; 8: 17386., ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-018-35888-1

Simultaneous dual-contrast multi-phase liver imaging using spectral photon-counting computed tomography: a proof-of-concept study

Auteurs: Daniela Muenzel, Heiner Daerr, Roland Proksa, Alexander A. Fingerle, Felix K. Kopp, Philippe Douek, Julia Herzen, Franz Pfeiffer, Ernst J. Rummeny, Peter B. Noël
Publié dans: European Radiology Experimental, Numéro 1/1, 2017, Page(s) 2017;1(1):25., ISSN 2509-9280
Éditeur: European Radiology Experimental
DOI: 10.1186/s41747-017-0030-5

Improved Peritoneal Cavity and Abdominal Organ Imaging Using a Biphasic Contrast Agent Protocol and Spectral Photon Counting Computed Tomography K-Edge Imaging

Auteurs: Salim Si-Mohamed, Arnaud Thivolet, Pierre-Emmanuel Bonnot, Daniel Bar-Ness, Vahan Képénékian, David P. Cormode, Philippe Douek, Pascal Rousset
Publié dans: Investigative Radiology, Numéro 53/10, 2018, Page(s) 629-639, ISSN 0020-9996
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/rli.0000000000000483

Differentiation between blood and iodine in a bovine brain—Initial experience with Spectral Photon-Counting Computed Tomography (SPCCT)

Auteurs: Isabelle Riederer, Salim Si-Mohamed, Sebastian Ehn, Daniel Bar-Ness, Peter B. Noël, Alexander A. Fingerle, Franz Pfeiffer, Ernst J. Rummeny, Philippe Douek, Daniela Pfeiffer
Publié dans: PLOS ONE, Numéro 14/2, 2019, Page(s) e0212679, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0212679

Liquid Embolic Agents in Spectral X-Ray Photon-Counting Computed Tomography using Tantalum K-Edge Imaging

Auteurs: Isabelle Riederer, Daniel Bar-Ness, Melanie A. Kimm, Salim Si-Mohamed, Peter B. Noël, Ernst J. Rummeny, Philippe Douek, Daniela Pfeiffer
Publié dans: Scientific Reports, Numéro 9/1, 2019, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-019-41737-6

Tomodensitométrie spectrale : de la double énergie à la multiénergie

Auteurs: S.A. Si-Mohamed, P.C. Douek, L. Boussel
Publié dans: Journal d'imagerie diagnostique et interventionnelle, Numéro 2/1, 2019, Page(s) 32-45, ISSN 2543-3431
Éditeur: ELSEVIER
DOI: 10.1016/j.jidi.2018.11.004

Effect of Gold Nanoparticle Size on Their Properties as Contrast Agents for Computed Tomography

Auteurs: Yuxi C. Dong, Maryam Hajfathalian, Portia S. N. Maidment, Jessica C. Hsu, Pratap C. Naha, Salim Si-Mohamed, Marine Breuilly, Johoon Kim, Peter Chhour, Philippe Douek, Harold I. Litt, David P. Cormode
Publié dans: Scientific Reports, Numéro 9/1, 2019, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-019-50332-8

Spectral Photon-Counting Computed Tomography for Coronary Stent Imaging

Auteurs: Grischa Bratke, Tilman Hickethier, Daniel Bar-Ness, Alexander Christian Bunck, David Maintz, Gregor Pahn, Philippe Coulon, Salim Si-Mohamed, Philippe Douek, Monica Sigovan
Publié dans: Investigative Radiology, Numéro 55/2, 2020, Page(s) 61-67, ISSN 0020-9996
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/rli.0000000000000610

Spectral Photon-Counting Computed Tomography (SPCCT): in-vivo single-acquisition multi-phase liver imaging with a dual contrast agent protocol

Auteurs: Salim Si-Mohamed, Valérie Tatard-Leitman, Alexis Laugerette, Monica Sigovan, Daniela Pfeiffer, Ernst J. Rummeny, Philippe Coulon, Yoad Yagil, Philippe Douek, Loic Boussel, Peter B. Noël
Publié dans: Scientific Reports, Numéro 9/1, 2019, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-019-44821-z

Spectral Photon-counting CT: Initial Experience with Dual–Contrast Agent K-Edge Colonography

Auteurs: Daniela Muenzel, Daniel Bar-Ness, Ewald Roessl, Ira Blevis, Matthias Bartels, Alexander A. Fingerle, Stefan Ruschke, Philippe Coulon, Heiner Daerr, Felix K. Kopp, Bernhard Brendel, Axel Thran, Michal Rokni, Julia Herzen, Loic Boussel, Franz Pfeiffer, Roland Proksa, Ernst J. Rummeny, Philippe Douek, Peter B. Noël
Publié dans: Radiology, Numéro 283/3, 2017, Page(s) 723-728, ISSN 0033-8419
Éditeur: Radiological Society of North America
DOI: 10.1148/radiol.2016160890

ChromAIX2: A large area, high count-rate energy-resolving photon counting ASIC for a Spectral CT Prototype

Auteurs: Roger Steadman, Christoph Herrmann, Amir Livne
Publié dans: Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Numéro 862, 2017, Page(s) 18-24, ISSN 0168-9002
Éditeur: Elsevier BV
DOI: 10.1016/j.nima.2017.05.010

Evaluation of spectral photon counting computed tomography K-edge imaging for determination of gold nanoparticle biodistribution in vivo

Auteurs: Salim Si-Mohamed, David P. Cormode, Daniel Bar-Ness, Monica Sigovan, Pratap C. Naha, Jean-Baptiste Langlois, Lara Chalabreysse, Philippe Coulon, Ira Blevis, Ewald Roessl, Klaus Erhard, Loic Boussel, Philippe Douek
Publié dans: Nanoscale, 2017, ISSN 2040-3364
Éditeur: Royal Society of Chemistry
DOI: 10.1039/C7NR01153A

Multicolor spectral photon-counting computed tomography: in vivo dual contrast imaging with a high count rate scanner

Auteurs: David P. Cormode, Salim Si-Mohamed, Daniel Bar-Ness, Monica Sigovan, Pratap C. Naha, Joelle Balegamire, Franck Lavenne, Philippe Coulon, Ewald Roessl, Matthias Bartels, Michal Rokni, Ira Blevis, Loic Boussel, Philippe Douek
Publié dans: Scientific Reports, Numéro 7/1, 2017, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-017-04659-9

Review of an initial experience with an experimental spectral photon-counting computed tomography system

Auteurs: Salim Si-Mohamed, Daniel Bar-Ness, Monica Sigovan, David P. Cormode, Philippe Coulon, Emmanuel Coche, Alain Vlassenbroek, Gabrielle Normand, Loic Boussel, Philippe Douek
Publié dans: Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2017, ISSN 0168-9002
Éditeur: Elsevier BV
DOI: 10.1016/j.nima.2017.04.014

Feasibility of spectral computed tomography to assess knee cartilage

Auteurs: C. Chappard, J. Abascal, S. Bussod, S. Uk, S. Si-Mohamed, P. Douek, F. Peyrin
Publié dans: Osteoarthritis and Cartilage, Numéro 28, 2020, Page(s) S277-S278, ISSN 1063-4584
Éditeur: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.joca.2020.02.442

Tropoelastin: an in vivo imaging marker of dysfunctional matrix turnover during abdominal aortic dilation

Auteurs: Begoña Lavin, Sara Lacerda, Marcelo E Andia, Silvia Lorrio, Robert Bakewell, Alberto Smith, Imran Rashid, René M Botnar, Alkystis Phinikaridou
Publié dans: Cardiovascular Research, 2019, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1093/cvr/cvz178

In Vivo Molecular K-Edge Imaging of Atherosclerotic Plaque Using Photon-counting CT

Auteurs: Salim A. Si-Mohamed, Monica Sigovan, Jessica C. Hsu, Valérie Tatard-Leitman, Lara Chalabreysse, Pratap C. Naha, Thibaut Garrivier, Riham Dessouky, Miruna Carnaru, Loic Boussel, David P. Cormode, Philippe C. Douek
Publié dans: Radiology, Numéro 300/1, 2021, Page(s) 98-107, ISSN 0033-8419
Éditeur: Radiological Society of North America
DOI: 10.1148/radiol.2021203968

What stroke image do we want? European survey on acute stroke imaging and revascularisation treatment

Auteurs: Anne-Claire Peultier, William K. Redekop, Diederik W.J. Dippel, Daniel Bereczki, Salim Si-Mohamed, Philippe C. Douek, Johan L. Severens
Publié dans: Health Policy and Technology, Numéro 8/3, 2019, Page(s) 261-267, ISSN 2211-8837
Éditeur: Elsevier BV
DOI: 10.1016/j.hlpt.2019.08.005

Comparison of five one-step reconstruction algorithms for spectral CT

Auteurs: Cyril Mory, Bruno Sixou, Salim Si-Mohamed, Loïc Boussel, Simon Rit
Publié dans: Physics in Medicine & Biology, Numéro 63/23, 2018, Page(s) 235001, ISSN 1361-6560
Éditeur: iopSience
DOI: 10.1088/1361-6560/aaeaf2

Generalized least squares for spectral and dual energy CT: a simulation study

Auteurs: Cyril Mory, Bernhard Brendel, Klaus Erhard, Simon Rit
Publié dans: Fifth international conference on image formation in X-ray computed tomography, 2018
Éditeur: Fifth international conference on image formation in X-ray computed tomography

Experimental evaluation of the influence of scattered radiation on quantitative spectral CT imaging

Auteurs: Klaus Erhard, Artur Sossin, Axel Thran, Michal Rokni, Bernhard Brendel, Heiner Daerr
Publié dans: Medical Imaging 2018: Physics of Medical Imaging, 2018, Page(s) 46, ISBN 9781-510616363
Éditeur: SPIE
DOI: 10.1117/12.2293476

A sparse and prior based method for 3D image denoising

Auteurs: J. F. P. J. Abascal, S. Si-Mohamed, P. Douek, C. Chappard, F. Peyrin
Publié dans: 2019 27th European Signal Processing Conference (EUSIPCO), 2019, Page(s) 1-5, ISBN 978-9-0827-9703-9
Éditeur: IEEE
DOI: 10.23919/eusipco.2019.8902564

Human Knee Phantom for Spectral CT: Validation of a Material Decomposition Algorithm

Auteurs: S. Bussod, J.F.P.J. Abascal, N. Ducros, C. Olivier, S. Si-Mohamed, P. Douek, C. Chappard, F. Peyrin
Publié dans: 2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI 2019), 2019, Page(s) 1170-1173, ISBN 978-1-5386-3641-1
Éditeur: IEEE
DOI: 10.1109/isbi.2019.8759192

Experimental feasibility of dual contrast agent based spectral photon-counting computed tomografy for detection of endoleaks following EVAR

Auteurs: J Dangelmaier, D Bar-Ness, D Münzel, H Daerr, F Pfeiffer, R Proksa, E Rummeny, P Douek, P Noël
Publié dans: RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, Numéro 189/S 01, 2017, Page(s) S1-S124
Éditeur: RoFo
DOI: 10.1055/s-0037-1600231

Spatially varying regularization weights for one-step spectral CT with SQS

Auteurs: Pierre-Antoine Rodesch, Si-Mohamed Salim, Simon Rit
Publié dans: Sixth international conference on image formation in X-ray computed tomography, 2020
Éditeur: Sixth international conference on image formation in X-ray computed tomography

Tracking cells in the brain of small animals using synchrotron multi-spectral phase contrast imaging

Auteurs: Clément Tavakoli, Elisa Cuccione, Chloe Dumot, David P. Cormode, Marlène Wiart, Hélène Elleaume, Emmanuel Brun
Publié dans: Medical Imaging 2021: Physics of Medical Imaging, Numéro Proceedings Volume 11595, 2021, Page(s) 164, ISBN 9781510640207
Éditeur: SPIE
DOI: 10.1117/12.2580841

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